LOCUS       NM_028264               2285 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
            (Pip4p2), transcript variant 1, mRNA.
ACCESSION   NM_028264
VERSION     NM_028264.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Morioka,S., Nigorikawa,K., Okada,E., Tanaka,Y., Kasuu,Y.,
            Yamada,M., Kofuji,S., Takasuga,S., Nakanishi,H., Sasaki,T. and
            Hazeki,K.
  TITLE     TMEM55a localizes to macrophage phagosomes to downregulate
            phagocytosis
  JOURNAL   J Cell Sci 131 (5) (2018)
   PUBMED   29378918
  REMARK    GeneRIF: these results suggest that TMEM55a negatively regulates
            the phagocytosis of large particles by reducing phagosomal
            PtdIns(4,5)P2 accumulation during cup formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Stoller,J.Z., Huang,L., Tan,C.C., Huang,F., Zhou,D.D., Yang,J.,
            Gelb,B.D. and Epstein,J.A.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831792.6.
            
            On Mar 29, 2023 this sequence version replaced NM_028264.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021435.2, AK049213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL831792.6         64390-64608
            220-368             AL831792.6         86705-86853
            369-475             AL831792.6         92564-92670
            476-599             AL831792.6         93672-93795
            600-652             AL831792.6         102658-102710
            653-743             AL831792.6         112603-112693
            744-2285            AL831792.6         113895-115436
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.41 cM"
     gene            1..2285
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /note="phosphatidylinositol-4,5-bisphosphate 4-phosphatase
                     2"
                     /db_xref="GeneID:72519"
                     /db_xref="MGI:MGI:1919769"
     exon            1..219
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..887
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /EC_number="3.1.3.78"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ptdIns-4,5-P2 4-Ptase II; type II phosphatidylinositol
                     4,5-bisphosphate 4-phosphatase; type 2 PtdIns-4,5-P2
                     4-Ptase; type 2 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase; transmembrane protein 55A"
                     /codon_start=1
                     /product="type 2 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase isoform 1"
                     /protein_id="NP_082540.1"
                     /db_xref="CCDS:CCDS17981.1"
                     /db_xref="GeneID:72519"
                     /db_xref="MGI:MGI:1919769"
                     /translation="MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTA
                     IASPGTSGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCN
                     CLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNT
                     FLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIAVGLTVGTQDFSR
                     RFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA"
     exon            220..368
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     exon            369..475
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     exon            476..599
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     exon            600..652
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     exon            653..743
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     exon            744..2285
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2264..2269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /note="hexamer: AATAAA"
     polyA_site      2285
                     /gene="Pip4p2"
                     /gene_synonym="2610319K07Rik; Tmem55a"
                     /note="major polyA site"
ORIGIN      
        1 atcctgggcc ctcccggagg ccgtagcggc ggcgcggcgg cattgctggc caccacctcc
       61 tccctagccg cagcccagct caacccgcgg cccgccgcgc tgtcgctgca gtcatggctg
      121 ctgacggggt ggacgaacgt tcgcctctgc tgtcagcatc ccattcggga aatgtcactc
      181 ccacagcccc gccgtacttg caggaaagca gccccagagc tgaactccca cctccgtata
      241 cagccatcgc cagtccagga acaagtggta ttcccgtgat caactgtcgt gtgtgccaat
      301 ctctaatcaa cctggatggt aaacttcacc agcatgtggt taagtgcaca gtttgcaatg
      361 aagctacgcc aatcaaaacc cccccaacag ggaagaaata tgttagatgc ccttgtaatt
      421 gtctactcat ttgtaaggat acatctcggc gaataggatg tccgagaccc aactgtcgac
      481 gcataattaa ccttggcccc gtaatgctca tttctgaaga gcaaccagcc caacctgcat
      541 tgccgatcca gccagaaggc acaagggtag tgtgcgggca ctgcgggaac acattcctgt
      601 ggatggaact gaggttcaac actctggcaa aatgcccaca ctgcaaaaaa atctcctcgg
      661 taggtagcgc ccttccccgg agacgctgct gtgcgtatgt caccatcgga atgatatgta
      721 ttttcattgc agttggatta actgttggca cacaagattt ttcaaggcga tttcatgcaa
      781 cctatgtgtc ttgggcaatt gcttatctgc taggtttgat ttgccttatc cgagcttgtt
      841 actggggcgc aatcagagtc agttatccag agcacggctt tgcttaagtc tcctcatgaa
      901 tccttgatgc aggcgagagt gtccagtagt ccttgagaag ctctgctgga cgccttcaaa
      961 tcatttatcc tcctggattc catcctggtt tgtatagtag tctcaagaat ttgtgagtct
     1021 tttctgaaca gacgctcact gaagtacatt atatgcaagt tcattttgct gctaggtttt
     1081 cagacttgga aaaataaagc tgtgtctctg ttcttttaaa tcataaaggt atttttgcat
     1141 ttgtcctccc acgttatatc taatatcagt ctttcattat gtttaaacca gttgttccat
     1201 tacttgttgc tgtgggacta tccccaagaa gtgtttataa atgtttctac aatagggtca
     1261 catttatact tacattttaa acagaattgc ttgctttaaa aatctaagca atatgcattt
     1321 ttgcttgaac tgcttactgt aattttaacc taagagtata gataccttat tcaggaaaaa
     1381 caaattgagt gtactttgaa aaacttgaca ttcttgtcag agaatcattt ctagatagta
     1441 tatgcttgtt ttttttgttt tttttttttt ttgttattgt ttgtagaaag atacaatatt
     1501 ttggtagtaa attaaaatac ctaggatgaa catatatata gtccacagtt ggagatgtta
     1561 gataaatgtc ttttctctaa gattacagga ctttttgcct ttcagtcttg tctttttatt
     1621 tagcatttac aaaaatctgg tctggattta tggaatttaa tgttactctg ctgaatgtat
     1681 tcctttataa actggaggaa gtatttcaga caacatgttt tataatactt catcatctcg
     1741 tcaaagacat gttgacactg ggttgcagtc cttttcattc aatcatggta aacttatctt
     1801 cttgacatct gtgtacaccc gcttctctgg gaagagaact taggactttt ttgctttagc
     1861 tgaaagttag aattagagat tctcttacca tttctcacct ggtcagataa tgactcgact
     1921 tcttcaagag aacggatcag agagagagag tttcatcgtc acctaaaact tcgcgtggaa
     1981 ttcatggact cagctcttgc actgcccagt tttgcagttt agaaggaatt ccttgagagt
     2041 cagtggtcta aactctttca cattgtagaa ttagacaatg agatgccctg aatacattag
     2101 taggtgattc caagggacaa gactaatgtt ctaaattatt tatgttcctg attaatatga
     2161 aaatgtactt aatgcaaagt cggagtcagc tacacctcaa agagaaaatg ataaatgtat
     2221 aaatgaagta gctcaggatt ctatgtacct ttgaaaatat gctaataaag attattattc
     2281 aaaaa
//
