LOCUS       NM_008952               1774 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus pipecolic acid oxidase (Pipox), mRNA.
ACCESSION   NM_008952
VERSION     NM_008952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Dodt,G., Kim,D.G., Reimann,S.A., Reuber,B.E., McCabe,K., Gould,S.J.
            and Mihalik,S.J.
  TITLE     L-Pipecolic acid oxidase, a human enzyme essential for the
            degradation of L-pipecolic acid, is most similar to the monomeric
            sarcosine oxidases
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 487-494 (2000)
   PUBMED   10642506
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Herbst,R., Barton,J.L. and Nicklin,M.J.
  TITLE     A mammalian homolog of the bacterial monomeric sarcosine oxidases
            maps to mouse chromosome 11, close to Cryba1
  JOURNAL   Genomics 46 (3), 480-482 (1997)
   PUBMED   9441754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB561815.1, BY708439.1, AK149488.1 and U94700.1.
            
            On Oct 30, 2007 this sequence version replaced NM_008952.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U94700.1, AK008555.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB561815.1         1-50
            51-53               BY708439.1         12-14
            54-1693             AK149488.1         3-1642
            1694-1774           U94700.1           1606-1686
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1774
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /note="pipecolic acid oxidase"
                     /db_xref="GeneID:19193"
                     /db_xref="MGI:MGI:1197006"
     exon            1..206
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            207..355
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            356..569
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            570..752
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            753..899
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1058
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1134
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1774
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="Pipox"
                     /gene_synonym="LPIPOX; Pso"
                     /note="major polyA site"
ORIGIN      
        1 gaactctagt ttagctggac tttgcctccc tcctccccct gtagcctgga ggtgcctttg
       61 tttgccttct cttcagtggg ctttgtggca tcatggctgc tcagacagat ttctgggatg
      121 ctattgtgat tggagcaggc atccagggct gctttaccgc gtaccacctg gccaaacact
      181 ccaagagcgt cctcctgctg gagcagttct ttcttcccca ttcccgagga agctcacatg
      241 gacagagccg cataatcaga aaggcttatc cagaggactt ctacacgatg atgatgaagg
      301 aatgttatca gacatgggcc cagctggagc gtgaagccgg aacccagtta cacaggcaga
      361 ctgagctctt acttctgggg acgaaggaaa atccaggatt aaagacaatc caggccaccc
      421 tgtctaggca agggatcgac catgagtatc tttcgtcagt ggatttaaag caacgctttc
      481 caaacattcg gttcaccagg ggagaagtgg ggctcttgga caagactgga ggtgtcctct
      541 atgcagacaa ggccctcaga gccctccagc atataatttg tcagctagga ggcactgtgt
      601 gtgatggaga gaaggtagtg gagataagac ctggtctacc cgtcacagtg aaaaccacct
      661 tgaagagcta ccaagccaac agcttggtca tcactgctgg tccctggacc aaccggcttc
      721 tgcatcctct ggggattgag ttgcctctcc agacccttag gatcaatgtg tgttactggc
      781 gagagaaggt ccctgggagc tatggtgtat cacaagcttt tccatgcatc ctgggtctgg
      841 atctggcccc ccaccacatc tatggactgc cagcatccga gtacccgggg ctgatgaaga
      901 tctgctatca ccatggtgac aatgtggacc cagaggagcg ggactgcccc aaaaccttct
      961 cagacatcca agacgttcaa attctatgcc actttgtcag agatcattta ccaggcctgc
     1021 gggctgagcc agacatcatg gaacgctgca tgtacacgaa tactcctgat gagcacttta
     1081 ttcttgattg ccacccaaag tatgacaaca ttgtcatcgg cgctggattc tctggacatg
     1141 gattcaagtt ggcccctgtt gtggggaaga tcctctatga gctaagcatg aaattacccc
     1201 catcctatga cttggctccg tttcgaatga gtcgcttctc tacgctgagc aaagcccacc
     1261 tttgacccca gctgactctc tcctgggcag gaaagccctc ctaggggaga tttccaggag
     1321 atgtggcctt gacgagtttc ttctcctcct gattcaatgg aatctcccat aaacaccaaa
     1381 tgattgaaca ttttcccccc aatcagcctc cctagtctat ctcatttctc cttcccagaa
     1441 agtcagcgag attcaccatc acagaacagc aaggggcttt aagatggatg tctcaatggg
     1501 gaggggctgg agacaggctc agtagactaa gggactcctt taaatttctt tttgctggga
     1561 cactgggtga acttgcgatt gctttgacta aatctgctca gggggaatgt aaaacagatt
     1621 atattttata aaccactagt gcctttgggt ttctttgcca aaaacttaag ccagcctcta
     1681 tcaccaaaaa aaaagtctca cctctaataa atacacattt gccaggaaaa aaaaattgct
     1741 gaaaaaaaat aaacaaaaac ctggattgca taat
//
