LOCUS       NM_008842               2665 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus proviral integration site 1 (Pim1), transcript variant
            1, mRNA.
ACCESSION   NM_008842 XM_991765
VERSION     NM_008842.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Yang,K., Yu,X., Guo,Z., Fang,Z., Zhang,H., Zhang,W., Liu,C., Ji,Y.,
            Dong,Z., Gu,Q., Yao,J. and Liu,C.
  TITLE     PIM1 alleviated liver oxidative stress and NAFLD by regulating the
            NRF2/HO-1/NQO1 pathway
  JOURNAL   Life Sci 349, 122714 (2024)
   PUBMED   38735366
  REMARK    GeneRIF: PIM1 alleviated liver oxidative stress and NAFLD by
            regulating the NRF2/HO-1/NQO1 pathway.
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Noura,M., Tomita,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation
  JOURNAL   Cancer Med 13 (13), e7445 (2024)
   PUBMED   38940430
  REMARK    GeneRIF: NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation.
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Lim,P.X., Zaman,M., Feng,W. and Jasin,M.
  TITLE     BRCA2 promotes genomic integrity and therapy resistance primarily
            through its role in homology-directed repair
  JOURNAL   Mol Cell 84 (3), 447-462 (2024)
   PUBMED   38244544
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Yu,H., Li,Q., Zhu,H., Liu,C., Chen,W. and Sun,L.
  TITLE     Mesenchymal stem cells attenuate systemic lupus erythematosus by
            inhibiting NLRP3 inflammasome activation through Pim-1 kinase
  JOURNAL   Int Immunopharmacol 126, 111256 (2024)
   PUBMED   37992447
  REMARK    GeneRIF: Mesenchymal stem cells attenuate systemic lupus
            erythematosus by inhibiting NLRP3 inflammasome activation through
            Pim-1 kinase.
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Li,Y., Shi,L., Zhao,F., Luo,Y., Zhang,M., Wu,X. and Zhu,J.
  TITLE     PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation
  JOURNAL   Cell Signal 113, 110969 (2024)
   PUBMED   37967691
  REMARK    GeneRIF: PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1
            activation.
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Ebersole,T., Lai,F. and Artzt,K.
  TITLE     New molecular markers for the distal end of the t-complex and their
            relationships to mutations affecting mouse development
  JOURNAL   Genetics 131 (1), 175-182 (1992)
   PUBMED   1350556
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Himmelbauer,H., Pohlschmidt,M., Snarey,A., Germino,G.G.,
            Weinstat-Saslow,D., Somlo,S., Reeders,S.T. and Frischauf,A.M.
  TITLE     Human-mouse homologies in the region of the polycystic kidney
            disease gene (PKD1)
  JOURNAL   Genomics 13 (1), 35-38 (1992)
   PUBMED   1349580
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Sertic,J., Zaleska-Rutczynska,Z., Vincek,V., Nadeau,J.H.,
            Figueroa,F. and Klein,J.
  TITLE     Mapping of six DNA markers on mouse chromosome 17
  JOURNAL   Mamm Genome 2 (2), 138-142 (1992)
   PUBMED   1347473
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Acton,D., Domen,J., Jacobs,H., Vlaar,M., Korsmeyer,S. and Berns,A.
  TITLE     Collaboration of pim-1 and bcl-2 in lymphomagenesis
  JOURNAL   Curr Top Microbiol Immunol 182, 293-298 (1992)
   PUBMED   1337029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163629.5, AK158445.1, BC053019.1 and AA881360.1.
            
            On Jul 14, 2018 this sequence version replaced NM_008842.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042885.1, SRR7345562.1304505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC163629.5         139659-139667       c
            10-260              AK158445.1         2-252
            261-2019            BC053019.1         1-1759
            2020-2497           AC163629.5         134509-134986       c
            2498-2665           AA881360.1         4-171               c
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.38 cM"
     gene            1..2665
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /note="proviral integration site 1"
                     /db_xref="GeneID:18712"
                     /db_xref="MGI:MGI:97584"
     exon            1..441
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1301
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proto-oncogene serine/threonine-protein kinase pim-1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase pim-1 isoform 1"
                     /protein_id="NP_032868.2"
                     /db_xref="CCDS:CCDS79520.1"
                     /db_xref="GeneID:18712"
                     /db_xref="MGI:MGI:97584"
                     /translation="MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLL
                     GSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSG
                     VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHN
                     CGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRY
                     HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPS
                     DRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK"
     exon            442..548
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..599
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..966
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1143
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2665
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2644..2649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /note="hexamer: AATAAA"
     polyA_site      2665
                     /gene="Pim1"
                     /gene_synonym="Pim-1"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcagca gcggccgtgg cggcggagga ggctggaggg gagtcggcag tgccggcggc
       61 gggatcggca gtagcagcag cagcagcagt cacagtcagc agcagccctg ggtcccgcag
      121 cgcctctcgc cctgccgcct cccgcactgc ctgacccagc cggcgaaccc gcccgcggcc
      181 agccccgcca gcgccctcag tcgtcctccg actcgccctc ggccttgcgc gccagccgca
      241 gccagagccg caacgccacc cgcagtctga gtcccggccg tcggctcagc cccagctcgc
      301 tccgccgccg ctgctgctcg tcccggcacc ggcgccgcac cgacaccctg gaggtgggga
      361 tgctcctgtc caagatcaac tccctggccc acctgcgcgc cgcgccctgc aacgacctgc
      421 acgccaccaa gctggcgccg ggcaaagaga aggagcccct ggagtcgcag taccaggtgg
      481 gcccgctgtt gggcagcggt ggcttcggct cggtctactc tggcatccgc gtcgccgaca
      541 acttgccggt ggccattaag cacgtggaga aggaccggat ttccgattgg ggagaactgc
      601 ccaatggcac ccgagtgccc atggaagtgg tcctgttgaa gaaggtgagc tcggacttct
      661 cgggcgtcat tagacttctg gactggttcg agaggcccga tagtttcgtg ctgatcctgg
      721 agaggcccga accggtgcaa gacctcttcg actttatcac cgaacgagga gccctacagg
      781 aggacctggc ccgaggattc ttctggcagg tgctggaggc cgtgcggcat tgccacaact
      841 gcggggttct ccaccgcgac atcaaggacg agaacatctt aatcgacctg agccgcggcg
      901 aaatcaaact catcgacttc gggtcggggg cgctgctcaa ggacacagtc tacacggact
      961 ttgatgggac ccgagtgtac agtcctccag agtggattcg ctaccatcgc taccacggca
     1021 ggtcggcagc tgtctggtcc cttgggatcc tgctctatga catggtctgc ggagatattc
     1081 cgtttgagca cgatgaagag atcatcaagg gccaagtgtt cttcaggcaa actgtctctt
     1141 cagagtgtca gcaccttatt aaatggtgcc tgtccctgag accatcagat cggccctcct
     1201 ttgaagaaat ccggaaccat ccatggatgc agggtgacct cctgccccag gcagcttctg
     1261 agatccatct gcacagtctg tcaccggggt ccagcaagta gcagcctttc tgctgctgtc
     1321 tgtcagaccc tccagggagg gagagcttgt cttctggcct cccaacagga ccctgcgtga
     1381 cgatgcaggg acagcaatga caactcattc cagactccag gtccctggag gagcctccca
     1441 caagggaaag agactacttc actggtcctg ggcccctctt tgcgcgcccc gcccccagac
     1501 tcagcgtcta gtgttgctgg gctcccctga atccatccct ggttgggggt gggagtggat
     1561 cagagccctg tcgatggaac tttagtcacc atggagactg ggtcaccaag atgggccggg
     1621 gggggggggg ggggggggag aggaaaacag tctggggggt gggataaaaa ctagcaccat
     1681 atttaagtcc ctgtcacctc ttccaactcc tgagtgcctt ctgtggggac tccgcctgtg
     1741 ctgggagaaa tacttgaact ttacctctta cctgctgctt ctcaaactct gcctgggttt
     1801 tgcttccttc ctctcctctc ctttcccatc ccccacttcc tatgaaaggt gccatgggag
     1861 aggctacagg gccaactgct gagccacctg ccccttttct gtctccttta gtaaaattcc
     1921 caagcaaact ggtcttcctc tttggtttcg acttaactgt ttcaaaacca agacctcaca
     1981 cagaacgcac aaccaatgca aaacaaaaaa caaaaaaaac aaaaaaaaaa ccagacaagc
     2041 tgtaaatgtg tgtatagttc cggcatggta gcctgcaaaa ggactgtaga tgataacaat
     2101 tttaaagaag aaaaaaaaaa atgcctttaa gttattttat gtgttggggg tttggtttgg
     2161 ttttttgttt tttttttttt tttttttctt ttttattctt ttttgcttgt ttttgaaaga
     2221 tggcacgttc tagcccggaa gttttaatgt atttatttat ttatttattt ggttgccttc
     2281 ctgtccaagc ttccactgac tgttgccccc ggtttattgt catgttctgc cttttttttt
     2341 tctttccttc ctcctgactt ggggaccttt taggggaggg ctgtgacgct tgctggggtg
     2401 ttggggctcc ggtgggacag ctgctgtagc ccccttctcc aggggccccc ttggctgctt
     2461 gctggagtgg gtctagggtc tgctgactgt acataaaaca gttccggtgt ggtgtgcctt
     2521 ccggatcctc tctggggctg tgctttgagc agcgtgcagc ccgctggttt tatctgagta
     2581 aagtatactg tacaggggaa taaaagagat cttatttttt ttttttatac ttggcatttt
     2641 ttgaataaaa accttttgtc ttaaa
//
