LOCUS       NM_008852               1379 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus paired-like homeodomain transcription factor 3
            (Pitx3), mRNA.
ACCESSION   NM_008852
VERSION     NM_008852.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Rybiczka-Tesulov,M., Garritsen,O., Veno,M.T., Wieg,L., Dijk,R.V.,
            Rahimi,K., Gomes-Duarte,A., Wit,M., van de Haar,L.L., Michels,L.,
            van Kronenburg,N.C.H., van der Meer,C., Kjems,J., Vangoor,V.R. and
            Pasterkamp,R.J.
  TITLE     Circular RNAs regulate neuron size and migration of midbrain
            dopamine neurons during development
  JOURNAL   Nat Commun 15 (1), 6773 (2024)
   PUBMED   39117691
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Ayon-Olivas,M., Wolf,D., Andreska,T., Granado,N., Luningschror,P.,
            Ip,C.W., Moratalla,R. and Sendtner,M.
  TITLE     Dopaminergic Input Regulates the Sensitivity of Indirect Pathway
            Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor
  JOURNAL   Biology (Basel) 12 (10), 1360 (2023)
   PUBMED   37887070
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Webster,E.H. Jr., Zwaan,J. and Cooper,P.
  TITLE     Abnormal accumulation of sulphated materials in lens tissue of mice
            with the aphakia mutation
  JOURNAL   J Embryol Exp Morphol 92, 85-101 (1986)
   PUBMED   3522797
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Zwaan,J. and Webster,E.H. Jr.
  TITLE     Histochemical analysis of extracellular matrix material during
            embryonic mouse lens morphogenesis in an aphakic strain of mice
  JOURNAL   Dev Biol 104 (2), 380-389 (1984)
   PUBMED   6745489
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Zwaan,J. and Kirkland,B.M.
  TITLE     Malorientation of mitotic figures in the early lens rudiment of
            aphakia mouse embryos
  JOURNAL   Anat Rec 182 (3), 345-354 (1975)
   PUBMED   1155804
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Zwaan,J.
  TITLE     Immunofluorescent studies on aphakia, a mutation of a gene involved
            in the control of lens differentiation in the mouse embryo
  JOURNAL   Dev Biol 44 (2), 306-312 (1975)
   PUBMED   1093912
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Varnum,D.S. and Stevens,L.C.
  TITLE     Aphakia, a new mutation in the mouse
  JOURNAL   J Hered 59 (2), 147-150 (1968)
   PUBMED   4970465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140233.3.
            
            On Oct 19, 2007 this sequence version replaced NM_008852.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF005772.1, BC137810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC140233.3         175423-175547       c
            126-255             AC140233.3         164587-164716       c
            256-458             AC140233.3         164205-164407       c
            459-1379            AC140233.3         162907-163827       c
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..1379
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /note="paired-like homeodomain transcription factor 3"
                     /db_xref="GeneID:18742"
                     /db_xref="MGI:MGI:1100498"
     exon            1..125
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..255
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1046
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /note="homeobox protein PITX3"
                     /codon_start=1
                     /product="pituitary homeobox 3"
                     /protein_id="NP_032878.1"
                     /db_xref="CCDS:CCDS29872.1"
                     /db_xref="GeneID:18742"
                     /db_xref="MGI:MGI:1100498"
                     /translation="MEFGLLGEAEARSPALSLSDAGTPHPPLPEHGCKGQEHSDSEKA
                     SASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLT
                     EARVRVWFKNRRAKWRKRERSQQAELCKGGFAAPLGGLVPPYEEVYPGYSYGNWPPKA
                     LAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGL
                     GGAPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHAS
                     FSYPAVPGPPPAANLSPCQYAVERPV"
     exon            256..458
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1379
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="Pitx3"
                     /gene_synonym="ak; aphakia; Ptx3"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgccc cagagcaggg gggcggcccc caccccgcag ggtgcctggc ccctggcccc
       61 tgcctgcgct ccagaacgcc gccgccacag ccaccacccg gagtctgcct gctgcgggac
      121 gcactagacc tccctccatg gagtttgggc tgcttggtga ggcagaggcg cgaagccctg
      181 cgctgtcgtt atcggacgca ggcactccac accctccgct tccagaacat ggctgcaagg
      241 ggcaggagca cagtgactcg gagaaggcct cggcctcact gccggggggc tcccccgagg
      301 acggctctct gaagaagaag cagcggcggc agcgcacgca cttcaccagc cagcagctgc
      361 aggagctgga ggccaccttc cagaggaatc gctaccctga catgagcacc cgcgaagaga
      421 tcgcggtgtg gaccaacctc actgaggccc gcgtgcgggt gtggttcaag aaccggcgcg
      481 ccaagtggcg gaagcgggag cgcagccagc aggcggagct gtgcaaaggt ggcttcgcag
      541 ccccgctcgg gggcctggtg ccaccctacg aggaggtgta cccgggctac tcgtacggca
      601 actggccgcc caaggctctc gccccgccgc tcgccgccaa gaccttcccg ttcgccttca
      661 actcggtcaa cgtggggcct ctggcttcac agcctgtatt ctcaccgccc agctccatcg
      721 ccgcttctat ggtgccctcg gccgccgctg ccccgggcac cgtaccaggt cccggagcct
      781 tgcagggcct gggcggggca ccccccgggc tggctccagc cgccgtgtcc tccggggcag
      841 tgtcctgccc ttacgcctcg gccgccgcag ccgccgctgc agccgcctcc tccccctatg
      901 tataccggga cccgtgtaac tcgagcctgg ctagcctgcg gctcaaagcc aagcagcacg
      961 cctctttcag ctatcccgcc gtgcccgggc cgccgccggc cgctaacctt agcccctgcc
     1021 agtacgccgt ggaacggccg gtgtgagccg caggtctgtg gatccatccc cgagggcggg
     1081 gcagtaattc acagcctctc cggacagggg tcgcctagac tggcttgccc tcgtcccagg
     1141 gtctgaaagg ggtgccagag cacccgggaa gaggccgcgg gcttcgaaga gggccttttc
     1201 cctcgcagcc cccgagcggt ggtctgaccc ctatgcggag accgcgcccc taggactaag
     1261 gccaggaaca gggaccagct cccccagggc caattcaccc ttggctcacc ccgccttctc
     1321 cagactcccc ctatcccatt ttcaaagatc aatgaaataa acgtgcgcgg actgtcaaa
//
