LOCUS       NM_181422               3321 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus polycystic kidney disease 2-like 1 (Pkd2l1), mRNA.
ACCESSION   NM_181422
VERSION     NM_181422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Liu,X., Rich,K., Nasseri,S.M., Li,G., Hjaeresen,S., Finsen,B.,
            Scherberger,H., Svenningsen,A. and Zhang,M.
  TITLE     A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting
            Neurons in Spinal Cords of Rodents, Carnivores, and Primates
  JOURNAL   Int J Mol Sci 24 (17), 13582 (2023)
   PUBMED   37686387
  REMARK    GeneRIF: A Comparison of PKD2L1-Expressing Cerebrospinal Fluid
            Contacting Neurons in Spinal Cords of Rodents, Carnivores, and
            Primates.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Vien,T.N., Ta,M.C., Kimura,L.F., Onay,T. and DeCaen,P.G.
  TITLE     Primary cilia TRP channel regulates hippocampal excitability
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2219686120 (2023)
   PUBMED   37216541
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Shimizu,T., Fujii,T., Hanita,K., Shinozaki,R., Takamura,Y.,
            Suzuki,Y., Kageyama,T., Kato,M., Nishijo,H., Tominaga,M. and
            Sakai,H.
  TITLE     Polycystic kidney disease 2-like 1 channel contributes to the
            bitter aftertaste perception of quinine
  JOURNAL   Sci Rep 13 (1), 4271 (2023)
   PUBMED   36922541
  REMARK    GeneRIF: Polycystic kidney disease 2-like 1 channel contributes to
            the bitter aftertaste perception of quinine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Frederico,B., Martins,I., Chapela,D., Gasparrini,F.,
            Chakravarty,P., Ackels,T., Piot,C., Almeida,B., Carvalho,J.,
            Ciccarelli,A., Peddie,C.J., Rogers,N., Briscoe,J., Guillemot,F.,
            Schaefer,A.T., Saude,L. and Reis e Sousa,C.
  TITLE     DNGR-1-tracing marks an ependymal cell subset with
            damage-responsive neural stem cell potential
  JOURNAL   Dev Cell 57 (16), 1957-1975 (2022)
   PUBMED   35998585
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Ishimaru,Y., Inada,H., Kubota,M., Zhuang,H., Tominaga,M. and
            Matsunami,H.
  TITLE     Transient receptor potential family members PKD1L3 and PKD2L1 form
            a candidate sour taste receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (33), 12569-12574 (2006)
   PUBMED   16891422
  REMARK    GeneRIF: These results suggest that PKD1L3 and PKD2L1 heteromers
            may function as sour taste receptors.
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   LopezJimenez,N.D., Cavenagh,M.M., Sainz,E., Cruz-Ithier,M.A.,
            Battey,J.F. and Sullivan,S.L.
  TITLE     Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1,
            are co-expressed in a subset of taste receptor cells
  JOURNAL   J Neurochem 98 (1), 68-77 (2006)
   PUBMED   16805797
  REMARK    GeneRIF: Pkd1l3 and Pkd2l1 are co-expressed in a select subset of
            taste receptor cells and therefore may, like other PKD channels,
            function as a heteromer.
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Ramsey,I.S., Delling,M. and Clapham,D.E.
  TITLE     An introduction to TRP channels
  JOURNAL   Annu Rev Physiol 68, 619-647 (2006)
   PUBMED   16460286
  REMARK    Review article
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Murakami,M., Ohba,T., Xu,F., Shida,S., Satoh,E., Ono,K.,
            Miyoshi,I., Watanabe,H., Ito,H. and Iijima,T.
  TITLE     Genomic organization and functional analysis of murine PKD2L1
  JOURNAL   J Biol Chem 280 (7), 5626-5635 (2005)
   PUBMED   15548533
  REMARK    GeneRIF: PKD2L1 forms functional cation channels on the plasma
            membrane by interacting with PKD1
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Nomura,H., Turco,A.E., Pei,Y., Kalaydjieva,L., Schiavello,T.,
            Weremowicz,S., Ji,W., Morton,C.C., Meisler,M., Reeders,S.T. and
            Zhou,J.
  TITLE     Identification of PKDL, a novel polycystic kidney disease 2-like
            gene whose murine homologue is deleted in mice with kidney and
            retinal defects
  JOURNAL   J Biol Chem 273 (40), 25967-25973 (1998)
   PUBMED   9748274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125101.3.
            
            On Mar 21, 2009 this sequence version replaced NM_181422.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF271381.1, BC116297.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC125101.3         116647-117049       c
            404-517             AC125101.3         116028-116141       c
            518-645             AC125101.3         82244-82371         c
            646-899             AC125101.3         81659-81912         c
            900-1124            AC125101.3         80448-80672         c
            1125-1353           AC125101.3         80055-80283         c
            1354-1524           AC125101.3         79031-79201         c
            1525-1706           AC125101.3         78671-78852         c
            1707-1827           AC125101.3         78266-78386         c
            1828-1926           AC125101.3         76971-77069         c
            1927-2048           AC125101.3         76640-76761         c
            2049-2166           AC125101.3         75019-75136         c
            2167-2285           AC125101.3         74136-74254         c
            2286-2409           AC125101.3         73760-73883         c
            2410-3321           AC125101.3         72244-73155         c
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.91 cM"
     gene            1..3321
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /note="polycystic kidney disease 2-like 1"
                     /db_xref="GeneID:329064"
                     /db_xref="MGI:MGI:1352448"
     exon            1..403
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2451
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /note="polycystin-L; polycystin-2 homolog; polycystic
                     kidney disease 2-like 1 protein; polycystin-2L1"
                     /codon_start=1
                     /product="polycystin-2-like protein 1"
                     /protein_id="NP_852087.2"
                     /db_xref="CCDS:CCDS29846.1"
                     /db_xref="GeneID:329064"
                     /db_xref="MGI:MGI:1352448"
                     /translation="MNSMESPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICTVSSVA
                     LPETQPKKPEVRCQEKTQRTLVSSCCLHICRSIRGLWGTTLTENTAENRELYVKTTLR
                     ELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDSGVSFQTISSMSDFWDF
                     AQGPLLDSLYWTKWYNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFRE
                     DILNCYDVYSPDKEDQLPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPG
                     SRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSW
                     QIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLRYLSSVWNILDLV
                     VILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAW
                     IKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFST
                     FVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSE
                     VKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFEDFTST
                     LRELGHEEHEITAAFTRFDQDGDHILDEEEQEQMRQGLEEERVTLNAEIENLGRSVGH
                     SPPGELGAEAARGQSWVSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKLKMLERKGE
                     LAPSPGMGEPAVWENLYNPS"
     exon            404..517
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..645
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..899
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1124
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1353
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1524
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1706
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1827
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1926
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2048
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2166
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2285
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2409
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..3321
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3300..3305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="Pkd2l1"
                     /gene_synonym="B830002B15; PCL; PKD2L; Pkdl; TRPP3"
                     /note="major polyA site"
ORIGIN      
        1 atgtgagctc agctccccca cccagacagg aggccgaggt tgaaaggatc agctgctctt
       61 agacaatact gcctgggctc tctgctacca gtgtcagtct gggtctttgt ccctgtgtct
      121 cctgtgagag tgggcacctg tggtggcagg tttctacctc ctgtccccat gaatagtatg
      181 gaaagcccca agaatcagga gctacaaacc ctggggaaca gagcctggga caatcctgcc
      241 tacagcgacc ctccttcccc gaacaggacg ctgaggatct gcactgtctc cagtgtggct
      301 ctccctgaga ctcaacccaa aaagccagaa gtcagatgcc aggagaagac acagagaacc
      361 ctggtgtcca gctgctgtct ccatatctgt cggagcatca gaggactgtg ggggacaacg
      421 ctgactgaga acacagccga gaacagggag ctttatgtca agaccaccct gagggagctt
      481 gtggtataca tagtgttcct cgtggacatc tgtctgttga cctacggaat gacaagttct
      541 agtgcctatt actacaccaa agtgatgtct gaattgttcc tacacacccc atccgactct
      601 ggagtctcct tccaaaccat cagcagcatg tcagacttct gggattttgc tcagggccca
      661 ctcctggaca gtttgtactg gacaaagtgg tacaacaacc agagcctggg gcgtggctcc
      721 cactccttca tctactatga gaacctgctc ctgggagccc caaggttgcg gcagctgcgc
      781 gtgcgcaatg actcctgtgt ggttcatgaa gacttccggg aggacatttt gaactgttat
      841 gatgtgtact cgccggacaa agaagatcag ctcccctttg gacctcagaa cggcacagcg
      901 tggacatacc attcccagaa tgagctgggt ggctcctccc actggggcag gctcacaagc
      961 tacagcgggg gtggctacta cttggatctt ccaggatccc gacaagccag tgcagaggcc
     1021 ctccaaggac tccaggaggg actgtggctg gacaggggca ctcgggtggt ctttatcgac
     1081 ttctccgtct acaatgccaa catcaatctt ttctgtattc tgagactggt ggtagagttt
     1141 ccagccacag gagggaccat cccatcctgg cagatccgca cagttaagct gatccgctat
     1201 gtgaataact gggacttctt cattgtgggc tgtgaagttg tcttctgtgt cttcatcttc
     1261 tattatgtgg tggaggaaat cctggaaatc cacctgcatc ggcttcgcta cctcagcagc
     1321 gtctggaaca ttctggacct ggtggtcatc ttgctctcca tcgtggctgt gggtttccac
     1381 atattccgaa ccctggaagt gaaccgactg atgggaaagc ttctgcaaca gccagacacg
     1441 tatgcagact ttgagttcct ggccttctgg cagactcagt acaataacat gaacgcggtc
     1501 aaccttttct ttgcttggat caagatattc aagtatatca gcttcaacaa gaccatgaca
     1561 cagctctcct ccaccctggc tcgctgtgcc aaggacatcc tgggctttgc catcatgttc
     1621 ttcattgtct tcttcgctta cgcccagctt ggctacctgc tttttgggac ccaagtggaa
     1681 aactttagca ctttcgtcaa gtgcattttc actcagttcc ggataatcct tggggatttt
     1741 gactacaatg ccatcgacaa tgccaacaga atcctgggcc ctgtgtactt tgtcacctat
     1801 gtcttcttcg tcttcttcgt gctcctgaac atgttcctgg ccatcatcaa cgacacatac
     1861 tccgaggtca aggaggagct ggctggccag aaggatcagt tgcagctttc tgacttcctg
     1921 aaacagagct acaacaagac cctactaagg ctgcgcctga ggaaagagcg ggtttctgat
     1981 gtgcagaagg tcctgaaggg tggggaacca gagatccagt ttgaagattt caccagcacc
     2041 ttgagggaac tggggcacga ggagcacgag atcaccgctg ccttcaccag gtttgatcag
     2101 gatggggacc acatactgga tgaggaggag caggaacaga tgcggcaggg actggaagag
     2161 gagagggtga ccctcaatgc tgagattgag aacctaggcc ggtctgttgg acacagcccc
     2221 ccaggcgaat tgggcgcgga ggctgccaga ggacaaagct gggtttctgg agaagaattc
     2281 gacatgctca caaggagagt tctgcagctg cagtgtgttc tggaaggagt tgtgtcccag
     2341 attgatgctg taggctcaaa gctgaagatg ctggagagga aaggggagct ggctccctcc
     2401 ccaggaatgg gggaaccagc tgtttgggag aacctgtata atccgtccta ggtgtcactc
     2461 cagctccctg ggagttcagg gtggacagga ggatggaaaa ggggtcctaa agcaacagac
     2521 agcaaattct tctctctatg cctcccccac aagcctcatc tccatctcca tcctcatcct
     2581 ttctagggca gcatgtttca tgatggctgc tatgaagttc cccctgtatc tggccttttc
     2641 agccgatgtt tttgtgtgta gctgggcagc atgcttagac ttgtcccttg gtgtttcttt
     2701 atggagttgc acagctctgt gaagtagcat ttcctaccag gcccctctct tcctgggcac
     2761 ttacttctgc cagagttgat tgacatcaac aacaaacaag aaaaaggagc agatgggaat
     2821 gactctccgg aagacctcag acaaccacga ttagttaaca ggtagaagtc caaagagtgg
     2881 gcgatggatg tcttcctacg ttccagtaac tcttaccctt tgtgtgcatc acgatatctg
     2941 ccactggcag gcatggttgt gtgtaggagg ccttcccttt ctttcctcat ggggtttccc
     3001 tgtaaaagag aaaaggaagc tgtagtggaa agaagatttt tgtgtggtga gattccaaca
     3061 gaggagttaa gagtgacccc ctccaaaggt gaagtcagtg aattctggag gagcctgcct
     3121 tctggttctt atgttccagc gactagctgg aactgagggg acttcaaacc tggaatcaaa
     3181 caaaacctga aggaatcaag ccagaaaggc tatcaggatt cattgatctt ttggactaat
     3241 atgtggtggt ctctggctct cttcgtcata ggacaatgtg aggttccaag gtgattagca
     3301 ataaaattct ttagaaaacc a
//
