LOCUS       NM_008861               5221 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus polycystin 2, transient receptor potential cation
            channel (Pkd2), mRNA.
ACCESSION   NM_008861 XM_984803
VERSION     NM_008861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5221)
  AUTHORS   Garcia-Navarrete,C., Kretschmar,C., Toledo,J., Gutierrez,K.,
            Hernandez-Caceres,M.P., Budini,M., Parra,V., Burgos,P.V.,
            Lavandero,S., Morselli,E., Pena-Oyarzun,D. and Criollo,A.
  TITLE     PKD2 regulates autophagy and forms a protein complex with BECN1 at
            the primary cilium of hypothalamic neuronal cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167256 (2024)
   PUBMED   38782303
  REMARK    GeneRIF: PKD2 regulates autophagy and forms a protein complex with
            BECN1 at the primary cilium of hypothalamic neuronal cells.
REFERENCE   2  (bases 1 to 5221)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   3  (bases 1 to 5221)
  AUTHORS   Weisser,I., Eckberg,K., D'Amico,S., Buttram,D. and Aboudehen,K.
  TITLE     Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in
            Mouse Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 35 (1), 41-55 (2024)
   PUBMED   37953472
REFERENCE   4  (bases 1 to 5221)
  AUTHORS   Jung,H.J., Dixon,E.E., Coleman,R., Watnick,T., Reiter,J.F.,
            Outeda,P., Cebotaru,V., Woodward,O.M. and Welling,P.A.
  TITLE     Polycystin-2-dependent transcriptome reveals early response of
            autosomal dominant polycystic kidney disease
  JOURNAL   Physiol Genomics 55 (11), 565-577 (2023)
   PUBMED   37720991
  REMARK    GeneRIF: Polycystin-2-dependent transcriptome reveals early
            response of autosomal dominant polycystic kidney disease.
REFERENCE   5  (bases 1 to 5221)
  AUTHORS   Yanda,M.K., Ciobanu,C., Guggino,W.B. and Cebotaru,L.
  TITLE     CFTR and PC2, partners in the primary cilia in autosomal dominant
            polycystic kidney disease
  JOURNAL   Am J Physiol Cell Physiol 325 (3), C682-C693 (2023)
   PUBMED   37519231
  REMARK    GeneRIF: CFTR and PC2, partners in the primary cilia in autosomal
            dominant polycystic kidney disease.
REFERENCE   6  (bases 1 to 5221)
  AUTHORS   Pennekamp,P., Bogdanova,N., Wilda,M., Markoff,A., Hameister,H.,
            Horst,J. and Dworniczak,B.
  TITLE     Characterization of the murine polycystic kidney disease (Pkd2)
            gene
  JOURNAL   Mamm Genome 9 (9), 749-752 (1998)
   PUBMED   9716661
REFERENCE   7  (bases 1 to 5221)
  AUTHORS   Wu,G., D'Agati,V., Cai,Y., Markowitz,G., Park,J.H., Reynolds,D.M.,
            Maeda,Y., Le,T.C., Hou,H. Jr., Kucherlapati,R., Edelmann,W. and
            Somlo,S.
  TITLE     Somatic inactivation of Pkd2 results in polycystic kidney disease
  JOURNAL   Cell 93 (2), 177-188 (1998)
   PUBMED   9568711
REFERENCE   8  (bases 1 to 5221)
  AUTHORS   Wu,G., Mochizuki,T., Le,T.C., Cai,Y., Hayashi,T., Reynolds,D.M. and
            Somlo,S.
  TITLE     Molecular cloning, cDNA sequence analysis, and chromosomal
            localization of mouse Pkd2
  JOURNAL   Genomics 45 (1), 220-223 (1997)
   PUBMED   9339380
REFERENCE   9  (bases 1 to 5221)
  AUTHORS   Griffin,M.D., Torres,V.E. and Kumar,R.
  TITLE     Cystic kidney diseases
  JOURNAL   Curr Opin Nephrol Hypertens 6 (3), 276-283 (1997)
   PUBMED   9263671
  REMARK    Review article
REFERENCE   10 (bases 1 to 5221)
  AUTHORS   Mochizuki,T., Wu,G., Hayashi,T., Xenophontos,S.L., Veldhuisen,B.,
            Saris,J.J., Reynolds,D.M., Cai,Y., Gabow,P.A., Pierides,A.,
            Kimberling,W.J., Breuning,M.H., Deltas,C.C., Peters,D.J. and
            Somlo,S.
  TITLE     PKD2, a gene for polycystic kidney disease that encodes an integral
            membrane protein
  JOURNAL   Science 272 (5266), 1339-1342 (1996)
   PUBMED   8650545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU705556.1, AK053502.1, CX566027.1, AC123687.20 and AV517098.1.
            
            On Jan 9, 2008 this sequence version replaced NM_008861.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13278.1, AF014010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BU705556.1         7-102
            97-2578             AK053502.1         2-2483
            2579-3020           CX566027.1         306-747
            3021-5087           AC123687.20        150263-152329       c
            5088-5221           AV517098.1         53-186
FEATURES             Location/Qualifiers
     source          1..5221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..5221
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /note="polycystin 2, transient receptor potential cation
                     channel"
                     /db_xref="GeneID:18764"
                     /db_xref="MGI:MGI:1099818"
     exon            1..769
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3081
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /note="polycystic kidney disease 2 protein homolog;
                     transient receptor potential cation channel subfamily P
                     member 2"
                     /codon_start=1
                     /product="polycystin-2"
                     /protein_id="NP_032887.3"
                     /db_xref="CCDS:CCDS19487.1"
                     /db_xref="GeneID:18764"
                     /db_xref="MGI:MGI:1099818"
                     /translation="MVNSRRVQPQPPGDAGRSPAPRASGPGRLVAGGAGLAVPGGLGE
                     QRGLEIEMERIRQAAARDPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVE
                     GEEGGMVVEMDVEWRPGSRRSASSSAVSSVGARGRGLGSYRGAAHLSGRRRRLEDQGA
                     QCPSPAGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESNANREKYLKSV
                     LRELVTYLFFLVVLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMED
                     FWKFTEGSFLDGLYWKAQTSNHTQADNRSFIFYENLLLGVPRLRQLRVRNGSCSIPQD
                     LRDEIKECYDVYSVSSEDRAPFGPRNGTAWMYTSEKELNGSSHWGIIASYSGAGYYLD
                     LSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPATGGVV
                     PSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRIHRLSYFRSFWNCL
                     DVVIVVLSVVAMVINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNISAVMVFL
                     VWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDDF
                     STFQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSY
                     SEVKSDLAQQKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQGGGKLNFDELR
                     QDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQMRDDLEKEREDLDLEHSSLPRPM
                     SSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVS
                     KIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDARLGRDSEIHREQMERLVREELERW
                     ESDDAASQTGHGVSTQVGLGGQPHPRNPRPPSSQSAEGLEGGGGNGSANVHA"
     exon            770..883
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1017
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1268
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1493
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1722
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1890
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2072
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2193
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2292
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2414
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2532
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2696
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2844
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..5212
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /note="hexamer: AATAAA"
     polyA_site      5212
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /note="major polyA site"
ORIGIN      
        1 tggccgctgg ggccttttcg acgcgcctaa gtccagtcca ggcgaggcca gggcccggga
       61 ggcgggccga gggggcgggc ggaggcgggg agcagcaggc cgactccggg aagaaaagaa
      121 catggctcct gcggcagagg gcggcggcac tcccgggcgc gctgggcgcc agtgagcgcc
      181 atggttaact ccagacgcgt gcagccgcag ccgcccgggg acgcgggacg ctcgcccgcg
      241 ccgcgagcgt ccggacccgg gcgcctggtg gcgggaggcg ccggcctagc tgtccccggc
      301 ggcctcgggg agcagcgggg cctggagatc gagatggagc gcatccggca ggcggccgct
      361 cgggatcccc cggccggagc ctcggcctcg ccgtctcctc cgctttcgtc ctgctccagg
      421 caagcgtgga gccgcgacaa cccgggcttt gaggcagagg aggatgacga cgacgacgag
      481 gtggaaggag aagaaggagg gatggtggta gagatggatg tggagtggcg cccgggcagt
      541 cggaggtcgg cctcctcctc ggccgtgagc tcggtgggcg cccgcggccg agggctcggg
      601 agctaccgcg gcgcggctca cctgagcggg aggcggcgcc ggctagagga ccagggcgcg
      661 cagtgtccca gccccgcggg cggcggggac ccgctgcatc gccacctccc gctggagggc
      721 cagccacccc gagtggcctg ggcagagagg ctggtgcgag ggctgcgagg tctctgggga
      781 acaagactca tggaagagag caacgccaac cgagagaagt acctgaaaag tgtgttacgg
      841 gagctggtca cttacctctt tttcctcgta gtcttgtgca tcttgaccta cggcatgatg
      901 agctccaatg tgtactacta cactcggaca ctgtcacagc tattcataga caccccagtg
      961 tcgaaaacag agaaaaccaa ctttaaaact ctttcttcca tggaggactt ctggaagttc
     1021 accgaaggct ccttcctgga tgggctgtac tggaaggcac agaccagcaa ccacacgcaa
     1081 gctgacaacc gaagctttat cttctatgag aacctgctgc taggagtgcc gcgtctacgc
     1141 caactccgag tcagaaacgg atcctgctcc atccctcagg acctgcgaga tgaaattaaa
     1201 gagtgctatg acgtctactc cgtcagcagt gaggacagag ctccatttgg accgcggaat
     1261 ggaactgcgt ggatgtacac aagtgagaag gagctgaatg ggagcagtca ctgggggatc
     1321 attgcgtcgt acagtggagc gggttactac ctggatctgt ccagaaccag ggaggagaca
     1381 gcagcccagc ttgctggcct caggaggaac ttctggctgg accggggcac gcgggcagct
     1441 tttatagact tctcggtgta taacgcaaac attaacctgt tctgtgtggt caggttattg
     1501 gcggagttcc cagcaacggg tggcgtggta ccctcttggc agtttcagcc tgtaaaactg
     1561 atccgctatg tcacagcctt tgatttcttc ctggcagcct gtgagatcat cttttgtttc
     1621 tttatcattt actatgtggt ggaagagata ttggaaattc ggattcacag actgagctat
     1681 ttcaggagtt tctggaattg tctggatgtt gtgattgtcg tgttatctgt agtagctatg
     1741 gtgattaaca tttaccgaat gtcaaatgca gaggggctgc tacagtttct tgaagatcaa
     1801 aattctttcc ccaactttga gcatgtggca tactggcaaa tacagttcaa caatataagt
     1861 gctgtcatgg tatttttggt ctggattaag ctcttcaaat tcatcaattt taataggacc
     1921 atgagccagc tctccacaac catgtctcga tgtgccaaag acctcttcgg cttcaccata
     1981 atgttctcca tcatcttctt ggcatacgca cagctggcat accttgtctt cggcacccag
     2041 gtcgatgact tcagcacttt ccaagaatgt atcttcaccc agttccgcat cattttgggt
     2101 gatatcaact tcgcagagat cgaggaagct aaccgagttt tggggccact ttattttact
     2161 acatttgtgt tctttatgtt cttcattctt ttgaatatgt tcctggcgat catcaatgat
     2221 tcgtactctg aagtgaaatc cgatctggcc cagcagaaag cagaaatgga actctcagac
     2281 cttatcagaa agggctgcca aaaagcactg gtcaaactaa aactgaaaag aaacactgta
     2341 gatgccatct cagagagtct ccggcaaggt ggtggcaaac tgaactttga tgagcttcgg
     2401 caagacctga aagggaaggg ccatacagat gcagagattg aggccatatt cactaaatat
     2461 gaccaggatg gcgaccagga actgaccgag cgtgagcatc aacagatgag agatgacttg
     2521 gagaaagaga gggaggacct agacttggaa cacagctctt taccacgtcc gatgagcagc
     2581 agaagtttcc ccagaagcct ggatgactcc gaggaggagg atgacgaaga cagtggccat
     2641 agctccagga ggaggggaag catctccagt ggggtttcct atgaagagtt ccaagtactg
     2701 gtgaggcgcg tggaccgcat ggagcactcc attggcagca tcgtttccaa gattgatgcc
     2761 gtgattgtca agctggagat catggagcgg gccaagctga agagacgaga ggtgttagga
     2821 cggctgctgg atggcgtggc tgaggatgcg cgactgggtc gggacagtga gatccacagg
     2881 gagcagatgg agcgcctggt gcgggaagag ctggagcgct gggaatcgga tgatgcagct
     2941 tcgcaaacag gtcatggtgt aagcacacaa gtgggactcg gtggccagcc ccaccccaga
     3001 aacccgcgcc ctccttcctc ccagtctgca gagggcctgg aaggtggagg tggaaatgga
     3061 agtgccaacg tccatgccta ataatccaca cgtgtttgtg tgttcctgag acaccgagag
     3121 gtggctgtcc agtacgacaa tgataagttc ggtatttata taccccggct gcattatgat
     3181 gctggtcttt gtgaccaatt gttataattt tctgcacttt aatttatttt acgtaaactt
     3241 aaacccgtgg ttcaaggaag gtttgtctta cttttctcat gtgagaaatc taggtgtaaa
     3301 tattgagttc agaaagaaga aaactttgaa agtacgctga tttgctgccc tgcccgtgtc
     3361 ttcaggtgac agtgtttgga agttagagag ccttcactag tctctgagtt cgtgtggagc
     3421 caccacagtc tgctgcatta gtccagtgcg agatgctaag gaaaaacatg acatttcatt
     3481 ccactgaggt ataactcgga gcttactgca tatctttctt ctaaggaagg agtagtattt
     3541 cagcaacctt tctggggtgc agagaaagga tatgtatgta gccactgtgc taaaatgtgt
     3601 gtgaacagtt gagatagatg ctaagcgcca taccagtttg tggcactaag catatcattt
     3661 aatttttgtg ttatttagct tttgtttcag atttggcaag gaaagctcaa aagataaatt
     3721 ataagataaa gtgtaggatt ggagccgggc agtggtggtg aacgccttta atcccaacac
     3781 ttgggaggca gaggcaggtg gatttctgag ttcgaggcca gccagggcta cacagagaaa
     3841 ccctgtttcg aaaacccaaa aaaataggta ggattggaag gggccttcaa ttcttactac
     3901 atttgacttt tcaattattt gttagcatag aaatttctct atttttcttt cctatgtgtc
     3961 tcatttataa ccaaatttaa tattaaaaaa actaataaga caaacactga atattttcac
     4021 tgtgtagtga aagttttaac tcatcaaata tgtacatggg aagcagtatt ttaagaaagt
     4081 tttgaggtgc ataaaagctc tgtaaaagta gaggtctggt ttacgttgta tcttgaatat
     4141 tcttaatatc tagaatattc ttagtcatat atcaggatgg agtcatataa tgcaaattta
     4201 gttcattttt atgtgagggg ccttgggtat tgtaggttta tatatttgca gaagagatcc
     4261 actaaaagtt gactatcagc agtaagagag ggtctcacaa aatttatagg agaaatctat
     4321 atctcaatat cattttggtt tttgtgtctg tcaaagacag gttttcacta tatactcctg
     4381 gccggcctgg aactaactgt gtaaactagg ctgccctcag actcccagag atccactggc
     4441 tctcagcctc ttgagtgctg ggattagggc cagtgtgacc acagcagttg ttgaataact
     4501 tggccctttg agagctaggg gtcagaagaa acaaagccaa gctggtagag aagccagagg
     4561 tagagaacaa gtagaagaga atcctgggct tagtaccgta tttgaaattc acaagaattc
     4621 attgacttcc tagaatatac caaacctctc caacctctaa cagactgctg agtagacagg
     4681 ccttttctcg tcagcttcca cagaagcgag gcacgccatg tttccctgat tctgatggct
     4741 gcacatcaat cattttcttt tgaatatgct acactaattt tttttccttc ctaggtattg
     4801 gattttgcat tgcaggggta ttattgtatg tatgtattta tgtatgcgta ctgtactgtt
     4861 acaaagtgaa caaacttcaa cttgaagtgc attaattatg tggtatccat gtgtatcgac
     4921 catgtgccgt atgcctatta tggtcactag aacatctttt atgatgctta ttattacagt
     4981 gtttctcatt taacttgtaa acttttgtag aattctcctt tttttccctt tagatataag
     5041 ttcatatatt tttctacttt agtcctgtga agtttatccc tagtcacctt cctggtagtc
     5101 tcccctctgt taagggtata gttaagattt cacatataca aggttctttg gacatcaaca
     5161 atttcttaac tgtaataatg tgtacattac ttaataaaga cttgacatag taaaaaaaaa
     5221 a
//
