LOCUS       NM_054097               3374 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphatidylinositol-5-phosphate 4-kinase, type II,
            gamma (Pip4k2c), transcript variant 1, mRNA.
ACCESSION   NM_054097
VERSION     NM_054097.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3374)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3374)
  AUTHORS   Cao,X., Lenk,G.M. and Meisler,M.H.
  TITLE     Altered phenotypes due to genetic interaction between the mouse
            phosphoinositide biosynthesis genes Fig4 and Pip4k2c
  JOURNAL   G3 (Bethesda) 13 (8) (2023)
   PUBMED   36691351
  REMARK    GeneRIF: Altered phenotypes due to genetic interaction between the
            mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
REFERENCE   3  (bases 1 to 3374)
  AUTHORS   Magadum,A., Singh,N., Kurian,A.A., Sharkar,M.T.K., Sultana,N.,
            Chepurko,E., Kaur,K., Zak,M.M., Hadas,Y., Lebeche,D., Sahoo,S.,
            Hajjar,R. and Zangi,L.
  TITLE     Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac
            Hypertrophy and Fibrosis in the Failing Heart
  JOURNAL   Adv Sci (Weinh) 8 (10), 2004661 (2021)
   PUBMED   34026458
  REMARK    GeneRIF: Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates
            Cardiac Hypertrophy and Fibrosis in the Failing Heart.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3374)
  AUTHORS   Shim,H., Wu,C., Ramsamooj,S., Bosch,K.N., Chen,Z., Emerling,B.M.,
            Yun,J., Liu,H., Choo-Wing,R., Yang,Z., Wulf,G.M., Kuchroo,V.K. and
            Cantley,L.C.
  TITLE     Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase,
            results in hyperactivation of the immune system
  JOURNAL   Proc Natl Acad Sci U S A 113 (27), 7596-7601 (2016)
   PUBMED   27313209
  REMARK    GeneRIF: PI5P4Kgamma plays a role in the regulation of the immune
            system via mTORC1 signaling.
REFERENCE   5  (bases 1 to 3374)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3374)
  AUTHORS   Clarke,J.H., Emson,P.C. and Irvine,R.F.
  TITLE     Distribution and neuronal expression of phosphatidylinositol
            phosphate kinase IIgamma in the mouse brain
  JOURNAL   J Comp Neurol 517 (3), 296-312 (2009)
   PUBMED   19757494
  REMARK    GeneRIF: our data suggest that PIP4Kgamma may have a role in neuron
            function, specifically in the regulation of vesicular transport, in
            specific regions of the developed brain
REFERENCE   7  (bases 1 to 3374)
  AUTHORS   Clarke,J.H., Emson,P.C. and Irvine,R.F.
  TITLE     Localization of phosphatidylinositol phosphate kinase IIgamma in
            kidney to a membrane trafficking compartment within specialized
            cells of the nephron
  JOURNAL   Am J Physiol Renal Physiol 295 (5), F1422-F1430 (2008)
   PUBMED   18753295
  REMARK    GeneRIF: PIP4Kgamma may have a function in the regulation of
            vesicular transport in specialized kidney epithelial cells.
REFERENCE   8  (bases 1 to 3374)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 3374)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3374)
  AUTHORS   Akiba,Y., Suzuki,R., Saito-Saino,S., Owada,Y., Sakagami,H.,
            Watanabe,M. and Kondo,H.
  TITLE     Localization of mRNAs for phosphatidylinositol phosphate kinases in
            the mouse brain during development
  JOURNAL   Brain Res Gene Expr Patterns 1 (2), 123-133 (2002)
   PUBMED   15018809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856667.1, AB054591.1 and AC144852.3.
            
            On Aug 15, 2009 this sequence version replaced NM_054097.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021383.1, AB054591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BB856667.1         2-66
            66-2352             AB054591.1         9-2295
            2353-3374           AC144852.3         109948-110969
FEATURES             Location/Qualifiers
     source          1..3374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..3374
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /note="phosphatidylinositol-5-phosphate 4-kinase, type II,
                     gamma"
                     /db_xref="GeneID:117150"
                     /db_xref="MGI:MGI:2152214"
     exon            1..285
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1377
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /EC_number="2.7.1.149"
                     /note="PIP4KII-gamma; PI(5)P 4-kinase type II gamma;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     gamma"
                     /protein_id="NP_473438.1"
                     /db_xref="CCDS:CCDS24232.1"
                     /db_xref="GeneID:117150"
                     /db_xref="MGI:MGI:2152214"
                     /translation="MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAA
                     DPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHFFHRENLPSHFKFKE
                     YCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIA
                     DMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYD
                     LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQL
                     KIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLAGPPALVGSYGTSPEGIGG
                     YIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTV
                     KHGAGAEISTVHPEQYAKRFLDFIANIFA"
     exon            286..383
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            384..480
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            481..624
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            625..771
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            772..810
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            811..924
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1192
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1296
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..3374
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /note="major polyA site"
ORIGIN      
        1 gagggcgggc ctccggtcac atgacggctg cgcaggtgag caccgcttcc gggtcgggct
       61 tcggagtcgc ggctagctcc cgcttccact cgctcgggtg cgcgggagac tatggcgtcc
      121 tcctccgtcc ctcccgccac cgcacccgcg gcagctggag gccccggccc gggattcggc
      181 ttcgcctcca aaaccaagaa gaagcatttc gtacagcaga aagtgaaggt gttccgggcc
      241 gcggacccgc tggtgggcgt gttcctgtgg ggcgtcgctc actcgatcaa tgagctcagc
      301 caggtaccgc ccccagtgat gttgctgcca gatgacttta aagccagctc caagatcaag
      361 gtcaacaatc actttttcca tagagaaaat cttcccagtc atttcaagtt caaggagtat
      421 tgtccccagg tcttcaggaa cctgagagat cggtttgcca tcgatgatca cgattacttg
      481 gtgtccctta ctcgaagccc cccaagcgaa actgaaggca gtgatggccg tttccttatc
      541 tcctatgacc gcactctggt catcaaggaa gtgtcgagcg aagatattgc ggatatgcac
      601 agcaacctct ccaactacca ccagtacata gtgaaatgtc atggcaacac gcttctgccc
      661 cagttcctgg gcatgtaccg agtcagtgta gaaaatgaag acagctacat gctcgtgatg
      721 cgcaatatgt ttagtcatcg tcttcctgtg cataggaagt atgacctcaa gggctctcta
      781 gtgtcccggg aagccagcga taaggaaaag gttaaagaac tgccaacact aaaggatatg
      841 gactttctta acaagaacca gaaagtgtat attggtgaag aagaaaagaa agtattcctg
      901 gagaagctga agcgagatgt ggagtttcta gtgcagctga agatcatgga ctacagcctc
      961 ctgttgggca tccacgacat catccggggc tctgaacccg aggaagaggg gcctgtgagg
     1021 gaggaggagt ctgagtggga tggggactgt aacctggctg gacctcccgc cctggtgggc
     1081 tcctatggta cctcccctga gggtatcgga ggctacatcc attcccaccg gccactgggc
     1141 ccaggagagt ttgagtcctt catcgatgtc tatgctatcc ggagtgcgga gggggccccc
     1201 cagaaggagg tgtatttcat gggcctcatt gacattctga cacagtatga tgccaagaag
     1261 aaagcagctc atgcagccaa gactgtcaag cacggggcgg gggcagagat ctccactgtc
     1321 catcctgagc agtatgctaa gcgattcctg gactttattg ccaacatctt tgcctaagag
     1381 gctgcctgac tccagggtga ttgcggcttt atgttggagg tggcgggttc tgagaggctt
     1441 aggggagctg gacttggccg ttacttctct tctttgctaa attcaggctg caggctcctt
     1501 ccatccaaat aacttccttc tggtggatag ggttttctcg cccaccccag acatacactg
     1561 tcctttctcc ccttgtccat ttctctgccc tccctccttg ctcccagtaa gccctcctgc
     1621 ttctttagag tgttattgtc gactcttcta agtgccttga tctttgaaaa atatcttgtt
     1681 tctatgaaat aggaggagct gggggagggg ttgtttgcca tcttcgggac ctgactgaac
     1741 agtggacttg gctcaagcaa ctgcctggat gcacttttgc tgagtggaag aaactgaatg
     1801 tctggatttt gctgatactt ttatggggca ctttgtggca tgcttcctcc ctggtaagcc
     1861 ctggaatgga gggctttcag gatgctccag atgtgggtgc aggcattcac acatggacag
     1921 tctggcctgg aggtcaggtg gggagtggtc agcaggctgg cacctcacaa ggcaggacct
     1981 aagcctaagc ggacttttgt gactatgcag atgatggaga aggtccctgt ggagcaacga
     2041 ctgttcccga ctgttcccgt tctcccaccc caccccaccc cacgtccacc tctttctgtg
     2101 agcactttgg gtgcaggagc ccagaggcta gcggtgcccg agcttaggtg caggtgtgag
     2161 actcgggctg ctcttcccac aaccctgtgc cttgctggtg agcagggaga gcagtagagg
     2221 ccgggacagg tcggagtgca gggttcattg cctgggtgac accctttctt cctgtctcac
     2281 tactcctggg cttctttcta gcagagggga acagtaccat ctccataatt tggggaggat
     2341 agagctctcg agtgaaggag cctccgcatc cctggggcat gtgtacctag aactccccct
     2401 ccttctcaaa accctttctg gttggagttg ttattctgtc ccatcttcca ctgctaatgt
     2461 gtctcccagg ggacagatgg ccttctttgt catctcccct ctccgccccc agagaggagt
     2521 cagagccata actcaatcca cccagtcctc tccaaagaca gctgaatatt aatgcacgcc
     2581 atcctcagaa tggagaggac ctgctaggca tcttagctct cccagctcgt gcctgtaaag
     2641 ccagcactca ggaggctctg agagttcaag tccagcctgg gctactgagt gagacctggt
     2701 ctcaggaaca ctccaaatag gtttgggttt gagcgctgga gatcatagct gagttggtag
     2761 tgtgcttgcc tagcatgtac aaagctctgg gatccacccc cagcaccact taagccaggc
     2821 gtggcggtgc acgcctgcac tcctggccct gggaagtagt ggtaagcagg atggggcatt
     2881 caaggtcatc gccagttagt tacttgacga ggttgaggcc agccaaggaa acaggagacc
     2941 atcttgggga aaatgattct aaggagagat agattgtctt tgtctctgcc taaagccttt
     3001 ggaagcaagc cactcatctt cgctgtttgg cgctctggag gtggggtggg cattgaaggc
     3061 aaggagctgc tttgctgtgt gtccatgagg tcctcaggga gaagcccacc tccctcacca
     3121 aaggaagcag caagatgggt gcccggttgg ggtgggtggg acctgctgag tctcccatcc
     3181 ctcaagcaac ctttcccctg ttgaatgcaa taagtgactc cggtccctta acaactgggg
     3241 tctcaccgtg cggctgtggt cgtgggcagt gttgccatct tcacttactg cttccgtttt
     3301 ccatctgttt tgttaataaa atatgtatat ttactcccga tatcacaata aaataaatta
     3361 tttgatctaa gtca
//
