LOCUS       NM_138606               2054 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus proviral integration site 2 (Pim2), mRNA.
ACCESSION   NM_138606 NM_145736 NM_145737 XM_977259
VERSION     NM_138606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Htun,T.S., Tanaka,H., Singh,S.K., Diez,D. and Akira,S.
  TITLE     Regnase-1 D141N mutation induces CD4+ T cell-mediated lung
            granuloma formation via upregulation of Pim2
  JOURNAL   Int Immunol 36 (10), 497-516 (2024)
   PUBMED   38700370
  REMARK    GeneRIF: Regnase-1 D141N mutation induces CD4+ T cell-mediated lung
            granuloma formation via upregulation of Pim2.
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Wang,M., Fan,R., Jiang,J., Sun,F., Sun,Y., Wang,Q., Jiang,A., Yu,Z.
            and Yang,T.
  TITLE     PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing
            Glycolysis and Fibrosis
  JOURNAL   Reprod Sci 30 (9), 2692-2702 (2023)
   PUBMED   37059967
  REMARK    GeneRIF: PIM2 Promotes the Development of Ovarian Endometriosis by
            Enhancing Glycolysis and Fibrosis.
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Ma,S., Han,J., Li,Z., Xiao,S., Zhang,J., Yan,J., Tang,T., Barr,T.,
            Kraft,A.S., Caligiuri,M.A. and Yu,J.
  TITLE     An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated
            survival of natural killer cells
  JOURNAL   Sci Immunol 8 (81), eabn7993 (2023)
   PUBMED   36897958
  REMARK    GeneRIF: An XBP1s-PIM-2 positive feedback loop controls
            IL-15-mediated survival of natural killer cells.
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Lu,C., Qiao,P., Fu,R., Wang,Y., Lu,J., Ling,X., Liu,L., Sun,Y.,
            Ren,C. and Yu,Z.
  TITLE     Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and
            cell proliferation in endometriosis
  JOURNAL   Cell Death Dis 13 (9), 790 (2022)
   PUBMED   36109523
  REMARK    Erratum:[Cell Death Dis. 2024 Jul 2;15(7):469. doi:
            10.1038/s41419-024-06613-w.. PMID: 38956061]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Heo,S.C., You,J.C., Jung,S., Kim,Y.N., Shin,S.H., Lee,J.Y. and
            Kim,H.J.
  TITLE     Pim-2 regulates bone resorptive activity of osteoclasts via
            V-ATPase a3 isoform expression in periodontal disease
  JOURNAL   J Cell Physiol 237 (8), 3381-3393 (2022)
   PUBMED   35696529
  REMARK    GeneRIF: Pim-2 regulates bone resorptive activity of osteoclasts
            via V-ATPase a3 isoform expression in periodontal disease.
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Allen,J.D., Verhoeven,E., Domen,J., van der Valk,M. and Berns,A.
  TITLE     Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy
            with c-myc
  JOURNAL   Oncogene 15 (10), 1133-1141 (1997)
   PUBMED   9294606
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Scheijen,B., Jonkers,J., Acton,D. and Berns,A.
  TITLE     Characterization of pal-1, a common proviral insertion site in
            murine leukemia virus-induced lymphomas of c-myc and Pim-1
            transgenic mice
  JOURNAL   J Virol 71 (1), 9-16 (1997)
   PUBMED   8985317
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Zornig,M., Schmidt,T., Karsunky,H., Grzeschiczek,A. and Moroy,T.
  TITLE     Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell
            lymphomagenesis by reducing the requirements for IL-2
  JOURNAL   Oncogene 12 (8), 1789-1801 (1996)
   PUBMED   8622900
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   van der Lugt,N.M., Domen,J., Verhoeven,E., Linders,K., van der
            Gulden,H., Allen,J. and Berns,A.
  TITLE     Proviral tagging in E mu-myc transgenic mice lacking the Pim-1
            proto-oncogene leads to compensatory activation of Pim-2
  JOURNAL   EMBO J 14 (11), 2536-2544 (1995)
   PUBMED   7781606
  REMARK    GeneRIF: Invitro transcription/translation, site-directed
            mutagenesis, and immunoprecipitation studies described here, show
            that translation initiates at three different start sites, with the
            two major upstream sites initiating at non-AUG (CUG) codons.
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Breuer,M.L., Cuypers,H.T. and Berns,A.
  TITLE     Evidence for the involvement of pim-2, a new common proviral
            insertion site, in progression of lymphomas
  JOURNAL   EMBO J 8 (3), 743-748 (1989)
   PUBMED   2721500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L41495.1 and BC022727.1.
            
            On or before Mar 21, 2007 this sequence version replaced
            NM_145736.1, NM_145737.2, NM_138606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41495.1, SRR1660817.176182.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 7781606
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-960               L41495.1           1-960
            961-2054            BC022727.1         502-1595
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.55 cM"
     gene            1..2054
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /note="proviral integration site 2"
                     /db_xref="GeneID:18715"
                     /db_xref="MGI:MGI:97587"
     exon            1..251
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1126
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /EC_number="2.7.11.1"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="serine/threonine-protein kinase pim-2"
                     /protein_id="NP_613072.1"
                     /db_xref="CCDS:CCDS29976.1"
                     /db_xref="GeneID:18715"
                     /db_xref="MGI:MGI:97587"
                     /translation="MARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPC
                     GLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGF
                     GTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIR
                     LLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGV
                     VHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHAL
                     PATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRP
                     SLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP"
     exon            252..361
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..412
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..785
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..962
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..2041
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="Pim2"
                     /gene_synonym="DXCch3; Pim-2"
                     /note="major polyA site"
ORIGIN      
        1 agtagcgttg gggctggcgc gcgcgacgaa tcttaacgct gcgccgtctg caggcgcttc
       61 cgggccgcca gattccctgc cttccaccct ggcgcccccc agccctggct ctccggccgc
      121 tctgccccgg gcatccacgc cctgcgggct cagcggattc agcgggctca atatacgcag
      181 cacctcctcc atgttgacca agcctctgca ggggcatcct tcgccccctg tgacccccac
      241 gcagcctcca ggaggcaagg atcgggcagc tttcgaggcc gaataccgac ttggccccct
      301 cctgggtaag ggaggctttg gcaccgtctt cgcgggacac cgcgtcacgg atagacgtca
      361 ggtggccatc aaagtaatct cccggaaccg tgtgctaggc tggtccaccg tgtcagactc
      421 agtcacctgc ccacttgagg ttgcgctgct gtggaaggtg ggtgaaggca atggccatcc
      481 gggtgtgata cgccttcttg actggttcga aacacccgaa ggcttcatgc tggtccttga
      541 gcggcctatg cctgctcagg atctcttcga ctatatcaca gagaaggggc cgctgggtga
      601 aagctgtagc cgcagcttct ttacccaagt cgtggcagct gtccagcact gccacgcccg
      661 tggagttgtc catcgggata tcaaggatga gaacatcctg atcgacctat gccggggttc
      721 cattaaactc attgattttg gttccggcgc cctgcttcac gatgagccgt acactgactt
      781 tgatgggaca agagtgtata gccctccaga gtggatctcg cgacaccagt accatgccct
      841 gccagcgacc gtctggtcac taggtgtcct actctatgac atggtctgtg gggacattcc
      901 cttcgagaga gaccaggaga ttctggaggc tgagctgcac ttccctgctc atgtctcccc
      961 agattgctgt gccctaatcc gccggtgcct ggcccctaaa ccctgctccc gaccctcact
     1021 ggaggagatt ctgctggacc cctggatgca atcaccagct gaagaaaagc ccatcaactc
     1081 ctccaaagga agccccaccc ccttgccctg gtccctgctt ccctagaccc agccaggctc
     1141 tctggttgga atcccatggt cacgctacag ggatagatgg acatctgttg acctggttat
     1201 acaggttgtt aaaaatccag tattactaag gtcagggaat agggatcagg ggtcagaaga
     1261 agatgatagc caagtctgcc cagttcctat cccaattctg ggaaggagct ctcctcccag
     1321 aacctgtggt ccctaatttg ggagggggag ttacttgttt cttgttctgt taaagatgtt
     1381 tatttggttg gattccttcc ctctgggccc taagattctt aatctgacat tgtagtccct
     1441 acactggcac ttcctatact accacaaacc acgtagacac ttagttcaaa tgctctcact
     1501 tgggcaaggg tgctttcctt aaaattaccc ccatccccag cagctcttta ggcaaagggc
     1561 cttaccctgg gatctcattc tgttgctgcc tgcctgcctt agcccagact tggtgattct
     1621 gggggaggta ctgctcatta attagttaat atcccacgct tccttccttt ttcttccttt
     1681 gtttggtgag gggaccctac tgttatccca agtgctctta ttccggtgag aagaacctca
     1741 cttccatgat ttgggaagga atgggagatg gacatcaccg gacaccacca gagactagga
     1801 tgggatggat ggttttgggg ggatgagatg gaggaaataa gtcttattgt tgttctcctg
     1861 gggtcccccc tttccaactt ttgctgcctc ctcctgagcc aggattgtcc agtggttgaa
     1921 atgtaaataa ttctgtactg gaggtggaga gcggcaagtg ccctcctgtc ccttctcccc
     1981 ctgcctggat tatttaaaaa gccatgtgtg gaaacctatt taataaataa tgaagtcaca
     2041 aaaaaaaaaa aaaa
//
