LOCUS       NM_011105               7058 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus polycystin (PKD) family receptor for egg jelly
            (Pkdrej), mRNA.
ACCESSION   NM_011105
VERSION     NM_011105.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7058)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   2  (bases 1 to 7058)
  AUTHORS   Asai,Y., Holt,J.R. and Geleoc,G.S.
  TITLE     A quantitative analysis of the spatiotemporal pattern of transient
            receptor potential gene expression in the developing mouse cochlea
  JOURNAL   J Assoc Res Otolaryngol 11 (1), 27-37 (2010)
   PUBMED   19834762
REFERENCE   3  (bases 1 to 7058)
  AUTHORS   Lechner,S.G., Frenzel,H., Wang,R. and Lewin,G.R.
  TITLE     Developmental waves of mechanosensitivity acquisition in sensory
            neuron subtypes during embryonic development
  JOURNAL   EMBO J 28 (10), 1479-1491 (2009)
   PUBMED   19322198
REFERENCE   4  (bases 1 to 7058)
  AUTHORS   Sutton,K.A., Jungnickel,M.K. and Florman,H.M.
  TITLE     A polycystin-1 controls postcopulatory reproductive selection in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8661-8666 (2008)
   PUBMED   18562295
  REMARK    GeneRIF: Pkdrej controls the timing of fertilization in vivo
            through effects on sperm transport and exocytotic competence and is
            a factor in postcopulatory sexual selection.
REFERENCE   5  (bases 1 to 7058)
  AUTHORS   LopezJimenez,N.D., Cavenagh,M.M., Sainz,E., Cruz-Ithier,M.A.,
            Battey,J.F. and Sullivan,S.L.
  TITLE     Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1,
            are co-expressed in a subset of taste receptor cells
  JOURNAL   J Neurochem 98 (1), 68-77 (2006)
   PUBMED   16805797
REFERENCE   6  (bases 1 to 7058)
  AUTHORS   Butscheid,Y., Chubanov,V., Steger,K., Meyer,D., Dietrich,A. and
            Gudermann,T.
  TITLE     Polycystic kidney disease and receptor for egg jelly is a plasma
            membrane protein of mouse sperm head
  JOURNAL   Mol Reprod Dev 73 (3), 350-360 (2006)
   PUBMED   16261614
REFERENCE   7  (bases 1 to 7058)
  AUTHORS   Hughes,J., Ward,C.J., Aspinwall,R., Butler,R. and Harris,P.C.
  TITLE     Identification of a human homologue of the sea urchin receptor for
            egg jelly: a polycystic kidney disease-like protein
  JOURNAL   Hum Mol Genet 8 (3), 543-549 (1999)
   PUBMED   9949214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117784.13.
            
            On Oct 6, 2006 this sequence version replaced NM_011105.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7058              AC117784.13        155821-162878       c
FEATURES             Location/Qualifiers
     source          1..7058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.42 cM"
     gene            1..7058
                     /gene="Pkdrej"
                     /note="polycystin (PKD) family receptor for egg jelly"
                     /db_xref="GeneID:18766"
                     /db_xref="MGI:MGI:1338786"
     exon            1..7058
                     /gene="Pkdrej"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..6381
                     /gene="Pkdrej"
                     /note="receptor for egg jelly-like protein; polycystic
                     kidney disease and receptor for egg jelly-related protein;
                     PKD and REJ homolog; polycystic kidney disease
                     (polycystin) and REJ (sperm receptor for egg jelly
                     homolog, sea urchin); polycystin family receptor for egg
                     jelly"
                     /codon_start=1
                     /product="polycystin family receptor for egg jelly
                     precursor"
                     /protein_id="NP_035235.2"
                     /db_xref="CCDS:CCDS27723.1"
                     /db_xref="GeneID:18766"
                     /db_xref="MGI:MGI:1338786"
                     /translation="MWPGPALLLLGLGLGLGSQPPPTGPRGLPGVLRGAPGLGQGAES
                     SVRGGDTGGLSPRAAPRHASPTPPRRCPSGAAARVLLKVNSSDPAAAKANVSCQTAPC
                     IMQPVKINRKDQNAPLILSRDEEATLNITVRWYCPDALVIRKSWVYFSVASVNDTPDW
                     NRPVLLPQVAVSKGFSLHIPKYALPYGVYVFNFTLSIFRWDLAWPTVTGSDIIYIWVR
                     KRPLKAVLLGAPRVTVKFSDELILNGSMSYDPEADIPTWGLQFFWYCTTNPRYYSGNY
                     VLVINQAVCHPEQDSLNWPWAVGSVLTIPPKTLRGNGVYYFRMVVQKQNRTAFSDKTV
                     HVLQGLQPKAHISCIENCGPTLGVSDRFSLFLNCPSCGRQDLYSWSILSLTGHEVMFD
                     WAGQAITRRNGPYLSIKAFAFRNFLENRVWVSLILKSWSGMTTTLRHPVVINHGPRVG
                     KCKINPASGISMVTKFAVECSDFKDENLPLKYKIIVSELDSIGAISSVEENTLGSVVY
                     SGAEPITPAFFLPVGTVTDEYNVRLYVQVYDSLGTFSQVTLQATVTAPTVRDSSKDVL
                     QQLLNVTMKPTSLLSTLLQKQDWLQAGYLTYVVISVLNNIKGEQELQDDRARLLEHLV
                     KQSLTFAMNTADEIGQSVMVITKLTQKASDLSQADLEATSFRLRQASQDLQEYQHRHK
                     HLQQVEVVGTGILTSLSNLLKLINPYYTLQDPLFVVESLSDTILANKVPGSKTTALRT
                     SNFNMYVEKVENWNVFKAFRNDSLCPNCLRATLNASTVPRLPAKAPISMMFCEFADDP
                     FPWLTYPENISVDVVGFRMTGVADNNKVIEITPDIAEVYLVRKDLTPSSFNLTVGPGI
                     KSDGFSKVTTGGISFEVDSRWTGELLIHIVTNVTVLFEALVYEGCQLTPTNLMATFLV
                     PNDIPPIVKWSGLFDPTCSVKEARVVCLSSSLLRSIAQRRFSFKYNISMVLQASRFVL
                     KPTNKLVRIALFMVHCLDMYGIQSDWQQSTCVLGEKTTWKTVHCVCRNGRRSRRQLTS
                     VKLTYHHLHTHFVTAKVIVVPNPVDLRLAIISNLTQNPATFLAVLFIMILYAILAFWA
                     LHRDVIDLYFRDNVVILTDNDPFDTLCYLVTIFTGSRWGSGTRANVFIQLMGTEGTSD
                     VHCLSHPYFKTLYRGSINTFLLTTKNDLGDIHSIRVWHDNSGEAPSWYLSRIKVENLF
                     NKRIWLFVCRRWLSVDTTLDATFSVTNPDEPLKRTDFFMIDVRDKLRKNHMWISIFTE
                     IVPKPFNRLQRLSCCLAMLLSSLVCNIMFFNLNQKEKIESRHMHIIRSMLIGIESVVI
                     TIPVQLLITFFFTYSQKNLKMNLDKVAPQKHPLMSEEGLSWKERLHKWHEYEMKALPR
                     RAAVSTSAPEEKEAFETSQKHEKADTQMSNKNSSNNNQEASEGVPPKAFSSQPHTTES
                     VQKKTQIILPRWCVYIAWFLVFATSGISSFFIVFYGVTYGYAKSIEWLFASFCSFCQS
                     VFLVQPCNILLRSGTRSYKPKYCKNLSWSSKYHYSEIRLQGLTMTQEEMEQLHEDIAY
                     VRSLSMYQPITEDKIQILRRENRIRRRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSF
                     YYNQFIRHRFSVDLATVMKLGDIYTWLHGVFLPLLHNDPNPTFLPDSSSKILGLPLVR
                     QVRARPSNKTCLLAKKFVQSSVAGEIHCHPQYGIDPEDTQHYSSVWSKAGKQSTDKAS
                     HGFTYKPPGKRWVYHSYGVLNTYGSGGYVFYFFPGQQMFNSTVRLKELEGKNWLDELT
                     WAVIVELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTSSEIYLYA
                     AILIFFCAYVVDEGYIIRQERASYIRSVYNLLNFSLKCMFALLIVLFFWKYFLATKMV
                     QLYLADPEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAA
                     LPGICHTALVVSIYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSG
                     NKVLGVLFLSSFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCNRLK
                     SGFDFLTTRSRDKDQSNFFVDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV"
ORIGIN      
        1 atgtggccgg gccccgcgct gctgctcctg ggcctgggcc tgggtctagg cagccagccg
       61 ccacccaccg gccctcgcgg gctgccgggc gtgctcaggg gcgccccggg gttggggcag
      121 ggcgcggaga gcagcgtccg gggcggtgac accgggggcc tgtccccgcg tgcagccccg
      181 cgccacgcca gccctacgcc gccccgtagg tgtccctcgg gcgcagctgc acgcgtcctc
      241 ctgaaagtca actcttcgga ccccgcagcc gccaaggcta acgtgtcctg ccagacggcc
      301 ccctgtatca tgcagccagt gaagatcaac aggaaggacc agaacgctcc ccttatcctg
      361 agcagagacg aggaagccac cctcaatatc actgtgcgtt ggtactgtcc tgatgccttg
      421 gtcattcgca agagctgggt gtacttttcg gtggcctctg tgaacgacac ccctgattgg
      481 aaccgacctg tgctcttgcc gcaggtggca gtgtctaagg gtttctccct ccacatcccc
      541 aaatatgccc tgccttacgg ggtgtatgtg tttaacttta cgctgtccat cttcaggtgg
      601 gacctcgcct ggcccacggt gacaggctcg gatatcatct acatttgggt tagaaaacgc
      661 cccctgaagg ctgttcttct tggagccccc agagtaaccg tgaagttctc cgatgaactg
      721 attctgaatg gaagcatgtc ctacgaccca gaggcagaca tccccacatg gggactccag
      781 tttttttggt attgtaccac aaatccaaga tactatagtg gcaactatgt attagtgatc
      841 aaccaggctg tctgccaccc agagcaggat tcactgaact ggccttgggc agtgggctct
      901 gtactaacca ttccaccaaa aactcttagg ggcaatggtg tgtattactt cagaatggtg
      961 gtacagaagc aaaacagaac tgcattttct gataaaactg tacacgtgct ccaggggctt
     1021 cagcccaagg cacacatttc ctgcattgaa aattgtggcc ccacgttagg tgtgtcagat
     1081 agattttctc tgtttctgaa ctgcccaagt tgtggccgcc aggatttgta tagctggtcc
     1141 attttgtctc taacgggcca tgaagtgatg tttgactggg cagggcaagc aatcaccagg
     1201 aggaatggac cttatttgtc cataaaagct tttgccttta ggaatttttt ggaaaatagg
     1261 gtttgggttt ccctgattct gaaatcttgg agtggtatga ccacgacctt gagacatccc
     1321 gttgtcatta accatggccc tcgagttggc aaatgcaaga taaatccagc tagtgggatt
     1381 tccatggtta ctaaatttgc tgttgaatgt agtgatttta aggatgagaa ccttcccctt
     1441 aagtataaaa taatagtatc tgagttggac agcattggcg cgatcagttc cgtagaagag
     1501 aatacactgg gttccgtggt gtattcaggg gcagagccga taacaccagc cttctttctc
     1561 cctgtcggta cggtgacaga tgagtacaat gtgaggcttt atgttcaggt ctatgactcc
     1621 ttagggacat tttctcaagt gactttgcaa gcgactgtga cggcacctac tgtcagggac
     1681 tcttcaaagg atgttttaca acagctgctc aacgtcacca tgaaaccgac gtcactgttg
     1741 tctaccttgc ttcaaaagca ggactggcta caggctggct acttaaccta tgtggtgatt
     1801 tctgtcttga ataacataaa aggggagcag gaacttcaag atgacagagc ccgtctcctg
     1861 gagcacctcg tcaaacagtc tctcacgttt gctatgaaca cagcggatga gatcggtcag
     1921 tcggtgatgg tgattaccaa attaacccag aaagcctctg acttgagtca agcggattta
     1981 gaggccacct cgttccggct taggcaagca agccaagacc tacaagaata ccagcacaga
     2041 cacaagcacc ttcagcaggt tgaagttgtg ggcactggca tcctaaccag tctgtctaac
     2101 cttcttaagc tgattaatcc ctactatacg ttacaagatc ctttgtttgt agtcgaatca
     2161 ctatcagaca caatactggc taacaaggtt ccggggagca agaccactgc tctgaggacc
     2221 agtaacttta acatgtatgt ggagaaagtt gaaaactgga atgtttttaa ggccttcaga
     2281 aatgattcac tctgtccaaa ctgcctccgt gcgacactga acgcaagcac ggtccccagg
     2341 ctacccgcaa aggctccgat ttctatgatg ttttgtgagt tcgcagacga cccctttcct
     2401 tggttgactt acccggaaaa catttctgta gatgtggttg ggttcaggat gactggagtc
     2461 gcagataaca ataaggtcat agagatcaca cccgacatag cagaagtgta cctggtcaga
     2521 aaagatctga ccccttcgag ttttaacctt acggtgggac ccggcattaa aagcgatggg
     2581 ttctcaaagg tgacaacggg tggaattagc tttgaggtag acagcaggtg gactggggag
     2641 ctactcattc acattgtcac aaatgtgaca gtgttgtttg aggccttggt atatgaaggc
     2701 tgtcagctca cgcccaccaa tctgatggcc actttccttg ttcctaatga catccctccc
     2761 attgtcaagt ggagtggcct gtttgaccca acctgttcag tcaaggaggc ccgcgtggtt
     2821 tgtctgtcat catccctgct tcgaagcata gctcagcgca gattttcatt caagtataac
     2881 atatccatgg tcctgcaggc atcgcgtttt gtcctgaagc ccactaacaa gctagtgaga
     2941 attgctctct ttatggttca ctgtttggac atgtatggga tccagagtga ttggcaacaa
     3001 agtacctgcg tgctgggtga gaagaccacg tggaaaacag tacactgtgt ctgtaggaat
     3061 ggaaggcgga gccggcggca gctgacttct gtgaagctga cctaccatca tctgcacacc
     3121 cactttgtga ctgctaaggt aattgtggtc cctaaccccg tggatctgag gctagcgatc
     3181 attagtaacc ttacccaaaa ccctgcgact ttcctggccg tgcttttcat tatgatcttg
     3241 tatgcaattc tggctttctg ggccttgcac agggatgtga tagatctgta ttttcgggac
     3301 aatgtggtaa tactgactga taatgatcct tttgataccc tatgctatct agtaaccatc
     3361 tttactggga gtcgctgggg gtctggaacc agagccaatg tttttatcca gcttatggga
     3421 acggagggta ccagtgatgt tcactgttta agccatccat attttaaaac cctataccga
     3481 ggaagtatca atactttcct cctgacaaca aaaaatgact tgggggatat ccattccatc
     3541 cgagtgtggc atgacaattc gggcgaagca cctagctggt acctaagtcg aatcaaagta
     3601 gaaaatctct tcaacaagcg catttggctt tttgtgtgcc ggaggtggct ctctgtggac
     3661 accactttgg atgcaacgtt ttctgtcacc aacccggatg agcctctgaa aaggacagac
     3721 ttcttcatga ttgatgtgag ggataagctt cggaagaacc acatgtggat ctccattttc
     3781 acggaaattg tccccaaacc attcaacagg ctccagaggc tgtcctgctg cttggccatg
     3841 ctgctaagct ctcttgtttg caatatcatg ttttttaact tgaaccaaaa ggagaaaatt
     3901 gagtccagac acatgcacat tatcaggtca atgctgatag gcatcgagag cgtcgtaatc
     3961 acaatccccg tgcaattact gataactttt ttcttcacct attcccagaa gaatcttaaa
     4021 atgaatctag acaaagtggc accccagaag caccccctga tgtcagagga aggtctgtcc
     4081 tggaaagagc gattgcacaa atggcatgaa tatgaaatga aggctctccc caggagagct
     4141 gccgtgtcca cctctgctcc cgaggaaaag gaagcctttg aaacctcaca gaagcatgag
     4201 aaagcagaca cccaaatgtc caataagaac agcagtaaca ataaccaaga agccagtgaa
     4261 ggtgtccctc cgaaagcttt ctcttcccaa ccgcatacta ctgagtctgt tcaaaagaag
     4321 acccagatta tcctgcccag gtggtgtgtt tacatagcct ggtttttggt gtttgccact
     4381 tccggtatat cgtcattctt tattgtattt tacggcgtga cttacggcta tgccaagtca
     4441 atagagtggc tctttgcgtc gttctgttcc ttctgtcagt ctgtgttcct cgtacaacca
     4501 tgcaatattc tcctgaggtc aggcaccagg agctacaagc ccaagtactg taagaacctc
     4561 tcgtggtcca gcaagtacca ttactcagaa atcaggctgc aggggttgac gatgacacag
     4621 gaggagatgg agcagcttca tgaggacatc gcctacgtcc gaagcttgag catgtaccag
     4681 cccatcactg aggacaaaat ccagatcctc aggcgggaga acaggatccg gaggaggtcc
     4741 ttcttgttcc tgagctacct cgtgactcac ttcatattcc tgacccttct cctgttgctc
     4801 attttctcac tgcgccacaa cgacagcttc tactataacc agtttattcg ccatcggttc
     4861 tccgtggatc tcgccactgt gatgaagctg ggagatatct acacctggct ccacggcgtg
     4921 ttcctccctt tgttacacaa tgacccaaac ccaacattcc ttccggacag ctcttctaaa
     4981 atccttggcc ttccgcttgt gaggcaagtg agggccagac ctagcaacaa gacgtgtctg
     5041 ttggccaaga agtttgtaca gagcagcgtt gcaggggaaa tccattgtca cccacagtac
     5101 ggcattgacc cagaagacac acaacactat tccagtgtct ggagtaaggc tggcaagcag
     5161 tcaacagaca aagctagcca tgggtttact tataagcctc cggggaaaag atgggtgtat
     5221 cattcctatg gagtactaaa cacctatgga tctggagggt atgtgttcta cttctttcca
     5281 ggacagcaga tgtttaattc tacagtgagg ctcaaggaac tcgagggaaa gaattggctg
     5341 gatgagttga catgggccgt gattgtggaa ctgaccactc tgaatccaga caccagtctg
     5401 atgtgtagca tttcggttgt attcgaagtc tctcccttag gggttgtcaa ctctagcctt
     5461 tctgtgtact ccttctcgct ggctgacttc aacagaaaaa cctcgtcaga aatctacctc
     5521 tacgccgcca ttcttatttt cttttgtgcc tatgttgtgg acgagggcta catcatcagg
     5581 caagagaggg cttcctacat aaggagtgtg tacaacctgc tcaacttctc tctcaagtgc
     5641 atgttcgctc tcctgatagt gcttttcttc tggaagtact tcctggccac caaaatggtc
     5701 cagctttacc ttgctgaccc cgaagccttc attcccttcc atgccgtttc tcgggttgac
     5761 cacttcatga gaatcatctt ggctttcctg ttgtttctga ccatactgaa gacactcaga
     5821 tattccaggt tcttctataa tgtgcgcctg gctcagaagg ccatccaggc tgcccttcct
     5881 ggcatctgcc acacggcttt ggtggtgtct atatattcct tcatgtacgt agcttttggg
     5941 tacttggtgt tcggtcagca tgaatggaat tacagcaata tgattcacgc cacccaaacc
     6001 atcttctcct actgcgtgtc agcctttcag aacacagaat tttccggcaa caaggttctc
     6061 ggggtcctgt ttctgtcgtc tttcatgttg gtgatgatct gtatcttcat caacttgttt
     6121 caggcagtga ttctgtctgc ctatgatgag atgaagcagc ctgtgtacga ggagccgtct
     6181 gatgaggccg aggctgtaac ctatctgtgc aacaggctaa aatctgggtt tgactttctc
     6241 accacccgat ctagagacaa agaccaatcc aacttcttcg tcgacatgct ctatgggcag
     6301 ccggagaaga atactcgccg gttcctggga ctgaaggcca gaaatatcaa cgggaagaaa
     6361 atgatttacc ttgttgtctg attaatgacg gtcaggaggg ccacaagcaa agagtgtccc
     6421 aaacatgact tatgtttctc aaggggacta aagagtgcct gatggctcag tcaagctcac
     6481 ctccacatct gaagtatccc cacgctgggc cctgctcttg ggaacaagaa catgaacaga
     6541 gaggcaaatc aggggagaga agtggatggc aaggtgggac tctctctgga tgggattctg
     6601 cgactcctgg tccagaggca gagctccttt tgtgggagct tgcagcagtg gggaagagtg
     6661 gcagccgctc actttgagac ccagcttcaa gggaaagagc tggccaggtc ccatcatgga
     6721 ttaagccaca gcccagcagc ctctaaacag aaacagactg gtcagcctcc ctggaagtct
     6781 cctctgcaga ccatgcctgg gaagcgtctc ttcaagtcct cctgcaggcc agggctagag
     6841 gggatcctgt gggggagttc cagagcttgc tttaagagtt tgagaatgca gagacgagag
     6901 agcaggggac aaggacctga agcgtcctgt cccactttaa ctccctcagg gcgtagaaga
     6961 acaagggctg acagttgtta ccttgttact cagaagcacg tgccttgatg ttgacgccac
     7021 ttttaagttt tatatgaatt aaatttgaga tttcttct
//
