LOCUS       NM_027181                468 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus peptidyl-prolyl cis/trans isomerase, NIMA-interacting,
            4 (parvulin) (Pin4), transcript variant 1, mRNA.
ACCESSION   NM_027181 XM_135990 XM_906695 XM_983941
VERSION     NM_027181.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Zhang,J., Nakatsu,Y., Shinjo,T., Guo,Y., Sakoda,H., Yamamotoya,T.,
            Otani,Y., Okubo,H., Kushiyama,A., Fujishiro,M., Fukushima,T.,
            Tsuchiya,Y., Kamata,H., Iwashita,M., Nishimura,F., Katagiri,H.,
            Takahashi,S., Kurihara,H., Uchida,T. and Asano,T.
  TITLE     Par14 protein associates with insulin receptor substrate 1 (IRS-1),
            thereby enhancing insulin-induced IRS-1 phosphorylation and
            metabolic actions
  JOURNAL   J Biol Chem 288 (28), 20692-20701 (2013)
   PUBMED   23720771
  REMARK    GeneRIF: Data indicate the association of Par14 with insulin
            receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing
            both as well as endogenously in the mouse liver.
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Surmacz,T.A., Bayer,E., Rahfeld,J.U., Fischer,G. and Bayer,P.
  TITLE     The N-terminal basic domain of human parvulin hPar14 is responsible
            for the entry to the nucleus and high-affinity DNA-binding
  JOURNAL   J Mol Biol 321 (2), 235-247 (2002)
   PUBMED   12144781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807784.11.
            
            On Jan 24, 2023 this sequence version replaced NM_027181.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119355.1, AW012413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AL807784.11        64345-64440
            97-170              AL807784.11        66544-66617
            171-290             AL807784.11        71893-72012
            291-468             AL807784.11        72369-72546
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 45.14 cM"
     gene            1..468
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /note="peptidyl-prolyl cis/trans isomerase,
                     NIMA-interacting, 4 (parvulin)"
                     /db_xref="GeneID:69713"
                     /db_xref="MGI:MGI:1916963"
     exon            1..96
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..449
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase NIMA-interacting 4;
                     PPIase Pin4; parvulin-14; rotamase Pin4; peptidyl-prolyl
                     cis-trans isomerase Pin4; protein (peptidyl-prolyl
                     cis/trans isomerase) NIMA-interacting, 4 (parvulin)"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase
                     NIMA-interacting 4 isoform 1"
                     /protein_id="NP_081457.1"
                     /db_xref="CCDS:CCDS41082.1"
                     /db_xref="GeneID:69713"
                     /db_xref="MGI:MGI:1916963"
                     /translation="MPPKGKSGSGKGGKGGAASGSDSADKKSQGPKGGGNAVKVRHIL
                     CEKHGKIMEAMEKLKSGMRFSEVATQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALP
                     VSGMDKPVFTDPPVKTKFGYHIIMVEGRK"
     exon            97..170
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /inference="alignment:Splign:2.1.0"
     exon            171..290
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /inference="alignment:Splign:2.1.0"
     exon            291..468
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      445..450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /note="hexamer: AATAAA"
     polyA_site      468
                     /gene="Pin4"
                     /gene_synonym="2410002I22Rik; EPVH; Par14"
                     /note="major polyA site"
ORIGIN      
        1 ccttttgcta gcaccggaac agttgccgga gagttcatcc gccagcttaa gagatgccgc
       61 cgaaggggaa aagtggttct ggaaaaggag ggaaaggagg tgcagcctct gggagtgaca
      121 gtgctgacaa gaagtctcag ggtcctaaag gtggtggcaa tgcagtaaag gtcagacaca
      181 ttctgtgtga aaaacatggg aaaatcatgg aagccatgga aaagttaaag tctgggatga
      241 gattcagtga agtggccaca caatatagtg aagataaagc cagacaaggg ggtgacttgg
      301 gttggatgac cagaggatcc atggtggggc catttcaaga agcagcgttt gccttgcctg
      361 taagtgggat ggataagcct gtgtttacag acccaccagt taagacaaaa tttggatatc
      421 atattattat ggttgaaggg agaaaataaa atcacatgaa agactgac
//
