LOCUS       NM_023371                948 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus peptidyl-prolyl cis/trans isomerase, NIMA-interacting
            1 (Pin1), transcript variant 1, mRNA.
ACCESSION   NM_023371
VERSION     NM_023371.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Fan,G., Li,G., Li,L. and Da,Y.
  TITLE     Pin1 maintains the effector program of pathogenic Th17 cells in
            autoimmune neuroinflammation
  JOURNAL   J Autoimmun 147, 103262 (2024)
   PUBMED   38833897
  REMARK    GeneRIF: Pin1 maintains the effector program of pathogenic Th17
            cells in autoimmune neuroinflammation.
REFERENCE   2  (bases 1 to 948)
  AUTHORS   Nakatsu,Y., Matsunaga,Y., Nakanishi,M., Yamamotoya,T., Sano,T.,
            Kanematsu,T. and Asano,T.
  TITLE     Prolyl isomerase Pin1 in skeletal muscles contributes to systemic
            energy metabolism and exercise capacity through regulating SERCA
            activity
  JOURNAL   Biochem Biophys Res Commun 715, 150001 (2024)
   PUBMED   38676996
  REMARK    GeneRIF: Prolyl isomerase Pin1 in skeletal muscles contributes to
            systemic energy metabolism and exercise capacity through regulating
            SERCA activity.
REFERENCE   3  (bases 1 to 948)
  AUTHORS   Chen,Y., Pang,J., Ye,L., Zhang,Z., Kang,J., Qiu,Z., Lin,N. and
            Liu,H.
  TITLE     Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced
            Failure of Neural Tube Closure
  JOURNAL   Int J Mol Sci 25 (11), 5588 (2024)
   PUBMED   38891776
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 948)
  AUTHORS   Qiu,D., Liu,T. and Qianping,W.
  TITLE     Upregulation of Pin1 contributes to alleviation of cognitive
            dysfunction in diabetic mice
  JOURNAL   Brain Behav 13 (12), e3336 (2023)
   PUBMED   37990376
  REMARK    GeneRIF: Upregulation of Pin1 contributes to alleviation of
            cognitive dysfunction in diabetic mice.
REFERENCE   5  (bases 1 to 948)
  AUTHORS   Hoshino,Y. and Uchida,T.
  TITLE     Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse
            Oocytes
  JOURNAL   Cells 11 (23), 3772 (2022)
   PUBMED   36497033
  REMARK    GeneRIF: Prolyl Isomerase, Pin1, Controls Meiotic Progression in
            Mouse Oocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 948)
  AUTHORS   Zheng,H., You,H., Zhou,X.Z., Murray,S.A., Uchida,T., Wulf,G.,
            Gu,L., Tang,X., Lu,K.P. and Xiao,Z.X.
  TITLE     The prolyl isomerase Pin1 is a regulator of p53 in genotoxic
            response
  JOURNAL   Nature 419 (6909), 849-853 (2002)
   PUBMED   12397361
  REMARK    GeneRIF: The prolyl isomerase Pin1 is a regulator of p53 in
            genotoxic response
            Erratum:[Nature 2002 Nov 28;420(6914):445]
REFERENCE   7  (bases 1 to 948)
  AUTHORS   Liou,Y.C., Ryo,A., Huang,H.K., Lu,P.J., Bronson,R., Fujimori,F.,
            Uchida,T., Hunter,T. and Lu,K.P.
  TITLE     Loss of Pin1 function in the mouse causes phenotypes resembling
            cyclin D1-null phenotypes
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1335-1340 (2002)
   PUBMED   11805292
REFERENCE   8  (bases 1 to 948)
  AUTHORS   Ryo,A., Nakamura,M., Wulf,G., Liou,Y.C. and Lu,K.P.
  TITLE     Pin1 regulates turnover and subcellular localization of
            beta-catenin by inhibiting its interaction with APC
  JOURNAL   Nat Cell Biol 3 (9), 793-801 (2001)
   PUBMED   11533658
REFERENCE   9  (bases 1 to 948)
  AUTHORS   Fujimori,F., Takahashi,K., Uchida,C. and Uchida,T.
  TITLE     Mice lacking Pin1 develop normally, but are defective in entering
            cell cycle from G(0) arrest
  JOURNAL   Biochem Biophys Res Commun 265 (3), 658-663 (1999)
   PUBMED   10600477
REFERENCE   10 (bases 1 to 948)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003931.1 and AK054045.1.
            
            On Jun 19, 2018 this sequence version replaced NM_023371.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY704185.1, AK003931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK003931.1         2-13
            13-948              AK054045.1         2-937
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.6 cM"
     gene            1..948
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /note="peptidyl-prolyl cis/trans isomerase,
                     NIMA-interacting 1"
                     /db_xref="GeneID:23988"
                     /db_xref="MGI:MGI:1346036"
     exon            1..80
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /inference="alignment:Splign:2.1.0"
     exon            81..299
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /inference="alignment:Splign:2.1.0"
     exon            300..410
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /inference="alignment:Splign:2.1.0"
     exon            411..948
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      909..914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /note="hexamer: ATTAAA"
     polyA_site      926
                     /gene="Pin1"
                     /gene_synonym="0610025L01Rik; D9Bwg1161e"
                     /note="major polyA site"
ORIGIN      
        1 aggcgctgcg gcaggaggga agatggcgga cgaggagaag ctgccaccag gctgggagaa
       61 gcgtatgagt cgcagctcag gccgggtgta ctacttcaat cacatcacca acgccagcca
      121 gtgggagcgg cccagcggcg gcagcactgt tggaggcagc agcaagaatg gccagggtga
      181 gcctgccaag gtgcgctgct cacatctgct ggtgaagcac agccagtctc ggaggccctc
      241 atcctggcgg caggaaaaga tcaccaggag caaggaggag gccctggagc tcatcaatgg
      301 ctatatccag aagattaagt caggagagga agactttgaa tctctggcct cacagttcag
      361 tgattgcagc tctgccaaag ccaggggaga cctgggtccc ttcagcagag gtcagatgca
      421 gaaaccattt gaggatgcgt cgtttgctct acggacaggg gagatgagtg ggcccgtgtt
      481 cacggactcg ggcatccata tcatcctgcg cacagaatga gggcaggcac ctggccagcc
      541 tgctctggct gccacacagc ccacggatgc ccttcctgct actgtcacac agtatttatt
      601 gttcctaaaa tgactgggag gggctctgag catcccgctc cctgtttgcc cctattcggg
      661 gctgtcctag ccaggctcct tctggaggaa ttgacttcag aagggcagtg gggatgggga
      721 ggcccccagg ctcagggggt cagaggtgac ctgatccccc aggtctcaga ggcaggcagg
      781 agggccttct ttcttgttag ttatatgctc cattcgttcc tctgttcagt tgcaaaaagc
      841 agacgctcca tacctggcgg tgcagcaact cagcctcagg gtgcagtgca gcaccctacg
      901 caccttccat taaatctgga accactggtt ggtggtcctg tatcatta
//
