LOCUS       NP_032887                966 aa            linear   ROD 10-FEB-2025
DEFINITION  polycystin-2 [Mus musculus].
ACCESSION   NP_032887 XP_989897
VERSION     NP_032887.3
DBSOURCE    REFSEQ: accession NM_008861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 966)
  AUTHORS   Garcia-Navarrete,C., Kretschmar,C., Toledo,J., Gutierrez,K.,
            Hernandez-Caceres,M.P., Budini,M., Parra,V., Burgos,P.V.,
            Lavandero,S., Morselli,E., Pena-Oyarzun,D. and Criollo,A.
  TITLE     PKD2 regulates autophagy and forms a protein complex with BECN1 at
            the primary cilium of hypothalamic neuronal cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167256 (2024)
   PUBMED   38782303
  REMARK    GeneRIF: PKD2 regulates autophagy and forms a protein complex with
            BECN1 at the primary cilium of hypothalamic neuronal cells.
REFERENCE   2  (residues 1 to 966)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   3  (residues 1 to 966)
  AUTHORS   Weisser,I., Eckberg,K., D'Amico,S., Buttram,D. and Aboudehen,K.
  TITLE     Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in
            Mouse Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 35 (1), 41-55 (2024)
   PUBMED   37953472
REFERENCE   4  (residues 1 to 966)
  AUTHORS   Jung,H.J., Dixon,E.E., Coleman,R., Watnick,T., Reiter,J.F.,
            Outeda,P., Cebotaru,V., Woodward,O.M. and Welling,P.A.
  TITLE     Polycystin-2-dependent transcriptome reveals early response of
            autosomal dominant polycystic kidney disease
  JOURNAL   Physiol Genomics 55 (11), 565-577 (2023)
   PUBMED   37720991
  REMARK    GeneRIF: Polycystin-2-dependent transcriptome reveals early
            response of autosomal dominant polycystic kidney disease.
REFERENCE   5  (residues 1 to 966)
  AUTHORS   Yanda,M.K., Ciobanu,C., Guggino,W.B. and Cebotaru,L.
  TITLE     CFTR and PC2, partners in the primary cilia in autosomal dominant
            polycystic kidney disease
  JOURNAL   Am J Physiol Cell Physiol 325 (3), C682-C693 (2023)
   PUBMED   37519231
  REMARK    GeneRIF: CFTR and PC2, partners in the primary cilia in autosomal
            dominant polycystic kidney disease.
REFERENCE   6  (residues 1 to 966)
  AUTHORS   Pennekamp,P., Bogdanova,N., Wilda,M., Markoff,A., Hameister,H.,
            Horst,J. and Dworniczak,B.
  TITLE     Characterization of the murine polycystic kidney disease (Pkd2)
            gene
  JOURNAL   Mamm Genome 9 (9), 749-752 (1998)
   PUBMED   9716661
REFERENCE   7  (residues 1 to 966)
  AUTHORS   Wu,G., D'Agati,V., Cai,Y., Markowitz,G., Park,J.H., Reynolds,D.M.,
            Maeda,Y., Le,T.C., Hou,H. Jr., Kucherlapati,R., Edelmann,W. and
            Somlo,S.
  TITLE     Somatic inactivation of Pkd2 results in polycystic kidney disease
  JOURNAL   Cell 93 (2), 177-188 (1998)
   PUBMED   9568711
REFERENCE   8  (residues 1 to 966)
  AUTHORS   Wu,G., Mochizuki,T., Le,T.C., Cai,Y., Hayashi,T., Reynolds,D.M. and
            Somlo,S.
  TITLE     Molecular cloning, cDNA sequence analysis, and chromosomal
            localization of mouse Pkd2
  JOURNAL   Genomics 45 (1), 220-223 (1997)
   PUBMED   9339380
REFERENCE   9  (residues 1 to 966)
  AUTHORS   Griffin,M.D., Torres,V.E. and Kumar,R.
  TITLE     Cystic kidney diseases
  JOURNAL   Curr Opin Nephrol Hypertens 6 (3), 276-283 (1997)
   PUBMED   9263671
  REMARK    Review article
REFERENCE   10 (residues 1 to 966)
  AUTHORS   Mochizuki,T., Wu,G., Hayashi,T., Xenophontos,S.L., Veldhuisen,B.,
            Saris,J.J., Reynolds,D.M., Cai,Y., Gabow,P.A., Pierides,A.,
            Kimberling,W.J., Breuning,M.H., Deltas,C.C., Peters,D.J. and
            Somlo,S.
  TITLE     PKD2, a gene for polycystic kidney disease that encodes an integral
            membrane protein
  JOURNAL   Science 272 (5266), 1339-1342 (1996)
   PUBMED   8650545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU705556.1, AK053502.1, CX566027.1, AC123687.20 and AV517098.1.
            
            On Jan 9, 2008 this sequence version replaced NP_032887.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13278.1, AF014010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     Protein         1..966
                     /product="polycystin-2"
                     /note="polycystic kidney disease 2 protein homolog;
                     transient receptor potential cation channel subfamily P
                     member 2"
                     /calculated_mol_wt=108851
     Region          1..106
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13563; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13563; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            135
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Region          147..179
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            218..239
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Region          267..461
                     /region_name="Polycystin_dom"
                     /note="Polycystin domain; pfam20519"
                     /db_xref="CDD:466668"
     Site            297
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            303
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            326
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            360
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            373
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Region          462..685
                     /region_name="PKD_channel"
                     /note="Polycystin cation channel; pfam08016"
                     /db_xref="CDD:462341"
     Site            467..487
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            504..524
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            551..571
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            596..617
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Region          639..641
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:Q13563"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            653..673
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Region          <732..772
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          764..828
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            799
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13563; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Region          801..820
                     /region_name="Linker.
                     /evidence=ECO:0000250|UniProtKB:Q13563"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            806
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Region          808..819
                     /region_name="Important for interaction with PACS1 and
                     PACS2. /evidence=ECO:0000250|UniProtKB:Q13563"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     Site            810
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Site            827
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O35245.2)"
     Region          832..866
                     /region_name="Fer4_24"
                     /note="Ferredoxin I 4Fe-4S cluster domain; pfam18109"
                     /db_xref="CDD:436280"
     Region          914..966
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35245.2)"
     CDS             1..966
                     /gene="Pkd2"
                     /gene_synonym="C030034P18Rik; PC2; TRPP2"
                     /coded_by="NM_008861.3:181..3081"
                     /db_xref="CCDS:CCDS19487.1"
                     /db_xref="GeneID:18764"
                     /db_xref="MGI:MGI:1099818"
ORIGIN      
        1 mvnsrrvqpq ppgdagrspa prasgpgrlv aggaglavpg glgeqrglei emerirqaaa
       61 rdppagasas pspplsscsr qawsrdnpgf eaeeddddde vegeeggmvv emdvewrpgs
      121 rrsasssavs svgargrglg syrgaahlsg rrrrledqga qcpspagggd plhrhlpleg
      181 qpprvawaer lvrglrglwg trlmeesnan rekylksvlr elvtylfflv vlciltygmm
      241 ssnvyyytrt lsqlfidtpv sktektnfkt lssmedfwkf tegsfldgly wkaqtsnhtq
      301 adnrsfifye nlllgvprlr qlrvrngscs ipqdlrdeik ecydvysvss edrapfgprn
      361 gtawmytsek elngsshwgi iasysgagyy ldlsrtreet aaqlaglrrn fwldrgtraa
      421 fidfsvynan inlfcvvrll aefpatggvv pswqfqpvkl iryvtafdff laaceiifcf
      481 fiiyyvveei leirihrlsy frsfwncldv vivvlsvvam viniyrmsna egllqfledq
      541 nsfpnfehva ywqiqfnnis avmvflvwik lfkfinfnrt msqlsttmsr cakdlfgfti
      601 mfsiiflaya qlaylvfgtq vddfstfqec iftqfriilg dinfaeieea nrvlgplyft
      661 tfvffmffil lnmflaiind sysevksdla qqkaemelsd lirkgcqkal vklklkrntv
      721 daiseslrqg ggklnfdelr qdlkgkghtd aeieaiftky dqdgdqelte rehqqmrddl
      781 ekeredldle hsslprpmss rsfprsldds eeeddedsgh ssrrrgsiss gvsyeefqvl
      841 vrrvdrmehs igsivskida vivkleimer aklkrrevlg rlldgvaeda rlgrdseihr
      901 eqmerlvree lerwesddaa sqtghgvstq vglggqphpr nprppssqsa egleggggng
      961 sanvha
//
