LOCUS       NM_008851               4533 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus phosphatidylinositol transfer protein,
            membrane-associated 1 (Pitpnm1), transcript variant 1, mRNA.
ACCESSION   NM_008851
VERSION     NM_008851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Kirmiz,M., Gillies,T.E., Dickson,E.J. and Trimmer,J.S.
  TITLE     Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing
            recruit Nir proteins and affect phosphoinositide homeostasis
  JOURNAL   J Biol Chem 294 (47), 17735-17757 (2019)
   PUBMED   31594866
  REMARK    GeneRIF: the VAP-interacting membrane-associated
            phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal
            domain-interacting receptor 2 (Nir2) and Nir3 specifically
            associate with Kv2.1 complexes.
REFERENCE   4  (bases 1 to 4533)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4533)
  AUTHORS   Keinan,O., Kedan,A., Gavert,N., Selitrennik,M., Kim,S., Karn,T.,
            Becker,S. and Lev,S.
  TITLE     The lipid-transfer protein Nir2 enhances epithelial-mesenchymal
            transition and facilitates breast cancer metastasis
  JOURNAL   J Cell Sci 127 (Pt 21), 4740-4749 (2014)
   PUBMED   25179602
  REMARK    GeneRIF: results suggest that Nir2 not only enhances EMT in vitro
            and breast cancer metastasis in animal models, but also contributes
            to breast cancer progression in human patients.
            Erratum:[J Cell Sci. 2019 Mar 7;132(5):jcs227868. doi:
            10.1242/jcs.227868. PMID: 30846603]
REFERENCE   6  (bases 1 to 4533)
  AUTHORS   Chang,J.T., Milligan,S., Li,Y., Chew,C.E., Wiggs,J., Copeland,N.G.,
            Jenkins,N.A., Campochiaro,P.A., Hyde,D.R. and Zack,D.J.
  TITLE     Mammalian homolog of Drosophila retinal degeneration B rescues the
            mutant fly phenotype
  JOURNAL   J Neurosci 17 (15), 5881-5890 (1997)
   PUBMED   9221785
REFERENCE   7  (bases 1 to 4533)
  AUTHORS   Aikawa,Y., Hara,H. and Watanabe,T.
  TITLE     Molecular cloning and characterization of mammalian homologues of
            the Drosophila retinal degeneration B gene
  JOURNAL   Biochem Biophys Res Commun 236 (3), 559-564 (1997)
   PUBMED   9245688
REFERENCE   8  (bases 1 to 4533)
  AUTHORS   Rubboli,F., Bulfone,A., Bogni,S., Marchitiello,A., Zollo,M.,
            Borsani,G., Ballabio,A. and Banfi,S.
  TITLE     A mammalian homologue of the Drosophila retinal degeneration B
            gene: implications for the evolution of phototransduction
            mechanisms
  JOURNAL   Genes Funct 1 (3), 205-213 (1997)
   PUBMED   9680295
REFERENCE   9  (bases 1 to 4533)
  AUTHORS   Banfi,S., Borsani,G., Bulfone,A. and Ballabio,A.
  TITLE     Drosophila-related expressed sequences
  JOURNAL   Hum Mol Genet 6 (10), 1745-1753 (1997)
   PUBMED   9300667
  REMARK    Review article
REFERENCE   10 (bases 1 to 4533)
  AUTHORS   Vihtelic,T.S., Hyde,D.R. and O'Tousa,J.E.
  TITLE     Isolation and characterization of the Drosophila retinal
            degeneration B (rdgB) gene
  JOURNAL   Genetics 127 (4), 761-768 (1991)
   PUBMED   1903119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109138.10, CJ097166.1, BY261372.1 and BC048150.1.
            
            On Jan 31, 2013 this sequence version replaced NM_008851.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048150.1, Y08922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC109138.10        109040-109353
            315-322             CJ097166.1         1-8
            323-346             BY261372.1         4-27
            347-4533            BC048150.1         1-4187
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.81 cM"
     gene            1..4533
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /note="phosphatidylinositol transfer protein,
                     membrane-associated 1"
                     /db_xref="GeneID:18739"
                     /db_xref="MGI:MGI:1197524"
     exon            1..641
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..856
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..978
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1203
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1530
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1626
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1734
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1796
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2047
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2237
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2345
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2503
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2706
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2877
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3042
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3191
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3302
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3419
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3568
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3718
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3902
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4031
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4512
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4494..4499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /note="hexamer: AATAAA"
     polyA_site      4512
                     /gene="Pitpnm1"
                     /gene_synonym="DRES9; Mpt-1; Nir-2; Pitpnm; PITPnm 1; Rd9;
                     RdgB; RdgB1"
                     /note="major polyA site"
ORIGIN      
        1 gtaagttagt attagcagag ttgcagaggc ccattggggg tcgcttcctg aaagatatct
       61 tggcggacaa gggtctaggt gaacgtctag gagtggagta cacagaaccc caccgacttc
      121 aggggatgaa atggtgaagg gggcgggtcc ctaaggttct ggtcttggaa gccaggcgcg
      181 gcccggaggg atgctgtttc gggatgcgac ctcggtgcag acgcgaggat ggccttgcgg
      241 cgtgtcggct cgcgtccgcc gctctggggg gcccgcgtca gcgcgcggtt gccatgacga
      301 caggcaggcg gggggcgggg gctgcgtgga aaagaggtca gctctgagcc tttctactgc
      361 tctgggctcc gcggtgcggg aggcaacact gggttcgcct ctgcctcccc cgcggcgggc
      421 ccggccatgg ggttccgcgg cccgagcccc tccgcaggcg tgcagggctc agtaccgcgc
      481 accaccgtcc tgcactgact gccgcgcggt accctgcgct aggaggagca gaggccgcac
      541 gcggtcagcg gagcgtcttc aggatgctta tcaaggagta ccacatcctg ctgcccatga
      601 gcctggacga gtatcaagtg gcccagctct acatgatcca gaaaaagagc cgtgaggagt
      661 ctagtggtga gggcagcggc gtggagatcc tggccaaccg gccctacaca gatgggcctg
      721 gaggcaacgg gcagtataca cacaaggtgt accacgtggg ctcccacatc ccaggctggt
      781 tccgggcact gttacccaag gctgctctgc aggtagaaga ggaatcttgg aacgcttacc
      841 catatacccg gacacggtac acctgcccct ttgtggagaa gttctccatt gagatagaga
      901 cctactactt gcctgatggg gggcagcaac ctaacgtctt caacctgagt ggggctgaga
      961 gaagacagag aatcgtggat accatcgaca tcgtgcggga tgcagtggcc ccaggagaat
     1021 acaaagcgga agaggaccct cggctgtacc gctcagccaa gacaggccga gggccgctgg
     1081 ctgatgactg ggcacggaca gcggcccaga caggacctct catgtgtgcc tataagctgt
     1141 gcaaggttga attccgctac tggggcatgc aggccaagat tgagcagttc atccatgacg
     1201 taggtctgcg cagggtgatg cttcgcgccc atcgccaggc ctggtgttgg caagatgagt
     1261 ggatagaact gagcatggct gacatccggg cactggagga ggagactgca cgcatgctag
     1321 cgcagcgtat ggctaagtgc aacactggca gtgagggacc agaggctcag acccctggga
     1381 aatccagcac tgaggcccga cctgggacca gcactgctgg cacccctgat ggacctgagg
     1441 cccctcccgg ccccgacgcc tccccagatg ccagctttgg gaagcagtgg tcctcatcct
     1501 cccgttcctc ctactcatcc caacatggag gcggcgtgtc tccacagagc ttgtctgagt
     1561 ggcgcatgca gaacattgcc cgagactctg agaacagctc cgaggaagaa ttctttgatg
     1621 cccatgaagg tttctcggac agtgatgagg tcttccccaa ggagatgacc aagtggaatt
     1681 ccaatgattt tatcgatgcc tttgcctccc caaccgaggt ggagggggta ccagatccta
     1741 cagtcatggc taccaaaggc attgaagatg gggcccgagc tcccagggac tcagagggcc
     1801 tagatggagc gggggatcta gtggtcgagg cgtgctctgt gcatgccctc ttcctcatcc
     1861 tgcacagcgg cagcatcctg gactctggcc ctggagacac caactccaag caggccgacg
     1921 tgcaaacgct gagcacagcc tttgaggccg tcacccgagt ccatttcccc gaggccctgg
     1981 gtcacgtggc actgcggctg gtgccctgtc cacccatttg cgcggctgcc tatgctcttg
     2041 tctccaacct gagcccctac agccatgatg gggatagcct gtcccgctcc caagaccaca
     2101 ttccgctggc tgccctgccg ctcctggcca cctcatcctc tcgctaccag ggtgccgtgg
     2161 ccactgtcat cgctcgcacc aaccaggcct atgcagcctt cctgcgctca tcggagggca
     2221 caggtttctg cgggcaggtg gtgctgatcg gagatggtgt tggtggcatc ctgggctttg
     2281 atgcgctctg ccacagtgcc agtgcaggcc cagggagtcg gggcagcagc cgccgtggga
     2341 gcatgaacaa tgagatgctc tcccctgaag ttggtccagt acgggacccg ctggcagatg
     2401 gggtggaggt actgggtcgt gctagcccag aaccctcagc cctacctgct cagcgtacct
     2461 tcagtgacat ggccaatcct gatcctgatg gctctcagaa cagcctccag gtagcctcca
     2521 cagctacctc ctctggggag ccccgccgtg caagcacagc ctcctgtcca cctgccagtt
     2581 ctgaggctcc tgacggcccc acgaacgctg ctcgcctgga cttcaaggtc tcaggcttct
     2641 tcctctttgg ctccccactg ggcctggtgc tggctcttcg caaaaccgtg atgcccgcct
     2701 tggaggtggc tcagctgcgt ccagcctgcg agcagatcta caatctcttc catgccgctg
     2761 acccctgtgc ctcccgcctg gaacccctgc tggcccccaa gttccaggcc atcgcccccc
     2821 tggctgtacc tcgttaccag aagtttcccc taggagacgg ctcgtccttg ctgctggctg
     2881 acactttgca aacccattcg agtctcttcc tggaagagct ggagatgatg gtgccctcca
     2941 cacccacctc ggccagtggt gccttctgga agggcagtga actaggcaat gagccagcat
     3001 cccagacagc agcccccagc accaccagcg aggttgttaa gatcctggac cgctggtggg
     3061 gaaacaagcg gatcgactat tcactgtact gccccgaggc actcacggcc ttccccacgg
     3121 tcacgctgcc ccacctcttc cacgccagct actgggaatc agcggatgta gtggccttca
     3181 ttctgcgcca ggtcattgag aaggagcggc cacagctgac agagtgtgag gagccatcca
     3241 tctatagccc cgccttcccc agggagaagt ggcagcgcaa acgcacacag gtcaagatcc
     3301 ggaacgtcac ttccaaccac cgagcgagtg acaccgtggt atgtgagggc cgtccccagg
     3361 tgctgaatgg gcgcttcatg tatggaccat tggatgtggt cacgctcact ggagagaagg
     3421 tggatgtcta cgtcatgaca cagccactgt caggcaagtg gatccacttt ggcacagagg
     3481 tcactaacag ctcaggccgt ctcaccttcc cagtgccctc agaacgtgca ctgggcattg
     3541 gtgtctaccc tgtgcgcatg gtggtcaggg gagaccacac ctatgccgag tgctgtctga
     3601 ctgtggtgtc ccgaggcaca gaagctgtgg tcttcagcat cgatggttct ttcactgcca
     3661 gtgtctctat catgggcagc gaccccaagg tgcgcgctgg cgcagtggac gtggtcaggc
     3721 actggcagga ctctggctac ttgattgtgt atgtaactgg ccggcctgac atgcaaaagc
     3781 accgtgtagt ggcctggctg tcgcaacaca acttccccca tggtgttgtc tccttctgtg
     3841 atggcctcac ccacgacccg ctgcggcaga aagccatgtt tctgcagagc ctggtgcaag
     3901 aggtagaact gaacatcgtg gctggatatg ggtcaccaaa agatgtggca gtgtatgcag
     3961 cactggggct ctctccgagc cagacctaca ttgttggccg tgctgtgcgc aaactgcagg
     4021 cacagtgtca gttcctgtca gatggctatg tggcccactt gggccagctg gaggcaggct
     4081 cccactccca tgctccctca ggacctccga gagccgctct ggccaagagt agctatgctg
     4141 tggctgcccc tgtggacttc ctccggaagc agagccagct gcttcgatcc agaggcccta
     4201 gccaggtgga ccgtgagggt ccaggaacac ctcccaccac cctggccagg ggcaagactc
     4261 gcagcatcag cctcaagttg gacagtgaag agtgagggaa ccttggctgc aactgggtta
     4321 tttattgact cgcaaggggc cttggtgact gtgggaatct ggggccccca caccctgtat
     4381 gactacacca cagtattact tccctttgtc gggggtaggg gacccagccc ccaggggagg
     4441 aaggagggag tgggttaggg cccagcagcg tttccagtgt gtgaacctat aaaaataaac
     4501 aactgcactc taaaaaaaaa aaaaaaaaaa aaa
//
