LOCUS       NM_054051               5068 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol-5-phosphate 4-kinase, type II,
            beta (Pip4k2b), mRNA.
ACCESSION   NM_054051 XM_914635 XM_923349 XM_923356
VERSION     NM_054051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5068)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5068)
  AUTHORS   Ravi,A., Palamiuc,L., Loughran,R.M., Triscott,J., Arora,G.K.,
            Kumar,A., Tieu,V., Pauli,C., Reist,M., Lew,R.J., Houlihan,S.L.,
            Fellmann,C., Metallo,C., Rubin,M.A. and Emerling,B.M.
  TITLE     PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria
            interplay
  JOURNAL   Dev Cell 56 (11), 1661-1676 (2021)
   PUBMED   33984270
REFERENCE   3  (bases 1 to 5068)
  AUTHORS   Noch,E.K., Yim,I., Milner,T.A. and Cantley,L.C.
  TITLE     Distribution and localization of phosphatidylinositol 5-phosphate,
            4-kinase alpha and beta in the brain
  JOURNAL   J Comp Neurol 529 (2), 434-449 (2021)
   PUBMED   32449185
  REMARK    GeneRIF: Distribution and localization of phosphatidylinositol
            5-phosphate, 4-kinase alpha and beta in the brain.
REFERENCE   4  (bases 1 to 5068)
  AUTHORS   Lundquist,M.R., Goncalves,M.D., Loughran,R.M., Possik,E.,
            Vijayaraghavan,T., Yang,A., Pauli,C., Ravi,A., Verma,A., Yang,Z.,
            Johnson,J.L., Wong,J.C.Y., Ma,Y., Hwang,K.S., Weinkove,D.,
            Divecha,N., Asara,J.M., Elemento,O., Rubin,M.A., Kimmelman,A.C.,
            Pause,A., Cantley,L.C. and Emerling,B.M.
  TITLE     Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid
            Metabolism By Facilitating Autophagy
  JOURNAL   Mol Cell 70 (3), 531-544 (2018)
   PUBMED   29727621
REFERENCE   5  (bases 1 to 5068)
  AUTHORS   Fiume,R., Stijf-Bultsma,Y., Shah,Z.H., Keune,W.J., Jones,D.R.,
            Jude,J.G. and Divecha,N.
  TITLE     PIP4K and the role of nuclear phosphoinositides in tumour
            suppression
  JOURNAL   Biochim Biophys Acta 1851 (6), 898-910 (2015)
   PUBMED   25728392
  REMARK    GeneRIF: Suppression of PIP4K expression selectively prevents tumor
            cell growth in vitro and prevents tumor development in mice that
            have lost the tumor suppressor p53. (Review)
            Review article
REFERENCE   6  (bases 1 to 5068)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5068)
  AUTHORS   Lamia,K.A., Peroni,O.D., Kim,Y.B., Rameh,L.E., Kahn,B.B. and
            Cantley,L.C.
  TITLE     Increased insulin sensitivity and reduced adiposity in
            phosphatidylinositol 5-phosphate 4-kinase beta-/- mice
  JOURNAL   Mol Cell Biol 24 (11), 5080-5087 (2004)
   PUBMED   15143198
REFERENCE   8  (bases 1 to 5068)
  AUTHORS   Akiba,Y., Suzuki,R., Saito-Saino,S., Owada,Y., Sakagami,H.,
            Watanabe,M. and Kondo,H.
  TITLE     Localization of mRNAs for phosphatidylinositol phosphate kinases in
            the mouse brain during development
  JOURNAL   Brain Res Gene Expr Patterns 1 (2), 123-133 (2002)
   PUBMED   15018809
REFERENCE   9  (bases 1 to 5068)
  AUTHORS   Kleiter,N., Artner,I., Gmachl,N., Ghaffari-Tabrizi,N. and
            Kratochwil,K.
  TITLE     Mutagenic transgene insertion into a region of high gene density
            and multiple linkage disruptions on mouse chromosome 11
  JOURNAL   Cytogenet Genome Res 97 (1-2), 100-105 (2002)
   PUBMED   12438746
  REMARK    GeneRIF: located within a 185-kb contig surrounding a transgene on
            chromosome 11
REFERENCE   10 (bases 1 to 5068)
  AUTHORS   Castellino,A.M., Parker,G.J., Boronenkov,I.V., Anderson,R.A. and
            Chao,M.V.
  TITLE     A novel interaction between the juxtamembrane region of the p55
            tumor necrosis factor receptor and phosphatidylinositol-4-phosphate
            5-kinase
  JOURNAL   J Biol Chem 272 (9), 5861-5870 (1997)
   PUBMED   9038203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC047282.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_914635.1, XM_923349.1, XM_923356.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047282.1, AK171497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.07 cM"
     gene            1..5068
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /note="phosphatidylinositol-5-phosphate 4-kinase, type II,
                     beta"
                     /db_xref="GeneID:108083"
                     /db_xref="MGI:MGI:1934234"
     exon            1..259
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1351
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /EC_number="2.7.1.149"
                     /note="PIP4KII-beta; PI(5)P 4-kinase type II beta;
                     diphosphoinositide kinase 2-beta;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, beta;
                     1-phosphatidylinositol 5-phosphate 4-kinase 2-beta"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     beta"
                     /protein_id="NP_473392.1"
                     /db_xref="CCDS:CCDS25329.1"
                     /db_xref="GeneID:108083"
                     /db_xref="MGI:MGI:1934234"
                     /translation="MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILS
                     VLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMV
                     FRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEM
                     HNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLK
                     GSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKI
                     MDYSLLVGIHDVDRAEQEEMEVEERAEEEECENDGVGGSLLCSYGTPPDSPGNLLSFP
                     RFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAG
                     AEISTVNPEQYSKRFNEFMSNILT"
     exon            260..357
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..454
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            455..607
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            608..754
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            755..793
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            794..907
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1166
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1270
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..5053
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5027..5032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /note="hexamer: AATAAA"
     polyA_site      5051
                     /gene="Pip4k2b"
                     /gene_synonym="c11; PI5P4Kbeta; Pip5k2b"
                     /note="major polyA site"
ORIGIN      
        1 gaggcagcgg gggtggggat cggttcgggg gaggcctggg gccgctcgct ggtgcgctgt
       61 ctccgccgcc ccccctttcg ccgccgccgc cgccccgggc atgtcgtcca actgcaccag
      121 caccacggcg gtggcggtgg cgccgctcag cgccagcaaa accaagacca agaagaagca
      181 tttcgtgtgc cagaaagtga agctattccg ggccagcgag ccgattctca gcgtcctgat
      241 gtggggggtg aaccacacga tcaatgagct gagcaatgtc cctgttcctg tcatgctaat
      301 gccggatgac ttcaaagctt acagcaagat caaggtggac aatcatctct tcaataagga
      361 aaacctcccc agccgcttca agttcaagga gtactgcccc atggtgttcc gaaacctcag
      421 ggagaggttc ggcatcgatg accaggacta ccagaattca gtgacacgca gtgcacctat
      481 caacagtgac agccagggca ggtgtggcac tcgcttcctc accacctatg accggcgttt
      541 cgtcatcaag actgtgtcaa gtgaggatgt ggccgagatg cacaacatcc taaagaaata
      601 ccaccagttc atagtggaat gtcacggcaa taccctcttg ccacagttcc tgggcatgta
      661 ccgcctgacc gtggatgggg tggaaaccta catggtggtc accaggaatg tattcagtca
      721 tcggcttact gtgcatcgca aatacgacct gaagggttcc actgttgcca gagaagccag
      781 tgacaaggaa aaggctaagg acttgccaac tttcaaagat aatgacttcc tcaacgaagg
      841 gcagaagctg cacgtgggag aagagagcaa aaagaacttc ctggaaaaac tgaagcggga
      901 cgttgagttc ctggcccagc tgaagatcat ggattacagt ctcctggtgg gcatccacga
      961 cgtggaccgg gcagagcagg aggagatgga ggtggaagag cgagcggagg aggaggaatg
     1021 cgagaatgat ggggtgggtg gcagcctgct ctgctcctat ggcacgcctc cagacagccc
     1081 tggcaacctc ctgagcttcc cccggttctt cggcccagga gagttcgacc cctctgtgga
     1141 cgtctatgcc atgaaaagcc atgaaagtgc ccctaagaag gaggtctatt tcatggccat
     1201 cattgacatc ctcacaccct atgacgctaa gaagaaagct gcacacgccg ccaaaacggt
     1261 gaaacatggg gcaggggctg agatctccac tgtgaacccg gagcagtact caaaacgctt
     1321 caacgagttc atgtccaaca tcctgacgta atcatctctg ccttctgcca gagccagact
     1381 gctggaccag gggtcgggga tcgggagagg gagagggtat atctgggccg ggagggtggg
     1441 gagcagagtg ggggcttgcg agggctttag ttaagggact gcagcctgtg acctgaagga
     1501 agaaggggac gggctgtttg cacgtgctca caggatgcag ccttacttcc cgagcaccct
     1561 cgatccgcct cttttgcccc tggttaaaac agggtttcct cttcggtatc tccgtaacct
     1621 atgatacccg ggagctggag ttgactttgt gggtttcttt gggtttgttt cttcaattca
     1681 ctgctccagg attgctcttt ctaatgctgt atgtcatcac cctcggggcc ctccctcttc
     1741 ctgtcaggct ctcagttccc ttcagttcag gccagcacaa gggacgagaa gagcagttgc
     1801 tcagacacct cagtcagcca cggtttgttc tcacctagat ggactctttt atttcctgga
     1861 gtattgtgca tcacccctcc ccccctcatg cttccacctt ggagccaagt gaaaccttgg
     1921 ctccctcacc ccatcctcac agaagaacat ggcaggttga ccctgacgcc ttggaccgga
     1981 gtcagaggcc tcagagggga acaggttcgt cttcatgaga cggtgaatga ccaggaagca
     2041 gccctcagac agccggttct caaagaaccc agagatcacc accccggcca cctgcgcctc
     2101 tgagtggaat tctgatgtct gtcaaggccg ccacccaccg gctccagagg aactatcaag
     2161 catcgtggca tttattgggg cccctgtgtt tcgatgactg tttccctttg ggaaaatccc
     2221 agaaactaag atgtgtaaac cgggcccgta tgcaccctcc atatcctaac tactgacctc
     2281 tgggtgcagt cgcctgtaac tggcaaatgg tcaatgcaga gctcatcgca gagctgccac
     2341 tccaagcctg gcccgccgtg caggtgtgtc tggctcctgt gcctgtgact tctcacctgg
     2401 acagctttag ccagcaaggt gctccacctg aggttgcctg agtcacctga ggaggtgacc
     2461 ccaggaaagc ctgtttgttt ggaggcctga cacggggctt tgcccatccc ccagccccag
     2521 ggctgacgga ttttccttgt caccctcact ctttctggac ttgggatctg cccccggtcc
     2581 tccttggaaa gagtgacagc ccgcagcctc cttcaggatt ctggcccagg gcctcagaag
     2641 ggagctacac aagtcattct gatgccacca gagcaagtgg ttgccaggaa gaaaaacaaa
     2701 acggtctcgc cggcctgccc ttggaggagg taaactccct acctcttccc agctccctca
     2761 ggaggaatcc ggaatttagg atgagatgga tttttgtaga taaccccaaa gatgtgaagc
     2821 tggtttgtga agctgtcgtg ggtgaataga tgattcccaa cgcctgcccc ccaaactggc
     2881 ccagctcagc ttggggagct ggggagtggc cactgtgccg tgtcctccct atccctgcac
     2941 tgaactaaga caggaaaagc aagatggcag tcttgggctt ctctggggct gccaattggg
     3001 tgaggcaggt gggggcccac tccttcccag gaagagaacc aggtaaggtt ctggtgggca
     3061 gaaccacggg ggacttgggg aaggactcag aaaccatgtg attcgaggag aaaggatttt
     3121 aatgtaggag aggggttacg taggaataat gtctggactt gatttctcac ctcacaatca
     3181 agagtaagga ctctggatct gccccaggct tggaagtcga agctcctggc tgatcctgtt
     3241 gtgtgtttgc agccggctaa ctgggttaac ggtgggattt gggggggggg ttatttcgtt
     3301 tcgttgtata ttgtttacaa ttttgagagg tagctttctg tttcaagctc tctgttttcc
     3361 tgacagtatt gttgagtggg tcaaaatatt caagctgtgg tttggtggat tttaggtttg
     3421 ttgttttttt gttttgtttt gttttgtttt ttaggtcatt ctctgcgcca tcttcaaaac
     3481 cctgaggttt gactttctga ttccttggca ttcattcgtg tgtttaaaag ctatttatct
     3541 tcatttcaga caagttttct ttctctttgt gacaaagatg tgctatttgg cttcaatctc
     3601 cacataaccc cctcccccca tttatctgct cccctcttcc tgagtcccac cagtcacgct
     3661 ctgggcagca ggtgccaagg ggaagacaag acccttagct tgactcctca gggccgtgaa
     3721 gaacagccag actgtcttat ggcatccaga atcatgttgg gtcttccaga aatagacatt
     3781 taagaataga gtcctggaca actgggtgag gtctggatgc ggggaaaggg ggggattcca
     3841 ttcccaggcc cttaccctcc cgattactgt gtggcagcca gtccccattc cttctgtgga
     3901 aactgtggaa ctgagaaaat atgtctcgca tccagctgac acaagggata ctatgaacac
     3961 tctgacacca agcagtggcc tcaggccgtg ttcccagtct gcagggcagc gccaggagtg
     4021 cggttcagtt ccgctgcagt gctaaatcct tatctagctc aggggttact ggtctgtggc
     4081 tggcgccatg agtggccccc aggctgttct cagtggcact atagtccccc accccacccc
     4141 caggcagctg tccccctcct tacccccctc cccccaaaat cacttttctc agtcctgggc
     4201 tttaggcctg aacaggtccc ctagcagtgc tcaagggagg agagactgga ctcctgtcga
     4261 gacttccccc cttcaccatg tgccaggcct ccctggggag gtggaccaaa gacccaggac
     4321 tttctcagta gccagtcccc caccccaccc caccccaacc ccagttgtct ttttaacaat
     4381 tcaggttgag agggaaaaac cattagctgt ttctagtgct tgaccgactc aagtatttcg
     4441 ggcagaaagg acagtgcacc gagacagccc tcagagctct ggccttgtgg tttcccaagt
     4501 ttagagacct caccagcagt aatggccggt ggggtggggg tagggggtct caaagggaaa
     4561 cacatttaga cagctagcca aaatctgcca gccgtggtcc cagtcctctg aagtgtgcca
     4621 cttaggatga gtgtcaccaa ggggaagtga gacgtagctg tccttcaggt tgagtcacca
     4681 ggaaagaggc tgaggacacc cgaagagcct gtcccttgcc cacagccatt tttcaaggtg
     4741 ggagcccata catttagggg gaccatctgc ttagcacatc tcagcggctg gtcagaacat
     4801 tgcacacacg aaatgtgaat gaaatctaga gtcatctttg ggcccgcagg attaaagttc
     4861 tacccaccac atgtgacttg tccatttccg gctgcaagct ccattttttt aaaaatagga
     4921 attttcaccc ctgtgcttgt ctaatgtctg ctctgaacag ttcgagcctc tgttactgtt
     4981 ttaaaatgca tgcatgttaa aaaagaatct ccaaatggga ggacaaaata aaactcgaaa
     5041 agctttgtgt acaaaaaaaa aaaaaaaa
//
