LOCUS       NM_011097               2448 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus paired-like homeodomain transcription factor 1
            (Pitx1), mRNA.
ACCESSION   NM_011097 XM_984816
VERSION     NM_011097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Yu,H., Chiang,A., Rubinstein,M. and Low,M.J.
  TITLE     The homeodomain transcription factor Six3 regulates hypothalamic
            Pomc expression and its absence from POMC neurons induces
            hyperphagia and mild obesity in male mice
  JOURNAL   Mol Metab 87, 101993 (2024)
   PUBMED   39025297
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Shao,F., Phan,A.V., Yu,W., Guo,Y., Thompson,J., Coppinger,C.,
            Venugopalan,S.R., Amendt,B.A., Van Otterloo,E. and Cao,H.
  TITLE     Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling
            lineage specification of mandibular epithelium during tooth
            initiation
  JOURNAL   PLoS Genet 20 (7), e1011364 (2024)
   PUBMED   39052671
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Chen,K.Q., Kawakami,H., Anderson,A., Corcoran,D., Soni,A.,
            Nishinakamura,R. and Kawakami,Y.
  TITLE     Sall genes regulate hindlimb initiation in mouse embryos
  JOURNAL   Genetics 227 (1) (2024)
   PUBMED   38386912
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Shang,J., Li,X., Ring,H.Z., Clayton,D.A. and Francke,U.
  TITLE     Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT)
            and mouse chromosome 13 (Bft)
  JOURNAL   Genomics 40 (1), 108-113 (1997)
   PUBMED   9070926
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Sornson,M.W., Wu,W., Dasen,J.S., Flynn,S.E., Norman,D.J.,
            O'Connell,S.M., Gukovsky,I., Carriere,C., Ryan,A.K., Miller,A.P.,
            Zuo,L., Gleiberman,A.S., Andersen,B., Beamer,W.G. and
            Rosenfeld,M.G.
  TITLE     Pituitary lineage determination by the Prophet of Pit-1 homeodomain
            factor defective in Ames dwarfism
  JOURNAL   Nature 384 (6607), 327-333 (1996)
   PUBMED   8934515
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Szeto,D.P., Ryan,A.K., O'Connell,S.M. and Rosenfeld,M.G.
  TITLE     P-OTX: a PIT-1-interacting homeodomain factor expressed during
            anterior pituitary gland development
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7706-7710 (1996)
   PUBMED   8755540
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Lamonerie,T., Tremblay,J.J., Lanctot,C., Therrien,M., Gauthier,Y.
            and Drouin,J.
  TITLE     Ptx1, a bicoid-related homeo box transcription factor involved in
            transcription of the pro-opiomelanocortin gene
  JOURNAL   Genes Dev 10 (10), 1284-1295 (1996)
   PUBMED   8675014
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Muccielli,M.L., Martinez,S., Pattyn,A., Goridis,C. and Brunet,J.F.
  TITLE     Otlx2, an Otx-related homeobox gene expressed in the pituitary
            gland and in a restricted pattern in the forebrain
  JOURNAL   Mol Cell Neurosci 8 (4), 258-271 (1996)
   PUBMED   9026314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129780.5.
            
            On Nov 17, 2006 this sequence version replaced NM_011097.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U71206.1, AK142455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-654               AC129780.5         26705-27358
            655-890             AC129780.5         29455-29690
            891-2448            AC129780.5         31519-33076
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..2448
                     /gene="Pitx1"
                     /gene_synonym="Bft; P-OTX; Potx; Ptx1"
                     /note="paired-like homeodomain transcription factor 1"
                     /db_xref="GeneID:18740"
                     /db_xref="MGI:MGI:107374"
     exon            1..654
                     /gene="Pitx1"
                     /gene_synonym="Bft; P-OTX; Potx; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..1433
                     /gene="Pitx1"
                     /gene_synonym="Bft; P-OTX; Potx; Ptx1"
                     /note="homeobox protein P-OTX; homeobox protein PITX1;
                     pituitary OTX-related factor; hindlimb-expressed homeobox
                     protein backfoot"
                     /codon_start=1
                     /product="pituitary homeobox 1"
                     /protein_id="NP_035227.1"
                     /db_xref="CCDS:CCDS26556.1"
                     /db_xref="GeneID:18740"
                     /db_xref="MGI:MGI:107374"
                     /translation="MDAFKGGMSLERLPEGLRPPPPPPHDMGPSFHLARAADPREPLE
                     NSASESSDADLPDKERGGEAKGPEDGGAGSAGCGGGAEDPAKKKKQRRQRTHFTSQQL
                     QELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGG
                     YVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAP
                     SSISSMTMPSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYR
                     DTCNSSLASLRLKSKQHSSFGYGGLQGPASGLNACQYNS"
     exon            655..890
                     /gene="Pitx1"
                     /gene_synonym="Bft; P-OTX; Potx; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..2448
                     /gene="Pitx1"
                     /gene_synonym="Bft; P-OTX; Potx; Ptx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggggag ggcgcggcgc gggcggctcg aggctggatt ccgcccgcgc ccgctccctc
       61 gctcgcttgc tcactcgctc gcgccctccc tccttctctc ccagccccct cccaccgagg
      121 cccaccccac ccaccacccc tggcgcaggg actgctggaa cctggctgcg cgcactgtcg
      181 ttttcagaca gactctgcgg gctccgaccc gagccttaga aaccggcctc gaatcgggac
      241 tggggcccgg gccggccggg cagctgaggc cggagcagca ggagcgcgtg gcggagcccc
      301 gagccccgaa cccggtcccg cagcctggag aggtcgatgg agctcgaacg gcgtcgctgt
      361 gggcgcgggc agccctgggg ggcagccgct taggcgccac tctcttgtcc ccaacaggtc
      421 gcagcctggg cggccgggag ctcccagccc cggcccctgg agcgcccgtt gcggtcccca
      481 cctccatgga cgccttcaag ggaggcatga gcctggagag gctaccggag gggctgcggc
      541 caccgccacc accaccgcac gacatggggc ccagcttcca cctggcccgc gccgccgacc
      601 cccgggagcc gctggagaac tccgccagcg aatcgtccga cgctgatctg ccagacaagg
      661 agcgcggtgg ggaagccaag gggccagagg atggtggcgc gggcagtgct ggctgcggcg
      721 gcggtgcaga ggacccagct aagaagaaga aacagcggcg gcaacgcact cacttcacaa
      781 gccagcagtt gcaagagctg gaggccacgt tccaaaggaa ccgctacccc gacatgagca
      841 tgagagagga gatcgcggtg tggaccaacc tcactgaacc gcgagtgcgg gtctggttca
      901 agaaccggcg agccaaatgg cgcaagcggg agcggaacca gcagttggac ctgtgcaagg
      961 gcggctatgt gccgcagttc agcggcctgg tgcagcccta cgaggacgtg tacgctgccg
     1021 gctactccta caacaactgg gcggccaaga gcctggcccc ggcgccgctg tctaccaaga
     1081 gctttacctt cttcaactcc atgagcccgc tctcctctca atccatgttc tcggccccca
     1141 gctccatctc ttccatgacc atgccgtcca gcatgggccc gggcgccgtg cccggcatgc
     1201 ccaactcggg cctcaacaac atcaacaacc tcaccggctc ctcgctcaac tcggccatgt
     1261 cgccgggcgc ctgcccctac ggcaccccag cctcgcccta cagcgtctac cgggacacgt
     1321 gcaactcgag ccttgccagc ctgcggctca agtccaagca gcactcgtcg tttggctatg
     1381 gcggtctgca gggtccggcg tcggggctca acgcttgcca gtacaacagc tgaccgcccc
     1441 gcctggtccc cggggccgcc ggccagcaag gctcacagaa gggagcgcgc gggagcacgc
     1501 ggggcgctcg cagctcctcg gacctcacct ctgcgcagcc ccttcctccc caccccgcct
     1561 ccaggttggt tttgtgtttg ctttttccag acccccgctc tgtcccccaa tgaatgaaaa
     1621 gaaaagaaag caagccaagg gagggggtcg ggtggggaag aaagaaaaaa aaagaaaaaa
     1681 aaaaaagacg tcggagaaaa atgctggagg tgggggtaag ttgcaatgtc cctggcgatg
     1741 gcgcagatgg tgcgttcaaa cccgggatcc cagctgtcca ctacaccaat gggacatggc
     1801 ggggagaagc cagtgttcgg agaagatgcc gcgcgtcccc gccggagcgc ctcaacccgt
     1861 gaactgaatg tagggaacct ggaggccctg ggatcgttca cccggtcaag aaccgaggcg
     1921 ccctctccta gcccgacccg tccgagtgca cgcgggcgcg gatcactgct ggagtttacg
     1981 cctggctgag gatggctgcg tcgccgagga tctggcgttt gcgctggatt agcctaaggt
     2041 cccgggatgc caggaagagc ccagcagcac tgagctctgg agccgcacac ttgaggccac
     2101 tgagccgcag ctggccgagg ccagccagca gcaggaggag aagggctcag ctctgagttc
     2161 cccagcccca agcttagccg ctagcccggc cctctgctcc actctgggtc caggaggtgg
     2221 cccagcgaac agcccccttc tccactgtcc gcctgcccgt gcaagagtcg agccaggaga
     2281 gcgaggggcc acagccccag ggcccccgcc cactttgcac acccgctctc cggcccgcgc
     2341 ccgtttacag cgtccctgtg tatgtcggac tgactgtata gaattataaa tctgtctata
     2401 tcaacttgtc catgtacgtc tattaaaacc atagtcggag cgtgctaa
//
