LOCUS       NM_145478               2419 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus proviral integration site 3 (Pim3), mRNA.
ACCESSION   NM_145478 XM_001003705 XM_001003713
VERSION     NM_145478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   Marayati,R., Julson,J., Bownes,L.V., Quinn,C.H., Stafman,L.L.,
            Beierle,A.M., Markert,H.R., Hutchins,S.C., Stewart,J.E.,
            Crossman,D.K., Hjelmeland,A.B., Mroczek-Musulman,E. and
            Beierle,E.A.
  TITLE     PIM3 kinase promotes tumor metastasis in hepatoblastoma by
            upregulating cell surface expression of chemokine receptor cxcr4
  JOURNAL   Clin Exp Metastasis 39 (6), 899-912 (2022)
   PUBMED   36315303
  REMARK    GeneRIF: PIM3 kinase promotes tumor metastasis in hepatoblastoma by
            upregulating cell surface expression of chemokine receptor cxcr4.
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Ebeid,D.E., Firouzi,F., Esquer,C.Y., Navarrete,J.M., Wang,B.J.,
            Gude,N.A. and Sussman,M.A.
  TITLE     PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit
            Protein Expression
  JOURNAL   Cells 9 (9), 2001 (2020)
   PUBMED   32878131
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2419)
  AUTHORS   Zan,T., Piao,L., Yang,X., Gu,Y. and Liu,B.
  TITLE     Downregulation of microRNA-124 prevents the development of acute
            liver failure through the upregulation of PIM-3
  JOURNAL   Exp Physiol 105 (1), 108-119 (2020)
   PUBMED   31628693
  REMARK    GeneRIF: Downregulation of microRNA-124 prevents the development of
            acute liver failure through the upregulation of PIM-3.
REFERENCE   4  (bases 1 to 2419)
  AUTHORS   Daenthanasanmak,A., Wu,Y., Iamsawat,S., Nguyen,H.D., Bastian,D.,
            Zhang,M., Sofi,M.H., Chatterjee,S., Hill,E.G., Mehrotra,S.,
            Kraft,A.S. and Yu,X.Z.
  TITLE     PIM-2 protein kinase negatively regulates T cell responses in
            transplantation and tumor immunity
  JOURNAL   J Clin Invest 128 (7), 2787-2801 (2018)
   PUBMED   29781812
REFERENCE   5  (bases 1 to 2419)
  AUTHORS   Liu,J., Qu,X., Shao,L., Hu,Y., Yu,X., Lan,P., Guo,Q., Han,Q.,
            Zhang,J. and Zhang,C.
  TITLE     Pim-3 enhances melanoma cell migration and invasion by promoting
            STAT3 phosphorylation
  JOURNAL   Cancer Biol Ther 19 (3), 160-168 (2018)
   PUBMED   29370558
  REMARK    GeneRIF: Study found that by promoting the phosphorylation of Stat3
            Pim-3 induced the expression of Slug, Snail, and Zeb1, which
            enhanced epithelial-mesenchymal transition-related changes and
            induced melanoma migration and invasion. Exploration of the
            mechanism revealed that Pim-3 bound directly to Stat3 and promoted
            its phosphorylation.
REFERENCE   6  (bases 1 to 2419)
  AUTHORS   Aksoy,I., Sakabedoyan,C., Bourillot,P.Y., Malashicheva,A.B.,
            Mancip,J., Knoblauch,K., Afanassieff,M. and Savatier,P.
  TITLE     Self-renewal of murine embryonic stem cells is supported by the
            serine/threonine kinases Pim-1 and Pim-3
  JOURNAL   Stem Cells 25 (12), 2996-3004 (2007)
   PUBMED   17717068
  REMARK    GeneRIF: Pim-3 kinase has a novel role in the control of
            self-renewal of embryonic stem cells.
REFERENCE   7  (bases 1 to 2419)
  AUTHORS   Macdonald,A., Campbell,D.G., Toth,R., McLauchlan,H., Hastie,C.J.
            and Arthur,J.S.
  TITLE     Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3
            binding and dissociation from Bcl-XL
  JOURNAL   BMC Cell Biol 7, 1 (2006)
   PUBMED   16403219
  REMARK    GeneRIF: All three Pim kinase family members predominantly
            phosphorylate Bad on Ser112 and in addition are capable of
            phosphorylating Bad on multiple sites associated with the
            inhibition of the pro-apoptotic function of Bad in HEK-293 cells
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2419)
  AUTHORS   Mikkers,H., Nawijn,M., Allen,J., Brouwers,C., Verhoeven,E.,
            Jonkers,J. and Berns,A.
  TITLE     Mice deficient for all PIM kinases display reduced body size and
            impaired responses to hematopoietic growth factors
  JOURNAL   Mol Cell Biol 24 (13), 6104-6115 (2004)
   PUBMED   15199164
REFERENCE   9  (bases 1 to 2419)
  AUTHORS   Eichmann,A., Yuan,L., Breant,C., Alitalo,K. and Koskinen,P.J.
  TITLE     Developmental expression of pim kinases suggests functions also
            outside of the hematopoietic system
  JOURNAL   Oncogene 19 (9), 1215-1224 (2000)
   PUBMED   10713710
REFERENCE   10 (bases 1 to 2419)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Tocco,G., Marcheselli,V.L.,
            Bazan,N.G., Baudry,M. and Herschman,H.R.
  TITLE     KID-1, a protein kinase induced by depolarization in brain
  JOURNAL   J Biol Chem 273 (26), 16535-16543 (1998)
   PUBMED   9632723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC117700.22.
            
            On Nov 17, 2006 this sequence version replaced NM_145478.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017621.1, AK168014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               AC117700.22        41110-41668         c
            560-669             AC117700.22        40915-41024         c
            670-720             AC117700.22        40771-40821         c
            721-1090            AC117700.22        40314-40683         c
            1091-1267           AC117700.22        39370-39546         c
            1268-2419           AC117700.22        38136-39287         c
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.36 cM"
     gene            1..2419
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /note="proviral integration site 3"
                     /db_xref="GeneID:223775"
                     /db_xref="MGI:MGI:1355297"
     exon            1..559
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..669
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..720
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1090
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1267
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2419
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /note="hexamer: ATTAAA"
     polyA_site      2415
                     /gene="Pim3"
                     /gene_synonym="Kid1"
                     /note="major polyA site"
ORIGIN      
        1 gcagggcggg tgagagcgcc gtgaaagccg cggaacgccg tgcacctccg cgactctact
       61 acggcaagct agtccggacg ggtcgtcgtc cccgcgcgcc accagccctt ggtgaaacga
      121 cagggagcgt ccggcttccc cagcaccgcc ctgcgagact caaaacagcc acaccgcaaa
      181 gcgagcctcg ggcggaagga ggcggagctt caggcggccc cgcctccgcg gaaggataca
      241 catctccgtg gtccaaaacc ccggggcgag gcggccgggg cgtgtgagct gctcggccag
      301 ctgccgtcta cgcgctttcg cgcggccacc gggcaactgc gccgcgcggc tgccccgctg
      361 agcgctcggc ctcggggccg tgggatccgc cgcgctgtct gcggtcagga agaccgccct
      421 cccgcgtcct tgccggacgg gtcagaggcg gcaccgcacg cgaggccacc cgcgatgctg
      481 ctgtccaagt tcggctccct ggcgcacctc tgcgggcctg gcggcgtgga ccacctccca
      541 gtgaagatcc tacagccagc caaggctgac aaggagagct tcgagaaggt gtaccaggtg
      601 ggcgccgtgc tgggcagcgg cggcttcggc acggtctacg cgggcagccg catcgccgac
      661 ggactcccgg tggctgtgaa gcacgtggtg aaggagcggg tgaccgagtg gggcagtctc
      721 ggcggagtgg ccgtgcccct ggaggtggtg ctgctgcgca aggtgggcgc ggcgggcggc
      781 gcgcgcggcg tcatccgctt gctggactgg ttcgagcggc ccgacggctt cttgttggtg
      841 ctggagcgac ccgagccggc acaggacctc ttcgacttca tcactgaacg aggcgccctg
      901 gacgagccgc tggcgcgtcg cttcttcgcg caggtgcttg ccgctgtgcg gcactgccac
      961 aattgtgggg tcgtgcaccg cgacatcaag gacgagaacc tgctggtgga cctgcgctcg
     1021 ggagagctga agctcatcga cttcggctcg ggcgcggtgc tcaaggacac ggtctacact
     1081 gactttgatg gcacccgtgt gtacagcccc ccagagtgga tccgatatca ccgatatcac
     1141 gggcggtctg ccactgtgtg gtctctgggt gtactgctct acgacatggt gtgtggggac
     1201 attccctttg agcaggatga ggagatcttg cgcggcaggc tctttttccg gaggagggtc
     1261 tccccagagt gccagcagct tattgagtgg tgtctctccc tgaggccctc agagaggccc
     1321 tccctggacc aaattgctgc ccacccctgg atgctgggga cagaggggag cgttccagag
     1381 aactgtgacc ttcggctttg tgccctggat actgacgacg gagccagtac cacttccagc
     1441 agtgagagct tgtgaggagg agaaggggcc tgggctcggc ctagccagcg ctctcccaga
     1501 attgaacact ttctgcctgg gatgtctgct gcaaaagcag tgacctctga cccctggtga
     1561 cctttgctct cggcaccggg cctgtttcct ttgctttgag tgcctttttg aacgctgctc
     1621 cacagggcct gggttttctt gagctcttct gtccaaagat ggctgcgggc taagcaaggt
     1681 cctgccctgg gtggatactt gaaccagaga tcccgaccct gctgctccat ctcaggaggc
     1741 agccttcctg accaagtgtg tttgacatgg agcgccctgt ggtgcccacc tccaaccctc
     1801 cagtctcctg gtgttcatct gggcatgtct gcacaagcaa tgcaacgctg ggccactgct
     1861 gcccgtctgc ctccccggca cggcacggct ccgcacgcaa cctaagcgtg ccaccacggt
     1921 ctcttattta tggtgtgatc accctggagg gcgcccccgc cctgctgggg ctatttattg
     1981 tttaatttat ttgctgaggt tcctccaagc aaccaccttc tccaggcccc tggggtgttg
     2041 aaagtcaaat gtggctgttg agtccacaga cccccatcct aattcctgca cctggaggag
     2101 ttccccaacc cccgtgtttg cgggaggaag catttgtaca gtggctaatt taaggggagt
     2161 gggagaccct gtcaccctga gcactctgcg ctggggaggg gtttaaatta ttgaccttgt
     2221 acagtctgct tgctggctct gaaagctggg gttgggggac agagtctcaa gcccttaatt
     2281 tattttagca gctgtgtttc tgtgaccctg gtgtgactaa gcatcagggg tggggttgta
     2341 taagttcaaa agtgtgaaat gtctgaagat catatttttt atacaggtat ttcaattaaa
     2401 tgttttggta tataatgga
//
