LOCUS       NM_016927               2461 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus polycystic kidney disease 2-like 2 (Pkd2l2),
            transcript variant 1, mRNA.
ACCESSION   NM_016927
VERSION     NM_016927.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Wu,X., Indzhykulian,A.A., Niksch,P.D., Webber,R.M.,
            Garcia-Gonzalez,M., Watnick,T., Zhou,J., Vollrath,M.A. and
            Corey,D.P.
  TITLE     Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice
  JOURNAL   PLoS One 11 (5), e0155577 (2016)
   PUBMED   27196058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   Kaja,S., Hilgenberg,J.D., Rybalchenko,V., Medina-Ortiz,W.E.,
            Gregg,E.V. and Koulen,P.
  TITLE     Polycystin-2 expression and function in adult mouse lacrimal acinar
            cells
  JOURNAL   Invest Ophthalmol Vis Sci 52 (8), 5605-5611 (2011)
   PUBMED   21508103
  REMARK    GeneRIF: All channel-forming isoforms of TRPP channels
            (polycystin-2, polycystin-L, and polycystin-2L2) were expressed in
            adult mouse lacrimal gland.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   Asai,Y., Holt,J.R. and Geleoc,G.S.
  TITLE     A quantitative analysis of the spatiotemporal pattern of transient
            receptor potential gene expression in the developing mouse cochlea
  JOURNAL   J Assoc Res Otolaryngol 11 (1), 27-37 (2010)
   PUBMED   19834762
REFERENCE   7  (bases 1 to 2461)
  AUTHORS   Lechner,S.G., Frenzel,H., Wang,R. and Lewin,G.R.
  TITLE     Developmental waves of mechanosensitivity acquisition in sensory
            neuron subtypes during embryonic development
  JOURNAL   EMBO J 28 (10), 1479-1491 (2009)
   PUBMED   19322198
REFERENCE   8  (bases 1 to 2461)
  AUTHORS   Chen,Y., Zhang,Z., Lv,X.Y., Wang,Y.D., Hu,Z.G., Sun,H., Tan,R.Z.,
            Liu,Y.H., Bian,G.H., Xiao,Y., Li,Q.W., Yang,Q.T., Ai,J.Z., Feng,L.,
            Yang,Y., Wei,Y.Q. and Zhou,Q.
  TITLE     Expression of Pkd2l2 in testis is implicated in spermatogenesis
  JOURNAL   Biol Pharm Bull 31 (8), 1496-1500 (2008)
   PUBMED   18670078
  REMARK    GeneRIF: Pkd2l2 may be involved in the mid-late stage of
            spermatogenesis through modulation of the intracellular calcium
            concentration.
REFERENCE   9  (bases 1 to 2461)
  AUTHORS   LopezJimenez,N.D., Cavenagh,M.M., Sainz,E., Cruz-Ithier,M.A.,
            Battey,J.F. and Sullivan,S.L.
  TITLE     Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1,
            are co-expressed in a subset of taste receptor cells
  JOURNAL   J Neurochem 98 (1), 68-77 (2006)
   PUBMED   16805797
REFERENCE   10 (bases 1 to 2461)
  AUTHORS   Guo,L., Schreiber,T.H., Weremowicz,S., Morton,C.C., Lee,C. and
            Zhou,J.
  TITLE     Identification and characterization of a novel polycystin family
            member, polycystin-L2, in mouse and human: sequence, expression,
            alternative splicing, and chromosomal localization
  JOURNAL   Genomics 64 (3), 241-251 (2000)
   PUBMED   10756092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090534.10, BC138717.1 and AC115305.4.
            
            On Jul 9, 2009 this sequence version replaced NM_016927.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182033.1, BC138717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC090534.10        29734-29748         c
            16-2238             BC138717.1         1-2223
            2239-2461           AC115305.4         98814-99036         c
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.62 cM"
     gene            1..2461
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /note="polycystic kidney disease 2-like 2"
                     /db_xref="GeneID:53871"
                     /db_xref="MGI:MGI:1858231"
     exon            1..75
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1910
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /note="polycystic kidney disease 2-like 2 protein;
                     polycystin-2L2; polycystin-L2; Polycystin - L2"
                     /codon_start=1
                     /product="polycystin-2-like protein 2"
                     /protein_id="NP_058623.2"
                     /db_xref="CCDS:CCDS29127.1"
                     /db_xref="GeneID:53871"
                     /db_xref="MGI:MGI:1858231"
                     /translation="MSEATWWYRGGTSKHDLHYRREAEVNTTLEELLLYFIFLINLCI
                     LTFGMVNPHMYYLNKVMSSLFVDTSLPDDERSSFRSIRSITEFWKFMEGPLIDGLYWD
                     SWYGNKQLYSVKNSSRIYYENVLLGIPRVRQLRVRNNTCKVYPAFQSLVSDCYSKYTV
                     ENEDFSDFGLKRNPEWTHTPSSRTAPWHWGFVGVYRDGGYIVTLSKSKSETKAKFVDL
                     RLNNWISRGTRAVFIDFSLYNANVNLFCIIRLLAEFPATGGLLTSWQFYSVKLLRYVS
                     YYDYFIASCEVIFCIFLFVFIIQELRKVNEFKSAYFRSVWNWLEMLLLLLCFLAVSFY
                     AYCNMQSFLLLGQLLKNTDSYPDFYFLAYWHIYYNNVIAITIFFAWIKIFKFISFNET
                     MSQLSSTLSRCMKDIVGFAIMFFIIFSAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV
                     LGDFNFAGIQQANWILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRPD
                     FELGKIIQKSCFNVLEKLRLKKAQAKEEKKMQTTDLAQRARRDGFDESEIQEAEQMKR
                     WKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELEKELHYVSLKLNQLMRKLH"
     exon            76..177
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            178..311
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            312..568
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            569..790
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1019
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1190
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1372
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1493
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1595
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1660
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1712
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1825
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1927
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2461
                     /gene="Pkd2l2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagaacgg gcatagtgga acggaccgtg tggtatgctc cgcgatgtct gaggcgactt
       61 ggtggtaccg aggagggact tcaaaacatg acctgcatta cagaagggaa gcggaggtta
      121 acaccacact cgaggagttg ttactctatt ttattttctt aataaatcta tgcatattga
      181 cttttgggat ggtcaatcca catatgtact atttaaacaa agttatgtcg tctctgtttg
      241 tggacacttc tctacctgat gatgaaagaa gcagctttag gtccattcgg agcataactg
      301 agttttggaa gttcatggaa ggacccctca tcgacggctt gtactgggac tcgtggtatg
      361 gcaacaaaca gctgtacagt gtgaagaaca gcagccgcat ctactacgag aacgttcttc
      421 tcggcatccc cagagtgcgg caactgcgag tccgaaacaa cacttgcaag gtctacccag
      481 ctttccagtc cctggtcagc gactgctaca gcaagtacac agtggaaaac gaagacttct
      541 ctgattttgg cctcaaacgc aatccagaat ggacgcacac accttcttcc cgcactgccc
      601 catggcactg ggggtttgtt ggcgtatacc gagatggagg atatatagtc acgttatcaa
      661 aatcaaaatc tgaaaccaaa gccaaatttg ttgaccttcg actgaacaac tggattagca
      721 gaggcaccag ggctgttttt attgatttct ccctgtacaa tgctaatgtc aacctgtttt
      781 gcatcatcag gctgctggca gagttccctg cgacgggtgg gctcctcacc tcctggcagt
      841 tctactctgt gaagctcctc agatacgtct cctactacga ctacttcatt gcctcctgtg
      901 aagtcatatt ttgtattttt ctctttgtct tcataataca agaactgagg aaagtgaacg
      961 agtttaagtc tgcctatttc agaagtgtct ggaactggct ggagatgctg ctcctgctgc
     1021 tctgttttct cgccgtgtct ttctatgcat actgtaacat gcagagcttt ctcttgcttg
     1081 gacagctgct gaaaaacact gacagctatc ccgactttta cttccttgca tactggcaca
     1141 tttactataa caacgtaatt gctatcacta tcttctttgc atggataaag atattcaagt
     1201 tcataagctt caatgagaca atgtcgcagc tgtcatcaac actctcccgc tgcatgaagg
     1261 acatcgtggg gttcgccatc atgttcttca tcatcttctc tgcttatgcc cagttgggat
     1321 ttctggtttt tgggtcacag gttgatgatt tttcaacttt tcaaaattcc atatttgcac
     1381 aatttcgaat tgtcctcggg gactttaatt ttgctggcat ccagcaggcc aactggatct
     1441 tggggcccat ctacttcatc acgttcatct tcttcgtgtt ctttgtgctc ctgaacatgt
     1501 tcttggcaat aattaatgac acctattctg aagttaaggc tgattattca ataggcagaa
     1561 gaccagattt tgaacttggt aaaataattc aaaagagttg ctttaatgtt ctcgagaaac
     1621 tcagactcaa gaaagctcaa gctaaagaag aaaagaaaat gcaaaccact gacttggccc
     1681 agagagccag aagagacggc tttgatgaaa gtgagatcca agaggcagag cagatgaaaa
     1741 gatggaagga aaggcttgaa aaaaagtatt attctacaga aattcaagac gattatcagc
     1801 ctgtcactca gcaagaattc cgagagctct ttttatacgc ggtggagctt gagaaggaat
     1861 tacactatgt cagtttaaaa ctgaaccaac tgatgagaaa gctgcactag caggctgaca
     1921 agtggagtca ttttataaga aaaggcaacc gaagaatttc attcagtatg aagatttttt
     1981 cctctcaatt ttcttcagta atgcaaaaga aaaaacaaaa agtaaacaga agagcttttt
     2041 atttcaaagt tcttgaagta aaagagtaaa actcttgtcc tttgctaaca gccgtgtctg
     2101 cagtaaaaca atgaaggagc ctgcgtgttt cctaagtgtg gagaggatct gcgggaatgt
     2161 ggaacagctt tccttgccta ctggaaccac aaacaagcac acaatgggac tctctgagtg
     2221 cctgacaaag tgaacgcaag tacagccaag cacacatggt gaactgtcag ggaacacaag
     2281 cactttatgg cgtcaacttt caaggaacat attttatatg gattttgaag agtcttgttt
     2341 gctgataaga acttcaagaa gtctaagctt ggctttgatt ctcttgtatt ccttatattc
     2401 ctcaagcacc ggaacacgat cctccttctg ggcattccta gggaagataa aactctgtaa
     2461 a
//
