LOCUS       NM_008850               3796 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphatidylinositol transfer protein, alpha (Pitpna),
            mRNA.
ACCESSION   NM_008850
VERSION     NM_008850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Hashimoto,D., Fujimoto,K., Morioka,S., Ayabe,S., Kataoka,T.,
            Fukumura,R., Ueda,Y., Kajimoto,M., Hyuga,T., Suzuki,K., Hara,I.,
            Asamura,S., Wakana,S., Yoshiki,A., Gondo,Y., Tamura,M., Sasaki,T.
            and Yamada,G.
  TITLE     Establishment of mouse line showing inducible priapism-like
            phenotypes
  JOURNAL   Reprod Med Biol 21 (1), e12472 (2022)
   PUBMED   35765371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Xie,Z. and Bankaitis,V.A.
  TITLE     Phosphatidylinositol transfer protein/planar cell polarity axis
            regulates neocortical morphogenesis by supporting interkinetic
            nuclear migration
  JOURNAL   Cell Rep 39 (9), 110869 (2022)
   PUBMED   35649377
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Capitano,M., Zhao,L., Cooper,S., Thorsheim,C., Suzuki,A., Huang,X.,
            Dent,A.L., Marks,M.S., Abrams,C.S. and Broxmeyer,H.E.
  TITLE     Phosphatidylinositol transfer proteins regulate megakaryocyte
            TGF-beta1 secretion and hematopoiesis in mice
  JOURNAL   Blood 132 (10), 1027-1038 (2018)
   PUBMED   30042096
  REMARK    GeneRIF: these data show that ablating PITPs in MKs indirectly
            dysregulates hematopoiesis in the BM by disrupting alpha-granule
            physiology and secretion of TGF-beta1.
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Xie,Z., Hur,S.K., Zhao,L., Abrams,C.S. and Bankaitis,V.A.
  TITLE     A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution
            and Cell Polarity during Neurogenesis
  JOURNAL   Dev Cell 44 (6), 725-740 (2018)
   PUBMED   29587143
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   de Vries,K.J., Heinrichs,A.A., Cunningham,E., Brunink,F.,
            Westerman,J., Somerharju,P.J., Cockcroft,S., Wirtz,K.W. and
            Snoek,G.T.
  TITLE     An isoform of the phosphatidylinositol-transfer protein transfers
            sphingomyelin and is associated with the Golgi system
  JOURNAL   Biochem J 310 (Pt 2) (Pt 2), 643-649 (1995)
   PUBMED   7654206
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Burrows,H.L., Seasholtz,A.F. and Camper,S.A.
  TITLE     Localization of the corticotropin-releasing hormone receptor gene
            on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (1), 55-56 (1995)
   PUBMED   7719029
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Geijtenbeek,T.B., de Groot,E., van Baal,J., Brunink,F.,
            Westerman,J., Snoek,G.T. and Wirtz,K.W.
  TITLE     Characterization of mouse phosphatidylinositol transfer protein
            expressed in Escherichia coli
  JOURNAL   Biochim Biophys Acta 1213 (3), 309-318 (1994)
   PUBMED   8049244
REFERENCE   9  (bases 1 to 3796)
  AUTHORS   Fitzgibbon,J., Pilz,A., Gayther,S., Appukuttan,B., Dulai,K.S.,
            Delhanty,J.D., Helmkamp,G.M. Jr., Yarbrough,L.R. and Hunt,D.M.
  TITLE     Localization of the gene encoding human phosphatidylinositol
            transfer protein (PITPN) to 17p13.3: a gene showing homology to the
            Drosophila retinal degeneration B gene (rdgB)
  JOURNAL   Cytogenet Cell Genet 67 (3), 205-207 (1994)
   PUBMED   7914867
REFERENCE   10 (bases 1 to 3796)
  AUTHORS   Weimar,W.R., Lane,P.W. and Sidman,R.L.
  TITLE     Vibrator (vb): a spinocerebellar system degeneration with autosomal
            recessive inheritance in mice
  JOURNAL   Brain Res 251 (2), 357-364 (1982)
   PUBMED   7139332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY316588.1, AK153569.1,
            AK168720.1 and BQ176339.1.
            
            On Sep 17, 2015 this sequence version replaced NM_008850.1.
            
            Summary: This gene encodes a member of a family of lipid-binding
            proteins that transfer molecules of phosphatidylinositol or
            phosphatidylcholine between membrane surfaces. The protein is
            implicated in phospholipase C signaling and in the production of
            phosphatidylinositol 3,4,5-trisphosphate by
            phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168720.1, U96725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY316588.1         2-18
            18-1673             AK153569.1         2-1657
            1674-3762           AK168720.1         1648-3736
            3763-3796           BQ176339.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..3796
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="phosphatidylinositol transfer protein, alpha"
                     /db_xref="GeneID:18738"
                     /db_xref="MGI:MGI:99887"
     exon            1..274
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1070
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="PI-TP-alpha; ptdInsTP alpha; ptdIns transfer
                     protein alpha; Pitp alpha"
                     /codon_start=1
                     /product="phosphatidylinositol transfer protein alpha
                     isoform"
                     /protein_id="NP_032876.1"
                     /db_xref="CCDS:CCDS25052.1"
                     /db_xref="GeneID:18738"
                     /db_xref="MGI:MGI:99887"
                     /translation="MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLV
                     NEPYEKDDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNE
                     YMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAIYIDIADRSQVLSKDYKAEED
                     PAKFKSVKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQE
                     KRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD"
     exon            275..305
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            306..454
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            455..546
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            547..554
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            555..629
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            630..713
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            714..791
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            792..902
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1025
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1091
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..3779
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="hexamer: TATAAA"
     polyA_site      1266
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="major polyA site"
     regulatory      3589..3594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="hexamer: AATAAA"
     polyA_site      3607
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
     regulatory      3751..3756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
                     /note="hexamer: AATAAA"
     polyA_site      3775
                     /gene="Pitpna"
                     /gene_synonym="Pitpn; vb; vibrator"
ORIGIN      
        1 agagacgccc cgcccccgcg tggcgctgcg gaaccggagc tccgggcggc gtcggcagag
       61 gcgcgggagg tggtgaggcc agggcagggc gacaggagcc cgcgcggcga ccgcagcgag
      121 agcagcgggg acagagcaga ccacgacgaa ggcgcacagg cagcggggcc gggccgggcc
      181 accgggagag cggccaccgg gtagcgggcg ggaggccggg ctggcagctg gcagccgccg
      241 agccgcgaag cgacatggtg ctgctcaagg agtatcgggt catcctgcct gtgtctgtag
      301 atgagtatca agtggggcag ctgtattctg tggctgaagc cagtaaaaat gaaactggtg
      361 gtggggaagg tgtggaggtc ctggtgaatg agccctacga gaaggacgat ggcgagaaag
      421 gccagtacac acacaagatc taccacttac agagcaaagt acccaccttt gttcgaatgc
      481 tggccccaga aggcgccctg aatatacacg agaaagcctg gaatgcctac ccttactgca
      541 gaaccgttat tacaaatgag tacatgaaag aagattttct gattaaaatt gaaacctggc
      601 acaagccaga ccttggcacc caggagaatg tgcataaact ggagcctgag gcatggaaac
      661 atgtggaagc tatatatata gacatcgctg atcgaagcca agtacttagc aaggattaca
      721 aggcagagga agacccagca aaatttaaat ctgtcaaaac aggacgcgga cctttgggcc
      781 cgaattggaa gcaagaactt gtcaatcaga aagactgccc atatatgtgt gcatacaaac
      841 tggttactgt caagttcaag tggtggggct tgcagaacaa agtggaaaac tttatacata
      901 agcaagagaa gcgtctgttt acaaactttc acaggcagct gttctgttgg ctcgataaat
      961 gggttgatct gactatggat gacattcgga ggatggaaga agagacgaag agacagctgg
     1021 atgagatgag acaaaaggac ccagtgaaag gaatgacagc agacgactag cgccaccgcc
     1081 ctttctgcac tttttgcaag acagtggtca acaggaaggc ccagcagctc caccctcctg
     1141 agtggcaggc catcttcgga cgcagccttt ctgtgctcat tcttcaggca actttcaatc
     1201 ccttactata gctatttcta gatgcccttt aacattgtga acaaatagac cgtctggtat
     1261 tataaagcct gtgtgtgcgg gagcctgatc ctctaagata catggtgtag ctgctgtgtt
     1321 tacagctcat cctctctcca ctgtgctctg acccatttct gtatgccctc cccttttatt
     1381 tccaagtgat ggtctcagtc ttcccaatga gctgcctttt gtgatgtgat tatttaagct
     1441 catttatttc agccttggga taaactgagc tattttgctt cctgggcaga tctttggcaa
     1501 tgctgaatat tcacttgggg agagaggagg agttaaaaat acagagacac ctacccccag
     1561 ctcctcacaa taggaatgtg gcttcagacc cctgacctct gctcctagta acctcttgtt
     1621 tgcgtgctct aagcaccaag aaggcaccca aggcccagcc agtctcagaa aatttagcaa
     1681 ataataaata acccctactc gagtcattgc atctctggtt aatattctta gaaatcttgg
     1741 cttctcagcc ctcctgttgc ccactctgtc tggatctctc tgtagagcct acaagacccc
     1801 accactgccc agctggagaa ctgtccagta tggcctgttg acaccattca gaccccacag
     1861 gagcgctgta tgtccgtgct ccttttccct tttgggctgg tgctgccact cagcaataat
     1921 cctctctgtg ctttcttaga cccctgtcct ctgtgaggct ggctaggatg caagagtcct
     1981 ggtcttttca tgctgcacaa acaagcatgc aaaaagcttt ttatccctag caaaacatgt
     2041 accttcctgt ttctaatcac tggacaagaa tttgcagata aagaactcag ctcatcctgc
     2101 cccacactga gttctgtcct ggacaatcaa aagcaagccg tgactgtagc ctggaacagt
     2161 tagcacagca ggctggggaa gcccaggctc caagggagtg gaagctgcaa agcactggct
     2221 tttctagatg ggcagaaact gaggatgcct ttctggtggg agagtgggat agaattgtgt
     2281 cacctgacat ttcccaagcc ttcttcagtc agtcagccca gtgtgtagtg atccaagccc
     2341 atgattgcca gggtacctgt tagagaccaa atctctacta ggggagtgag aagtaggatg
     2401 gatcgttctc cttgtttttg tctgtgttgg ccttactcat ttctaagtgc aataaggcag
     2461 tgtctcaggg actgcacctg tgacatcctg actggatgct tccctgtggt cctcctggaa
     2521 taagggtaga cagatttggg cccctcagca tggttagctc tgaccttcct tgaggttctt
     2581 ttaagaccag gagatgtctg gttactgaca cctttcaagg tattagtctc ctcaccttgt
     2641 agagtcttta ggcatgcact tggggcatct tggtgattag catatcagct gctagtagca
     2701 tgggaaagtt ggagaagagg cattcctaat ggaaatggaa aaaacataaa tgttctcata
     2761 taagctctgt attacctatc aaatcctatt tgtgcttaaa gatcttcctt cagtaactag
     2821 gttaaagttc agatgtgtta tcttgagaga agttgatagt ctacgcagat agtttacatg
     2881 atatgagggt caaaagatat ttgtctcctt cagcacttca taagatctat acatatcagt
     2941 cacattggcc tcaatcctgg cctgctctta cctgccttgc gcccctgctg ttgcccacat
     3001 ttgaaagcat ccaaatgatc cgaactagaa tttcctgaga ccagcctgga tttagggctc
     3061 ctgcccacat aaacacaaag gaggaatgtc cctgtcttgt tccatcccca tgggtggtgt
     3121 tgctgctgga caagtgttgg cttttaagta tccccttttt ttacccaccc ccaaaattaa
     3181 ctagcactca agagggctgg tgatgaaagg ctcacctctg gtgagaatcc ctgagagtgc
     3241 gacatgcttc ttcagactgg ctgcttccat tacatttcca gggtctgctt tactcccagc
     3301 gggagcagca gtgtctctgc acaaggcctg ctgggctcca gccttcttgt ggagagacac
     3361 tggggaggga caggtcaggg tcactgctgt gggcatgtgt gtatccttcc acattcttcc
     3421 tttcagtccc ccctggacct ctgacgtcct tgggttggtt cttagtgcta cttcttttac
     3481 agactacact ttatagaact gattagattt cctgtttatt taatgtgagt ttgtgccttt
     3541 ttgtctcaat cttccaatac aggtatattg gggggaaaaa agcagtctaa taaaatccta
     3601 gacagagttt tttggagtct agcttattgg tgatgttcct atgtccattt ttcaacttag
     3661 atgtccttaa agctcctact gatatctccc cagtttattt acaggagagg attatgagaa
     3721 gatacagtgg tatttctgac attttatgta aataaagtat tccttgtcca aaaaagtcaa
     3781 aaaaaaaaaa aaaaaa
//
