LOCUS       NM_134117               2455 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein kinase domain containing, cytoplasmic (Pkdcc),
            transcript variant 1, mRNA.
ACCESSION   NM_134117 XM_128778
VERSION     NM_134117.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Mohammed,J., Arora,N., Matthews,H.S., Hansen,K., Bader,M.,
            Walsh,S., Shaffer,J.R., Weinberg,S.M., Swigut,T., Claes,P.,
            Selleri,L. and Wysocka,J.
  TITLE     A common cis-regulatory variant impacts normal-range and
            disease-associated human facial shape through regulation of PKDCC
            during chondrogenesis
  JOURNAL   Elife 13, e82564 (2024)
   PUBMED   38483448
  REMARK    GeneRIF: A common cis-regulatory variant impacts normal-range and
            disease-associated human facial shape through regulation of PKDCC
            during chondrogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Pantasis,S., Friemel,J., Brutsch,S.M., Hu,Z., Krautbauer,S.,
            Liebisch,G., Dengjel,J., Weber,A., Werner,S. and Bordoli,M.R.
  TITLE     Vertebrate lonesome kinase modulates the hepatocyte secretome to
            prevent perivascular liver fibrosis and inflammation
  JOURNAL   J Cell Sci 135 (7) (2022)
   PUBMED   35293576
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Probst,S., Kraemer,C., Demougin,P., Sheth,R., Martin,G.R.,
            Shiratori,H., Hamada,H., Iber,D., Zeller,R. and Zuniga,A.
  TITLE     SHH propagates distal limb bud development by enhancing
            CYP26B1-mediated retinoic acid clearance via AER-FGF signalling
  JOURNAL   Development 138 (10), 1913-1923 (2011)
   PUBMED   21471156
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Kinoshita,M., Era,T., Jakt,L.M. and Nishikawa,S.
  TITLE     The novel protein kinase Vlk is essential for stromal function of
            mesenchymal cells
  JOURNAL   Development 136 (12), 2069-2079 (2009)
   PUBMED   19465597
  REMARK    GeneRIF: Vlk is a novel vertebrate-specific PK that is involved in
            the regulation of the rate of protein export from the Golgi,
            thereby playing an important role in the formation of functional
            stroma by mesenchymal cells.
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   9  (bases 1 to 2455)
  AUTHORS   Imuta,Y., Nishioka,N., Kiyonari,H. and Sasaki,H.
  TITLE     Short limbs, cleft palate, and delayed formation of flat
            proliferative chondrocytes in mice with targeted disruption of a
            putative protein kinase gene, Pkdcc (AW548124)
  JOURNAL   Dev Dyn 238 (1), 210-222 (2009)
   PUBMED   19097194
  REMARK    GeneRIF: These data indicate that Pkdcc encodes a protein kinase
            that is required for the appropriate timing of flat proliferative
            chondrocytes differentiation.
REFERENCE   10 (bases 1 to 2455)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122406.5.
            
            On Nov 16, 2022 this sequence version replaced NM_134117.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB436780.1, AB381893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               AC122406.5         81921-82746
            827-949             AC122406.5         86676-86798
            950-1221            AC122406.5         87608-87879
            1222-1301           AC122406.5         88432-88511
            1302-1406           AC122406.5         88768-88872
            1407-1580           AC122406.5         90425-90598
            1581-2455           AC122406.5         90834-91708
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 52.25 cM"
     gene            1..2455
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /note="protein kinase domain containing, cytoplasmic"
                     /db_xref="GeneID:106522"
                     /db_xref="MGI:MGI:2147077"
     exon            1..826
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1666
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vertebrate lonesome kinase; protein kinase-like
                     protein SgK493; sugen kinase 493; protein kinase
                     domain-containing protein, cytoplasmic; extracellular
                     tyrosine-protein kinase PKDCC"
                     /codon_start=1
                     /product="extracellular tyrosine-protein kinase PKDCC
                     isoform 1 precursor"
                     /protein_id="NP_598878.2"
                     /db_xref="CCDS:CCDS28994.2"
                     /db_xref="GeneID:106522"
                     /db_xref="MGI:MGI:2147077"
                     /translation="MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPGSSAA
                     PGPGRRGGRGELARQIRERYEEVQRYSRGGPGPGAGRPERRRLMDLAPGGPGLQRPRP
                     PRVRSPPDGAPGWPPAPGPGSPGPGPRLGCAALRNVSGAQYVGSGYTKAVYRVRLPGG
                     AAVALKAVDFSGHDLGSCVREFGARRGCYRLAAHKLLKEMVLLERLRHPNVLQLYGYC
                     YQDSEGIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTL
                     LDFRPRQFVLVNGELKVTDLDDARVEETPCTSSADCTLEFPARNFSLPCSAQGWCEGM
                     NEKRNLYNAYRFFFTYLLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLETALHLF
                     RSGQYLQNSTSSRAEYQRIPDSAITQEDYRCWPSYHHGGCLLSVFNLAEAIDVCESHA
                     QCRAFVVTNQTTWTGRKLVFFKTGWNQVVPDAGKTTYVKAPG"
     exon            827..949
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1221
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1301
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1406
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1580
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2455
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Pkdcc"
                     /gene_synonym="Adtk1; ESTM17; MAd1; Sgk493; Vlk"
                     /note="major polyA site"
ORIGIN      
        1 aggcaagtgt caggccgatg tgccgcccgc cgggggccgg ggtcggggct gcccgggcca
       61 tgcgcgcggg ctgggcaggg ggccggcgcg gcgcgaagcc gagtcgcctc ggagcctgag
      121 ccgcccgggg ccggggccgg ggccggggcc ggggagcggc gcgcggccgg ccggggggag
      181 gggagcgatg cggcgccggc gggcggccgt ggccgctggt ttctgcgcct ccttcctgct
      241 gggctccgtc ctcaacgtgc tcttcgcacc gggctcggag cctccgcggc caggccagtc
      301 cccggggtcc tcggcagccc cgggcccggg ccgtcgcggg ggccgtgggg agctggcccg
      361 gcagatccgg gagcgctacg aggaggtgca gcgctattcc cgcggggggc cggggccggg
      421 agcgggccgg ccagagcggc ggcgcctgat ggacctggct ccgggcgggc cgggcctgca
      481 gcgtccccgg cccccgcggg tccggtcccc gcccgacggc gctccgggct ggccccctgc
      541 tcccggcccg ggctcccccg gcccgggccc gcgcctaggc tgcgccgcgc tccgcaacgt
      601 gtctggcgcg cagtacgtgg gctcaggcta cactaaggct gtgtaccggg tccgcctgcc
      661 cggcggcgcc gcggtggcgc ttaaagcagt ggacttcagc ggccacgatc tgggcagctg
      721 cgtgcgcgag ttcggggcgc gaaggggctg ctatcgcctg gcggcccaca agctgctcaa
      781 agagatggtg ctgctggagc ggctgcggca ccccaacgtg ctgcagctct atggctattg
      841 ctaccaggac agtgagggca tcccagacac gctgaccacc atcacagagc tgggtgcccc
      901 tgtggagatg atccagctgt tgcagacttc ctgggaggat cgattccgaa tctgcctcag
      961 ccttggccgc ctcctccacc acctggccca ctccccgctg ggctcggtca ccctgcttga
     1021 cttccgccct cggcagtttg tgctagtgaa cggggagctg aaagtgacag acctggatga
     1081 tgcccgcgtg gaagagacac cgtgcaccag cagtgccgac tgcacgctag agtttccagc
     1141 caggaacttc agcctgccct gctcggccca gggctggtgc gagggcatga atgagaaacg
     1201 gaacctctac aatgcctaca ggttcttctt cacatacctc ctgccacaca gtgccccgcc
     1261 ttccctccga cctctcctgg atagcatcgt caatgccacg ggagagctcg cctggggggt
     1321 ggatgagacc ctggcccagc tggagacagc gctacacttg ttccgaagtg ggcagtacct
     1381 gcagaactct acaagcagca gggctgagta ccagcgcatc ccggacagtg ccatcacaca
     1441 ggaggactat cgctgctggc catcctatca ccacggcggc tgcctcctgt ccgtgttcaa
     1501 cctggctgag gctatagatg tctgtgagag ccatgctcag tgtcgtgcct ttgtggtcac
     1561 caaccagacc acctggacag gtcggaagct ggtctttttt aagactggat ggaaccaagt
     1621 ggtccctgat gccggcaaga ccacatatgt gaaggcccct ggttgactgg ttgtgggctc
     1681 agctgaccag ctgggcttgc ctgctgcagg cgtgacttgc atcccacctg ggaacccctg
     1741 cagacaaaag ctagctccca gagcaactga tgtgaccagg acaaaacgtg caatatgcaa
     1801 aaatgttaaa atgtgagttt gccagcttca gtcccagact ggttggaacc cgattgcctc
     1861 tctggagctg taggctgtga gcagggctca ggctggtctt aactgggaca gtcccgtggg
     1921 cagcccatta ctgcattcat gctttgagaa tgtagccaga acactgctgc tgcataagcc
     1981 accgtgggca ggagctgcct ggggacaacc agtctcagag tgctctctca gctcagctcc
     2041 gctccaaatg gagagcgcgg gatgcggaga tgtgagtgaa ccagcactgg gaagaaggct
     2101 ctcgggcctc tccctagagg ttgctcctag gccagccccg aggccgtggg cagcagtgct
     2161 cgcatccata tgagccaaga ctagagtgga ggagcagatt gcatttgagc caggactggg
     2221 gtgggggtag ggtcggggcc tctctgcctc atttgctttc agtgaaagcc agggagcagc
     2281 cgcagccagg ctcctcccac tcctggaggc caggctcctc cccctcctgg aggccaggct
     2341 cctccccctc ctggagtttg cgtacccaga agcttttata cttctcgttc attaaattgt
     2401 ttatttttgt aaaaaaaaaa attaatcaat taataaaatg atgttttgtg acaaa
//
