LOCUS       NM_177298               2150 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus phosphatidylserine decarboxylase (Pisd), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_177298
VERSION     NM_177298.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Johnson,J.M., Peterlin,A.D., Balderas,E., Sustarsic,E.G.,
            Maschek,J.A., Lang,M.J., Jara-Ramos,A., Panic,V., Morgan,J.T.,
            Villanueva,C.J., Sanchez,A., Rutter,J., Lodhi,I.J., Cox,J.E.,
            Fisher-Wellman,K.H., Chaudhuri,D., Gerhart-Hines,Z. and Funai,K.
  TITLE     Mitochondrial phosphatidylethanolamine modulates UCP1 to promote
            brown adipose thermogenesis
  JOURNAL   Sci Adv 9 (8), eade7864 (2023)
   PUBMED   36827367
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Wang,F., Tan,P., Zhang,P., Ren,Y., Zhou,J., Li,Y., Hou,S., Li,S.,
            Zhang,L., Ma,Y., Wang,C., Tang,W., Wang,X., Huo,Y., Hu,Y., Cui,T.,
            Niu,C., Wang,D., Liu,B., Lan,Y. and Yu,J.
  TITLE     Single-cell architecture and functional requirement of alternative
            splicing during hematopoietic stem cell formation
  JOURNAL   Sci Adv 8 (1), eabg5369 (2022)
   PUBMED   34995116
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Heden,T.D., Johnson,J.M., Ferrara,P.J., Eshima,H., Verkerke,A.R.P.,
            Wentzler,E.J., Siripoksup,P., Narowski,T.M., Coleman,C.B.,
            Lin,C.T., Ryan,T.E., Reidy,P.T., de Castro Bras,L.E., Karner,C.M.,
            Burant,C.F., Maschek,J.A., Cox,J.E., Mashek,D.G., Kardon,G.,
            Boudina,S., Zeczycki,T.N., Rutter,J., Shaikh,S.R., Vance,J.E.,
            Drummond,M.J., Neufer,P.D. and Funai,K.
  TITLE     Mitochondrial PE potentiates respiratory enzymes to amplify
            skeletal muscle aerobic capacity
  JOURNAL   Sci Adv 5 (9), eaax8352 (2019)
   PUBMED   31535029
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Selathurai,A., Kowalski,G.M., Mason,S.A., Callahan,D.L.,
            Foletta,V.C., Della Gatta,P.A., Lindsay,A., Hamley,S., Kaur,G.,
            Curtis,A.R., Burch,M.L., Ang,T., McGee,S.L. and Bruce,C.R.
  TITLE     Phosphatidylserine decarboxylase is critical for the maintenance of
            skeletal muscle mitochondrial integrity and muscle mass
  JOURNAL   Mol Metab 27, 33-46 (2019)
   PUBMED   31285171
  REMARK    GeneRIF: The phosphatidylserine decarboxylase pathway has a
            significant role in maintaining phospholipid homeostasis in adult
            skeletal muscle. Moreover, phosphatidylserine decarboxylase is
            essential for maintenance of mitochondrial integrity and skeletal
            muscle mass.
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Cajigas,I., Chakraborty,A., Swyter,K.R., Luo,H., Bastidas,M.,
            Nigro,M., Morris,E.R., Chen,S., VanGompel,M.J.W., Leib,D.,
            Kohtz,S.J., Martina,M., Koh,S., Ay,F. and Kohtz,J.D.
  TITLE     The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially
            Organizes Megabase Distant Genes in the Developing Forebrain
  JOURNAL   Mol Cell 71 (6), 956-972 (2018)
   PUBMED   30146317
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Hwang,D.Y., Hong,S., Jeong,J.W., Choi,S., Kim,H., Kim,J. and
            Kim,K.S.
  TITLE     Vesicular monoamine transporter 2 and dopamine transporter are
            molecular targets of Pitx3 in the ventral midbrain dopamine neurons
  JOURNAL   J Neurochem 111 (5), 1202-1212 (2009)
   PUBMED   19780901
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Steenbergen,R., Nanowski,T.S., Beigneux,A., Kulinski,A., Young,S.G.
            and Vance,J.E.
  TITLE     Disruption of the phosphatidylserine decarboxylase gene in mice
            causes embryonic lethality and mitochondrial defects
  JOURNAL   J Biol Chem 280 (48), 40032-40040 (2005)
   PUBMED   16192276
  REMARK    GeneRIF: phosphatidylserine decarboxylase in mice is required for
            embryonic survival and mitochondria
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2150)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX201846.1 and BC070408.1.
            
            On Mar 8, 2007 this sequence version replaced NM_177298.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034656.1, BC070408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               CX201846.1         16-463
            449-2150            BC070408.1         448-2149
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.33 cM"
     gene            1..2150
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /note="phosphatidylserine decarboxylase"
                     /db_xref="GeneID:320951"
                     /db_xref="MGI:MGI:2445114"
     exon            1..78
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1234
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /EC_number="4.1.1.65"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylserine decarboxylase proenzyme, mitochondrial"
                     /codon_start=1
                     /product="phosphatidylserine decarboxylase proenzyme,
                     mitochondrial isoform 1"
                     /protein_id="NP_796272.2"
                     /db_xref="CCDS:CCDS19194.1"
                     /db_xref="GeneID:320951"
                     /db_xref="MGI:MGI:2445114"
                     /translation="MAASGGRACVRSLRGGVLWRSSPCHYESTATRHFLGTLQKLPLQ
                     AGVRNFHTAPVRSLFLLRPVPILLATGGGYAGYRQYEKYRERKLEKLGLEIPPKLASH
                     WEVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEDLHHYR
                     NLSEFFRRKLKPQARPVCGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGP
                     RANTEDLPFPPASSSDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRH
                     FPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDL
                     HTNSPRYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLK
                     AGQKIRFGEALGSL"
     exon            79..149
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            150..325
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..562
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..701
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..848
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1009
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..2150
                     /gene="Pisd"
                     /gene_synonym="9030221M09Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggaggc gagatggcgg cgtctggggg ccgcgcgtgt gtgcgctcgc ttcgtggagg
       61 tgtgctgtgg cggagcagcc cctgtcacta tgaatctact gccacacgcc attttctggg
      121 gaccttacag aaattgcctc ttcaggcagg tgtcagaaat ttccatactg ctcctgtccg
      181 atccttgttc ctgctgcgcc ctgtgcccat cctgttggca acaggtggag ggtatgccgg
      241 gtaccggcag tatgagaagt acagggaacg gaagcttgag aagctgggct tggagatccc
      301 gcccaaactt gctagtcact gggaggtgtc cctgtataaa tctgtgccaa cgcgtttgct
      361 gtcacgtgcc tgtggtcgcc tcaaccaagt agaacttcct tactggctcc ggaggccagt
      421 ctacagcctg tatatctgga cctttggggt gaacatgact gaggctgcag tggaggacct
      481 gcaccactac cgcaacctca gcgagttctt ccggcgtaag ctgaagcctc aggcacggcc
      541 cgtatgtggc ttgcactgtg tgaccagccc atcagatggc aagatcctca cctttgggca
      601 ggtgaagaac tctgaggtgg agcaggtaaa gggcgtaacc tactccttgg agtccttcct
      661 gggccctcga gccaatacag aggacctgcc cttccctcca gcttcctcca gtgactcctt
      721 cagaaaccag ctggtcaccc gggaagggaa tgagctgtac cactgtgtca tctacctggc
      781 cccaggagac taccactgct tccactcccc cactgactgg accatctcac atcggcgcca
      841 cttcccaggt tccctgatgt cagtgaaccc tggcatggcc cgatggatca aagagctctt
      901 ttgtcacaat gagcgtgtag tcctaactgg agactggaaa catgggttct tctcgttgac
      961 agcagtggga gccaccaatg tgggctctat ccgtatccac tttgaccgag acctgcacac
     1021 aaacagcccc aggtacagca agggctccta caatgacctg agctttgtaa cacatgccaa
     1081 caaggagggc attcccatgc gcaagggtga gcccctgggg gagttcaacc tgggctccac
     1141 catcgtgctc atcttcgagg cacccaagga cttcaacttc aggctgaagg cagggcagaa
     1201 gatccgcttt ggggaagcac tgggctccct ctagtcctct cggttgtggc tgccaaagga
     1261 tctttccaca caggagcatg agggtcttca gcggagcctc aggctgtctg ggtgaggggc
     1321 actgcggggc tgaccttata agattgcctg tccatgggtg cagaggagag gttctgggtc
     1381 tctcaggaca ggacctagac cccttttcag agtatgggtg ggtgtgattt gaccccaaag
     1441 tcactttcag gggtgtttta aatttttgta caagccagag cctcccaccc ctaactcctg
     1501 gctgtgtact accacaccct ctagctgtga cccctcccgt cacagggctc tctcaatgtg
     1561 cacagggtga ggtgcctgct gggcacagac tgtggatcca ctgtcttcct agagcaggcc
     1621 acatggcctt cataactgct ttctgctccc caatttcacc cgtctgcttt ctggaaaagt
     1681 aaaatcattt atataatgct gaatgtgtta tcctgggctc tgccagtgtc ttctgaggac
     1741 aatgactaat gatgtagacc tttgtaggct ctaagaagct ggctgaatcc ttttgctggt
     1801 aggcaaaacc aattaattac tggcttgtct ggtagagtct ggagtgaaag ggcaggtgga
     1861 ggccctgccc tgcagaacta ggggacatgc tgctattggt ctagggactg tgttggaggc
     1921 agagggtata gaggtcagta cctagaaaac aggtatgcag gccatgggga acccagtggt
     1981 agggacaaga ccagagttca tgtcgatctt gggaatgcca tgaatttctc ctgcaggaga
     2041 aatcacttaa ctttttcaac tgtatcagta gtaccgtatt ttgtatgaaa agtaggagac
     2101 ttctgaacag taattcattt cattgcaaga cattttgaaa ttaaaaaaac
//
