LOCUS       NM_001033271            1623 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
            (Pip4p1), transcript variant 1, mRNA.
ACCESSION   NM_001033271 XM_127719 XM_919901 XM_919912 XM_919920 XM_919940
            XM_919952 XM_919965
VERSION     NM_001033271.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Odfalk,K.F., Wickline,J.L., Smith,S., Dobrowolski,R. and Hopp,S.C.
  TITLE     Hippocampal TMEM55B overexpression in the 5XFAD mouse model of
            Alzheimer's disease
  JOURNAL   Hippocampus 34 (1), 29-35 (2024)
   PUBMED   37961834
  REMARK    GeneRIF: Hippocampal TMEM55B overexpression in the 5XFAD mouse
            model of Alzheimer's disease.
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Qin,Y., Ting,F., Kim,M.J., Strelnikov,J., Harmon,J., Gao,F.,
            Dose,A., Teng,B.B., Alipour,M.A., Yao,Z., Crooke,R., Krauss,R.M.
            and Medina,M.W.
  TITLE     Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma
            Cholesterol Through LDL (Low-Density Lipoprotein) Receptor
            Lysosomal Degradation
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (5), 1311-1324 (2020)
   PUBMED   32188273
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Takemasu,S., Nigorikawa,K., Yamada,M., Tsurumi,G., Kofuji,S.,
            Takasuga,S. and Hazeki,K.
  TITLE     Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal
            positioning
  JOURNAL   J Biochem 166 (2), 175-185 (2019)
   PUBMED   31329883
  REMARK    GeneRIF: The TMEM55B has been implicated in starvation induced
            lysosomal translocation. Amino acid starvation induces perinuclear
            lamp1 clustering in RAW264.7 macrophages, which was attenuated by
            shRNA-mediated knock-down or CRISPR/Cas9-mediated knock-out of
            TMEM55B.
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Hashimoto,Y., Shirane,M. and Nakayama,K.I.
  TITLE     TMEM55B contributes to lysosomal homeostasis and amino acid-induced
            mTORC1 activation
  JOURNAL   Genes Cells 23 (6), 418-434 (2018)
   PUBMED   29644770
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Morioka,S., Nigorikawa,K., Okada,E., Tanaka,Y., Kasuu,Y.,
            Yamada,M., Kofuji,S., Takasuga,S., Nakanishi,H., Sasaki,T. and
            Hazeki,K.
  TITLE     TMEM55a localizes to macrophage phagosomes to downregulate
            phagocytosis
  JOURNAL   J Cell Sci 131 (5) (2018)
   PUBMED   29378918
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Ungewickell,A., Hugge,C., Kisseleva,M., Chang,S.C., Zou,J.,
            Feng,Y., Galyov,E.E., Wilson,M. and Majerus,P.W.
  TITLE     The identification and characterization of two
            phosphatidylinositol-4,5-bisphosphate 4-phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 102 (52), 18854-18859 (2005)
   PUBMED   16365287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144251.1 and BE943635.1.
            
            On Jul 15, 2015 this sequence version replaced NM_001033271.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144251.1, AK159641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1607              AK144251.1         1-1607
            1608-1623           BE943635.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.3 cM"
     gene            1..1623
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /note="phosphatidylinositol-4,5-bisphosphate 4-phosphatase
                     1"
                     /db_xref="GeneID:219024"
                     /db_xref="MGI:MGI:2448501"
     exon            1..237
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..929
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /EC_number="3.1.3.78"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PtdIns-4,5-P(2) 4-phosphatase type I; ptdIns-4,5-P2
                     4-Ptase I; type I phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase; transmembrane protein 55b; type 1
                     PtdIns-4,5-P2 4-Ptase; type 1 phosphatidylinositol
                     4,5-bisphosphate 4-phosphatase"
                     /codon_start=1
                     /product="type 1 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase isoform 1"
                     /protein_id="NP_001028443.1"
                     /db_xref="CCDS:CCDS27028.1"
                     /db_xref="GeneID:219024"
                     /db_xref="MGI:MGI:2448501"
                     /translation="MAADGERSPLLSEAGDGGAGGNGLAGPGGSATGPGGGLTPSAPP
                     YGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSPINVEG
                     KMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINL
                     GPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKR
                     CICCFLLGLLLAVTATGLAFGTWKHAQQYGGIYAAWAFVILLAVLCLGRALYWACMKV
                     SHPVQNFS"
     exon            238..428
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     exon            429..535
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     exon            536..641
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     exon            642..694
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     exon            695..785
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1608
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /note="hexamer: AATAAT"
     polyA_site      1608
                     /gene="Pip4p1"
                     /gene_synonym="Tmem55b"
                     /note="major polyA site"
ORIGIN      
        1 ggacccggta gcgacggcgg cggcggcggt ggcagcggcg gcgggagctg gtcgctgacc
       61 gagcgggagt cgccatggcg gcagacggag agcgctcccc gctgctctcc gaggccggcg
      121 atggcggcgc tggtggcaac ggcttagcgg gcccgggcgg gagcgcgacc gggcccggtg
      181 gaggcctgac gccctccgca cctccgtacg gagccggtaa acatgccccg ccccaggcat
      241 ttcccccgtt ccctgaggga catccagccg tgttgcctgg agaggaccca cccccctact
      301 cacccttgac tagcccggat agtgggagtg cccccatgat tacctgtcgc gtctgtcagt
      361 ctccgatcaa cgtggaaggc aagatgcatc agcatgtagt caaatgtggt gtctgcaacg
      421 aagccactcc catcaagaat gcacctccag gaaagaagta tgtccgatgc ccctgtaatt
      481 gtctccttat ctgcaaagtg acttctcagc ggattgcctg ccctcggccc tactgcaaaa
      541 gaatcatcaa cctagggcct gtgcatccag gacctctgag tccagagcca cagccaatgg
      601 gtgtcagggt catctgtgga cattgcaaga acacgtttct gtggacagaa ttcacagacc
      661 gaaccttggc acgatgccct cactgcagaa aagtgtcatc tattgggaga cgatatccta
      721 ggaagagatg tatttgctgc ttcttgcttg gtttactctt ggcagtcact gccactggcc
      781 ttgcttttgg tacatggaag catgcacagc aatatggagg gatctacgca gcctgggcat
      841 ttgtcatttt gttggctgtt ctatgtttgg gtcgggccct ttattgggct tgtatgaagg
      901 tcagccatcc tgtccagaac ttctcctgag ccccttgatg cagtctgtgc ctgaccgctg
      961 cctggtacca acagtaacac tacaaaaggc tctctggact tctacaagga agccaaacag
     1021 ctgcctccct tttccctggg gagaggtagg aaggaagcag tcccttcctt ccttatgttt
     1081 ggaagggtag gtaagaccat tgctggctgg ctgctctctt ccaggggttg ctgtttaggg
     1141 taaataggca acattgcccc taagcctgga tcctaaagat ggttctagcc atgcccttcc
     1201 tgtacgtgct cccgagaacc attcctgtcc cttaatacat tccagggcag ggttggggtg
     1261 ggagatggga gggggtgttc ccctccctct gtgcaccatt aggaccttgc tgctgctatt
     1321 gcacttcacc aggggctggc tctggcctca atacccagtc tcttctcccc acatttctcg
     1381 tcctgtgggg tggggtaagc cactgctctg tacagaacta taggaactga tgtgtatata
     1441 tataactatt taatatggga tatgttcccc taatcctgta cttccctgaa ttcctccttc
     1501 cgattttact tccagttgca gtattgaact gggctgaggt agggtcactg tcttgggaga
     1561 ggttagggac tcatctgtgc ttgtaaataa ataatgtcat gactctaaaa aaaaaaaaaa
     1621 aaa
//
