LOCUS       NM_001371068            3209 bp    mRNA    linear   ROD 21-APR-2022
DEFINITION  Mus musculus paired-Ig-like receptor A1 (Pira1), transcript variant
            1, mRNA.
ACCESSION   NM_001371068 XM_017322035
VERSION     NM_001371068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3209)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3209)
  AUTHORS   Ben Baruch-Morgenstern N, Shik D, Moshkovits I, Itan M, Karo-Atar
            D, Bouffi C, Fulkerson P, Rashkovan D, Jung S, Rothenberg ME and
            Munitz A.
  TITLE     Paired immunoglobulin-like receptor A is an intrinsic,
            self-limiting suppressor of IL-5-induced eosinophil development
  JOURNAL   Nat Immunol 15 (1), 36-44 (2014)
   PUBMED   24212998
  REMARK    GeneRIF: Data indicate a critical role for PIR-B and PIR-A in
            eosinophil development.
REFERENCE   3  (bases 1 to 3209)
  AUTHORS   Licciulli S, Cambiaghi V, Scafetta G, Gruszka AM and Alcalay M.
  TITLE     Pirin downregulation is a feature of AML and leads to impairment of
            terminal myeloid differentiation
  JOURNAL   Leukemia 24 (2), 429-437 (2010)
   PUBMED   20010624
REFERENCE   4  (bases 1 to 3209)
  AUTHORS   Torii I, Oka S, Hotomi M, Benjamin WH Jr, Takai T, Kearney JF,
            Briles DE and Kubagawa H.
  TITLE     PIR-B-deficient mice are susceptible to Salmonella infection
  JOURNAL   J Immunol 181 (6), 4229-4239 (2008)
   PUBMED   18768880
  REMARK    GeneRIF: Disruption of paired immunoglobulin-like activating
            (PIR-A) and inhibitory (PIR-B) receptor isoform balance affects
            their regulatory roles in host defense during Salmonella infection.
REFERENCE   5  (bases 1 to 3209)
  AUTHORS   Masuda K, Kubagawa H, Ikawa T, Chen CC, Kakugawa K, Hattori M,
            Kageyama R, Cooper MD, Minato N, Katsura Y and Kawamoto H.
  TITLE     Prethymic T-cell development defined by the expression of paired
            immunoglobulin-like receptors
  JOURNAL   EMBO J 24 (23), 4052-4060 (2005)
   PUBMED   16292344
REFERENCE   6  (bases 1 to 3209)
  AUTHORS   Takai T.
  TITLE     Paired immunoglobulin-like receptors and their MHC class I
            recognition
  JOURNAL   Immunology 115 (4), 433-440 (2005)
   PUBMED   16011512
  REMARK    Review article
REFERENCE   7  (bases 1 to 3209)
  AUTHORS   Kasahara M, Watanabe Y, Sumasu M and Nagata T.
  TITLE     A family of MHC class I-like genes located in the vicinity of the
            mouse leukocyte receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13687-13692 (2002)
   PUBMED   12370446
REFERENCE   8  (bases 1 to 3209)
  AUTHORS   Kubagawa H, Burrows PD and Cooper MD.
  TITLE     A novel pair of immunoglobulin-like receptors expressed by B cells
            and myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 5261-5266 (1997)
   PUBMED   9144225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171680.5.
            
            On Jun 26, 2019 this sequence version replaced XM_017322035.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC171680.5         153161-153250       c
            91-126              AC171680.5         152971-153006       c
            127-411             AC171680.5         152505-152789       c
            412-717             AC171680.5         152052-152357       c
            718-1026            AC171680.5         150173-150481       c
            1027-1323           AC171680.5         149649-149945       c
            1324-1626           AC171680.5         149085-149387       c
            1627-1677           AC171680.5         148803-148853       c
            1678-3209           AC171680.5         144959-146490       c
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.15 cM"
     gene            1..3209
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /note="paired-Ig-like receptor A1"
                     /db_xref="GeneID:18722"
                     /db_xref="MGI:MGI:1195971"
     exon            1..90
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1814
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /note="paired immunoglobulin-like receptor"
                     /codon_start=1
                     /product="paired-Ig-like receptor A1 precursor"
                     /protein_id="NP_001357997.1"
                     /db_xref="GeneID:18722"
                     /db_xref="MGI:MGI:1195971"
                     /translation="MSCTFTALLCLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRRTK
                     VTFFCEETIGANEYHLYKDGKLYKTVTKNKQKPANKAEFSFSNVDLRNAGQYRCSYST
                     QDESSGYSDLLELVVTEDYWTPSLSAQASPVVTSGGYVTLQCESWPSYDRFILTVAGP
                     QKFSWTQDSQYNYSTRKNHALFSVGPVTPNQRWIFRCYSYDRNRPYVFSAPSESVELL
                     VSGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFHYDKFILTKEDKKFTSSLDTEHIS
                     SSRQYRALFIIGPTTPTHTGTFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTH
                     QGHTMDPGMTLTLQCFSDINYDRYALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSS
                     STGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVKPNHTVHSGETVSLLCW
                     SMDPVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSF
                     YLLSSASAPVELTVSETIESSTWSPKRPIPPIPTENKDHTMENLIRMGMAVLVLIVLS
                     ILATEAWRSHRQTHPAAGN"
     exon            91..126
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..411
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..717
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1026
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1323
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1626
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1677
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3209
                     /gene="Pira1"
                     /gene_synonym="6M21; Gm15922; Ly89; Pir; PIR-A1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggctct gtagctctgc cctcaagcac agttggagcc actgagggga gatgccatgt
       61 cctgcacctt cacagccctg ctctgtcttg gactgactct gagcctctgg atcccagtgc
      121 tgacagggtc cctccctaag cctatcctca gagtacagcc agactctgtg gtctccagga
      181 ggactaaggt gactttcttt tgtgaggaga caattggagc caatgagtac cacctctata
      241 aagatggaaa gctatataaa accgtaacaa agaacaaaca gaagccagca aacaaggctg
      301 aattctcatt ctcaaatgta gacctgagaa atgcaggtca atatcgatgt tcctacagca
      361 cccaggatga atcatcaggc tacagtgacc tcctggagct ggtggtgaca gaagactact
      421 ggacacccag cctttcagcc caggccagcc cagtggtaac ttcaggaggg tatgtcaccc
      481 tccagtgtga gtcctggccg agctatgaca ggttcatttt gactgtagca ggaccacaga
      541 agttctcatg gacacaagac tcacagtata actactctac acggaagaac cacgccctgt
      601 tctctgtggg ccctgtgacc cccaaccaga gatggatatt cagatgttac agttatgaca
      661 ggaatagacc atatgtgttc tcagctccaa gtgaatccgt ggagctcctg gtctcaggaa
      721 tctatgaata ctatgaaccc aggctgtcag tactgcccag ccctgtggtg acagcaggag
      781 ggaacatgac actccactgt gcctcagact ttcactacga taaattcatt ctcaccaagg
      841 aagataagaa attcaccagc tcactggaca cagagcatat atcttctagt agacagtacc
      901 gagccctgtt tattatagga cccacaaccc caacccacac agggacattc agatgttatg
      961 gttactacaa gaatgcccca cagctgtggt cagtacctag tgctcttcaa caaatactca
     1021 tctcagggct gtccaagaag ccctctctgc tgactcacca aggccatacc atggaccctg
     1081 gaatgaccct caccctgcag tgtttctctg acatcaacta tgacagatat gctctgcaca
     1141 aggtgggggg agctgacatc atgcagcact ctagccagca gactgacact ggcttctctg
     1201 tggccaactt cacactgggc tatgtgagta gctccactgg aggccaatac agatgctatg
     1261 gtgcacacaa cctctcctct gagtggtcag cctccagtga gcccctggac atcctgatca
     1321 caggacagct ccctctcact ccttccctct cagtgaagcc taaccacaca gtgcactcag
     1381 gagagaccgt gagcctgctg tgttggtcaa tggaccctgt ggatactttc attctgtcca
     1441 aggagggatc agcccagcaa cccctgcgac taaaatcgaa gtcccatgat cagcagtccc
     1501 aggcagaatt ctccatgagt gctgtgacct cccatctctc aggcacctac aggtgctatg
     1561 gagctcaaga ctcatctttc tacctcttgt catctgccag tgcccctgtg gagctcacag
     1621 tctcagaaac cattgaatcc tccacctggt ctcccaaaag gcccatccca ccaattccca
     1681 cagagaacaa ggatcacaca atggagaatc tcatcaggat ggggatggca gtcctggtcc
     1741 tcatcgtcct ttcgattcta gccactgagg cttggcgaag ccatagacag acccaccctg
     1801 cagctgggaa ctaatctaaa gaaaaaagaa tgcatcttca atgttctaca ctctgggaaa
     1861 taaagctgat gacccaaagt tttctgtcaa aagaaaaaaa aaatcctgtt gtggtattga
     1921 ggaactgttg taagaatgtc taggaagcaa aagtttgggg ttcagaggga agtggaagtg
     1981 tcataatgag gtgcttcctc aataaatgaa ttactgtccc tccacatact gggagccttt
     2041 gtttcctgaa cccacactct tctgagccca taaagtgagg gaataggctg tcccacctgc
     2101 ctggaatatc tttcacctgt gaattgtatt tttctgtatt actttatggg atgtattcat
     2161 tcacatttaa aggcctctgt catctttatg aattgtattt aaggacagtt ccttgtatgt
     2221 gtgtgagtgt gcatatacag gagggtcggg tgtatgtatt agcctactgc cattgtgtgt
     2281 tctttcaggc aacttggtgg gcaggggctt gggagacaaa ggcttagttg atgttccttg
     2341 tggcagcaga cctcctggaa agcatgcagt ccttggggta ggaaatggag tactcagtgt
     2401 aggttattgc tctttcctaa gttttcaggg gagttggcag gacagggctt ggtgaggaga
     2461 cgcttacctg gtgtccctta ggacggcagc cctctgagta atcaggcagg gttgtggctg
     2521 ctactatttt ttaaagaaac aaaccaataa aatgactcct gggtcaatgt cttgctcagc
     2581 atcctcctgc aggagatggg aacttatgca gatacccaca actgaacact gcagagaaag
     2641 atctgaaaat actgaatcct gaatgggtaa atacttgcaa aagaacattt agtttttcta
     2701 acaagtcaca ctggtacaca aagcacactg aagggcaggt ctcatgccca gcggtacgtg
     2761 gccaacacta aatgaactca ctggtatttt cgaagtctgt gcttataatg cttgtctgtt
     2821 acttatatat tatgatgacc tgtcatgtgc ttttagacga cttcagggaa ttcataatgt
     2881 atatgtataa aaaaaaatca cagtactaga cacctcacaa atatacagtt ctatttacca
     2941 aggattcctg tataattagc aaaaagattt tcattgtttt cttcttccat ttttccattc
     3001 tgtgtgacta cttacattat tgtgcctaat gtcatttcac tgtgaatttc attttttaag
     3061 tttttgtgat ttaaatgcat ttatacatca aatgtattag taatgagtac tttgagaatc
     3121 atataataca taaaactttg ttcaactttt atattcatat cctttcatat cctaaactat
     3181 cattaataaa tatttaatac tatctataa
//
