LOCUS       NM_011256               6970 bp    mRNA    linear   ROD 16-DEC-2022
DEFINITION  Mus musculus phosphatidylinositol transfer protein,
            membrane-associated 2 (Pitpnm2), transcript variant 1, mRNA.
ACCESSION   NM_011256 XM_001000333 XM_006530222
VERSION     NM_011256.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6970)
  AUTHORS   Kirmiz M, Gillies TE, Dickson EJ and Trimmer JS.
  TITLE     Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing
            recruit Nir proteins and affect phosphoinositide homeostasis
  JOURNAL   J Biol Chem 294 (47), 17735-17757 (2019)
   PUBMED   31594866
  REMARK    GeneRIF: the VAP-interacting membrane-associated
            phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal
            domain-interacting receptor 2 (Nir2) and Nir3 specifically
            associate with Kv2.1 complexes.
REFERENCE   2  (bases 1 to 6970)
  AUTHORS   Walker MT, Rupp A, Elsaesser R, Guler AD, Sheng W, Weng S, Berson
            DM, Hattar S and Montell C.
  TITLE     RdgB2 is required for dim-light input into intrinsically
            photosensitive retinal ganglion cells
  JOURNAL   Mol Biol Cell 26 (20), 3671-3678 (2015)
   PUBMED   26269578
  REMARK    GeneRIF: Here we found that under high light intensities,
            RdgB2(-/-) mutant mice showed normal pupillary light responses and
            circadian photoentrainment
REFERENCE   3  (bases 1 to 6970)
  AUTHORS   Carlisle FA, Pearson S, Steel KP and Lewis MA.
  TITLE     Pitpnm1 is expressed in hair cells during development but is not
            required for hearing
  JOURNAL   Neuroscience 248, 620-625 (2013)
   PUBMED   23820044
REFERENCE   4  (bases 1 to 6970)
  AUTHORS   He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER,
            Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J and Cvekl
            A.
  TITLE     Chromatin remodeling enzyme Brg1 is required for mouse lens fiber
            cell terminal differentiation and its denucleation
  JOURNAL   Epigenetics Chromatin 3 (1), 21 (2010)
   PUBMED   21118511
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6970)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 6970)
  AUTHORS   Tomsig JL, Snyder SL and Creutz CE.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   7  (bases 1 to 6970)
  AUTHORS   Takano N, Owada Y, Suzuki R, Sakagami H, Shimosegawa T and Kondo H.
  TITLE     Cloning and characterization of a novel variant (mM-rdgBbeta1) of
            mouse M-rdgBs, mammalian homologs of Drosophila retinal
            degeneration B gene proteins, and its mRNA localization in mouse
            brain in comparison with other M-rdgBs
  JOURNAL   J Neurochem 84 (4), 829-839 (2003)
   PUBMED   12562526
REFERENCE   8  (bases 1 to 6970)
  AUTHORS   Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR and
            Helmkamp GM Jr.
  TITLE     Structure of a multifunctional protein. Mammalian
            phosphatidylinositol transfer protein complexed with
            phosphatidylcholine
  JOURNAL   J Biol Chem 276 (12), 9246-9252 (2001)
   PUBMED   11104777
REFERENCE   9  (bases 1 to 6970)
  AUTHORS   Lu C, Peng YW, Shang J, Pawlyk BS, Yu F and Li T.
  TITLE     The mammalian retinal degeneration B2 gene is not required for
            photoreceptor function and survival
  JOURNAL   Neuroscience 107 (1), 35-41 (2001)
   PUBMED   11744244
REFERENCE   10 (bases 1 to 6970)
  AUTHORS   Lu C, Vihtelic TS, Hyde DR and Li T.
  TITLE     A neuronal-specific mammalian homolog of the Drosophila retinal
            degeneration B gene with expression restricted to the retina and
            dentate gyrus
  JOURNAL   J Neurosci 19 (17), 7317-7325 (1999)
   PUBMED   10460238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082303.1, AF058693.1, BC070452.1 and AW060604.1.
            
            [WARNING] On Sep 27, 2023 this sequence was replaced by
            NM_011256.4.
            
            On or before Jan 22, 2014 this sequence version replaced
            XM_006530222.1, NM_011256.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082303.1, SRR14995048.2303734.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1323              BC082303.1         1-1323
            1324-5246           AF058693.1         992-4914
            5247-6952           BC070452.1         4507-6212
            6953-6970           AW060604.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..6970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.39 cM"
     gene            1..6970
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /note="phosphatidylinositol transfer protein,
                     membrane-associated 2"
                     /db_xref="GeneID:19679"
                     /db_xref="MGI:MGI:1336192"
     exon            1..333
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..435
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..611
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..4379
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-associated phosphatidylinositol transfer protein
                     2; drosophila retinal degeneration B homolog 2; pyk2
                     N-terminal domain-interacting receptor 3; retinal
                     degeneration B2 homolog"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 2 isoform 1"
                     /protein_id="NP_035386.1"
                     /db_xref="CCDS:CCDS19674.1"
                     /db_xref="GeneID:19679"
                     /db_xref="MGI:MGI:1336192"
                     /translation="MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILE
                     NRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCP
                     FVEKFSIDIETFYKTDTGENNNVFNLSPVEKSQLITDIIDIVKDPVPPSEYKTEEDPK
                     LFQSVKTCRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRR
                     VMVRAHRQAWCWQDEWYGLTMEKIRELEREVQLMLSRKMAQFSEEGPSELSKDSATKD
                     QASGTTSDPGSKNGEPLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDS
                     DEGSEEEFFDAHENLYCTEEKQAKDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEF
                     RVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTIT
                     NVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPL
                     AALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFD
                     ALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGTLANAAHCSGGSGGGGSGGSSLESS
                     RHLSRSNIDIPRSNGTEDSRRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPS
                     SRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQ
                     VYNLFHPADPSASRLEPLLERRFHSLPPFSIPRYQRYPLGDGCSTLLADVLQTHNTVF
                     QEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYA
                     LYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSILELDGKEVSVFTP
                     SQPRERWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVD
                     VHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYI
                     TVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDM
                     QKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDV
                     AVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMA
                     LRKGSFGLPGQSDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDSEQRGQRSMSVAAS
                     CWGRAMAGRLEPGAATGPK"
     exon            612..826
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..948
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1176
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1476
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1572
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1677
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1748
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1996
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2186
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2306
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2545
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2724
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2895
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3060
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3209
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3326
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3443
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3592
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3742
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3926
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4055
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..6953
                     /gene="Pitpnm2"
                     /gene_synonym="mKIAA1457; NIR3; Rdgb2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctgagg cgcgtggggg gcacggcggt ggcgccgcgg ctcagagcgc tccagtcggc
       61 ccggcccggc ccgcgtcccc ccgtcaagcc cgcgctcacc gaaggccacc gcggccagcg
      121 gcccgagtcg cgcgccaaca cgtgcgccgc cgccaccgcc gccggcccgg agcatgcccg
      181 ccgccgtccg gacgctcgcg cgggaccagc tggcggcggg ggcgcgcggg gccacggggt
      241 gcagccggcc cggccggggc cgtggagccc gcgctgcccg ggacgcggcg tgaggcggca
      301 gccgaggagc ccggagcgcg gcccgccgag cgggatgctg gcacatgtgt cttggtccct
      361 gactcccttc tgtggacaca ctgatcattc ctcctcctgt ggtggagacg tcgagggagc
      421 tgctcagatc tacaggtctt cattgaattc tgtcatggtt gtctaaggaa tcttgcctag
      481 aaagtcccca caagcacgca gctccctgcc gcctggaagg cgtggactcc aagatgatca
      541 taaaggaata ccggattccc ctgccaatga ccgtggatga ataccgcatt gcccagctgt
      601 acatgataca gaagaagagc cggaatgaga cccacgggca aggcagcggg gtagagatcc
      661 tggagaaccg gccctacaca gacggccctg gcggctccgg gcaatacacc cacaaggtgt
      721 atcatgtggg catgcacatt cctggctggt ttcgctccat cttgcccaaa gcagccttgc
      781 gggtggtgga ggagtcctgg aatgcctacc cctatacccg aacaaggttc acctgcccct
      841 ttgtggagaa gttctccatt gacattgaaa ccttttataa gacagacact ggggaaaaca
      901 ataatgtgtt caacctgtct cctgtggaaa agagccagct gataacagac atcatcgaca
      961 tcgtcaagga tcctgtgccc cccagtgagt ataagacaga agaagacccc aagctgttcc
     1021 agtcagtcaa gacttgccgg ggacctcttt ctgaaaactg gattcaggag tacaagaagc
     1081 ggctcctccc catcatgtgc gcctacaagc tctgcaaggt ggagttccga tactggggca
     1141 tgcagtccaa gattgaaagg ttcatccatg acacaggtct gcggcgggtg atggtgaggg
     1201 cccaccggca ggcctggtgc tggcaggacg agtggtacgg actgaccatg gagaaaatcc
     1261 gagagctgga gagggaggtg cagctcatgc tgtcccgcaa aatggcccag ttttcggagg
     1321 aaggcccctc agaactaagc aaggacagtg ccaccaagga ccaggcatct ggaacaacct
     1381 ctgatcctgg cagcaaaaac ggggagcctc tggggcgggg cctgaagaag cagtggtcca
     1441 cctcctccaa gtcctcaagg tcctccaagc ggggagccag cccctcccga catagcatct
     1501 cagagtggag gatgcagagt atcgccaggg actccgacga aggctcggaa gaggagttct
     1561 tcgatgcaca tgagaacctg tactgcacag aggaaaaaca agccaaggac atgaccaagt
     1621 ggaactccaa cgacctcatg gacaaaatgg agagtccgga gcctgaggaa tcacaagatg
     1681 aaatctacca gcagagtggc tctgagttca gggtggcctc cagcgtggag cagctgaaca
     1741 tcatcgagga tgaggtgagc cagccactag ccgcgccacc ctccaagatt cacgtgctgc
     1801 tgctggtgct gcatggaggc accatcctgg acactggagc gggggacccc agctccaagc
     1861 agggggacac caatactatc accaacgtgt tcgacaccgt catgcgcgtg cactacccca
     1921 gtgccctagg ccacctagcc atccgcctgg tgccctgccc acccatctgt gctgatgcct
     1981 tcgccctcgt ctccaacctc agtccctatg gccatgatga gggctgtctg tctagcagcc
     2041 aggaccacat ccccctagct gccctgcccc tgctggccac ttcctcaccc cagtaccagg
     2101 aggcagttgc tacagtgatt cagcgggcca acctggccta cggagacttc atcaagtccc
     2161 aggaaggtgt gaccttcaat ggtcaggtct gcctgattgg agactgtgtt gggggcatcc
     2221 tggcatttga tgccttatgc tacagtggcc agccagtgtc tgagagtcaa agcagtagcc
     2281 gccgaggcag tgtggtcagc atgcaggacg ctgacctgct gtccccgggc accctggcga
     2341 atgcagcaca ctgctccggt ggcagtggcg gtggcggcag cggaggctcc agcctggaga
     2401 gcagtcggca cctgagccgc agcaacattg acatcccccg aagcaacggc actgaggact
     2461 ccagaaggca gctgccccgc aaaaggagtg actcgtccac ctatgagctg gacaccatcc
     2521 agcagcacca ggccttccta tccagcctcc acgccagcgt gctgaggaat gagcccagct
     2581 cccgccgctc aagcagttcc acgatgctgg acggtgccgg ggccctgggc aagtttgact
     2641 tcgagattgc cgacctcttc ctcttcgggt gcccgctggg gctagtccta gccttgagga
     2701 aaacagtcat cccttccctg gacgttttcc agctgcgtcc agcgtgtcag caagtgtaca
     2761 acctcttcca ccccgcggac ccctcagcct cccgcctgga gccgctgctg gagcggcgtt
     2821 tccacagcct gccgcctttc agcatccctc ggtaccagcg ctacccgctg ggggacggct
     2881 gctccacact gctggcggat gtgcttcaga cccacaacac agtcttccaa gagcatgcag
     2941 ccccctcgtc acctggcaca gcccctgctg gccgtggctt ccgcagagcc agtgagatca
     3001 gtatcgccag tcaggtgtca ggcatggccg agagctacac agcgtccagc atcgcccaga
     3061 ttgctgccaa gtggtgggga cagaagcgga ttgactatgc cctgtattgc ccggacgccc
     3121 tcacggcctt ccccacggtg gccttgcccc acctcttcca cgccagctac tgggagtcaa
     3181 ccgacgtggt ctcctttctg ctgagacagg tcatgcggca cgacagctcg agcatcctag
     3241 agctggacgg caaggaggtg tccgtgttca cgccttcaca gcccagggaa aggtggcagc
     3301 gcaagaggac ccacgtgaag ctgcggaacg tggcagccaa ccaccggatc aatgacgcag
     3361 ttgccaatga ggatggcccg caggttgtga cgggccggtt catgtatggg cccttagaca
     3421 tggtcaccct gactggggaa aaggtggatg tgcacatcat gacgcaacca ccttcaggtg
     3481 agtggctgca cctagacact ctagtgacca acagcagtgg gcgcgtctcc tacaccattc
     3541 cagaaacaca ccgcctgggg gtgggcgtct accccatcaa gatggtggtc aggggagacc
     3601 acacattcgc cgacagctac atcactgtgc tccccagggg cacagagttt gtggtcttca
     3661 gtatagacgg ctcctttgcc gccagtgtgt ccatcatggg cagcgacccc aaggtgcgcg
     3721 ccggggctgt ggacgtggtg cgacactggc aggacctggg ctacctcatc atctatgtga
     3781 ccggccggcc cgacatgcaa aagcagcggg tggtggcatg gctggctcag cacaatttcc
     3841 ctcatggtgt ggtgtccttc tgtgatggcc tggtgcacga cccactgcgc cacaaggcta
     3901 actttctgaa gctgctcatc tctgagcttc acctgcgcgc acatgcggcc tacggctcca
     3961 cgaaggatgt cgcagtctat aactccatca gcctctctcc catgcacatc tacattgtgg
     4021 gccgccccac caagaagctg cagcagcagt gccagttcat cacggacggc tatgcggccc
     4081 acctggccca gctcaagtac aatcaccggg ctcgcccagc ccggaacacg gccacgcgca
     4141 tggctttgcg caagggcagc ttcggcctac ctggccagag tgacttcctt cgctctcgga
     4201 atcacctgct ccgcaccatc tcggcccagc ccagtgggcc cagccatcgg cacgatcgga
     4261 cacagaccca gatggacagc gagcagcggg gccagcgcag catgagcgtg gcagccagct
     4321 gctggggccg agccatggca ggccggcttg aaccaggggc agccacggga cccaagtagg
     4381 acactctcag gaggcgctgt ggtctccatg gtgctaggcc agggcaccgg ccctcctggg
     4441 aggcctggcc tgggcacaca cgtcagtggc tggggacatg cacagacatg gcctgagagc
     4501 gacccagggc cccttggaag acatggccat gccaacacag ccctcccagc cttgcctgat
     4561 gccctaggct ctaaggagcc cagctggtta tgggatctgg caggatgtcc agcccatgat
     4621 ggaagaggag ccaggatcgg ccgcctagcc cagcctggga ggcattcctg ggcatcttgc
     4681 tccgtgttga tctctcagcc tcctggtgcc aggcgtgggt ctgggccctg cctgccacct
     4741 ctctgtccac tggcgcccct tcccatttgg tagcggctcc aatgggtcca gtccacttct
     4801 tgttgactcc agttctcaac tgtccaacct cactggtttt gcactagttt ttgagagtgg
     4861 agacccgtta ccatctcctg gctccagaca tgttgacatg catgaaaatc cagtctctgc
     4921 tgacccaggc cagggcctgt caccacacag agtagtccag tgtgggaaat cttcacgcaa
     4981 gcaggagaga aaggccatat cgtaatttct gctgcctgcc cggtctgttg acaccacggc
     5041 agcccagtgg cagtcccaga ctgctaccca cccgtccacc tgccccaccc agagctcagt
     5101 gcagtcccgg aactgatgtc actccgggct gtgagcacag cacaggtgtg aggccagcca
     5161 cgtgcacagc tggctcttgg tagcccacct tgggcagctg gacctggaga agcctggcct
     5221 ccaccgacgc tcccgcctgc tcaggggcgg gcgggggggg gggtccccat gtcatggctg
     5281 ctgcccactg cgtttctacg cctttctact tctccatctg gtttctataa ggtttttttt
     5341 aaacaggcaa tcttcggctg cttccttttc ttaactcagt gtcagcgcag cctgctacat
     5401 taggaacacc cagcactgtg acagggcccc actcagtctg gcctgtgggc cctgcacctg
     5461 gcccacaatt ccactgactt cctattctgg ggtgggtggg gctcttaggt tttcttaatg
     5521 ccgttcgttt aatgtcgact ccaggaagcc acagctcact ctccagccta agggcacaca
     5581 gccatcttat tgctccccaa atacggttgg gcatcctaca cactgggtct gagcccctgc
     5641 cttccacaca gcactgacca cacctctcct gcaccttccc tgcattggct gagcccatgg
     5701 agctccagcc ctgggtccag cgatggggct ctgtgcctga gtctgccagg ccagactcag
     5761 atgcagggcc aagtggctgg gcccaacagg tgtacaggag acactgactc tgctgtgtag
     5821 ctgtgtacag cacaggcgtg tgggactccc gccatggcgg gtctacacaa gaagaaagct
     5881 atttattttg tgcagaggaa aaaaaaaact gtctggaggg gtgagacctt cagggtcttc
     5941 tcataaggtg tagctttgtg ttgtttccag cgttctgtat aaagcagtga ttattttatg
     6001 gaccaagatt ccatggaact gtcacagtaa aagtgcaata tctgtcccac cactccccac
     6061 tgggggcccc acaggaagct gctggcccga caatcactgc cccaccgggg gtccccgggg
     6121 gccagggcct cctccctcag ccccacccgt cttgcctcag cctaggtgac cagccattgt
     6181 gagaagcacc tggaagcctc aagccacctg cagtaaaggc agggggggcc tgaggtcagt
     6241 gggcttggtc tctcccctgg gcagcccctt gtggctctga atgcccatgc ctgcccagct
     6301 gtcagccatg ccaaggacaa cagcaatagt cccctgggct ctcccagggc cctcagccat
     6361 agatggtgag acgggcagcc tccctccaaa accttactcc agtctgcttt ttgtctccct
     6421 taagatttcc tttggctcgt tctcttgagg aagccccact tctacagaaa gtaagagagg
     6481 aaggaaggtc aaagtccttt aaaaatacca aaaaaatgtt tacagtgtca ggtgctgagc
     6541 tgcagggctc aggcctggcc atttgtaacc aaagggtgag gcagatcttg ctggctgcca
     6601 cccaccccag gcctgttaga atagaagcct tagtcagtcc ctccccatcc ccagtcccca
     6661 ggactgagcc ttgatgccac ccatcaccaa ccacctgcct tctctttgat ttctaaagaa
     6721 ggattcagcc aagttccccc atcccctttc ccggctctgt gtgagctagc ccccaccctg
     6781 ccccgtttca ccttcacatc tcagacccct cccatctgtc cttgtactgt cttgtttctc
     6841 ccgaccattg tgtaaactgt gtcctgtccc caccccatgc tgtctggcct tagtgtgctc
     6901 tctgtatacc gtgtcacagt ctgttacacc aattaaagaa gcaggaggct tccaaaaaaa
     6961 aaaaaaaaaa
//
