LOCUS       NM_008843                574 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prolactin induced protein (Pip), mRNA.
ACCESSION   NM_008843
VERSION     NM_008843.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Terceiro,L.E.L., Blanchard,A.A.A., Edechi,C.A., Freznosa,A.,
            Triggs-Raine,B., Leygue,E. and Myal,Y.
  TITLE     Generation of prolactin-inducible protein (Pip) knockout mice by
            CRISPR/Cas9-mediated gene engineering
  JOURNAL   Can J Physiol Pharmacol 100 (1), 86-91 (2022)
   PUBMED   34379992
  REMARK    GeneRIF: Generation of prolactin-inducible protein (Pip) knockout
            mice by CRISPR/Cas9-mediated gene engineering.
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Edechi,C.A., Nasr,M.R., Karim,A., Blanchard,A.A., Ellison,C.A.,
            Qui,H., Uzonna,J.E. and Myal,Y.
  TITLE     The prolactin inducible protein/gross cystic disease fluid
            protein-15 deficient mice develop anomalies in lymphoid organs
  JOURNAL   Immunobiology 224 (6), 811-816 (2019)
   PUBMED   31447246
  REMARK    GeneRIF: we observed that the deficiency of Pip led to anomalies in
            the histology of lymphoid organs including the lymph nodes, spleen
            and thymus. We also observed anomalies in the morphology of the
            Eustachian tube and tympanic membrane in Pip deficient mice.
            Collectively, these data strongly suggest that Pip is an important
            regulator of immune responses.
REFERENCE   4  (bases 1 to 574)
  AUTHORS   Ihedioha,O., Blanchard,A.A., Balhara,J., Okwor,I., Jia,P.,
            Uzonna,J. and Myal,Y.
  TITLE     The human breast cancer-associated protein, the prolactin-inducible
            protein (PIP), regulates intracellular signaling events and
            cytokine production by macrophages
  JOURNAL   Immunol Res 66 (2), 245-254 (2018)
   PUBMED   29536339
  REMARK    GeneRIF: studies show that deficiency of PIP significantly affects
            intracellular signaling events leading to decreased
            pro-inflammatory cytokine production, and further confirms a role
            for PIP as an important immunoregulatory protein. This direct link
            between PIP and cell-mediated immunity, a key component of the
            immune system that is critical for cancer control, may have
            significant therapeutic implications.
REFERENCE   5  (bases 1 to 574)
  AUTHORS   Ihedioha,O.C., Shiu,R.P., Uzonna,J.E. and Myal,Y.
  TITLE     Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune
            Modulator-Novel Insights from Knockout Mice
  JOURNAL   DNA Cell Biol 35 (10), 537-541 (2016)
   PUBMED   27602994
  REMARK    GeneRIF: Recent work with Pip-deficient mice, linking PIP not only
            to a role in innate immunity but for the first time, providing
            evidence for a role in cell-mediated immunity. [Review]
            Review article
REFERENCE   6  (bases 1 to 574)
  AUTHORS   Lee,B., Modha,G., Watson,P.H., Dodd,J., Troup,S., Blanchard,A. and
            Myal,Y.
  TITLE     Expression of the mouse homologue for the human GCDFP-15/PIP gene
            during pre- and early post-natal development
  JOURNAL   Mol Cell Endocrinol 205 (1-2), 33-41 (2003)
   PUBMED   12890565
  REMARK    GeneRIF: examined the endogenous pattern of mouse SMGP/PIP
            (mSMGP/mPIP) gene expression in mid-and late-embryonic, and in
            early postnatal development
REFERENCE   7  (bases 1 to 574)
  AUTHORS   Yoshida,M., Kaneko,M., Kurachi,H. and Osawa,M.
  TITLE     Identification of two rodent genes encoding homologues to seminal
            vesicle autoantigen: a gene family including the gene for
            prolactin-inducible protein
  JOURNAL   Biochem Biophys Res Commun 281 (1), 94-100 (2001)
   PUBMED   11178965
REFERENCE   8  (bases 1 to 574)
  AUTHORS   Myal,Y., Iwasiow,B., Cosby,H., Yarmill,A., Blanchard,A.,
            Tsuyuki,D., Fresnoza,A., Duckworth,M.L. and Shiu,R.P.
  TITLE     Analysis of tissue- and hormone-specific regulation of the human
            prolactin-inducible protein/gross cystic disease fluid protein-15
            gene in transgenic mice
  JOURNAL   J Mol Endocrinol 21 (2), 217-223 (1998)
   PUBMED   9801465
REFERENCE   9  (bases 1 to 574)
  AUTHORS   Myal,Y., Iwasiow,B., Yarmill,A., Harrison,E., Paterson,J.A. and
            Shiu,R.P.
  TITLE     Tissue-specific androgen-inhibited gene expression of a
            submaxillary gland protein, a rodent homolog of the human
            prolactin-inducible protein/GCDFP-15 gene
  JOURNAL   Endocrinology 135 (4), 1605-1610 (1994)
   PUBMED   7925123
REFERENCE   10 (bases 1 to 574)
  AUTHORS   Windass,J.D., Mullins,J.J., Beecroft,L.J., George,H., Meacock,P.A.,
            Williams,B.R. and Brammar,W.J.
  TITLE     Molecular cloning of cDNAs from androgen-independent mRNA species
            of DBA/2 mouse sub-maxillary glands
  JOURNAL   Nucleic Acids Res 12 (3), 1361-1376 (1984)
   PUBMED   6546617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138795.1 and CK616212.1.
            
            On Feb 24, 2018 this sequence version replaced NM_008843.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG867868.1, AK138795.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AK138795.1         2-572
            572-574             CK616212.1         2-4                 c
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.05 cM"
     gene            1..574
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /note="prolactin induced protein"
                     /db_xref="GeneID:18716"
                     /db_xref="MGI:MGI:102696"
     exon            1..120
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..472
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /note="prolactin-inducible protein homolog; 14 kDa
                     submandibular gland protein; gross cystic disease fluid
                     protein 15"
                     /codon_start=1
                     /product="prolactin-inducible protein homolog precursor"
                     /protein_id="NP_032869.2"
                     /db_xref="CCDS:CCDS39469.1"
                     /db_xref="GeneID:18716"
                     /db_xref="MGI:MGI:102696"
                     /translation="MQGLSFTFSAVTLFLVLCLQLGIIESQDDENVRKPLLIEIDVPS
                     TAQENQEITVQVTVETQYRECMVIKAYLVSNEPMEGAFNYVQTRCLCNDHPIRFFWDI
                     IITRTVTFATVIDIVREKNICPNDMAVVPITANRYYTYNTVRMN"
     exon            121..232
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /inference="alignment:Splign:2.1.0"
     exon            233..347
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /inference="alignment:Splign:2.1.0"
     exon            348..574
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      554..559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /note="hexamer: AATAAA"
     polyA_site      574
                     /gene="Pip"
                     /gene_synonym="GCDFP-15; GP17; SMGP"
                     /note="major polyA site"
ORIGIN      
        1 agtactggtc tggtgttctg acttctccac tatgcagggt ctctcattca cattcagtgc
       61 tgtgacactc ttcttggtcc tatgtctgca gctggggatc attgaaagcc aggatgatga
      121 aaatgtccga aagccacttt tgattgaaat agatgttcca tcaacagcac aggaaaatca
      181 ggagatcact gtgcaagtta cagttgaaac acaatataga gaatgtatgg tgatcaaagc
      241 ttaccttgta agtaatgaac caatggaagg tgccttcaac tatgtacaaa cccgctgcct
      301 ctgtaatgat catcctatta gatttttctg ggatataata atcacaagaa ctgtaacatt
      361 tgcaacagtg attgatattg ttcgagaaaa gaatatctgt cctaatgata tggcagtggt
      421 gcccatcaca gcaaaccggt actatactta taatactgtg cgaatgaatt aacggaggct
      481 tcttatgcgt ctttcaaaac cattatcatt ttctccaagt acaattgact ggaatatcca
      541 ttgtagtctg tcaaataaac ttcttacaag cata
//
