LOCUS       NM_008844               4300 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus phosphatidylinositol-4-phosphate 5-kinase, type 1
            gamma (Pip5k1c), transcript variant 1, mRNA.
ACCESSION   NM_008844 XM_988009
VERSION     NM_008844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Yan,Q., Gao,H., Yao,Q., Ling,K. and Xiao,G.
  TITLE     Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
            (Pip5k1c) in mesenchymal stem cells leads to osteopenia by
            impairing bone remodeling
  JOURNAL   J Biol Chem 298 (3), 101639 (2022)
   PUBMED   35090892
  REMARK    GeneRIF: Loss of phosphatidylinositol-4-phosphate 5-kinase type-1
            gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by
            impairing bone remodeling.
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Huang,G., Yang,C., Guo,S., Huang,M., Deng,L., Huang,Y., Chen,P.,
            Chen,F. and Huang,X.
  TITLE     Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity
            and insulin resistance by increasing energy expenditure
  JOURNAL   Lipids Health Dis 21 (1), 6 (2022)
   PUBMED   34996482
  REMARK    GeneRIF: Adipocyte-specific deletion of PIP5K1c reduces
            diet-induced obesity and insulin resistance by increasing energy
            expenditure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4300)
  AUTHORS   Chomphoo,S., Sakagami,H., Kondo,H. and Hipkaeo,W.
  TITLE     Discrete localization patterns of Arf6, and its activators EFA6A
            and BRAG2, and its effector PIP5kinasegamma on myofibrils of
            myotubes and plasma membranes of myoblasts in developing skeletal
            muscles of mice
  JOURNAL   Acta Histochem 122 (3), 151513 (2020)
   PUBMED   32059926
REFERENCE   4  (bases 1 to 4300)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4300)
  AUTHORS   Sohn,M., Korzeniowski,M., Zewe,J.P., Wills,R.C., Hammond,G.R.V.,
            Humpolickova,J., Vrzal,L., Chalupska,D., Veverka,V., Fairn,G.D.,
            Boura,E. and Balla,T.
  TITLE     PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8
            recruitment to ER-PM contact sites
  JOURNAL   J Cell Biol 217 (5), 1797-1813 (2018)
   PUBMED   29472386
REFERENCE   6  (bases 1 to 4300)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4300)
  AUTHORS   Ling,K., Doughman,R.L., Firestone,A.J., Bunce,M.W. and
            Anderson,R.A.
  TITLE     Type I gamma phosphatidylinositol phosphate kinase targets and
            regulates focal adhesions
  JOURNAL   Nature 420 (6911), 89-93 (2002)
   PUBMED   12422220
  REMARK    GeneRIF: we show that the type I phosphatidylinositol phosphate
            kinase isoform-gamma 661 (PIPKI gamma 661), an enzyme that makes
            PtdIns(4,5)P(2), is targeted to focal adhesions by an association
            with talin
REFERENCE   8  (bases 1 to 4300)
  AUTHORS   Di Paolo,G., Pellegrini,L., Letinic,K., Cestra,G., Zoncu,R.,
            Voronov,S., Chang,S., Guo,J., Wenk,M.R. and De Camilli,P.
  TITLE     Recruitment and regulation of phosphatidylinositol phosphate kinase
            type 1 gamma by the FERM domain of talin
  JOURNAL   Nature 420 (6911), 85-89 (2002)
   PUBMED   12422219
  REMARK    GeneRIF: we show that the predominant brain splice variant of
            PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short
            carboxy-terminal peptide, to the FERM domain of talin, and is
            strongly activated by this interaction
REFERENCE   9  (bases 1 to 4300)
  AUTHORS   Divecha,N., Roefs,M., Los,A., Halstead,J., Bannister,A. and
            D'Santos,C.
  TITLE     Type I PIPkinases interact with and are regulated by the
            retinoblastoma susceptibility gene product-pRB
  JOURNAL   Curr Biol 12 (7), 582-587 (2002)
   PUBMED   11937028
  REMARK    GeneRIF: Type I PIPkinases interact with and are regulated by the
            retinoblastoma susceptibility gene product-pRB.
REFERENCE   10 (bases 1 to 4300)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Wada,T., Yazaki,Y., Asano,T.
            and Oka,Y.
  TITLE     Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the
            third isoform and deletion/substitution analysis of members of this
            novel lipid kinase family
  JOURNAL   J Biol Chem 273 (15), 8741-8748 (1998)
   PUBMED   9535851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155937.4, AK041402.1, BC094665.1 and AI844562.1.
            
            [WARNING] On Mar 22, 2024 this sequence was replaced by
            NM_008844.4.
            
            On Jun 12, 2014 this sequence version replaced NM_008844.2.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 3. The encoded
            protein (isoform 1) is shorter, compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006916.1, SRR1660821.176221.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC155937.4         17754-17769
            17-2001             AK041402.1         3-1987
            2002-2079           AC155937.4         42117-42194
            2080-2339           BC094665.1         2052-2311
            2340-4070           BC094665.1         2316-4046
            4071-4300           AI844562.1         1-230               c
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..4300
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /note="phosphatidylinositol-4-phosphate 5-kinase, type 1
                     gamma"
                     /db_xref="GeneID:18717"
                     /db_xref="MGI:MGI:1298224"
     exon            1..190
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2082
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /EC_number="2.7.1.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PIP5K1-gamma; ptdIns(4)P-5-kinase 1 gamma;
                     phosphatidylinositol 4-phosphate 5-kinase type I gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     gamma isoform 1"
                     /protein_id="NP_032870.2"
                     /db_xref="CCDS:CCDS35994.1"
                     /db_xref="GeneID:18717"
                     /db_xref="MGI:MGI:1298224"
                     /translation="MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAGLAEAP
                     LVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDV
                     LMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC
                     NEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLP
                     KFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYK
                     DLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQ
                     AEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLL
                     HIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSL
                     KSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLL
                     PCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEEPH
                     AEDLQKITVQVEPVCGVGVVPKEEGAGVEVPPCGASAAASVEIDAASQASEPASQASD
                     EEDAPSTDIYFPTDERSWVYSPLHYSARPASDGESDT"
     exon            191..222
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            223..315
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            316..446
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            447..564
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            565..717
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1017
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1223
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1307
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1356
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1441
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1603
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1742
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1775
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1874
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2001
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2079
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..4288
                     /gene="Pip5k1c"
                     /gene_synonym="Pip5kIgamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgccctg tagtgcaggc ggcgcttgtt gttcagcggc ggcggccgag ctcgggtgca
       61 tcctcgggcc cgccgccgcc gccggagcgt tcggccatgg agctagaggt gccggacgag
      121 gcggagagcg ccgaagcggg ggccgtgacg gcggaagcgg cctggtctgc ggagagtggg
      181 gcggcggcag gtatgaccca gaagaaggct ggccttgcag aggccccctt ggtgacaggg
      241 cagccaggcc ctggccatgg gaagaagctg ggccaccgag gcgtggatgc gtcgggagag
      301 actacgtata agaagaccac ctcgtccacc ctgaagggcg ccatccagct ggggatcggg
      361 tacacggtgg gcaacctgag ctctaagccg gagcgggacg tgctcatgca ggacttctac
      421 gtggtggaga gcatcttctt ccccagtgaa gggagcaacc tcacccctgc ccaccacttc
      481 caggatttcc gcttcaagac ctatgcacct gttgccttcc gctacttccg ggagctcttt
      541 ggcatccgtc cagatgacta tttgtactcc ctgtgcaatg agccactcat cgagctctcc
      601 aaccccgggg ccagcggctc tgtcttctac gtcaccagcg acgacgagtt catcatcaag
      661 actgtcatgc acaaggaggc agagttcctg cagaagctgc tgcctggcta ctacatgaat
      721 ctcaaccaga acccacggac gctgctgccc aagttctatg ggctgtactg cgtgcagtct
      781 ggtggcaaga acatccgcgt ggtggtcatg aacaatgtgc tgccccgtgt cgtcaaaatg
      841 caccttaagt tcgacctcaa gggctccacg tacaagcgca gggccagcaa gaaggagaag
      901 gagaagagcc tgcccaccta caaggacctg gacttcatgc aggacatgcc cgaggggctg
      961 ctgctggact ccgacacctt tggcgccctg gtcaagacgc tgcagcgaga ctgcctggtg
     1021 ctggagagct tcaagataat ggactacagc ctgctgctgg gcgtgcacaa catcgatcag
     1081 caggagcgag agcgccaggc cgagggcgcc cagagcaagg cggatgagaa gcggcccgtg
     1141 gcccagaagg ctctgtattc cacggccatg gagtctatcc agggcggagc tgcccgtggg
     1201 gaggccattg agacagatga cacgatgggt gggattccag cagtgaatgg gcgcggggag
     1261 cgactgctcc tccacatcgg gatcattgat attctgcagt cctacaggtt catcaagaag
     1321 ttagaacaca cctggaaggc cctcgtccat gatggggaca ctgtctcagt ccaccggccc
     1381 agcttctatg cagagcgctt cttcaagttc atgagcagca cggtgttccg gaagagttcc
     1441 tccctgaagt cctctccatc caagaaagga cgtggtgccc tgctggcggt caaacccctg
     1501 gggcccactg ctgccttctc agccagccag atccccagcg agagagagga tgtgcagtat
     1561 gacctgcggg gggcccgcag ctaccccacg cttgaggatg aaggccggcc tgacctcctg
     1621 ccctgcaccc caccgtcctt tgaggaagcc accacagcct ccatcgccac caccctgtcg
     1681 tccacctccc tctccatccc agagcggtcc ccttcagata catcggagca gccccggtac
     1741 aggcggcgca cgcagtcttc aggccaggat ggccggcccc aggaggagcc ccatgcggaa
     1801 gacctgcaga agataactgt gcaggtggag ccagtgtgcg gtgtgggggt tgtccccaag
     1861 gaggagggtg caggagtgga ggtcccccca tgtggggcat cggctgcagc ctctgtggaa
     1921 atagacgctg ccagccaggc ctcagagcct gccagccagg cctcagatga ggaggatgca
     1981 ccctctacag acatctattt tcccaccgac gagaggagct gggtgtactc cccgcttcac
     2041 tatagcgcgc ggcccgcctc cgacggcgag agcgacacat aacttctatg cagtccccaa
     2101 tctggagccc agcgtccttc tgccacccca gccacttcct ggaggcgctg ccccccactg
     2161 gggctcagag ctcagcgaca tcacctggcc caaccttgtt ctctccctcc ccactgacgg
     2221 acggcactgg ccaggcccag acccaggata gctcaggccg ccatcagctg ctacctgtgc
     2281 ctgttggggc agcaagattt ggagtgccca tcctgtattt attttgggtc tttttttttg
     2341 gacgaagagt gagcacaggt gtgattttct agaaagacga caagacacag aaaacccagg
     2401 aagaggctgc agccaccagc ctaggtggat caggctctac gtgtctcact actctgggga
     2461 cagtggcccc gtagctccag taaaagccac acactctagg gctcttgtta tggcctgcag
     2521 aggagacagg ccctggagcc tccgcttgcc agcccaggtg tgtgctcctg agttgggtca
     2581 cctcaacaga gcccctctgt cacctcaggt ttgggacccg agcaaaccag gactaggcat
     2641 gccctgtggt ctttctgcat ctgtttactg ccactggaag gacatcccca cgcatgactg
     2701 tcacctaatg ctggactggg agggtccatg ttgtctgcct ctcatcccct tgaagccctg
     2761 agctggtgcc gtgggtcccc tcaactacca ggggattctc tgccctaaga agggcacagt
     2821 caggctgcag gctgagggct gggtcctaag acaccgtggc tgaagaaaat aagggagaaa
     2881 gtgacatcac ctcagcaaag ccaactatgt ccaccgaaca ccagggagat tgcggccagt
     2941 ctcctcccct gggcacaccc cagtgtgttg ggtacagtcc aatcgtgtca tgcccctgct
     3001 tcatggatgt tccacccacg gtgtgctggt aggaggaatc aggctgaaat gttctgaaag
     3061 ccagcagcct gaagccactg cttttgggcc agccgcgtag gcctcttggg ttgcaccttc
     3121 agggacagag gtcaggacct ggctggcttc caaggactgc agcagccatg gaggcagtga
     3181 ggagcatgac acaatcatca tggccagaaa aggcatggcc agggacagga cccgtgcggg
     3241 ggtggggcaa ccgaaggaga gatggacaga tgtctgtccc tggacctcag tccccttcct
     3301 gttttgggat gcacagtgaa cacactggta agctgctgca ggagttaatt caggggctgc
     3361 aaaggcaact tgggttgggc cttgcacaga ccaggcaggt ataatatcac acctgtcatc
     3421 ccagcacttg gaaagttaaa gcaagagggt tgtggcaaat tccaggctag cctgggctac
     3481 agagcgaaat gagaccaaaa gataaaactc ccagggctgg ccctaccact cagtgggcag
     3541 agctcaccca gctgcgtaag ccctgagttc catcccagca ccgcagaaac cagatggggt
     3601 ggcacacagc tgccgtccct gacttgggaa gtagaggcag aaagcaggca tgcaaggtca
     3661 tccttggctg taaccagttg gaggccagcc tgggctacat gagaccctct caaaagagaa
     3721 tctgtaaata tctttgtgac tccccatcgt gtccccatcc tgttctctcc aacggccact
     3781 attgccccac cgtggacggt gtgtgaactg tactgtaagg cctgggggct cctccaaggc
     3841 tgaagaggtg ccctctccgg cccacttctg ttctcctcaa gccatcccag caagtcccct
     3901 gtccagcccc acatcaacct cagtgcaata tgccctcccc gtggggtccc ttggcacggt
     3961 actgtctgca gccccttgtc tctcacccct agctccactc tccggtggtt aaaaatcgca
     4021 tcgcacatcc tccccccaat cctgttttta ttgttgaatc cattctgtaa actacaaacc
     4081 tcgtgtgtct tactcatcag gacttgggat ccctcgtcct cagcctatgt ggtctggtgt
     4141 ttgacaatcc aagcacagtg tcctcttggc accaaccaga ggggcctgtc cctccagcgc
     4201 agccggcaaa tgtatgcagt ccaggtcccc gccccacctg tcacagcccc tctttttgag
     4261 atctgtaata aatctctaat aagaaacaaa aaaaaaaaaa
//
