LOCUS       NM_023058               1920 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus protein kinase, membrane associated tyrosine/threonine
            1 (Pkmyt1), transcript variant 1, mRNA.
ACCESSION   NM_023058
VERSION     NM_023058.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Yang,L., Wang,H., Guo,M., He,M., Zhang,W., Zhan,M. and Liu,Y.
  TITLE     ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling
            pathway in gallbladder cancer
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1085-1095 (2023)
   PUBMED   36988891
  REMARK    GeneRIF: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1
            signaling pathway in gallbladder cancer.
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Oh,J.S., Susor,A. and Conti,M.
  TITLE     Protein tyrosine kinase Wee1B is essential for metaphase II exit in
            mouse oocytes
  JOURNAL   Science 332 (6028), 462-465 (2011)
   PUBMED   21454751
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Oh,J.S., Han,S.J. and Conti,M.
  TITLE     Wee1B, Myt1, and Cdc25 function in distinct compartments of the
            mouse oocyte to control meiotic resumption
  JOURNAL   J Cell Biol 188 (2), 199-207 (2010)
   PUBMED   20083600
REFERENCE   8  (bases 1 to 1920)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122821.4.
            
            On Mar 21, 2023 this sequence version replaced NM_023058.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165164.1, AK158550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC122821.4         136871-137051       c
            182-669             AC122821.4         130688-131175       c
            670-1163            AC122821.4         129196-129689       c
            1164-1270           AC122821.4         128440-128546       c
            1271-1443           AC122821.4         128140-128312       c
            1444-1601           AC122821.4         127792-127949       c
            1602-1679           AC122821.4         127111-127188       c
            1680-1920           AC122821.4         126777-127017       c
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.02 cM"
     gene            1..1920
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /note="protein kinase, membrane associated
                     tyrosine/threonine 1"
                     /db_xref="GeneID:268930"
                     /db_xref="MGI:MGI:2137630"
     exon            1..181
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..669
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1791
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; MYT1
                     kinase; membrane-associated tyrosine- and
                     threonine-specific cdc2-inhibitory kinase"
                     /codon_start=1
                     /product="membrane-associated tyrosine- and
                     threonine-specific cdc2-inhibitory kinase isoform 1"
                     /protein_id="NP_075545.2"
                     /db_xref="CCDS:CCDS28460.1"
                     /db_xref="GeneID:268930"
                     /db_xref="MGI:MGI:2137630"
                     /translation="MTMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPGGLSRSLPP
                     RPPAKGCIPVSRLFPPRTPGWHQPQPRRVSFLCETSEPLQSPGYDPSRPESFFQQNFQ
                     RLSRLGHGSYGEVFKVRSKEDGRLYAVKRYMSPFRGPKDRTRKLAEVGGHEKVGQHPH
                     CVRLERAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLALDHLHSQ
                     GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGSAGAGEAQEGDPRYMAPELLQGSYGT
                     AADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLAMMLEPD
                     PQLRATAEALLALPMLRQPRPWNVLWYMAAEALSRGWALWQALVTLLCWLWHGLVHPA
                     SWLQPPGPPATPPGSPPCSPLLDSTLSSSWDNDSIGPSLSPETVLSRITRRTSTPRGR
                     YIPRDALDLTDVDSEPPRGPCPTFEPRNLLSLFEDSLDPA"
     exon            670..1163
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1270
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1443
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1601
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1679
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1920
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /note="hexamer: AATAAA"
     polyA_site      1920
                     /gene="Pkmyt1"
                     /gene_synonym="6230424P17; Myt1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgttcac gggcggttcc ccttcttgga gggtgcttcg tcccggtgtc cagaggcccc
       61 gctgcccgac cccggcctgc ctggcctctg tgaggtcccc agcggccccc gccgacccgg
      121 aacctgggac ctcgctgctg cgccacgctg cgccacgctg cgccacgccc agcctcccca
      181 ggtacttgtg gcccacacga ccttcatgtg gacaatacaa cgtgtgtgtg gcaaagaagt
      241 ggctctcttg tgggccacag gaccaagtgc tgtttgagtg gacacattgc tttgtgctcg
      301 gatcctttag cgttggccat gaccatgccc accgagggca ccccaccacc cctaagtggt
      361 acccccatcc cagttccagc ttacttccga cacgcagagc ctggtttctc cctcaaaagg
      421 cctgggggcc tcagtcggag cctcccacct cggccccctg ccaagggctg catccctgtc
      481 agccgtctat tcccccctcg caccccaggc tggcaccagc cccagccccg gagggtgtct
      541 ttcctgtgtg agacctcaga gcccctgcag agtcctgggt atgacccgag ccggcccgag
      601 tccttctttc agcagaactt ccagaggctc agccgcctgg gtcatggctc atatggagaa
      661 gtcttcaagg tgcgctctaa ggaagatggg cgactctatg ctgttaagcg ctacatgtcg
      721 ccattccgcg gccccaaaga ccgaactcgt aaactggctg aggtaggtgg ccatgagaaa
      781 gtggggcagc atccacactg cgtgagactg gagcgggcct gggaggaggg tggcatccta
      841 tacctgcaga cagaactctg cgggcccagc ctgcagcaac actgtgaagc ctggggggcc
      901 agcctgccag aggcccaggt ctggggctac ttgcgggaca ttcttctggc tctggaccat
      961 ctacatagtc aaggcctagt tcaccttgat gtcaagcctg ccaacatctt cttgggcccc
     1021 cggggccgct gcaagctggg cgactttgga ctactggtgg agctgggttc agccggtgct
     1081 ggcgaggccc aggagggaga tcctcgctac atggccccag aactgctgca gggctcttat
     1141 gggacagcag cagatgtgtt cagtctgggt ctcaccatct tggaagtggc ctgtaacatg
     1201 gaactgcccc atggtgggga gggctggcag cagctgcgcc agggatactt gccccctgag
     1261 ttcactgctg gtctgtcttc tgagctgcgt tctgtcctcg ccatgatgct ggagcctgac
     1321 ccccagcttc gagccacagc tgaggccctg ttggccttac ccatgctgag gcagccacgt
     1381 ccctggaatg ttctgtggta tatggctgcg gaagccctaa gtcgaggctg ggccctgtgg
     1441 caggccctgg tcactctgct ctgctggctc tggcacgggc tggtgcatcc tgccagttgg
     1501 ctgcagcctc caggcccacc ggccacacca cctggctctc caccttgcag ccccctcctg
     1561 gacagcaccc tctccagcag ctgggataat gacagcatag gtccctcact ctccccagag
     1621 accgtcctgt cccggatcac tagaagaacc tctacccctc ggggcaggta catacctagg
     1681 gatgccctgg acctaactga tgtggactca gagcctccaa gaggtccctg ccccaccttt
     1741 gagccaagga acctcctcag cctgtttgag gactccctag acccagcctg agcacaggcc
     1801 cagccagcct tggtgctttt aaacctctga ccgtcttgcc cacctctccc ctgaaacttc
     1861 cgtgtctaat aaaaagtaat gcgtcttggg aacacccaag gttgctcatg tggcagcata
//
