LOCUS       NM_001359217            2711 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol transfer protein, beta (Pitpnb),
            transcript variant 7, mRNA.
ACCESSION   NM_001359217 XM_006535143
VERSION     NM_001359217.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Xie,Z. and Bankaitis,V.A.
  TITLE     Phosphatidylinositol transfer protein/planar cell polarity axis
            regulates neocortical morphogenesis by supporting interkinetic
            nuclear migration
  JOURNAL   Cell Rep 39 (9), 110869 (2022)
   PUBMED   35649377
REFERENCE   2  (bases 1 to 2711)
  AUTHORS   Capitano,M., Zhao,L., Cooper,S., Thorsheim,C., Suzuki,A., Huang,X.,
            Dent,A.L., Marks,M.S., Abrams,C.S. and Broxmeyer,H.E.
  TITLE     Phosphatidylinositol transfer proteins regulate megakaryocyte
            TGF-beta1 secretion and hematopoiesis in mice
  JOURNAL   Blood 132 (10), 1027-1038 (2018)
   PUBMED   30042096
  REMARK    GeneRIF: these data show that ablating PITPs in MKs indirectly
            dysregulates hematopoiesis in the BM by disrupting alpha-granule
            physiology and secretion of TGF-beta1.
REFERENCE   3  (bases 1 to 2711)
  AUTHORS   Xie,Z., Hur,S.K., Zhao,L., Abrams,C.S. and Bankaitis,V.A.
  TITLE     A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution
            and Cell Polarity during Neurogenesis
  JOURNAL   Dev Cell 44 (6), 725-740 (2018)
   PUBMED   29587143
REFERENCE   4  (bases 1 to 2711)
  AUTHORS   Dina,C., Bouatia-Naji,N., Tucker,N., Delling,F.N., Toomer,K.,
            Durst,R., Perrocheau,M., Fernandez-Friera,L., Solis,J., Le
            Tourneau,T., Chen,M.H., Probst,V., Bosse,Y., Pibarot,P.,
            Zelenika,D., Lathrop,M., Hercberg,S., Roussel,R., Benjamin,E.J.,
            Bonnet,F., Lo,S.H., Dolmatova,E., Simonet,F., Lecointe,S.,
            Kyndt,F., Redon,R., Le Marec,H., Froguel,P., Ellinor,P.T.,
            Vasan,R.S., Bruneval,P., Markwald,R.R., Norris,R.A., Milan,D.J.,
            Slaugenhaupt,S.A., Levine,R.A., Schott,J.J., Hagege,A.A. and
            Jeunemaitre,X.
  CONSRTM   PROMESA investigators; MVP-France; Leducq Transatlantic MITRAL
            Network
  TITLE     Genetic association analyses highlight biological pathways
            underlying mitral valve prolapse
  JOURNAL   Nat Genet 47 (10), 1206-1211 (2015)
   PUBMED   26301497
REFERENCE   5  (bases 1 to 2711)
  AUTHORS   Schenning,M., Goedhart,J., Gadella,T.W. Jr., Avram,D., Wirtz,K.W.
            and Snoek,G.T.
  TITLE     The anti-apoptotic activity associated with phosphatidylinositol
            transfer protein alpha activates the MAPK and Akt/PKB pathway
  JOURNAL   Biochim Biophys Acta 1783 (10), 1700-1706 (2008)
   PUBMED   18501717
REFERENCE   6  (bases 1 to 2711)
  AUTHORS   Routt,S.M. and Bankaitis,V.A.
  TITLE     Biological functions of phosphatidylinositol transfer proteins
  JOURNAL   Biochem Cell Biol 82 (1), 254-262 (2004)
   PUBMED   15052341
  REMARK    GeneRIF: The PITPbeta deficiency results in catastrophic failure
            early in murine embryonic development, and the PITPbeta is an
            essential housekeeping PIPT in murine cells.
            Review article
REFERENCE   7  (bases 1 to 2711)
  AUTHORS   van Tiel,C.M., Westerman,J., Paasman,M.A., Hoebens,M.M., Wirtz,K.W.
            and Snoek,G.T.
  TITLE     The Golgi localization of phosphatidylinositol transfer protein
            beta requires the protein kinase C-dependent phosphorylation of
            serine 262 and is essential for maintaining plasma membrane
            sphingomyelin levels
  JOURNAL   J Biol Chem 277 (25), 22447-22452 (2002)
   PUBMED   11953429
  REMARK    GeneRIF: The Golgi localization of phosphatidylinositol transfer
            protein beta requires the protein kinase C-dependent
            phosphorylation of serine
REFERENCE   8  (bases 1 to 2711)
  AUTHORS   Alb,J.G. Jr., Phillips,S.E., Rostand,K., Cui,X., Pinxteren,J.,
            Cotlin,L., Manning,T., Guo,S., York,J.D., Sontheimer,H.,
            Collawn,J.F. and Bankaitis,V.A.
  TITLE     Genetic ablation of phosphatidylinositol transfer protein function
            in murine embryonic stem cells
  JOURNAL   Mol Biol Cell 13 (3), 739-754 (2002)
   PUBMED   11907258
  REMARK    GeneRIF: Data suggest that phosphatidylinositol transfer protein
            (PITP) beta is an essential housekeeping PITP in murine cells,
            whereas PITP alpha plays a far more specialized function in
            mammals.
REFERENCE   9  (bases 1 to 2711)
  AUTHORS   Yoder,M.D., Thomas,L.M., Tremblay,J.M., Oliver,R.L., Yarbrough,L.R.
            and Helmkamp,G.M. Jr.
  TITLE     Structure of a multifunctional protein. Mammalian
            phosphatidylinositol transfer protein complexed with
            phosphatidylcholine
  JOURNAL   J Biol Chem 276 (12), 9246-9252 (2001)
   PUBMED   11104777
REFERENCE   10 (bases 1 to 2711)
  AUTHORS   de Vries,K.J., Heinrichs,A.A., Cunningham,E., Brunink,F.,
            Westerman,J., Somerharju,P.J., Cockcroft,S., Wirtz,K.W. and
            Snoek,G.T.
  TITLE     An isoform of the phosphatidylinositol-transfer protein transfers
            sphingomyelin and is associated with the Golgi system
  JOURNAL   Biochem J 310 (Pt 2) (Pt 2), 643-649 (1995)
   PUBMED   7654206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122226.3.
            
            On Dec 29, 2017 this sequence version replaced XM_006535143.1.
            
            Summary: This gene encodes a member of the phosphatidylinositol
            transfer protein family. The encoded protein catalyzes the transfer
            of phospholipids (phosphatidylinositol and phosphatidylcholine)
            between membranes. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (7) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (7) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BQ443027.1, BU613662.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC122226.3         75340-75476
            138-168             AC122226.3         80138-80168
            169-283             AC122226.3         82957-83071
            284-375             AC122226.3         91126-91217
            376-383             AC122226.3         91763-91770
            384-458             AC122226.3         92424-92498
            459-542             AC122226.3         94134-94217
            543-620             AC122226.3         115955-116032
            621-731             AC122226.3         124835-124945
            732-854             AC122226.3         127631-127753
            855-2711            AC122226.3         131146-133002
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.79 cM"
     gene            1..2711
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /note="phosphatidylinositol transfer protein, beta"
                     /db_xref="GeneID:56305"
                     /db_xref="MGI:MGI:1927542"
     exon            1..137
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            138..168
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            169..283
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            284..375
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..905
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /note="isoform 7 is encoded by transcript variant 7;
                     phosphotidylinositol transfer protein, beta; ptdInsTP
                     beta; ptdIns transfer protein beta; Pitp beta"
                     /codon_start=1
                     /product="phosphatidylinositol transfer protein beta
                     isoform isoform 7"
                     /protein_id="NP_001346146.1"
                     /db_xref="GeneID:56305"
                     /db_xref="MGI:MGI:1927542"
                     /translation="MIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKP
                     DLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGP
                     NWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWID
                     KWIDLTMEDIRRMEDETQKELETLRSQGQVRGTSAACDD"
     exon            376..383
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            384..458
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            543..620
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            621..731
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            732..854
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            855..2711
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="Pitpnb"
                     /gene_synonym="PI-TP-beta"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggacg cgcaggcgct cccggggctc ggacgattgg gaggcggggc tacgcttgcg
       61 tgttgcgagg cccggcggtg gcggctggcg gcggcggctg tgaggggttc ccggaagatg
      121 gtgctgatta aggaattccg tgtggttttg ccgtgttctg ttcaagagaa gcgagtaaga
      181 atgaaactgg tggtggagaa ggaatcgaag tcctgaagaa tgaaccttat gaaaacgatg
      241 gcgagaaggg acagtacaca cacaaaatct accacctgaa gagcaaagtt cctgcatttg
      301 tgaggatgat tgctcccgag ggctccctgg tgtttcatga gaaagcctgg aatgcctacc
      361 cctactgcag aacaattgta acgaatgaat acatgaaaga tgacttcttc atcaaaattg
      421 aaacatggca taaacctgac ttgggaacat tagaaaatgt tcacggttta gatcccaaca
      481 cttggaaaac tgttgaaatt gtccacatag acattgcaga tcgaagtcaa gttgaaccag
      541 cagactacaa agctgatgaa gaccctgcat tattccattc agtcaagacc aagagaggac
      601 ccctgggacc taactggaag aaggagctgg caaacacccc tgactgtcct aggatgtgtg
      661 cctataagct ggtgaccatc aagttcaagt ggtgggggct gcagagcaaa gtagagaact
      721 ttatccagaa gcaagaaaaa cggatattta cgaacttaca tcgccagctc ttttgttgga
      781 ttgacaagtg gattgacctg acaatggaag acattaggcg aatggaggat gagactcaga
      841 aagaactaga aacactacgg agtcaaggcc aagtgagggg gaccagtgcg gcctgtgatg
      901 actgaagcca ccagcgtctc agtgttggac gtttccagtg tgtgtctgac gattcgagca
      961 cacgtgtgca cacacacgga cggacacaca cagacacaca cacacacata ttctcacaca
     1021 cttatgcgtg tgtgaatatg tgtgtggatg tctgtagctg tatgtaaagc acatatggct
     1081 acaggtctag atacacacat gagtgtatat atatatgtat gtccatgcta gatacacaca
     1141 cgagtgtata tatatgtatg tacatgctag atgcacacat gagtgtatat atatgtatgt
     1201 acatgtaaag atcgaaggga gcagggcgtt ttctccaaag tactgcacct gccttcaaca
     1261 aaaatactaa agaaaatatt ttcaatatat atacctggaa cagatattaa taatcatcaa
     1321 catgatgccc ttgatggaca aacggactgc cctgtggtgc cccgtggtgc tggctggcgt
     1381 gcttcgtgaa tgccaggtgt ggaccagtgt gtacagccta tgattatgtt tctgtttttt
     1441 caagtcacca catacacaca cttagtctca ttccatcagc aacaactcct acagaaagat
     1501 ttcttcaaat ttttagatac tccagtgact ctggaatgta aactctggat gtatttataa
     1561 ctatttattt ctgggtggcc actatcttcc agccaaatcc aacattatct gtcaagtaag
     1621 gagtcaaagc tctttattgg tttgcccgag ggttggggaa gtcctttttt aaaaattgcc
     1681 actttttatt ggatttttgt attttgaatt tcaagtattt ttctacatca aatttagcaa
     1741 aaaacagtga tgacggtttg tgatttataa taaacactag acaatattca gactctggct
     1801 aagcaaacgg cgatcaagca attaacctga gtggtattgc aggctgtgtg gagcacttct
     1861 gtggagtttt gtttctgaaa tggcttttct ggaattacag cctggagact ttgtggatag
     1921 tctgtattgt tctcagctca cagggtggga gagtgatcac gtccagctct ttttctgttg
     1981 tggtccaggc caggaggaaa tgaagagcta ggaacagctt gagtgtggcc caggtctgtc
     2041 gccatcctga cgcccagcca gacctgagcg ttgctgccga ctctgcttcc tcctcattgc
     2101 tcctcctctt cctcctcctc ctcttcctcc tcctcctctt cctcctcctc ctctgcctct
     2161 gttttttcct gtaagagaaa ggagcagtag ctgggtagga ttttctttcc ttatgacctt
     2221 tctgtctgat gctgtttcct cttgttagcc ctgggaccct gaccagaatc acactgctga
     2281 atccttcagg ttacacactg cctttttaac ccccaaccca gagcacagca ccctgccatc
     2341 agagcacccg agtgacccct ttgttggcag acttggcctt catgtcccct ccgccctgcc
     2401 ctgtgtccca tgggagcaat ggcagagatt cccactgcat cgcactgccc ggttaccctc
     2461 agcagcaaac cctgggttct aaccccggca ctggagagcc caaccgtccc cagtggaacc
     2521 aactcagaca tccatgtttc cttaggagct tgggcacaaa ggcaacggac tcctgtgttg
     2581 ttctaacagc tgtggagact gagggacgtg tatgagcgta aagcacctgc tttacttgcc
     2641 agtctcctgt gtaaattaca gtaaaacaaa ggaactgaaa cggaaacaaa ataaatttga
     2701 tctcaaaatt c
//
