LOCUS       NM_198191               1578 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus phosphatidylinositol-4-phosphate 5-kinase-like 1
            (Pip5kl1), transcript variant 2, mRNA.
ACCESSION   NM_198191
VERSION     NM_198191.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Chang,J.D., Field,S.J., Rameh,L.E., Carpenter,C.L. and Cantley,L.C.
  TITLE     Identification and characterization of a phosphoinositide phosphate
            kinase homolog
  JOURNAL   J Biol Chem 279 (12), 11672-11679 (2004)
   PUBMED   14701839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928710.6 and AY376879.2.
            
            On Nov 30, 2016 this sequence version replaced NM_198191.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY376879.2, BC119037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL928710.6         169328-169428
            102-1574            AY376879.2         1-1473
            1575-1578           AL928710.6         177390-177393
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..1578
                     /gene="Pip5kl1"
                     /note="phosphatidylinositol-4-phosphate 5-kinase-like 1"
                     /db_xref="GeneID:227733"
                     /db_xref="MGI:MGI:2448520"
     exon            1..177
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1335
                     /gene="Pip5kl1"
                     /EC_number="2.7.1.68"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PIPKH; PI(4)P 5-kinase-like protein 1;
                     ptdIns(4)P-5-kinase-like protein 1; phosphatidylinositol
                     phosphate kinase homolog; phosphatidylinositol 4-phosphate
                     5-kinase-like protein 1"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase-like
                     protein 1 isoform 2"
                     /protein_id="NP_937834.1"
                     /db_xref="CCDS:CCDS15920.1"
                     /db_xref="GeneID:227733"
                     /db_xref="MGI:MGI:2448520"
                     /translation="MATPSLRSHEIPAHSQEAGNKSISSGSRRGLLWHLRARQSRVGL
                     FEVGPGHELHRMTRMMQEGLWAATQVSKNNPPTGPTTQKDYLEVMTQVHEEGFELGTL
                     AGPAFARLRKSIGLTEEDYQATLGPGDPYLQFFSTSKSKASFFLTHDQRFFVKTQRRH
                     EVHVLLAHLPRYVEHLQQYPHSLLARLLGVYSLRVAQGKKKYFIIMQCIFYPTSRISE
                     RYDIKGCNISRWVDPAPEGSPLVLVLKDLNFQEKTMRLGAQRSWFLRQMELDTAFLRE
                     VNVLDYSLLVAIQFLHEDEKGIHHSVFSTFKSIQGVSKSKGTGDQNCRMLPDLPNALH
                     ILDGPDQRYFLGLVDMTTVYGFRKRLEHVWKMVRYPGQSVSTVSPAHYARRLCRWAEV
                     HTE"
     exon            178..378
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..432
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..587
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..712
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..747
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..803
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..916
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1067
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1578
                     /gene="Pip5kl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaaaggca agcgcccctt tcgaagattg ggcacagtgg taacaagagc gtcgcgattg
       61 gtcgttcgcc atgcagaggc ggggcctgat tcctgcatct gggcctccga gacaccgcca
      121 aagccagaga agcggcacct gggggcgatg gccacaccaa gccttaggtc ccacgagatc
      181 ccggcccact cccaggaggc tggaaacaag tccatttcct cagggagccg ccgcggcctt
      241 ctttggcacc tccgagccag gcagtctaga gttggcctgt ttgaggtcgg tccaggacat
      301 gagctgcata gaatgacacg aatgatgcag gaagggctgt gggctgccac ccaggtctcc
      361 aagaacaacc cacccacggg acctactacc cagaaggatt acctggaagt catgacccaa
      421 gttcacgaag agggcttcga gctgggcacc ttggctggcc cggcttttgc acggctgagg
      481 aaatccattg gcctgactga agaggactac caggctactc ttggccctgg tgatccctac
      541 cttcaattct tcagcacctc caaaagcaag gccagcttct tcctgaccca cgaccagcgc
      601 ttctttgtga agacccaacg gcgccacgaa gtgcatgtgc tgcttgccca cctgccccgc
      661 tatgtggagc acctgcagca atacccacac tccctgctgg cacggttgct gggcgtatac
      721 agtctgcggg tagctcaggg gaaaaagaag tacttcatca tcatgcagtg catcttctac
      781 cctaccagcc gcatttctga gaggtatgac atcaagggct gcaacataag ccgctgggta
      841 gatccagccc ctgagggcag cccccttgtc ttggtgctga aggacctcaa ctttcaagaa
      901 aagaccatga gattgggagc ccagcggagc tggttcctcc ggcagatgga gctagacacc
      961 gccttcctgc gggaggtgaa tgtactggat tacagcctcc tggtggccat ccagtttctc
     1021 cacgaagacg agaagggcat tcaccactct gtcttcagca cattcaagtc catacaaggt
     1081 gtgtcgaagt cgaagggaac gggggaccag aactgccgga tgctgcccga ccttcccaat
     1141 gccctccata tcttggacgg gccagaccaa cgctattttc tgggcttagt ggatatgact
     1201 accgtgtatg ggtttcgcaa acggctggaa catgtgtgga agatggtacg ctatccaggc
     1261 cagagcgtct ccactgtcag cccggctcac tacgcccgtc gcctctgtcg gtgggcagag
     1321 gtgcacacag aatgactcac gtgtctgcct tcttccctta tggacaatgc gccggcaact
     1381 attctgcagc tgtacccagg gagctagcct gcagttcatc ctaccagcca ccagagggaa
     1441 gcaccctcat aactaatgct gtgaagactc agccccattc ggtgacggtg ctgtaccctg
     1501 catagagcaa ggaccctgac cccaaccctt agctcattta ctattaaaaa atgttgatat
     1561 tctcttttta cagaccac
//
