LOCUS       NM_026880               2367 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus PTEN induced putative kinase 1 (Pink1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_026880 XM_916844 XM_924516 XM_924519 XM_924521
VERSION     NM_026880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Longo,M., Bishnu,A., Risiglione,P., Montava-Garriga,L., Cuenco,J.,
            Sakamoto,K., MacKintosh,C. and Ganley,I.G.
  TITLE     Opposing roles for AMPK in regulating distinct mitophagy pathways
  JOURNAL   Mol Cell 84 (22), 4350-4367 (2024)
   PUBMED   39532100
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Qiao,Y., Kou,J., Tian,Y., Ma,W., Yu,Y., Pang,J., Pei,Y., Zhang,Y.,
            Ye,B., Xie,Z., Liu,J., Wang,Z., Wang,L., Gao,X., Ma,N. and Zhang,Y.
  TITLE     Subcellular localization and function analysis of PINK1 mitron in
            PD progression: Mitron modulates mitochondrial morphology to
            regulate neuronal death
  JOURNAL   J Biol Chem 300 (10), 107773 (2024)
   PUBMED   39276929
  REMARK    GeneRIF: Subcellular localization and function analysis of PINK1
            mitron in PD progression: Mitron modulates mitochondrial morphology
            to regulate neuronal death.
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Richardson,K.K., Adam,G.O., Ling,W., Warren,A.,
            Marques-Carvalho,A., Thostenson,J.D., Krager,K., Aykin-Burns,N.,
            Byrum,S.D., Almeida,M. and Kim,H.N.
  TITLE     Mitochondrial protein deacetylation by SIRT3 in osteoclasts
            promotes bone resorption with aging in female mice
  JOURNAL   Mol Metab 88, 102012 (2024)
   PUBMED   39154858
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Watzlawik,J.O., Hou,X., Richardson,T., Lewicki,S.L., Siuda,J.,
            Wszolek,Z.K., Cook,C.N., Petrucelli,L., DeTure,M., Dickson,D.W.,
            Antico,O., Muqit,M.M.K., Fishman,J.B., Pirani,K., Kumaran,R.,
            Polinski,N.K., Fiesel,F.C. and Springer,W.
  TITLE     Development and characterization of phospho-ubiquitin antibodies to
            monitor PINK1-PRKN signaling in cells and tissue
  JOURNAL   Autophagy 20 (9), 2076-2091 (2024)
   PUBMED   38802071
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Wu,W., Jia,H., Chen,S., Ma,X., Zhou,S., Qiu,L., Wu,X., Li,P.,
            Chu,H. and Zhang,G.
  TITLE     Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2
            macrophage polarization and activating PINK1-mediated mitophagy
  JOURNAL   Mol Med 30 (1), 72 (2024)
   PUBMED   38822247
  REMARK    GeneRIF: Inhibition of OGG1 ameliorates pulmonary fibrosis via
            preventing M2 macrophage polarization and activating PINK1-mediated
            mitophagy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Zhou,H., Falkenburger,B.H., Schulz,J.B., Tieu,K., Xu,Z. and
            Xia,X.G.
  TITLE     Silencing of the Pink1 gene expression by conditional RNAi does not
            induce dopaminergic neuron death in mice
  JOURNAL   Int J Biol Sci 3 (4), 242-250 (2007)
   PUBMED   17389931
  REMARK    GeneRIF: A lack of PINK1 gene function is insufficient to cause
            dopaminergic neuron death in mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Taymans,J.M., Van den Haute,C. and Baekelandt,V.
  TITLE     Distribution of PINK1 and LRRK2 in rat and mouse brain
  JOURNAL   J Neurochem 98 (3), 951-961 (2006)
   PUBMED   16771836
  REMARK    GeneRIF: PINK1 mRNA abundance is rather uniform throughout the
            different brain regions with expression in cortex, striatum,
            thalamus, brainstem and cerebellum.
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Li,L., He,F., Litofsky,N.S., Recht,L.D. and Ross,A.H.
  TITLE     Profiling of genes expressed by PTEN haploinsufficient neural
            precursor cells
  JOURNAL   Mol Cell Neurosci 24 (4), 1051-1061 (2003)
   PUBMED   14697668
  REMARK    GeneRIF: PTEN +/- and PTEN +/+ mice weres compared in
            subventricular zone (SVZ) precursor cells. Using DNA microarrays,
            the expression profiles of PTEN +/+ and PTEN +/- cells and
            identified 91 differentially expressed genes in PTEN +/- precursor
            cells.
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Nakajima,A., Kataoka,K., Hong,M., Sakaguchi,M. and Huh,N.H.
  TITLE     BRPK, a novel protein kinase showing increased expression in mouse
            cancer cell lines with higher metastatic potential
  JOURNAL   Cancer Lett 201 (2), 195-201 (2003)
   PUBMED   14607334
REFERENCE   10 (bases 1 to 2367)
  AUTHORS   Unoki,M. and Nakamura,Y.
  TITLE     Growth-suppressive effects of BPOZ and EGR2, two genes involved in
            the PTEN signaling pathway
  JOURNAL   Oncogene 20 (33), 4457-4465 (2001)
   PUBMED   11494141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX238874.1 and BC067066.1.
            
            On Feb 27, 2007 this sequence version replaced NM_026880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067066.1, AB053476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CX238874.1         16-47
            33-2367             BC067066.1         1-2335
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.14 cM"
     gene            1..2367
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /note="PTEN induced putative kinase 1"
                     /db_xref="GeneID:68943"
                     /db_xref="MGI:MGI:1916193"
     exon            1..464
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1820
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase PINK1,
                     mitochondrial; PTEN-induced putative kinase protein 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PINK1,
                     mitochondrial precursor"
                     /protein_id="NP_081156.2"
                     /db_xref="CCDS:CCDS18825.1"
                     /db_xref="GeneID:68943"
                     /db_xref="MGI:MGI:1916193"
                     /translation="MAVRQALGRGLQLGRALLLRFAPKPGPLFGWGKPGPAAAWGRGE
                     RPGQVVSPGAQPRPVGLPLPDRYRFFRQSVAGLAARIQRQFMVRARGGAGPCGRAVFL
                     AFGLGLGLIEEKQAEGRRAASACQEIQAIFTQKTKRVSDPLDTRCWQGFRLEDYLIGQ
                     AIGKGCNAAVYEATMPTLPQHLEKAKHLGLIGKGPDVVLKGADGEQAPGTPTFPFAIK
                     MMWNISAGSSSEAILSKMSQELVPASRVALAGEYGAVTYRRSRDGPKQLAPHPNIIRV
                     FRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQTPS
                     SRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFGCCLADQH
                     VGLRLPFNSSSVERGGNGSLMAPEVSTAHSGPSAVIDYSKADTWAVGAIAYEIFGLAN
                     PFYGQGSAHLESRSYQEAQLPEMPESVPPEARRLVRSLLQREASKRPSARLAANVLHL
                     SLWGEHLLALKNLKLDKMIAWLLQQSAATLLADRLREKSCVETKLQMLFLANLECEAL
                     CQAALLLSSWRAAP"
     exon            465..749
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            750..850
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1033
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1197
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1325
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1562
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..2367
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /note="hexamer: ATTAAA"
     polyA_site      2367
                     /gene="Pink1"
                     /gene_synonym="1190006F07Rik; BRPK; mFLJ00387"
                     /note="major polyA site"
ORIGIN      
        1 acaggcgccg cccccgaagt ttgttgttgt cccagacgtt tgtggcggtg gcagctggct
       61 ccggtcaccg cgccaccatg gcggtgcgac aggcactggg ccgaggcctg cagctgggtc
      121 gggcgctgct gctgcgcttc gcgcccaagc ccggcccgct gttcggctgg gggaagcccg
      181 gccccgcggc ggcctggggc cgcggagagc gcccaggcca ggtcgtaagc cccggagcac
      241 agcctcggcc ggtcgggctc cccctcccgg accgctaccg cttcttccgc cagtcggtag
      301 ctgggctggc ggcgcggatc cagaggcagt tcatggtgcg ggcccggggc ggcgcaggcc
      361 cttgcggccg agcggtcttc ctggccttcg ggctggggct ggggctgatc gaggagaagc
      421 aggcggaagg ccggagggcc gcctcggcct gtcaggagat ccaggcaatt tttacacaga
      481 aaaccaagcg cgtgtctgac ccactggaca ctcgatgctg gcagggcttc cgtctggagg
      541 attatctgat agggcaagcc attggcaagg gttgcaatgc cgctgtgtat gaagccacca
      601 tgcccacgct gccccagcac ctggaaaagg ccaaacacct tggccttata ggaaagggcc
      661 cggatgtcgt cctgaaggga gcagacgggg agcaggctcc agggactccc acctttccct
      721 ttgccatcaa gatgatgtgg aatatctcgg caggttcctc cagcgaagcc atcttaagca
      781 aaatgagcca ggagctggtc ccggcaagcc gcgtggcttt ggctggagag tatggagcag
      841 ttacttacag aagatccaga gatggtccca agcagcttgc cccacaccct aacatcatcc
      901 gggttttccg cgccttcacc tcatctgtgc ccctcctgcc gggggccctg gctgactatc
      961 ctgatatgct gcccccacac tactacccag aaggcctggg ccacggtcgc acactgttcc
     1021 tcgttatgaa gaactacccc tgtaccctgc gccagtacct tgaggagcag actcccagtt
     1081 ctcgcctggc taccatgatg accttgcagt tgctggaggg cgtggaccat ctggttcagc
     1141 agggcattgc ccatcgggat ctcaagtccg acaacatcct tgtggagtgg gactcagatg
     1201 gctgtccctg gctagtgatc tcagactttg gctgctgcct ggctgaccag catgttggcc
     1261 tgcggctgcc tttcaacagc tccagtgtag agcgtggtgg caatggctcc ctgatggccc
     1321 ctgaggtgtc cacagcccat tctggcccca gtgcggtaat tgactacagc aaagccgata
     1381 cctgggctgt gggggccatc gcctatgaaa tctttgggct tgccaatccc ttctatggcc
     1441 aaggcagtgc ccacctcgag agccgcagct accaggaagc tcagctgcct gagatgcctg
     1501 agtcggtgcc tccagaggca agacggctgg tgaggtcact gctccagcga gaggccagca
     1561 agagaccgtc tgcacgctta gctgcaaatg tgctgcactt aagcctctgg ggcgagcatc
     1621 ttctagccct gaagaacctg aaattggaca agatgatcgc ctggctcttg cagcagtcag
     1681 cagccactct gctggctgac aggctgagag agaagagctg cgtggagaca aagctgcaga
     1741 tgctgtttct ggctaacctg gagtgtgagg ctctctgcca ggcagccctc ctcctctctt
     1801 cctggagggc agccccatga tggctctgtg ctccagttac taaaagacta aggggcatct
     1861 gtgtcctgat gtcatgacag tatacgaagg ctgaagaagg tggcttggct gggtgggcag
     1921 gagtcagggg acaagctgga gtagagggag gggctggtca gccttgggct cagcaaatgg
     1981 gaagaacagc cttgaacagc tcaggaggga gagaggcact acctgtgccc gtccagttag
     2041 gttcttgggc agaattaaga catcaggcca gaccaggagt tggtaagcta tagagggcca
     2101 gacagggaat gaagtagttg taatgactaa cctatcactg aggcaaaggc caagcaagca
     2161 ctgcagtgag gccaacactg aactttgctt gtcgtcaata agttctgctc atttttccca
     2221 accacttaga aatgcaaaaa cataggttta atttgtaagc agcaaccagc atggctcata
     2281 gtcaaattta ccaattcctg ggctaaatgc attctttatg tctaactctt taaagatgcg
     2341 agcattaaag acagtctcca tgccaaa
//
