LOCUS       NM_011098               1946 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus paired-like homeodomain transcription factor 2
            (Pitx2), transcript variant 2, mRNA.
ACCESSION   NM_011098
VERSION     NM_011098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Unda,S.R., Pomeranz,L.E., Marongiu,R., Yu,X., Kelly,L.,
            Hassanzadeh,G., Molina,H., Vaisey,G., Wang,P., Dyke,J.P.,
            Fung,E.K., Grosenick,L., Zirkel,R., Antoniazzi,A.M., Norman,S.,
            Liston,C.M., Schaffer,C., Nishimura,N., Stanley,S.A., Friedman,J.M.
            and Kaplitt,M.G.
  TITLE     Bidirectional regulation of motor circuits using magnetogenetic
            gene therapy
  JOURNAL   Sci Adv 10 (41), eadp9150 (2024)
   PUBMED   39383230
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Shao,F., Phan,A.V., Yu,W., Guo,Y., Thompson,J., Coppinger,C.,
            Venugopalan,S.R., Amendt,B.A., Van Otterloo,E. and Cao,H.
  TITLE     Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling
            lineage specification of mandibular epithelium during tooth
            initiation
  JOURNAL   PLoS Genet 20 (7), e1011364 (2024)
   PUBMED   39052671
  REMARK    GeneRIF: Transcriptional programs of Pitx2 and Tfap2a/Tfap2b
            controlling lineage specification of mandibular epithelium during
            tooth initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Kuriki,M., Korb,A., Comai,G. and Tajbakhsh,S.
  TITLE     Interplay between Pitx2 and Pax7 temporally governs specification
            of extraocular muscle stem cells
  JOURNAL   PLoS Genet 20 (6), e1010935 (2024)
   PUBMED   38875306
  REMARK    GeneRIF: Interplay between Pitx2 and Pax7 temporally governs
            specification of extraocular muscle stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Lamba,P., Hjalt,T.A. and Bernard,D.J.
  TITLE     Novel forms of Paired-like homeodomain transcription factor 2
            (PITX2): generation by alternative translation initiation and mRNA
            splicing
  JOURNAL   BMC Mol Biol 9, 31 (2008)
   PUBMED   18373856
  REMARK    GeneRIF: identification & characterization of 2 novel isoforms of
            PITX2, generated by alternative translation initiation (PITX2Cbeta)
            & alternative mRNA splicing (PITX2B2); they show similar DNA
            binding & trans-activation functions as other PITX2 isoforms in
            vitro
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Phillips,J.C., del Bono,E.A., Haines,J.L., Pralea,A.M., Cohen,J.S.,
            Greff,L.J. and Wiggs,J.L.
  TITLE     A second locus for Rieger syndrome maps to chromosome 13q14
  JOURNAL   Am J Hum Genet 59 (3), 613-619 (1996)
   PUBMED   8751862
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Heon,E., Sheth,B.P., Kalenak,J.W., Sunden,S.L., Streb,L.M.,
            Taylor,C.M., Alward,W.L., Sheffield,V.C. and Stone,E.M.
  TITLE     Linkage of autosomal dominant iris hypoplasia to the region of the
            Rieger syndrome locus (4q25)
  JOURNAL   Hum Mol Genet 4 (8), 1435-1439 (1995)
   PUBMED   7581385
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Murray,J.C., Bennett,S.R., Kwitek,A.E., Small,K.W., Schinzel,A.,
            Alward,W.L., Weber,J.L., Bell,G.I. and Buetow,K.H.
  TITLE     Linkage of Rieger syndrome to the region of the epidermal growth
            factor gene on chromosome 4
  JOURNAL   Nat Genet 2 (1), 46-49 (1992)
   PUBMED   1303248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116740.11.
            
            On Nov 23, 2013 this sequence version replaced NM_011098.3.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            protein (isoform b, also known as PITX2B1) is longer than isoform
            a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U80010.1, AB006321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC116740.11        122795-123079
            286-341             AC116740.11        126854-126909
            342-479             AC116740.11        127357-127494
            480-685             AC116740.11        138556-138761
            686-1946            AC116740.11        141251-142511
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 57.84 cM"
     gene            1..1946
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /note="paired-like homeodomain transcription factor 2"
                     /db_xref="GeneID:18741"
                     /db_xref="MGI:MGI:109340"
     exon            1..285
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /inference="alignment:Splign:2.1.0"
     exon            286..341
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /inference="alignment:Splign:2.1.0"
     exon            342..479
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /inference="alignment:Splign:2.1.0"
     exon            480..685
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1946
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /note="hexamer: AATATA"
     polyA_site      1943
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /note="major polyA site"
ORIGIN      
        1 acggagtcgg agcggaggga agagagaggg atgagagcga gggaggggag agagagtgcg
       61 agaccgagag agaaagccgg agagcagcag acagaaactg ccggcgcccg ctagctttag
      121 cagccccccg cgtggaccct ctcggaactt ggcaccctca agatccccgc agttccaccc
      181 agacccgctc cacggcgctg gctgtgcagc ccgagcctcg gccgcctggc agtcaccctg
      241 ggaagcggtg ggacggggag acagccgttc tctctccggt agccgataac cgggaatgga
      301 gaccaattgt cgcaaactag tgtcggcctg cgtgcaatta ggcgtgcagc cggcagccgt
      361 tgaatgtctc ttctccaaag actccgaaat caaaaaggtc gagttcacgg actctcccaa
      421 gagccggaaa gagtcggcca gcagcaagct gttcccgcgg cagcaccccg gcgccaatga
      481 gaaagataag ggccagcaag gaaagaatga ggatgtgggc gccgaggacc cgtccaagaa
      541 gaagcggcaa cgccggcaga ggactcattt cactagccag cagctgcagg agctggaagc
      601 cactttccag agaaaccgct acccagacat gtccactcgc gaagaaatcg ccgtgtggac
      661 caaccttacg gaagcccgag tccgggtttg gttcaagaat cgccgggcca aatggagaaa
      721 gcgggaacgc aaccagcagg ccgagctgtg caagaatggc tttgggccgc agttcaacgg
      781 gctcatgcag ccctacgatg acatgtaccc cggctattcg tacaacaatt gggctgccaa
      841 gggcctcacg tcagcgtctc tgtccaccaa gagcttcccc ttcttcaact ccatgaacgt
      901 caatcccctg tcctctcaga gtatgttttc cccgcccaac tccatctcat ctatgagtat
      961 gtcgtccagc atggtgccct ccgcggtgac cggcgtcccg ggctccagcc tcaatagcct
     1021 gaataacttg aacaacctga gcagcccgtc gctgaattcc gcggtgccca cgcccgcctg
     1081 tccttacgcg ccgccgactc ctccgtacgt ttatagggac acatgtaact cgagcctggc
     1141 cagcctgaga ctgaaagcaa agcagcactc cagcttcggc tacgccagcg tgcagaaccc
     1201 ggcctccaac ctgagtgctt gccagtatgc agtcgaccgg ccggtgtgaa ccgcgcccag
     1261 ggcgcgggga tccgaggact gtcggagtgg gcaactctgc cccagaaaga ctgagaattg
     1321 tgctagaagg tcgtgcgcac tatgggaagg aagagggggg aaaaaagatc agaggaaaag
     1381 aaaccactga attcaaagag agagcgcctt tgatttcaaa ggaatgtccc caagtgtcta
     1441 cgtctttcgc taagagtatt cccaacagtt ggaggacgcg tacgcccaca aatgtttgac
     1501 tggatatgac attttaacat tactataagc ttgttatttt ttaagtttag cattgttaac
     1561 attaaaatga ctgaaaggat gtatatatat cgaaatgtca aattaatttt ataaaagcag
     1621 ttgttagtac tatcacgaca gtgtttttaa aggctaggct ttaaaataaa gcatgttata
     1681 cagaatcagt taggattttt cgcttgcgag caaaggaatg tatatactaa atgccacact
     1741 gtatgtttct aacatattat tattataaaa atgtgtgaat ataagtttta gagtagtttc
     1801 tctggtggat gccttgtttc tgaaactgct atgtacgacc catcctgtgt ataacatttc
     1861 gtacgatatt attgttttac ttttcagcaa atatgaaaaa aaatgtgttt tatttcttgg
     1921 gagtaaaata tactgcatac aaattg
//
