LOCUS       NM_011095               2728 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus paired Ig-like receptor B (Pirb), transcript variant
            1, mRNA.
ACCESSION   NM_011095 XM_003946209 XM_905092 XM_919179
VERSION     NM_011095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Fiske,K.L., Brigleb,P.H., Sanchez,L.M., Hinterleitner,R.,
            Taylor,G.M. and Dermody,T.S.
  TITLE     Strain-specific differences in reovirus infection of murine
            macrophages segregate with polymorphisms in viral outer-capsid
            protein sigma3
  JOURNAL   J Virol 98 (11), e0114724 (2024)
   PUBMED   39431846
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Griswold,K.A., Vasylieva,I., Smith,M.C., Fiske,K.L., Welsh,O.L.,
            Roth,A.N., Watson,A.M., Watkins,S.C., Sutherland,D.M. and
            Dermody,T.S.
  TITLE     Sialic acid and PirB are not required for targeting of neural
            circuits by neurotropic mammalian orthoreovirus
  JOURNAL   mSphere 9 (10), e0062924 (2024)
   PUBMED   39320067
  REMARK    GeneRIF: Sialic acid and PirB are not required for targeting of
            neural circuits by neurotropic mammalian orthoreovirus.
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Meng,X., Li,D., Kan,R., Xiang,Y., Pan,L., Guo,Y., Yu,P., Luo,P.,
            Zou,H., Huang,L., Zhu,Y., Mao,B., He,Y., Xie,L., Xu,J., Liu,X.,
            Li,W., Chen,Y., Zhu,S., Yang,Y. and Yu,X.
  TITLE     Inhibition of ANGPTL8 protects against diabetes-associated
            cognitive dysfunction by reducing synaptic loss via the PirB
            signaling pathway
  JOURNAL   J Neuroinflammation 21 (1), 192 (2024)
   PUBMED   39095838
  REMARK    GeneRIF: Inhibition of ANGPTL8 protects against diabetes-associated
            cognitive dysfunction by reducing synaptic loss via the PirB
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Nechanitzky,R., Ramachandran,P., Nechanitzky,D., Li,W.Y.,
            Wakeham,A.C., Haight,J., Saunders,M.E., Epelman,S. and Mak,T.W.
  TITLE     CaSSiDI: novel single-cell 'Cluster Similarity Scoring and
            Distinction Index' reveals critical functions for PirB and
            context-dependent Cebpb repression
  JOURNAL   Cell Death Differ 31 (3), 265-279 (2024)
   PUBMED   38383888
  REMARK    GeneRIF: CaSSiDI: novel single-cell 'Cluster Similarity Scoring and
            Distinction Index' reveals critical functions for PirB and
            context-dependent Cebpb repression.
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Li,D.P., Huang,L., Kan,R.R., Meng,X.Y., Wang,S.Y., Zou,H.J.,
            Guo,Y.M., Luo,P.Q., Pan,L.M., Xiang,Y.X., Mao,B.B., Xie,Y.Y.,
            Wang,Z.H., Yang,M., He,R., Yang,Y., Liu,Z.L., Xie,J.H., Ma,D.L.,
            Zhang,B.P., Shao,S.Y., Chen,X., Xu,S.M., He,W.T., Li,W.J., Chen,Y.
            and Yu,X.F.
  TITLE     LILRB2/PirB mediates macrophage recruitment in fibrogenesis of
            nonalcoholic steatohepatitis
  JOURNAL   Nat Commun 14 (1), 4436 (2023)
   PUBMED   37481670
  REMARK    GeneRIF: LILRB2/PirB mediates macrophage recruitment in
            fibrogenesis of nonalcoholic steatohepatitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Berg,K.L., Carlberg,K., Rohrschneider,L.R., Siminovitch,K.A. and
            Stanley,E.R.
  TITLE     The major SHP-1-binding, tyrosine-phosphorylated protein in
            macrophages is a member of the KIR/LIR family and an SHP-1
            substrate
  JOURNAL   Oncogene 17 (19), 2535-2541 (1998)
   PUBMED   9824165
REFERENCE   7  (bases 1 to 2728)
  AUTHORS   Alley,T.L., Cooper,M.D., Chen,M. and Kubagawa,H.
  TITLE     Genomic structure of PIR-B, the inhibitory member of the paired
            immunoglobulin-like receptor genes in mice
  JOURNAL   Tissue Antigens 51 (3), 224-231 (1998)
   PUBMED   9550322
REFERENCE   8  (bases 1 to 2728)
  AUTHORS   Yamashita,Y., Fukuta,D., Tsuji,A., Nagabukuro,A., Matsuda,Y.,
            Nishikawa,Y., Ohyama,Y., Ohmori,H., Ono,M. and Takai,T.
  TITLE     Genomic structures and chromosomal location of p91, a novel murine
            regulatory receptor family
  JOURNAL   J Biochem 123 (2), 358-368 (1998)
   PUBMED   9538215
REFERENCE   9  (bases 1 to 2728)
  AUTHORS   Kubagawa,H., Burrows,P.D. and Cooper,M.D.
  TITLE     A novel pair of immunoglobulin-like receptors expressed by B cells
            and myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 5261-5266 (1997)
   PUBMED   9144225
REFERENCE   10 (bases 1 to 2728)
  AUTHORS   Hayami,K., Fukuta,D., Nishikawa,Y., Yamashita,Y., Inui,M.,
            Ohyama,Y., Hikida,M., Ohmori,H. and Takai,T.
  TITLE     Molecular cloning of a novel murine cell-surface glycoprotein
            homologous to killer cell inhibitory receptors
  JOURNAL   J Biol Chem 272 (11), 7320-7327 (1997)
   PUBMED   9054430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165255.1, AF148880.1 and AK161081.1.
            
            On or before Dec 1, 2013 this sequence version replaced
            XM_003946209.1, NM_011095.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96693.1, AK161081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AK165255.1         1-49
            50-2136             AF148880.1         1-2087
            2137-2728           AK161081.1         2108-2699
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.14 cM"
     gene            1..2728
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /note="paired Ig-like receptor B"
                     /db_xref="GeneID:18733"
                     /db_xref="MGI:MGI:894311"
     exon            1..90
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2582
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell-surface glycoprotein p91; paired
                     immunoglobulin-like receptor B; leukocyte
                     immunoglobulin-like receptor 3; leukocyte
                     immunoglobulin-like receptor subfamily B member 3;
                     leukocyte immunoglobulin-like receptor, subfamily B (with
                     TM and ITIM domains), member 3"
                     /codon_start=1
                     /product="paired immunoglobulin-like receptor B isoform 1
                     precursor"
                     /protein_id="NP_035225.2"
                     /db_xref="CCDS:CCDS39730.1"
                     /db_xref="GeneID:18733"
                     /db_xref="MGI:MGI:894311"
                     /translation="MSCTFTALLRLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRRTK
                     VTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYST
                     QYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGP
                     QKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELL
                     VSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGN
                     KGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVT
                     AGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGA
                     FRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINY
                     DRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSAS
                     SEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLR
                     LKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETS
                     TPPPTMSMPLGGLHMYLKALIGVSVAFILFLFIFIFILLRRRHRGKFRKDVQKEKDLQ
                     LSSGAEEPITRKGELQKRPNPAAATQEESLYASVEDMQTEDGVELNSWTPPEEDPQGE
                     TYAQVKPSRLRKAGHVSPSVMSREQLNTEYEQAEEGQGANNQAAESGESQDVTYAQLC
                     SRTLRQGAAASPLSQAGEAPEEPSVYATLAAARPEAVPKDMEQ"
     exon            91..126
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            127..411
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            412..717
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1002
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1311
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1608
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1911
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1962
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2079
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2155
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2193
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2246
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2402
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2728
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="Pirb"
                     /gene_synonym="Gp91; Lilrb3; LIR-3; PIR-B"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggctct gtagctctgc ccttgagcac agttgcagcc actgagggga gatgccatgt
       61 cctgcacctt cacagccctg ctccgtcttg gactgactct gagcctctgg atcccagtgc
      121 tgacagggtc cctccctaag cctatcctca gagtacagcc agactctgtg gtctccagga
      181 ggactaaggt gaccttcttg tgtgaagaga caattggagc caatgagtac cgcctctata
      241 aagatggaaa gctatataaa accgtaacaa agaacaaaca gaagccagaa aacaaggctg
      301 aattctcatt ctcaaatgta gacctgagta atgcaggtca atatcgatgt tcctacagca
      361 cccagtataa atcatcaggc tacagtgacc tcctggagct ggtggtgaca ggacactact
      421 ggacacccag ccttttagcc caagccagcc ctgtggtaac ttcaggaggg tatgtcaccc
      481 tccagtgtga gtcctggcac aacgatcaca agttcattct gactgtagaa ggaccacaga
      541 agctctcgtg gacacaagac tcacagtata attactctac aaggaagtac cacgccctgt
      601 tctctgtggg ccctgtgacc cccaaccaga gatggatatg cagatgttac agttatgaca
      661 ggaacagacc atatgtgtgg tcacctccaa gtgaatccgt ggagctcctg gtctcaggta
      721 atctccaaaa accaaccatc aaggctgaac caggatctgt gatcacctcc aaaagagcaa
      781 tgaccatctg gtgtcagggg aacctggatg cagaagtata ttttctgcat aatgagaaaa
      841 gccaaaaaac acagagcaca cagaccctac aggagcctgg gaacaagggc aagttcttca
      901 tcccttctgt gacactacaa catgcagggc aatatcgctg ttattgttac ggctcagctg
      961 gttggtcaca gcccagtgac accctggagc tggtggtgac aggaatctat gaatactatg
     1021 aacccaggct gtcagtactg cccagccctg tggtgacagc tggagggaac atgacactcc
     1081 actgtgcctc agactttccc tacgataaat tcattctcac caaggaagat aagaaattcg
     1141 gcaactcact ggacacagag catatatctt ctagtggaca gtaccgagcc ctgtttatta
     1201 taggacccac aaccccaacc catacagggg cattcagatg ttacggttac tacaagaatg
     1261 ccccacagct gtggtcagta cctagtgctc tccaacaaat actcatctca gggctgtcca
     1321 agaagccctc tctgctgact caccaaggcc atatcctgga ccctggaatg accctcaccc
     1381 tgcagtgttt ctctgacatc aactatgaca gatttgctct gcacaaggtg gggggagctg
     1441 acatcatgca gcactctagc cagcagactg acactggctt ctctgtggcc aacttcacac
     1501 tgggctatgt gagtagctcc actggaggcc aatacagatg ctatggtgca cacaacctct
     1561 cctctgagtg gtcagcctcc agtgagcccc tggacatcct gatcacagga cagctccctc
     1621 tcactccttc cctctcagtg cagcctaacc acacagtgca ctcaggagag accgtgagcc
     1681 tgctgtgttg gtcaatggac tctgtggata ctttcattct gtccaaggag ggatcagccc
     1741 agcaacccct gcgactaaaa tcaaagtccc atgatcagca gtcccaggca gaattctcca
     1801 tgagtgctgt gacctcccat ctctcaggca cctacaggtg ctatggagct caagactcat
     1861 ctttctacct cttgtcatct gccagtgccc ctgtggagct cacagtctca ggacccatcg
     1921 aaacctctac cccgccaccc acaatgtcca tgccactagg tggactgcat atgtacctga
     1981 aggctctcat tggagtgtct gtggccttca tcctgttcct cttcatcttc atcttcattc
     2041 ttcttcgacg aagacatcgg ggaaaattca ggaaagatgt ccagaaagag aaagacttgc
     2101 aactttcttc aggagctgaa gagcccataa ccaggaaagg agaactccag aagaggccca
     2161 acccagctgc tgccacccag gaagaaagcc tatatgcttc agtggaggac atgcaaactg
     2221 aggatggagt ggagctgaac agctggacac cacctgagga agatccccag ggagagactt
     2281 atgcccaggt gaaaccctcc aggctcagga aggcaggaca tgtctcacct tctgtcatgt
     2341 caagggaaca actgaacaca gaatatgaac aagcagaaga gggccaagga gcaaacaatc
     2401 aggctgccga atctggggag tcccaggatg tgacctatgc ccagctgtgc agcaggacac
     2461 tcagacaggg ggcagctgca tctcctctct cccaggcagg ggaagcccca gaggagccca
     2521 gtgtatatgc tactctggcg gctgctcgtc cagaggctgt tcccaaggac atggagcaat
     2581 gaccccctgc ctgccaggat gcctagcaga gacctccaag ggactctggg aacttttgga
     2641 aacgtgactg cactttaagt aacatcagag tttggaaata aagctagaga tttctcaata
     2701 atcaagtgaa atgagaaatg aaatggaa
//
