LOCUS       NM_001290555            3004 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Mus musculus praja ring finger ubiquitin ligase 1 (Pja1),
            transcript variant 3, mRNA.
ACCESSION   NM_001290555 XM_006527897
VERSION     NM_001290555.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3004)
  AUTHORS   Wang X, Jiang Y, Feng B, Ma X, Zhang K, Yang F, Liu Z, Yang L, Yue
            J, Lu L, Song D, Guo Q, Qi J, Li X, Wang M, Zhang H, Huang J, Zhao
            M and Liu S.
  TITLE     PJA1 mediates the effects of astrocytic GPR30 on learning and
            memory in female mice
  JOURNAL   J Clin Invest 133 (18), e165812 (2023)
   PUBMED   37712419
  REMARK    GeneRIF: PJA1 mediates the effects of astrocytic GPR30 on learning
            and memory in female mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3004)
  AUTHORS   Watabe K, Kato Y, Sakuma M, Murata M, Niida-Kawaguchi M, Takemura
            T, Hanagata N, Tada M, Kakita A and Shibata N.
  TITLE     Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation
  JOURNAL   Neuropathology 40 (6), 570-586 (2020)
   PUBMED   32686212
  REMARK    GeneRIF: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation.
REFERENCE   3  (bases 1 to 3004)
  AUTHORS   Lu Q, Murakami C, Murakami Y, Hoshino F, Asami M, Usuki T, Sakai H
            and Sakane F.
  TITLE     1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and
            activates Praja-1, the E3 ubiquitin ligase acting on the serotonin
            transporter in the brain
  JOURNAL   FEBS Lett 594 (11), 1787-1796 (2020)
   PUBMED   32134507
  REMARK    GeneRIF: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts
            with and activates Praja-1, the E3 ubiquitin ligase acting on the
            serotonin transporter in the brain.
REFERENCE   4  (bases 1 to 3004)
  AUTHORS   Chen J, Mitra A, Li S, Song S, Nguyen BN, Chen JS, Shin JH, Gough
            NR, Lin P, Obias V, He AR, Yao Z, Malta TM, Noushmehr H, Latham PS,
            Su X, Rashid A, Mishra B, Wu RC and Mishra L.
  TITLE     Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing
            TGFbeta Signaling
  JOURNAL   Cancer Res 80 (9), 1819-1832 (2020)
   PUBMED   32127355
REFERENCE   5  (bases 1 to 3004)
  AUTHORS   Lu Q, Murakami C, Hoshino F, Murakami Y and Sakane F.
  TITLE     Diacylglycerol kinase delta destabilizes serotonin transporter
            protein through the ubiquitin-proteasome system
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (3), 158608 (2020)
   PUBMED   31891772
REFERENCE   6  (bases 1 to 3004)
  AUTHORS   Sasaki A, Masuda Y, Iwai K, Ikeda K and Watanabe K.
  TITLE     A RING finger protein Praja1 regulates Dlx5-dependent transcription
            through its ubiquitin ligase activity for the Dlx/Msx-interacting
            MAGE/Necdin family protein, Dlxin-1
  JOURNAL   J Biol Chem 277 (25), 22541-22546 (2002)
   PUBMED   11959851
REFERENCE   7  (bases 1 to 3004)
  AUTHORS   Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L and
            Deng CX.
  TITLE     Smad proteins and hepatocyte growth factor control parallel
            regulatory pathways that converge on beta1-integrin to promote
            normal liver development
  JOURNAL   Mol Cell Biol 21 (15), 5122-5131 (2001)
   PUBMED   11438667
REFERENCE   8  (bases 1 to 3004)
  AUTHORS   Fang S, Jensen JP, Ludwig RL, Vousden KH and Weissman AM.
  TITLE     Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself
            and p53
  JOURNAL   J Biol Chem 275 (12), 8945-8951 (2000)
   PUBMED   10722742
REFERENCE   9  (bases 1 to 3004)
  AUTHORS   Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S and Weissman AM.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   10 (bases 1 to 3004)
  AUTHORS   Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E,
            Pavan WJ and Mishra B.
  TITLE     Praja1, a novel gene encoding a RING-H2 motif in mouse development
  JOURNAL   Oncogene 15 (19), 2361-2368 (1997)
   PUBMED   9393880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN695027.1, AK145943.1 and CD741074.1.
            
            [WARNING] On Nov 29, 2023 this sequence was replaced by
            NM_001290555.2.
            
            On Mar 14, 2014 this sequence version replaced XM_006527897.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (3) has a longer N-terminus than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.91951.1, AK145943.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                CN695027.1         1-43
            44-2549             AK145943.1         1-2506
            2550-3004           CD741074.1         1-455               c
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.38 cM"
     gene            1..3004
                     /gene="Pja1"
                     /gene_synonym="praja-1"
                     /note="praja ring finger ubiquitin ligase 1"
                     /db_xref="GeneID:18744"
                     /db_xref="MGI:MGI:1101765"
     exon            1..119
                     /gene="Pja1"
                     /gene_synonym="praja-1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..2986
                     /gene="Pja1"
                     /gene_synonym="praja-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2155
                     /gene="Pja1"
                     /gene_synonym="praja-1"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase Praja-1; RING-type E3 ubiquitin
                     transferase Praja-1; praja1, RING-H2 motif containing;
                     praja ring finger 1, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Praja-1 isoform 3"
                     /protein_id="NP_001277484.1"
                     /db_xref="GeneID:18744"
                     /db_xref="MGI:MGI:1101765"
                     /translation="MGQGPSKPVRPRAAGGYQSGTGRSYGRRHASVSFRPSMSHQERI
                     ASQRRTTAEVPMHRSTANQSKRSRSPFASTRRRWDDSESSGASLAVESEDYSRYPPRE
                     YRASGSRRGLAYGHIDTVVARDSEEEGAGPVDRLPVRGKAGKFKDDPEKGARSSRFTS
                     VNHDAKEECGKVESPPAARCSARRAELSKQNGSSASQISSAEGRAAAKGNNSLERERQ
                     NLPARPSRAPVSICGGGENTPKSAEEPVVRPKVRNVATPNCMKPKVFFDTDDDDDVPH
                     STSRWRDAADAEEAHAEGLARRGRGEAASSSEPRYAEDQDARSEQAKADKVPRRRRTM
                     ADPDFWAYTDDYYRYYEEDSDSDKEWMAALRRKYRSREQPQSSSGESWELLPGKEELE
                     RQQAGAGSLASAGSNGSGYPEEVQDPSLQEEEQASLEEGEIPWLRYNENESSSEGDNE
                     STHELIQPGMFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLT
                     YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMC
                     CPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL"
ORIGIN      
        1 cgcctgccct agtgctcttt agcgggggag gagccgagac ccggagcagc agcagtggtg
       61 gtggccgcgt ccggaggtcc gacagctctg cagctccgag cgcgcgacta gccagaaagg
      121 tccacaccag tcactggaat gctacctcag gccttagaag acagtgaaac taatttgaaa
      181 gggtccctgt cagtctgtta cctgcctcct gaaggaaaaa tagacctcct tgttctgtag
      241 ttctgaactg ggagcaagaa cccttacacc tgcatccaag ctctgttgga agctctgaat
      301 cagagccatg ggtcagggac ctagcaagcc tgttcggccc agagcagcag gagggtatca
      361 gtcaggtaca ggcaggagtt atggaaggag gcatgcttct gtcagtttca ggccatccat
      421 gagccaccag gaaaggattg ccagccagag gaggacaaca gccgaagtcc caatgcacag
      481 atcaactgcc aatcaaagca agaggagccg gtcaccattt gccagcacac gtcgtcgctg
      541 ggatgacagc gagagctcgg gagccagcct ggctgttgag agtgaggatt attccaggta
      601 tcctccaaga gagtacaggg cctcggggag ccgaagagga ttggcttatg gacacattga
      661 cactgtagtg gctcgtgata gtgaggagga gggggctggg cctgttgacc gactgccagt
      721 gagagggaaa gctggcaagt ttaaggatga tcccgagaag ggggcaaggt cttcccgctt
      781 tactagtgtt aaccatgatg cgaaggaaga gtgtggcaag gtagaatcac cccctgcagc
      841 gaggtgctcg gctcgcagag ctgagctctc gaagcagaat ggctcctcgg cctctcagat
      901 ttcttctgct gaaggcaggg cagctgcaaa aggtaacaac agcttggaga gggagaggca
      961 gaatttacca gctcgtccta gcagggctcc tgtgagtatt tgtggtggtg gggaaaacac
     1021 cccaaagagt gccgaggaac cggtggtgag acccaaagtc cggaatgtgg cgactccaaa
     1081 ctgcatgaaa cccaaagtgt tttttgatac tgatgatgat gatgatgtac cacacagtac
     1141 ttccaggtgg cgggatgctg ccgatgctga ggaggctcat gccgagggcc tagccagaag
     1201 aggccgaggt gaggctgcca gcagctcaga gccaaggtat gctgaagacc aggatgccag
     1261 gagtgaacaa gcgaaggcag acaaagtgcc aagacggcgg cgaaccatgg cagaccctga
     1321 cttctgggca tacaccgacg attactaccg atactacgag gaagattctg acagcgacaa
     1381 agagtggatg gctgccctgc gcaggaagta ccgaagccga gagcaacccc agtcctccag
     1441 cggagaaagc tgggagcttc tgccaggaaa ggaagaactg gaacgtcagc aagccggagc
     1501 tgggagcctc gccagtgctg gcagcaatgg cagtggttat cctgaagaag tacaagaccc
     1561 atctcttcag gaggaagaac aggcctctct ggaagaagga gaaatccctt ggcttcgcta
     1621 caatgagaat gaaagcagca gcgagggtga taatgagtct acccatgagc tcatacagcc
     1681 tgggatgttc atgctggatg gaaacaacaa cctggaagat gactccagcg tgagcgaaga
     1741 cctcgaagtg gactggagcc tgtttgatgg gtttgccgat ggcttgggag tggccgaagc
     1801 catctcctac gtggatcctc agttcctcac ctacatggct ctggaagagc gtctggccca
     1861 ggcaatggag acggccctgg cacacttgga gtctctcgcc gttgatgtcg aagtggccaa
     1921 cccaccagca agcaaggaga gcattgatgc ccttcctgag atcctggtca ccgaagatca
     1981 tggtgcagtg ggccaggaaa tgtgctgtcc tatctgctgc agcgaatatg tgaaggggga
     2041 ggtggcaact gagctaccat gccaccacta tttccacaag ccctgcgtgt ccatctggct
     2101 tcagaagtct ggcacctgcc cagtgtgccg ctgcatgttc cctcccccgc tctaaaagcc
     2161 aaggctcgtc gtaacagtca gcctggttac attccctgtc cgaaacccac aatactacag
     2221 gagcccttgt tctaaactta caatgaaacc agtcagtcaa ttagactaaa gttgttgatt
     2281 ccttgtgatt atttccatgt gaaaatggtt gtgtacaatg acatttaaaa aaaatcatcc
     2341 tctcgtttag aaggtagaaa gggggaaagg aaactttcta aatgctgctt gagattgcag
     2401 taagaacata cattttctaa cctgaaagtt gaaacaaatc ccacttgttc tgtagactgt
     2461 gtctctctta cctgttgctg tcagggttac ctatctgcta aactatgtcg gaaagacaaa
     2521 attacttttg ttgcatgtca tgggttaatg ttcctgtatt tgcagtggtg taaaagctta
     2581 ttaaagttct tcttttgctt tgacacagaa caatggcatc atttggattt ttgtctgaaa
     2641 tcgtgatacc aggtaactcc aaattgatcc cttgcatttg caacaaaagt attgtgtttc
     2701 agtgttctca cctgtagaaa actagttttc actagaaatg ctcatcagaa caccaaaaaa
     2761 aaaccatctt taataggaat aaggtgtata attgcttgtt gtacagaaat ggttgactaa
     2821 agagagagaa acaaagcgtg ggaaatttaa aaaaaaaacc cacagagaaa caatggtaaa
     2881 aaatgaatcc aaagtgtacg ggtgagcaag tacaaatcac ctttgagaaa acagaaactg
     2941 tcagaatggg tgaaaaataa aaataaataa ataaataaaa aaggtcaaaa aaaaaaaaaa
     3001 aaaa
//
