LOCUS       NM_008846               2588 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
            (Pip5k1b), mRNA.
ACCESSION   NM_008846 XM_989073
VERSION     NM_008846.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   Yang,Y.S., Liu,M.H., Yan,Z.W., Chen,G.Q. and Huang,Y.
  TITLE     FAM122A Is Required for Mesendodermal and Cardiac Differentiation
            of Embryonic Stem Cells
  JOURNAL   Stem Cells 41 (4), 354-367 (2023)
   PUBMED   36715298
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Zhao,X., Cui,P., Hu,G., Wang,C., Jiang,L., Zhao,J., Xu,J. and
            Zhang,X.
  TITLE     PIP5k1beta controls bone homeostasis through modulating both
            osteoclast and osteoblast differentiation
  JOURNAL   J Mol Cell Biol 12 (1), 55-70 (2020)
   PUBMED   30986855
  REMARK    GeneRIF: PIP5k1beta controls bone homeostasis through modulating
            both osteoclast and osteoblast differentiation.
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Tsai,M.T., Katagiri,N., Ohbayashi,N., Iwasaki,K., Ohkohchi,N.,
            Ding,S.T., Kanaho,Y. and Funakoshi,Y.
  TITLE     Regulation of HGF-induced hepatocyte proliferation by the small
            GTPase Arf6 through the PIP2-producing enzyme PIP5K1A
  JOURNAL   Sci Rep 7 (1), 9438 (2017)
   PUBMED   28842595
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Ip,W.K. and Medzhitov,R.
  TITLE     Macrophages monitor tissue osmolarity and induce inflammatory
            response through NLRP3 and NLRC4 inflammasome activation
  JOURNAL   Nat Commun 6, 6931 (2015)
   PUBMED   25959047
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   Pehrson,J.R., Changolkar,L.N., Costanzi,C. and Leu,N.A.
  TITLE     Mice without macroH2A histone variants
  JOURNAL   Mol Cell Biol 34 (24), 4523-4533 (2014)
   PUBMED   25312643
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Anderson,R.A., Boronenkov,I.V., Doughman,S.D., Kunz,J. and
            Loijens,J.C.
  TITLE     Phosphatidylinositol phosphate kinases, a multifaceted family of
            signaling enzymes
  JOURNAL   J Biol Chem 274 (15), 9907-9910 (1999)
   PUBMED   10187762
  REMARK    Review article
REFERENCE   7  (bases 1 to 2588)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Wada,T., Yazaki,Y., Asano,T.
            and Oka,Y.
  TITLE     Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the
            third isoform and deletion/substitution analysis of members of this
            novel lipid kinase family
  JOURNAL   J Biol Chem 273 (15), 8741-8748 (1998)
   PUBMED   9535851
REFERENCE   8  (bases 1 to 2588)
  AUTHORS   Davis,J.N., Rock,C.O., Cheng,M., Watson,J.B., Ashmun,R.A., Kirk,H.,
            Kay,R.J. and Roussel,M.F.
  TITLE     Complementation of growth factor receptor-dependent mitogenic
            signaling by a truncated type I phosphatidylinositol 4-phosphate
            5-kinase
  JOURNAL   Mol Cell Biol 17 (12), 7398-7406 (1997)
   PUBMED   9372970
REFERENCE   9  (bases 1 to 2588)
  AUTHORS   Rameh,L.E., Tolias,K.F., Duckworth,B.C. and Cantley,L.C.
  TITLE     A new pathway for synthesis of
            phosphatidylinositol-4,5-bisphosphate
  JOURNAL   Nature 390 (6656), 192-196 (1997)
   PUBMED   9367159
REFERENCE   10 (bases 1 to 2588)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Katagiri,H., Yazaki,Y.,
            Asano,T. and Oka,Y.
  TITLE     Cloning of cDNAs encoding two isoforms of 68-kDa type I
            phosphatidylinositol-4-phosphate 5-kinase
  JOURNAL   J Biol Chem 271 (39), 23611-23614 (1996)
   PUBMED   8798574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150898.2, AK146100.1 and AI844522.1.
            
            On Jan 19, 2017 this sequence version replaced NM_008846.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146100.1, AK133809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC150898.2         10765-10809
            46-2571             AK146100.1         2-2527
            2572-2588           AI844522.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.44 cM"
     gene            1..2588
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /note="phosphatidylinositol-4-phosphate 5-kinase, type 1
                     beta"
                     /db_xref="GeneID:18719"
                     /db_xref="MGI:MGI:107930"
     exon            1..108
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            109..195
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1815
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /EC_number="2.7.1.68"
                     /note="ptdIns(4)P-5-kinase 1 beta; phosphatidylinositol
                     4-phosphate 5-kinase type I beta; PIP5KI-beta; 68 kDa type
                     I phosphatidylinositol 4-phosphate 5-kinase beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     beta"
                     /protein_id="NP_032872.1"
                     /db_xref="CCDS:CCDS37940.1"
                     /db_xref="GeneID:18719"
                     /db_xref="MGI:MGI:107930"
                     /translation="MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNL
                     TSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKP
                     DDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLN
                     QNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKER
                     EKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHIL
                     DHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPA
                     KSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMN
                     SRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLD
                     EEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSS
                     TFTLEEGTIYLTAEPNTLDLQDDASVLDVYL"
     exon            196..264
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            265..395
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            396..513
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            514..666
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            667..966
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1178
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1262
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1311
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1396
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1552
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1697
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1812
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2573
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /note="hexamer: AATAAA"
     polyA_site      2573
                     /gene="Pip5k1b"
                     /gene_synonym="PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta;
                     Pipk5b; STM7"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccgcc cgctgcagcc accggagaac ccacgacatc ccgacaactt gcccgcggtg
       61 gcgcaactgg tctcggccgc caaggctcca gcacgccggc cgaaggagga acctggggga
      121 acaaaagcag tgtcaacgat gagcagacca cccgtcacca ccaactccag atgacttgcc
      181 attttcctta caaagatgtc gtcaactgct gaaaatggag acgccgtacc tggaaaacaa
      241 aacgaagaaa aaacctacaa aaagacggca tcgtcagcta ttaaaggtgc tatccagctg
      301 ggaataggat acacagtggg caacctcacg tccaagccag aacgcgatgt cctcatgcaa
      361 gacttctacg tggtggaaag tgtgttcctc cccagtgaag ggagcaacct gaccccagca
      421 catcactacc cagacttcag gtttaagacc tacgcaccgc tggccttccg gtacttccga
      481 gaactctttg gtatcaagcc cgatgattac ttgtactcca tctgcagtga acctctgata
      541 gaactgtcca atcctggagc cagtgggtcc ttgtttttct tgaccagcga tgatgaattt
      601 atcatcaaaa ccgttcagca taaggaagcc gagttcctgc agaagctgct gccgggctat
      661 tacatgaatt taaaccagaa tccaaggact cttctgccaa aattctatgg gctgtattgc
      721 atgcagtcag gaggcatcaa catccgcatt gtggtgatga acaatgtcct gccgcgtgcc
      781 atgaggatgc atttgaccta tgacctgaaa ggctccacat acaagcgaag agcatcccga
      841 aaagagaggg agaaacccaa ccccacgttt aaggacctgg acttcctgca ggacatgcac
      901 gaggggctgt atttcgatac agaaacatac aatgccctta tgaagacact acagagagac
      961 tgccgggttc tggaaagctt caagatcatg gactacagcc ttttgctggg tatccacatc
     1021 ttggaccatt ccctcaaaga caaagaagag gagcccctcc aaaacgtgcc tgatgcaaag
     1081 cggccgggga tgcagaaagt cctctattcc acagccatgg aatccatcca gggtccaggc
     1141 aagtctgcag atgggatcat tgcagagaat ccagacacaa tgggaggcat tccagctaaa
     1201 agccataagg gagagaagct gcttctattc atgggcatta ttgacatcct ccaatcatat
     1261 aggttaatga agaagttaga acattcctgg aaagcccttg tttatgatgg ggacaccgtt
     1321 tcagttcata gaccaagttt ttatgcagat agatttttaa agtttatgaa ttccagagtt
     1381 ttcaagaaaa ttcaagctct gaaagcctcg ccttctaaga aacgctgcaa ctccatcgct
     1441 gcactgaagg caacctccca ggagatcgta tcctccatca gccaggaatg gaaggacgag
     1501 aagcgggatt tgttaaccga aggacagagt ttcagcagcc tggatgaaga agccctggga
     1561 tcccgacaca ggcccgacct ggtacccagc actccatcat tatttgaagc tgcttcctta
     1621 gcgaccacaa tatcatcttc ttccttatat gtcggcgaac actatccaca tgacaggact
     1681 accctttact caaacagcaa agggttacct tccagttcaa ccttcacctt ggaagagggg
     1741 accatctacc tgacggctga gccaaacacc ctggacctgc aggatgatgc ctctgtgctg
     1801 gacgtctatt tataagtgaa agcggcagcc acctgagcac gtgagcggga cctgaacaca
     1861 gccatgggag ggaacttccc ccactgcaga attcctcaga agaactgggc tgaaccccag
     1921 cacacacagt aagactcagc tggaccttga agcccgcaag atgccgggga gcctcggtcc
     1981 gtggccgatc cgcagatgga tgtgaaaatc ccacaccgtt ccgtgggtgc tgctgcttgc
     2041 tgaccatgaa gacctgcatg acctctgtct aagccgcttt tctacaccat ggccaatcac
     2101 ccttttggac tgggaagcgc tattttccta taggctctct cggtgtttca ttctgcatgc
     2161 atagagtgat tacaaatagg caacctatgg aatctgcttc tatattttat ataaaaaaaa
     2221 tctatccgtg caaaatgata aataagatct aaatcctctc tctttgtttc agagattcta
     2281 atcatagccc ctgtcattga aagcttcaat ctgttttcct ttaaagatca gtatactagg
     2341 tctgccttta ctttatagaa agccagcttc tataaagatt tttttcactg tttactagtg
     2401 aaatgagaaa aagcaaagct atttataaaa ggccttatgt cttgtatata cattgtcttt
     2461 gaaatatttg tgatttagtt tattgctcgt aaaagagaaa ttatataatt tatttagtaa
     2521 atactactgt aaactatagt tttattgaaa gaaataaaat attttgttct caaaaaaaaa
     2581 aaaaaaaa
//
