LOCUS       NM_028228               1360 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus PIN2/TERF1 interacting, telomerase inhibitor 1
            (Pinx1), mRNA.
ACCESSION   NM_028228
VERSION     NM_028228.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Huang,E., Xu,K., Gu,X. and Zhu,Q.
  TITLE     PinX1 Depletion Improves Liver Injury in a Mouse Model of
            Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity
            and Inhibiting Apoptosis
  JOURNAL   Cytogenet Genome Res 161 (8-9), 449-462 (2021)
   PUBMED   34657040
  REMARK    GeneRIF: PinX1 Depletion Improves Liver Injury in a Mouse Model of
            Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity
            and Inhibiting Apoptosis.
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Chan,H.C., Lau,Y.T., Ding,Q., Li,C.K., Wong,C.M., Shaw,P.C.,
            Waye,M.M.Y. and Tsang,S.Y.
  TITLE     PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates
            Cardiogenesis of Embryonic Stem Cells
  JOURNAL   J Am Heart Assoc 9 (6), e010240 (2020)
   PUBMED   32157956
  REMARK    GeneRIF: PinX1t, a Novel PinX1 Transcript Variant, Positively
            Regulates Cardiogenesis of Embryonic Stem Cells.
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Zhou,X.Z., Huang,P., Shi,R., Lee,T.H., Lu,G., Zhang,Z., Bronson,R.
            and Lu,K.P.
  TITLE     The telomerase inhibitor PinX1 is a major haploinsufficient tumor
            suppressor essential for chromosome stability in mice
  JOURNAL   J Clin Invest 121 (4), 1266-1282 (2011)
   PUBMED   21436583
  REMARK    GeneRIF: PinX1 heterozygosity and PinX1 knockdown in mouse
            embryonic fibroblasts activated telomerase and led to concomitant
            telomerase-dependent chromosomal instability.
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Liao,C., Zhao,M.J. and Li,Z.P.
  TITLE     [The cloning and expression of a novel mouse gene mLPTS and its
            subcellular localization]
  JOURNAL   Yi Chuan Xue Bao 29 (10), 865-870 (2002)
   PUBMED   12561469
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Zhou,X.Z. and Lu,K.P.
  TITLE     The Pin2/TRF1-interacting protein PinX1 is a potent telomerase
            inhibitor
  JOURNAL   Cell 107 (3), 347-359 (2001)
   PUBMED   11701125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118607.12 and AC161764.4.
            
            On Sep 13, 2022 this sequence version replaced NM_028228.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF321817.1, BC115636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC118607.12        34058-34206         c
            150-259             AC118607.12        30180-30289         c
            260-352             AC118607.12        28310-28402         c
            353-431             AC118607.12        25908-25986         c
            432-524             AC118607.12        22111-22203         c
            525-601             AC118607.12        16317-16393         c
            602-1360            AC161764.4         131547-132305       c
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.34 cM"
     gene            1..1360
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="PIN2/TERF1 interacting, telomerase inhibitor 1"
                     /db_xref="GeneID:72400"
                     /db_xref="MGI:MGI:1919650"
     exon            1..149
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1129
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="PIN2/TRF1-interacting protein; PIN2-interacting
                     protein X1; TRF1-interacting protein 1; liver-related
                     putative tumor suppressor"
                     /codon_start=1
                     /product="PIN2/TERF1-interacting telomerase inhibitor 1"
                     /protein_id="NP_082504.1"
                     /db_xref="CCDS:CCDS27205.1"
                     /db_xref="GeneID:72400"
                     /db_xref="MGI:MGI:1919650"
                     /translation="MSMLAERRRKQKWTVDPRNTAWSNDDSKFGQKMLEKMGWSKGKG
                     LGAQEQGATEHIKVKVKNNHLGLGATNNNEDNWIAHQDDFNQLLAALNTCHGQETADS
                     SDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSETDLDCIFGKRRNKKLAQDGC
                     SNSSADEVNTSLTTTTTTTSAFTIQEYFAKRMAQLKNKPQASAPGSDLSETPVERKKG
                     KKKNKEAADTDVENSPQHKAKRHKKKKRVEAERGPVAKKRDRAELQPGGPSEDECSDA
                     SVEAAEDCVQTPDIQDDVPKPKKRKAKKKLQRPEGVEIDATLDRAPVKKKKKKVSR"
     exon            150..259
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..352
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..431
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..524
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..601
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1360
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="hexamer: AATAAA"
     polyA_site      1341
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="major polyA site"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="hexamer: AATAGA"
     polyA_site      1360
                     /gene="Pinx1"
                     /gene_synonym="2210403I16Rik; 2610028A01Rik; 67-11-3;
                     LPTS; LPTS1"
                     /note="major polyA site"
ORIGIN      
        1 agtagtacgc gccccagcga agctctccac ccggcgtgct ttccgagccg gcttcttcct
       61 taaccgcgct tcaggttcct cataaccgct gggcgtcagg ccagaggcag cgttcgacaa
      121 acttgagaca atgtcgatgc tagcagagcg gcggcggaag cagaaatgga ctgtggatcc
      181 cagaaacacc gcgtggagta acgatgattc caagtttggc cagaagatgc ttgagaagat
      241 ggggtggtct aaaggaaagg gtttgggagc tcaggagcaa ggagccacag aacatattaa
      301 agttaaagtt aaaaataacc acctgggact tggagctaca aacaataatg aagacaactg
      361 gattgctcac caggatgact tcaaccagct tttggcagca ctcaacactt gccacggtca
      421 ggaaacagca gattcctcag acaaaaagga aaagaaatct tttagccttg aagaaaaatc
      481 caaaatctcc aaaaaccggg ttcattatat gaaattcaca aaagggaagg atctgtcctc
      541 tcggagtgaa accgacctgg actgcatttt tggaaaaagg aggaacaaga agcttgctca
      601 ggatggctgc agcaactcct ctgcggatga ggtgaacacc tccctgacca caaccacgac
      661 caccactagt gccttcacca tccaggaata ttttgccaag agaatggccc aattaaagaa
      721 caagccacaa gcctcagctc cagggtctga cctttcagag acccctgttg aaaggaaaaa
      781 gggaaagaaa aaaaacaaag aggcagcaga cacagatgta gagaactctc cccaacacaa
      841 ggccaagagg cataaaaaga aaaagcgtgt ggaagcagag aggggccctg tggccaagaa
      901 gagagaccga gcagagctgc agcctggagg ccccagtgag gacgagtgtt ccgatgcctc
      961 tgtcgaagct gcagaagatt gtgtacaaac accagacatc caggatgatg tcccaaagcc
     1021 caagaagagg aaagcaaaga aaaagctgca aaggccagaa ggagtagaaa tagacgccac
     1081 actagacaga gcaccggtga aaaagaagaa gaagaaagtt tccagataac ttgtggcctc
     1141 caaccactca actgtcagca cactgcaggg cctgaagtga gagcacggcg aagcccaggt
     1201 ggctcagcat cttttaacat gcccacaggt tgctgcttct acgcaccaca tttccacatt
     1261 tcccccaggt caccttccta ggagaactga tttgaatgtt ccagatcatg tctttcaata
     1321 aataaaataa cttttaataa acaaatagat tcttttttaa
//
