LOCUS       NM_001039700            6970 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus polycystic kidney disease 1 like 3 (Pkd1l3),
            transcript variant 1, mRNA.
ACCESSION   NM_001039700
VERSION     NM_001039700.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6970)
  AUTHORS   Su,Q., Chen,M., Wang,Y., Li,B., Jing,D., Zhan,X., Yu,Y. and Shi,Y.
  TITLE     Structural basis for Ca2+ activation of the heteromeric
            PKD1L3/PKD2L1 channel
  JOURNAL   Nat Commun 12 (1), 4871 (2021)
   PUBMED   34381056
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6970)
  AUTHORS   Kashyap,P., Ng,C., Wang,Z., Li,B., Arif Pavel,M., Martin,H. and
            Yu,Y.
  TITLE     A PKD1L3 splice variant in taste buds is not cleaved at the G
            protein-coupled receptor proteolytic site
  JOURNAL   Biochem Biophys Res Commun 512 (4), 812-818 (2019)
   PUBMED   30928102
  REMARK    GeneRIF: PKD1L3 is cleaved at the N-terminal G protein-coupled
            receptor proteolytic site.Leucine-708 and Serine-709 are crucial
            for G protein-coupled receptor proteolytic site cleavage in mouse
            PKD1L3.
            Erratum:[Biochem Biophys Res Commun. 2019 Jun 25;514(2):565. doi:
            10.1016/j.bbrc.2019.04.150. PMID: 31056259]
REFERENCE   3  (bases 1 to 6970)
  AUTHORS   Wu,X., Indzhykulian,A.A., Niksch,P.D., Webber,R.M.,
            Garcia-Gonzalez,M., Watnick,T., Zhou,J., Vollrath,M.A. and
            Corey,D.P.
  TITLE     Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice
  JOURNAL   PLoS One 11 (5), e0155577 (2016)
   PUBMED   27196058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6970)
  AUTHORS   Ye,W., Chang,R.B., Bushman,J.D., Tu,Y.H., Mulhall,E.M.,
            Wilson,C.E., Cooper,A.J., Chick,W.S., Hill-Eubanks,D.C.,
            Nelson,M.T., Kinnamon,S.C. and Liman,E.R.
  TITLE     The K+ channel KIR2.1 functions in tandem with proton influx to
            mediate sour taste transduction
  JOURNAL   Proc Natl Acad Sci U S A 113 (2), E229-E238 (2016)
   PUBMED   26627720
REFERENCE   5  (bases 1 to 6970)
  AUTHORS   Horio,N., Yoshida,R., Yasumatsu,K., Yanagawa,Y., Ishimaru,Y.,
            Matsunami,H. and Ninomiya,Y.
  TITLE     Sour taste responses in mice lacking PKD channels
  JOURNAL   PLoS One 6 (5), e20007 (2011)
   PUBMED   21625513
REFERENCE   6  (bases 1 to 6970)
  AUTHORS   Ishii,S., Misaka,T., Kishi,M., Kaga,T., Ishimaru,Y. and Abe,K.
  TITLE     Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste
            receptor
  JOURNAL   Biochem Biophys Res Commun 385 (3), 346-350 (2009)
   PUBMED   19464260
  REMARK    GeneRIF: PKD1L3-PKD2L1 channel activation by acetic acid was
            pH-dependent and occurred when the ambient pH was <3.1.
REFERENCE   7  (bases 1 to 6970)
  AUTHORS   Inada,H., Kawabata,F., Ishimaru,Y., Fushiki,T., Matsunami,H. and
            Tominaga,M.
  TITLE     Off-response property of an acid-activated cation channel complex
            PKD1L3-PKD2L1
  JOURNAL   EMBO Rep 9 (7), 690-697 (2008)
   PUBMED   18535624
  REMARK    GeneRIF: The off-response property of PKD1L3-PKD2L1 channels might
            explain the physiological phenomena occurring during sour taste
            sensation.
REFERENCE   8  (bases 1 to 6970)
  AUTHORS   Ishimaru,Y., Inada,H., Kubota,M., Zhuang,H., Tominaga,M. and
            Matsunami,H.
  TITLE     Transient receptor potential family members PKD1L3 and PKD2L1 form
            a candidate sour taste receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (33), 12569-12574 (2006)
   PUBMED   16891422
  REMARK    GeneRIF: These results suggest that PKD1L3 and PKD2L1 heteromers
            may function as sour taste receptors.
REFERENCE   9  (bases 1 to 6970)
  AUTHORS   LopezJimenez,N.D., Cavenagh,M.M., Sainz,E., Cruz-Ithier,M.A.,
            Battey,J.F. and Sullivan,S.L.
  TITLE     Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1,
            are co-expressed in a subset of taste receptor cells
  JOURNAL   J Neurochem 98 (1), 68-77 (2006)
   PUBMED   16805797
  REMARK    GeneRIF: Pkd1l3 and Pkd2l1 are co-expressed in a select subset of
            taste receptor cells and therefore may, like other PKD channels,
            function as a heteromer
REFERENCE   10 (bases 1 to 6970)
  AUTHORS   Li,A., Tian,X., Sung,S.W. and Somlo,S.
  TITLE     Identification of two novel polycystic kidney disease-1-like genes
            in human and mouse genomes
  JOURNAL   Genomics 81 (6), 596-608 (2003)
   PUBMED   12782129
  REMARK    GeneRIF: genes are mapped to chromosomes and gene structures are
            characterized; protein structure is predicted and contains strong
            ion channel signature motifs that suggest their possible function
            as components of cation channel pores
            Erratum:[Genomics. 2003 Oct;82(4):498-500]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125162.4.
            
            On Jun 19, 2019 this sequence version replaced NM_001039700.2.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ382345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               AC125162.4         122717-123306
            591-713             AC125162.4         124822-124944
            714-821             AC125162.4         128910-129017
            822-871             AC125162.4         130149-130198
            872-2245            AC125162.4         131596-132969
            2246-2377           AC125162.4         135234-135365
            2378-2494           AC125162.4         137179-137295
            2495-2584           AC125162.4         138639-138728
            2585-2712           AC125162.4         139538-139665
            2713-2839           AC125162.4         139760-139886
            2840-2968           AC125162.4         141018-141146
            2969-3200           AC125162.4         141653-141884
            3201-3394           AC125162.4         143698-143891
            3395-3625           AC125162.4         144673-144903
            3626-3727           AC125162.4         146813-146914
            3728-3906           AC125162.4         147146-147324
            3907-4053           AC125162.4         149249-149395
            4054-4253           AC125162.4         154778-154977
            4254-4453           AC125162.4         155257-155456
            4454-4634           AC125162.4         155928-156108
            4635-4827           AC125162.4         156701-156893
            4828-5062           AC125162.4         156987-157221
            5063-5162           AC125162.4         159182-159281
            5163-5300           AC125162.4         163964-164101
            5301-5486           AC125162.4         164594-164779
            5487-5796           AC125162.4         169112-169421
            5797-5930           AC125162.4         170594-170727
            5931-6055           AC125162.4         172892-173016
            6056-6216           AC125162.4         174031-174191
            6217-6427           AC125162.4         175458-175668
            6428-6529           AC125162.4         176010-176111
            6530-6661           AC125162.4         177699-177830
            6662-6762           AC125162.4         179097-179197
            6763-6970           AC125162.4         180949-181156
FEATURES             Location/Qualifiers
     source          1..6970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.14 cM"
     gene            1..6970
                     /gene="Pkd1l3"
                     /note="polycystic kidney disease 1 like 3"
                     /db_xref="GeneID:244646"
                     /db_xref="MGI:MGI:2664670"
     exon            1..590
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..6889
                     /gene="Pkd1l3"
                     /note="isoform a is encoded by transcript variant 1;
                     polycystic kidney disease protein 1-like 3;
                     polycystin-1L3; PC1-like 3 protein; polycystin-1-like
                     protein 3"
                     /codon_start=1
                     /product="polycystin-1-like protein 3 isoform a"
                     /protein_id="NP_001034789.2"
                     /db_xref="CCDS:CCDS40472.1"
                     /db_xref="GeneID:244646"
                     /db_xref="MGI:MGI:2664670"
                     /translation="MLLQRRSWLWLYIRIGVILGDILGRKPSIREQHGGNSCYQLNRL
                     FCDFQEADNYCHAQRGRLAHTWNPKLRGFLKSFLNEETVWWVRGNLTLPGSHPGINQT
                     GGDDVLRNQKPGECPSVVTHSNAVFSRWNLCIEKHHFICQAAAFPPQGASIWRNEFGP
                     GPLLPMKRRGAETERHMIPGNGPPLAMCHQPAPPELFETLCFPIDPASSAPPKATHRM
                     TITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASS
                     SPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVT
                     SATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPAS
                     NSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQV
                     TSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPA
                     SSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTN
                     MTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSL
                     ANITSKAQEDSPLGVISTHPQMSFQSSTSQALDETAGERVPTIPDFQAHSEFQKACAI
                     LQRLRDFLPTSPTSAQKNNSWSSQTPAVSCPFQPLGRLTTTEKSSHQMAQQDMEQHPM
                     DGAHNAFGISAGGSEIQSDIQLRSEFEVEDMLETSLMALGEIHRAFCQQSLCPQSAVT
                     LASPSATLMLSSQNVSTLPLSTYTLGEPAPLTLGFPSAEALKELLNKHPGVNLQVTGL
                     AFNPFKTLDDKNIVGSIGNVQLSSAYQSIRVHDLIEDIEIMLWRNASMETQPTSLNTS
                     TDHFTISVNITSLEKTLIVTIEPESPLLMTLHLGFQDQLAHTHFYLNISLPRDQVWQK
                     DEEYTWVLTPENLWYGTGTYYIMAVENKSTEAAQHTPVLVSVVTAVTQCYFWDRYNRT
                     WKSDGCQVGPKSTILKTQCLCDHLTFFSSDFFIVPRTVDVENTIKLLLHVTNNPVGVS
                     LLSSLLGFYILLAMWASRKDREDMQKVKVTVLADNDPSSASHYLIQVYTGYRRRAATT
                     AKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGD
                     SPSWYVSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPASRSELSSFRHLFSS
                     TIVEKFTQDYLWLSVATRHPWNQFTRVQRLSCCMALLLCDMVINIMFWKMGGTTAKRG
                     TEQLGPLAVTLSELLVSIQTSIILFPIHLIFGRLFQLIHPPEALPQLPFIQAAWPPAL
                     VCESPSLTQVVKELKETVGFLLRRNTQLLSECEPSSCSSCDINKLAKLLSGLIYCHLE
                     DEGCHQQTESHWEDAVSENHYHFCRYLLQLLRRLKAHLEALGATQDHQSCDFSEAVSQ
                     LQNLQELLETQTLRRGPGPCRHSTSFPILSPGEGKKPMSFCLFRWLKCSCWLLLGVIS
                     LASAFFITLYSLELDKDQATSWVISMMLSVLQDIFISQPIKVIFLTLLFSLMANHMPW
                     LNKDKEQHARRIVALWAKCPWSAPGLRDKNNPIYTAPAMNNLAKPTRKAWKKQLSKLT
                     GGTLVQILFLTLLMTTVYSAKDSSRFFLHRAIWKRFSHRFSEIKTVEDFYPWANGTLL
                     PNLYGDYRGFITDGNSFLLGNVLIRQTRIPNDIFFPGSLHKQMKSPPQHQEDRENYGA
                     GWVPPDTNITKVDSIWHYQNQESLGGYPIQGELATYSGGGYVVRLGRNHSAATRVLQH
                     LEQRRWLDHCTKALFVEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDSLTSLQSS
                     ERGFAWIVSQVVYYLLVCYYAFIQGCRLKRQRLAFFTRKRNLLDTSIVLISFSILGLS
                     MQSLSLLHKKMQQYHCDRDRFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQ
                     LQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSISDYQSFFRSIVTVVGLL
                     MGTSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAFGKERKACEKEATLT
                     DMLLQKLSSLLGIRLHQNPSEEHADNTGSSNLRERSSKSMSSDAEVLAPADAVGSVSG
                     TDGNSGSTKVL"
     exon            591..713
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..821
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..871
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..2245
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2377
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2494
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2584
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2712
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2839
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2968
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3200
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3394
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3625
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3727
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3906
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4053
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4253
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4453
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4634
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..4827
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..5062
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5063..5162
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5300
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..5486
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..5796
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5930
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            5931..6055
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6056..6216
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6217..6427
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6428..6529
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6530..6661
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6662..6762
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     exon            6763..6970
                     /gene="Pkd1l3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6942..6947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkd1l3"
                     /note="hexamer: ATTAAA"
     polyA_site      6970
                     /gene="Pkd1l3"
                     /note="major polyA site"
ORIGIN      
        1 attggtgccc ccgactgtaa agccccgttt gctattcatt tgcagccggt gagaaatagc
       61 ttccctaaac aaaacaaaac ctttatctcc ttggcaggtt gttcccaacc cacaaaagaa
      121 caatacggac gattctgaca aactcactga gtcctattta aaagcccagg cagctgccaa
      181 gcctccgtac atcttctctc ttctcactcg agcctccgta catctctctt ctcactcgag
      241 cctccgtaca tcttctctct tctcactcgg cacagagaga aaaatgctct tgcagaggcg
      301 gtcctggctc tggctgtaca ttagaatcgg tgtcattctg ggtgatattt tgggacgtaa
      361 accaagcatc cgggagcaac atgggggaaa cagctgctat cagcttaaca gacttttctg
      421 tgacttccag gaagcagata actactgcca cgcccagaga ggacgcctag cccacacgtg
      481 gaaccccaag cttcggggtt tcctaaaaag cttcctgaat gaagaaacag tgtggtgggt
      541 caggggaaac ctgacgctgc ccggatcgca tccagggata aatcagacag gaggtgatga
      601 cgtcttaagg aaccaaaagc ctggcgagtg cccttccgtg gtcacacact ctaatgctgt
      661 cttctcaaga tggaacctgt gcatagagaa gcatcatttc atttgccagg ctgccgcctt
      721 tccccctcaa ggtgcaagca tttggagaaa tgagtttggt cctggtcctc tgttacccat
      781 gaaaagaaga ggagctgaga cagagagaca tatgatccca ggaaatggcc ccccgttagc
      841 catgtgtcac caacccgctc ctcctgagct ttttgagaca ttgtgctttc ccattgaccc
      901 agcttcttca gcacctccaa aagccacaca caggatgaca atcacatccc taactggaag
      961 gccacaggtg acatcagaca cacttgcatc cagcagccca ccacagggga catcagacac
     1021 acctgcatcc agcagcccac cacaggtgac atcagccaca tctgcatcta gcagcccacc
     1081 acaggggaca tcagacacac ctgcatccag cagcccacca caggtgacat cagccacatc
     1141 tgcatctagc agcccaccac aggggacatc agacacacct gcatccagca gcccaccaca
     1201 ggtgacatca gccacatctg catctagcag cccaccacag gggacatcag acacacctgc
     1261 atccagcagc ccaccacagg tgacatcagc cacatctgca tctagcagcc caccacaggg
     1321 gacatcagac acacctgcat ccagcagccc accacagggg acattagaca caccttcatc
     1381 tagcagccca ccacagggga catcagacac acctgcatcc agcagcccac cacaggggac
     1441 atcagagaca cctgcatcca acagcccacc acaggggaca tcagagacac ctggattcag
     1501 cagcccacca caggtgacaa cagccacact tgtatccagc agcccaccac aggtgacatc
     1561 agagacacct gcatccagca gcccaacaca ggtgacatca gagacacctg catccagcag
     1621 cccaacacag gtgacatcag acacacctgc atccaatagc ccaccacagg ggacatcaga
     1681 cacacctgga ttcagcagcc caacacaggt gacaacagcc acacttgtat ccagcagccc
     1741 accacaggtg acatcagaca cacctgcatc cagcagccca ccacaggtga catcagacac
     1801 acctgcatcc agcagcccac cacaggtgac atcagagaca cctgcatcca gcagcccacc
     1861 acaggtgaca tcagacacat ctgcatccat cagcccacca caggtaatat cagacacacc
     1921 tgcatccagc agcccaccac aggtgacatc agagacacct gcatccagca gcccaacaaa
     1981 catgacatca gacacacctg catccagcag cccaacaaac atgacatcag acacacctgc
     2041 atccagcagc ccaacaaaca tgacatcaga cacacctgca tccagcagcc caccatggcc
     2101 tgttataaca gaggtcacca ggcctgaatc cacaatacct gctggaagat ctttggcaaa
     2161 catcacttca aaggcacagg aagactctcc cctgggagtc atctctaccc atccacagat
     2221 gtcatttcag agttcaacca gtcaggcctt ggatgagaca gcaggggaac gggtcccaac
     2281 aattcctgat ttccaagccc acagtgaatt ccagaaagct tgtgccatcc tccagagact
     2341 gagagacttc ctgccgactt ctcccacatc agctcagaag aacaacagtt ggagctctca
     2401 aactccagca gtcagctgcc ccttccagcc tcttggacgt ctaacaacaa cggaaaaaag
     2461 cagtcatcag atggctcagc aagacatgga acagcacccc atggacggag cacacaatgc
     2521 atttgggatc agtgcagggg gatcggaaat tcaaagtgac atccagctac ggagtgagtt
     2581 tgaggttgaa gacatgctgg agacatccct gatggccctg ggggagatcc acagagcatt
     2641 ttgccagcag agtctgtgcc ctcagtcagc agtgaccctg gcctctccct ctgctactct
     2701 gatgttgagc agccaaaatg tgtcaacgtt gcccctgagc acctacactt tgggtgagcc
     2761 tgcacccttg actttgggct tcccgtcagc agaagctctg aaggagctct tgaacaaaca
     2821 cccaggcgtg aaccttcaag tgacaggtct ggctttcaac ccttttaaga ctttggatga
     2881 caagaacatt gttggaagca ttggaaatgt gcagctgagc tctgcttatc agtcgatcag
     2941 agtccacgac ttaatagaag atattgagat catgctctgg agaaatgcca gcatggagac
     3001 ccagcccacc agcctcaaca caagtacaga ccatttcaca atctctgtga acatcacttc
     3061 cttggagaag accctcattg tgaccatcga gcctgaaagt cccctcctaa tgacgctcca
     3121 cttgggcttc caggaccagc tggcccacac tcacttctat ctcaacatca gcctgccaag
     3181 ggaccaagtg tggcagaaag atgaggagta cacgtgggtg ctgacaccag agaacctgtg
     3241 gtacgggact ggcacctact acataatggc tgtggagaat aaaagtacag aggcggcaca
     3301 gcacacaccc gtcctggtct cagtggtcac agctgtcacc cagtgctatt tctgggaccg
     3361 atacaatagg acatggaaga gcgatggatg ccaagtgggg ccgaagagca ccattttaaa
     3421 gacacagtgt ctctgtgacc acctgacctt cttcagcagc gacttcttca tcgtgccgag
     3481 gacggtggat gtagaaaaca ccatcaaact gcttcttcat gtgaccaaca accctgtcgg
     3541 ggtgtcattg ctgtccagcc tcctaggatt ctatatcctc ttagccatgt gggcttccag
     3601 aaaggatcga gaagatatgc agaaggtgaa ggtaacagtc ctggctgaca atgaccccag
     3661 ctctgcatcc cactacctta tccaggtcta cactggctat cggaggaggg ctgctaccac
     3721 cgccaaggtc gttatcactc tctatggctc agaggggcac agtgagcccc accacctttg
     3781 tgaccctgag aagacagttt ttgagcgtgg agcactggat gttttccttc tttccaccgg
     3841 atcctggctg ggggacctgc atggccttcg gctgtggcat gacaattctg gcgacagccc
     3901 ttcttggtat gtaagccagg tgatcgtcag tgacatgacc acgaggaaga aatggcattt
     3961 ccagtgcaat tgttggctgg ccgtggactt gggcaactgt gagcgtgaca gggtgttcac
     4021 accagcctcc agaagcgagc tctcttcctt cagacacctg ttctcctcca caatcgtaga
     4081 aaagttcacc caggattatc tgtggctctc agttgcaact cgacatccct ggaaccagtt
     4141 tacacgagtc cagaggctct cctgctgcat ggcactactg ctctgtgaca tggtcatcaa
     4201 tattatgttc tggaagatgg gtggcaccac tgccaagagg ggcaccgaac aactaggtcc
     4261 acttgctgtg accttgtcgg agctgctcgt cagcatccag acctccatca tcctcttccc
     4321 catccacctc atctttgggc ggctcttcca gttgattcac ccaccagaag ctctgcccca
     4381 gcttcctttc atccaggctg cctggccccc tgctcttgtt tgtgagtccc cctctcttac
     4441 acaggtggtc aaggaattaa aggaaactgt gggattcctg ctcaggagaa atacacagct
     4501 gctctcggag tgtgagccgt cttcgtgcag ttcttgtgac attaacaagc tggcgaagct
     4561 tttatccggc ctcatttact gtcacttaga agacgaaggc tgtcaccagc agacagaatc
     4621 ccactgggaa gacgcagtgt ctgaaaacca ttaccatttc tgccgctacc ttctccaact
     4681 tctgcggaga ctgaaagcgc atttagaggc tcttggtgct acccaggatc accagtcttg
     4741 tgatttctca gaagcagtca gccaacttca aaacctccag gaactcctgg agacacagac
     4801 tctccgcaga gggccagggc catgcaggca ttccaccagt ttccccatcc tcagcccagg
     4861 agaagggaag aagcccatgt cattttgcct gttcagatgg ttgaagtgca gctgctggct
     4921 ccttcttggt gtcatcagcc tggcctcggc cttttttata acgctctata gcttggagtt
     4981 ggacaaagac caagccacca gctgggttat ttcaatgatg ctgtcggtac tacaagacat
     5041 ctttatcagc cagccgataa aggtcatctt cctgacattg ttgttctccc tgatggcaaa
     5101 ccacatgccg tggcttaaca aagacaagga acaacacgcc cggagaatcg tagcactttg
     5161 ggcaaagtgt ccttggtcgg cacctggctt gagagacaag aacaatccca tctacactgc
     5221 cccagcaatg aacaacctag ccaagcctac aaggaaggcc tggaagaagc agctctccaa
     5281 gctgacgggt ggtactctgg tgcaaatcct cttcctgacc ctgctgatga ctaccgtcta
     5341 ttctgcaaag gactctagtc gatttttcct ccatcgagct atctggaaga ggttttctca
     5401 ccgtttctca gaaatcaaaa ctgtagagga tttctacccc tgggccaacg gcaccctcct
     5461 tcctaaccta tatggggatt acagaggatt tattactgac gggaactcct ttcttctggg
     5521 caatgttttg atccgccaga ctcgcattcc taatgacata ttcttcccag gatctctcca
     5581 caagcaaatg aagtcgcctc cccaacatca ggaggacaga gagaactatg gggctggctg
     5641 ggtcccccct gacacaaaca tcacaaaagt agacagtatt tggcattatc agaatcagga
     5701 gtcgctggga ggctatccca tccaagggga gctagccact tactcaggag gaggctatgt
     5761 tgtgaggctt ggaagaaacc acagtgcggc aaccagggtt ctgcagcatc tggaacagag
     5821 gcgctggctg gaccactgca caaaagccct ctttgtagaa ttcacggtct tcaatgctaa
     5881 tgtgaatctg ctctgtgcgg tgaccctcat cttggaatcc agtggtgtgg ggactttcct
     5941 cacctccctg caactggaca gtttaacttc ccttcagtca tcagagaggg gcttcgcctg
     6001 gatcgtctca caggtcgtct actaccttct cgtctgttac tatgccttca tccagggctg
     6061 tcggctgaag cggcagaggc tggcgttctt cactaggaaa aggaacctcc tggacacaag
     6121 catcgtcctc attagcttca gcatcctggg cctcagcatg cagagcctct ctctacttca
     6181 caaaaagatg cagcagtacc actgtgaccg ggacaggttc atcagtttct acgaggcact
     6241 gagagtgaac tctgcagtca cccacctcag gggcttcctg cttctcttcg caactgtgcg
     6301 ggtctgggac ctactgcgac atcatgccca gttacaggtc atcaacaaga cactgtccaa
     6361 agcctgggac gaggtgctgg gctttatact gatcatcgtg gtcctgttaa gcagctatgc
     6421 catgactttc aacctgctgt ttggatggag catctctgac taccagagct tcttcagatc
     6481 tatagtgact gttgttggcc tcttgatggg aacttcaaag cacaaggagg ttattgctct
     6541 atacccaatc ctgggctccc ttttggttct cagtagcatc atcttgatgg gacttgtgat
     6601 cattaatctt tttgtttctg ccattctcat tgcctttggg aaagaaagga aggcctgtga
     6661 gaaagaagct acactgacag atatgttact acaaaagctc tcaagtctgt taggaatccg
     6721 cctgcaccag aatccatctg aggaacacgc tgacaacact ggttcctcaa atctccggga
     6781 aagatcatca aagtctatgt cttctgatgc tgaggtgctg gctccagcag atgcagttgg
     6841 aagtgtgtct ggcaccgatg gcaactctgg cagtacaaag gtgttgtaat tatccacagg
     6901 tctggaaggg ggctttgcag gagcttctgg cttgggtcct aattaaatca ggtcaaagag
     6961 cacaatctta
//
