LOCUS       NM_133209               1020 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus paired immunoglobin-like type 2 receptor beta 1
            (Pilrb1), mRNA.
ACCESSION   NM_133209 XM_916816
VERSION     NM_133209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1020)
  AUTHORS   Li,Y.T., Goswami,D., Follmer,M., Artz,A., Pacheco-Blanco,M. and
            Vestweber,D.
  TITLE     Blood flow guides sequential support of neutrophil arrest and
            diapedesis by PILR-beta1 and PILR-alpha
  JOURNAL   Elife 8, e47642 (2019)
   PUBMED   31385804
  REMARK    GeneRIF: Upon neutrophil arrest, binding of PILR-beta1 to CD99
            ceases, shifting the signaling balance towards inhibitory
            PILR-alpha. This enables integrin deactivation and supports cell
            diapedesis in venules of the mouse cremaster muscle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1020)
  AUTHORS   Tato,C.M., Joyce-Shaikh,B., Banerjee,A., Chen,Y., Sathe,M.,
            Ewald,S.E., Liu,M.R., Gorman,D., McClanahan,T.K., Phillips,J.H.,
            Heyworth,P.G. and Cua,D.J.
  TITLE     The myeloid receptor PILRbeta mediates the balance of inflammatory
            responses through regulation of IL-27 production
  JOURNAL   PLoS One 7 (3), e31680 (2012)
   PUBMED   22479310
  REMARK    GeneRIF: Data show that PILRbeta is important for regulating
            aberrant inflammatory responses through IL-27 production.
REFERENCE   3  (bases 1 to 1020)
  AUTHORS   Banerjee,A., Stevenaert,F., Pande,K., Haghjoo,E., Antonenko,S.,
            Gorman,D.M., Sathe,M., McClanahan,T.K., Pierce,R., Turner,S.P.,
            Bigler,M.E., Phillips,J.H. and Heyworth,P.G.
  TITLE     Modulation of paired immunoglobulin-like type 2 receptor signaling
            alters the host response to Staphylococcus aureus-induced pneumonia
  JOURNAL   Infect Immun 78 (3), 1353-1363 (2010)
   PUBMED   20065029
  REMARK    GeneRIF: Activation of PILRa or deletion of PILRb helps to control
            acute Staphylococcus aureus-mediated pneumonia and attenuate the
            inflammatory response.
REFERENCE   4  (bases 1 to 1020)
  AUTHORS   Mori,Y., Tsuji,S., Inui,M., Sakamoto,Y., Endo,S., Ito,Y.,
            Fujimura,S., Koga,T., Nakamura,A., Takayanagi,H., Itoi,E. and
            Takai,T.
  TITLE     Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively
            regulate osteoclast development
  JOURNAL   J Immunol 181 (7), 4742-4751 (2008)
   PUBMED   18802077
REFERENCE   5  (bases 1 to 1020)
  AUTHORS   Wang,J., Shiratori,I., Satoh,T., Lanier,L.L. and Arase,H.
  TITLE     An essential role of sialylated O-linked sugar chains in the
            recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR)
  JOURNAL   J Immunol 180 (3), 1686-1693 (2008)
   PUBMED   18209065
REFERENCE   6  (bases 1 to 1020)
  AUTHORS   Wilson,M.D., Cheung,J., Martindale,D.W., Scherer,S.W. and Koop,B.F.
  TITLE     Comparative analysis of the paired immunoglobulin-like receptor
            (PILR) locus in six mammalian genomes: duplication, conversion, and
            the birth of new genes
  JOURNAL   Physiol Genomics 27 (3), 201-218 (2006)
   PUBMED   16926269
REFERENCE   7  (bases 1 to 1020)
  AUTHORS   Shiratori,I., Ogasawara,K., Saito,T., Lanier,L.L. and Arase,H.
  TITLE     Activation of natural killer cells and dendritic cells upon
            recognition of a novel CD99-like ligand by paired
            immunoglobulin-like type 2 receptor
  JOURNAL   J Exp Med 199 (4), 525-533 (2004)
   PUBMED   14970179
REFERENCE   8  (bases 1 to 1020)
  AUTHORS   Fournier,N., Chalus,L., Durand,I., Garcia,E., Pin,J.J.,
            Churakova,T., Patel,S., Zlot,C., Gorman,D., Zurawski,S., Abrams,J.,
            Bates,E.E. and Garrone,P.
  TITLE     FDF03, a novel inhibitory receptor of the immunoglobulin
            superfamily, is expressed by human dendritic and myeloid cells
  JOURNAL   J Immunol 165 (3), 1197-1209 (2000)
   PUBMED   10903717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235581.1 and AJ400847.1.
            
            On Apr 22, 2008 this sequence version replaced NM_133209.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ400847.1, BC145880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY235581.1         2-54
            54-1020             AJ400847.1         3-969
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.82 cM"
     gene            1..1020
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /note="paired immunoglobin-like type 2 receptor beta 1"
                     /db_xref="GeneID:170741"
                     /db_xref="MGI:MGI:2450532"
     exon            1..190
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..780
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /note="paired immunoglobulin-like type 2 receptor beta;
                     immunoglobulin-like cell surface receptor FDFACT,
                     activating counterpart; activating receptor PILR-beta"
                     /codon_start=1
                     /product="paired immunoglobulin-like type 2 receptor beta
                     precursor"
                     /protein_id="NP_573472.2"
                     /db_xref="CCDS:CCDS51675.1"
                     /db_xref="GeneID:170741"
                     /db_xref="MGI:MGI:2450532"
                     /translation="MALLISLPGGTPAMAQVLLLLSSGCLHAGNSERYNRKNGFGVNQ
                     PERCSGVQGGSIDIPFSFYFPWKLAKDPQMSIAWKWKDFHGEVIYNSSLPFIHEHFKG
                     RLILNWTQGQTSGVLRILNLKESDQAQYFSRVNLQSTEGMKLWQSIPGTQLNVTQALN
                     TTMRSPFIVTSEFTTAGLEHTSDQRNPSLMNLGAMVTMLLAKVLVIVLVYGWMIFLRW
                     KQRPAH"
     exon            191..577
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /inference="alignment:Splign:2.1.0"
     exon            578..767
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /inference="alignment:Splign:2.1.0"
     exon            768..798
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1020
                     /gene="Pilrb1"
                     /gene_synonym="Fdact; FDFACT; Pilrb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcctccac atgtgaatgc ctggggatct gtttcacttt accctggttc tctctggact
       61 cctgagcacc ccagtgtccc tagacagagc atccttgcct tcctgatggc tttgctgatc
      121 tcgcttcctg gagggactcc agccatggct caggtcctgc ttctgctctc atcaggctgt
      181 ctgcatgctg gaaattcaga aagatacaac agaaaaaatg gctttggggt caaccaacct
      241 gaacgctgct ctggagtcca gggtggctcc atcgacatcc ccttctcctt ctatttcccc
      301 tggaagttgg ccaaggatcc acagatgagc atagcctgga aatggaagga tttccatggg
      361 gaagtcatct acaactcctc cctgcctttc atacatgagc acttcaaggg ccggctcatc
      421 ctgaactgga cacagggtca gacatctgga gtcctcagaa tcctgaactt gaaggagtct
      481 gaccaagccc agtactttag tcgagttaat ctgcagtcga cagaaggcat gaagttgtgg
      541 cagtcaattc ctggaaccca actcaacgtg acccaagcac tcaacaccac catgaggagc
      601 cccttcatcg tcacctctga attcaccaca gctggcctgg agcacacaag cgaccagagg
      661 aatccttcac tgatgaacct gggagccatg gtcacgatgc tcctggctaa agttttggtc
      721 atagtcctag tctatggatg gatgatcttc ctgaggtgga agcaaaggcc agcacactaa
      781 agcctaaacc ccagcaagaa tcagagctca tggctgcagg attgtgctgt gaaacatcac
      841 cattcttgga tagacataga agataacccc cacttctgcc agactctgat actctctggg
      901 ttctgatatt ctctcctcag aagccaggtc atactgtgtg tctctgattc tcaaagcctg
      961 actgtgctgt tctctgtctg ctcatggagt tattaacact ttcaataaat gtcttactcc
//
