LOCUS       NM_001359616            6248 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphatidylinositol transfer protein, cytoplasmic 1
            (Pitpnc1), transcript variant 1, mRNA.
ACCESSION   NM_001359616
VERSION     NM_001359616.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6248)
  AUTHORS   Tang,G., Ma,C., Li,L., Zhang,S., Li,F., Wu,J., Yin,Y., Zhu,Q.,
            Liang,Y., Wang,R., Huang,H., Zhao,T.J., Yang,H., Li,P. and
            Chen,F.J.
  TITLE     PITPNC1 promotes the thermogenesis of brown adipose tissue under
            acute cold exposure
  JOURNAL   Sci China Life Sci 65 (11), 2287-2300 (2022)
   PUBMED   36166181
  REMARK    GeneRIF: PITPNC1 promotes the thermogenesis of brown adipose tissue
            under acute cold exposure.
REFERENCE   3  (bases 1 to 6248)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 6248)
  AUTHORS   Takano,N., Owada,Y., Suzuki,R., Sakagami,H., Shimosegawa,T. and
            Kondo,H.
  TITLE     Cloning and characterization of a novel variant (mM-rdgBbeta1) of
            mouse M-rdgBs, mammalian homologs of Drosophila retinal
            degeneration B gene proteins, and its mRNA localization in mouse
            brain in comparison with other M-rdgBs
  JOURNAL   J Neurochem 84 (4), 829-839 (2003)
   PUBMED   12562526
REFERENCE   5  (bases 1 to 6248)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 6248)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153625.1, AK171340.1, AB077282.1, AL596116.14 and AI851387.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               AK153625.1         2-634
            634-722             AK171340.1         661-749
            723-1807            AB077282.1         1-1085
            1808-5820           AL596116.14        187453-191465       c
            5821-6248           AI851387.1         1-428               c
FEATURES             Location/Qualifiers
     source          1..6248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.21 cM"
     gene            1..6248
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /note="phosphatidylinositol transfer protein, cytoplasmic
                     1"
                     /db_xref="GeneID:71795"
                     /db_xref="MGI:MGI:1919045"
     exon            1..830
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             783..1781
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diabetic nephropathy-related protein; cytoplasmic
                     phosphatidylinositol transfer protein 1; mammalian rdgB
                     homolog beta; retinal degeneration B homolog beta"
                     /codon_start=1
                     /product="cytoplasmic phosphatidylinositol transfer
                     protein 1 isoform 1"
                     /protein_id="NP_001346545.1"
                     /db_xref="GeneID:71795"
                     /db_xref="MGI:MGI:1919045"
                     /translation="MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQN
                     EPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFL
                     PKFSIHIETKYEDNKGSNDSIFDSEAKDLEREVCFIDIACDEIPERYYKESEDPKHFK
                     SEKTGRGQLREGWRDNHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQ
                     AFAWVDEWYDMTMDEVREFERATQEATNKKIGVFPPAISISSIALLPSSVRSAPSSAP
                     STPLSTDAPEFLSIPKDRPRKKSAPETLTLPDPEKKATLNLPGVYTSEKPCRPKSE"
     exon            831..979
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1068
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1076
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1148
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1244
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1400
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1464
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..6231
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /note="hexamer: AATAAA"
     polyA_site      2689
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
     regulatory      6210..6215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /note="hexamer: AATAAA"
     polyA_site      6231
                     /gene="Pitpnc1"
                     /gene_synonym="1110020B03Rik; 5830436L09Rik;
                     C330017I21Rik; Dnr411; mrdgBbeta; rdgB-beta; RDGBB;
                     RDGBB1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggcg aggtggctgc aaactcacgg gcacgcacgg cgctctcaga gccgagggac
       61 tcgggggagg ggacgcgcgc aagccgctgg cagccaaccg cctaggttga agacacccgg
      121 ggcccagagc agggcagagc cttggcggct gcggcttccc ttttctctct cagctgagct
      181 ccggagagac tcggggactg gccctaaaaa agagcaggaa atcttgttta ccgcccgggg
      241 agaggagccc atcgagcctt tgtttggaaa gtcagcatcg cctgctcccg cggcaatgtg
      301 ttcctggtga cattaaccca cggtagacgg gtaggagaaa aagggggctc gccaggttca
      361 gctctgcttt cggaggagga tccagaggag acttttgtgc gtttgtttga atttgtggaa
      421 atcccttttc ctcctccttt tgcctctctt gcccgccgcc gggcatgtcc tgatctggtg
      481 gccgcgccta ccagcccggg gctgctgatc cgagctgtct cccgcgggtc tccctccctc
      541 agtgcctgac tttgcaatac cgagagggct gatctctgcg aggaaggagg cgggggagtc
      601 acagacaccg ggacccgaag cttgacatgc tccggggcgg accggaggca gttaggagct
      661 gagcgcacca ccggggctgc ttcgcttgcc ggttcccagc gtctttgccc tcctctgggc
      721 tccagccttg ctcatctgtt gggacgcccc cttctttccc gaggtctgcg gccggcagga
      781 acatgctgct caaggagtac cgaatctgca tgccgctcac cgtggacgag tacaaaatcg
      841 gacagctgta tatgatcagc aaacacagcc atgagcagag tgaccgggga gaaggggtag
      901 aggtcgtgca gaacgagccc tttgaggacc ctcaccatgg caacgggcag ttcactgaga
      961 agcgagtgta tctcaacagc aagctgccta gttgggccag agctgttgtt cccaaaatat
     1021 tttatgtgac cgagaaggcg tggaattatt acccatacac catcacagaa tacacttgtt
     1081 ccttcctgcc gaaattctcc atccacatag aaaccaagta tgaagacaac aagggaagca
     1141 acgatagtat ttttgacagt gaagccaaag acctcgagag agaagtgtgc ttcatcgata
     1201 tcgcctgtga tgaaattcca gaacgctact acaaagagtc tgaggatcct aaacacttca
     1261 agtctgagaa gacaggccga gggcagctaa gagaaggctg gcgagacaac catcaaccca
     1321 tcatgtgctc ctacaagctg gtcaccgtca agttcgaggt gtggggcctt cagacccgag
     1381 tggaacaatt tgtgcacaag gtggtccgag acatcttgct gattggacac agacaggcct
     1441 ttgcgtgggt tgatgagtgg tacgacatga caatggatga agtgcgagag ttcgaaagag
     1501 ccactcagga agccaccaac aagaagattg gcgttttccc accggccatt tctatctcca
     1561 gcatcgccct actgccttcc tcggtgcgca gcgccccctc cagcgcccca tccacccctc
     1621 tctccacaga tgcgccagaa tttctgtcca ttcccaaaga ccggccccgg aaaaaatctg
     1681 ctccagagac gctcacactt ccagatccgg agaaaaaagc caccctgaat ttacctggcg
     1741 tctacacttc cgaaaagcca tgtcggccca aatcagagta actcggtctg aacatccctt
     1801 tgggtccttt gttttcattt gtggcttttt tttttttttt ttttaaagaa ttctctggac
     1861 gaggaaaaga ctgcctcctt cactcagatg tgttcttgga tctcagacaa tgcatgtggt
     1921 taaataatct cacagatagc aagaacccct acgtgtgcca cacagcatca tagtgaatgt
     1981 gaaaagtatg atttagggaa aacaaaaaac aaaaaaaaaa aacaaaaaaa cgaaaggaaa
     2041 caaaacagga ggggctgagg acaccgctca gtgggtagag ctgctacagc tactgtggaa
     2101 cccggggttc catcccagcc atggtaacca ggcaggagga tcagaagttc agggtcaacc
     2161 tcagctacat acagagtttg aggccagcct gagttatttg agacactgtc tcaagaacaa
     2221 tcaaacaaaa cccacagaat cttctctagc tttagatgtg gaccagggag gaagccttgt
     2281 tttgggggct ttggtgagtc tgatgtggac ctcaatggta aaagggtaaa tggatgagaa
     2341 aacttttttt tttttttttg gtaaggtgtg gtaaattaat gatgtcagtt tcctcccatc
     2401 aaacctgaaa ttctcaacaa caacaaaaaa aaaaaaaaag aaaaaaaaat actctcaggt
     2461 gtcacatgcc taattgttct cttttgggac tgctgactac caatacttga attccagttg
     2521 ttatcaatat tcctattttg atttagtctg actcaggatt tggagcctga ttaacttctt
     2581 aaatttttga aaattttaat aaccaacttc ttgaggctcc aagtgcaatt aatgataatg
     2641 tctttatacc ttttcacaaa atttaataaa gcacccatct gtttgcgtct cttcgcttcc
     2701 cctttttgtg ccctggtggc ttctcaaatc ttgcctggat gacttatgac cacaactaat
     2761 acaatgtgga atattccgga aacagagagc cccaggtgag acagacatct tctcttcagg
     2821 gacctgcaaa gtttgacttg tgagcttcat ccataacgat tctcagaaat ttcgacaagc
     2881 taagtagaat tcattgacag tctcccactt gaggaaattg aggatagact aagggacccg
     2941 ggtttaacta gccagtgtct gaaccacaca gaagagaagc cacgcctcct ggtttactct
     3001 taggaacacc cagatattcc tggaaatggt ttgcccatca ccaggcttta ggaagcacca
     3061 ccattctctt aggccttcct tataatctaa atatcggggg ccagggtgta actcgattgt
     3121 agagttcttg cctaacattc aggaggccct gggactgatc cataaccctg caaaaaagga
     3181 aataatccag ctattgcctg tgtccctgga atccagtaaa tacaggcagg cgggaggagt
     3241 ggaatcgcag gctcctattt gtacagaggt gtgatcataa atgtcccttt ttgtcttgct
     3301 ctcattgctg aatgaagggg acatgtatgc cgacagctgg tgaggtcagt aggtcatcaa
     3361 agtggcagaa agagaaatct gtcaccctta cacctcactg cctttaaacc cacaaggaag
     3421 ggaagcagat agagcaatgc aggtggctgg ggagctccag agcccatgtc ctagctgtcc
     3481 cttcctgact cgtgaccttc aacctcagga aaggaaatgc cccccccccc cccaatccag
     3541 atcccaaagg aagcaaaaca gaccagggag tatattctcc ttccctgaca cctcccagcc
     3601 ggtggaccct gcctgcaccc tctcttcagt ctccacattc tgcaacatct ctggggttca
     3661 cgccctctcc catggcccag atgctggccc ctcaagccta gcaccaaagt gtttagagtg
     3721 tctagatcat ttcttgtcta tagatggaca ttgcgcccca gtactcaaag gaaagcaatt
     3781 acaagtagat taccataaca gcgcatcttt tccttaaggt gacagtacca tagtagggta
     3841 cccttctttg catggtatgg aagcatgaat cttgcttgtg ggaaaaccgt aatcttttct
     3901 caaacccttt gaactcctca gtggttccct cccccatgca gctgtactca gtgagaatgt
     3961 ctggctttca aaagcaaaat tccactttca gaggacgcgg aattcgcgtc tgtacctgct
     4021 taccatttgc aagctgatgc gggctggggt gggctcctcg gttttcgtgt agtacaagtt
     4081 gattttgcgc aggtggctag cccatctggc acctagtttt tccagtaaca ccacgccact
     4141 cttcctttct atagccgctt ccattgtcaa ggtcaacaat ctggttcact ttcaaaaggc
     4201 tacgttctca ttcccttcct gtgagttctc tctcctttgt agtcagcccg ggacttttga
     4261 caccaactgc agcgctaacc tatgataatg tgattcttaa ccaacgccta tgtgttcagt
     4321 ttttctgtct acatgtggtt tgcctgtgtt acaaataggg aaggggtggg attctggata
     4381 tatttcatta gctgctttga atatttaatc cagtcatcac aaagcataaa tgacttcgat
     4441 attttctgaa ccttgatttc caagtgtcgt ttcgctttgt ccttatgtga atctgctatt
     4501 gcgggatcca agcatttgag gaatatgtat atagaacatg agtaattctt gtgaggatgg
     4561 aaacaaaatg gatgcatgac ggaaatttag gaagaaaaaa aaaaaagcag aacttgaatt
     4621 gctaagcatg tttgaggggg aaatagaatc cttaactcag tgcctatgtc tgccatgtga
     4681 aatccttcag ctttgtgcac caaaactgta tcatacctgt acatatatat acatgtataa
     4741 aaggcagtat agcaagtcac acaccaccag tcctaaatct ctggtggtca aactgaaata
     4801 gttgcccata ggataacaca tatgtttacc cctcttcata tctgatggtg gcagatgcca
     4861 ctaaaatggc cacatgtgtc ttgactccag gtggcttccg aataggaaat atccctgcga
     4921 tcttggtgtg gcatggcagc agcatctctc tctctgcgct ttcctgggtc aaggttttgt
     4981 ggtgttttta ttgtataaag tttgtctgaa accgccccca aggagggttt ccttttatgc
     5041 tgtagtaaga gaaagcaaag gaaaaagaaa ctgtgacatt ttttgttgtc agtttgttgg
     5101 tggaccctgt taccatggct tcacatctaa gtggggacta ttttaactta tttacaggta
     5161 tatggtgtgg aaataagtta gctcaattgt ggatataatg aacatccaca cacagacaca
     5221 tacacacaca catacaaata aataaaaatt taaaagtaaa atacacaacc tcatgctaaa
     5281 actagtcatg tggtttttct ttcatggctc ataacaaact ttaagaggca ttttgataag
     5341 aactctcttc agtgctctga gacaacaggg taacaggaca ccagctggct tagatcgatg
     5401 ggaactttgc ttttgaaaag ggccagcata tagttaattg attatacttt tgatctataa
     5461 gcaaataatc caatggagag tgactctcta aatagtttcc aaacttttct ggtcacctga
     5521 ctagtaggct agatgacatt ctgccatcta agccatagct gtaaaaaaat aaaataaaaa
     5581 tataaatcct ggcctgtgct ataagttgac atgaataaag tatattaagc tctttattct
     5641 tggtgagacc aaagtgtggc actgtgttga caccatgggc agacacagga caccttgggt
     5701 tcttctgtat tccaccttca aagcggtctg tctgagtatg atatcttact gctcaagatc
     5761 cacaggactt cacgatgtaa gagggtgtga cttcatggag aacctcacag tccatgtccc
     5821 ttcactgtaa ccccatttta atgaatgctt agactaagcc tccccacctt cttgcttttc
     5881 gagttcaaac tgtatctgca gaatttcaag tctcccgttc ggtttcccag tgtccctgag
     5941 aagagaagag gttcttttct acgcccttgc cagtgtcatt tcagtgttta cattttcgag
     6001 ctgagacctt gatcggctaa cttagtcaaa ataccactgc caccgctgaa ggaccaggtg
     6061 ttcgaatgca cagtgttgca agcaacgcaa gcgaaagtga ccctcacaca cacagccctc
     6121 tgtgtccttt tatggctgtt ctgtcgtcga tgccaacccc caattattta ttattgttaa
     6181 taacttactt tttcttacat tctgttgtaa ataaagtatg aagcaatctt caaaaaaaaa
     6241 aaaaaaaa
//
