LOCUS       NM_153510               2588 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus paired immunoglobin-like type 2 receptor alpha
            (Pilra), mRNA.
ACCESSION   NM_153510
VERSION     NM_153510.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   Zheng,L., Han,X., Yao,S., Zhu,Y., Klement,J., Wu,S., Ji,L., Zhu,G.,
            Cheng,X., Tobiasova,Z., Yu,W., Huang,B., Vesely,M.D., Wang,J.,
            Zhang,J., Quinlan,E. and Chen,L.
  TITLE     The CD8alpha-PILRalpha interaction maintains CD8+ T cell quiescence
  JOURNAL   Science 376 (6596), 996-1001 (2022)
   PUBMED   35617401
  REMARK    GeneRIF: The CD8alpha-PILRalpha interaction maintains CD8(+) T cell
            quiescence.
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Rivera,C.A., Randrian,V., Richer,W., Gerber-Ferder,Y.,
            Delgado,M.G., Chikina,A.S., Frede,A., Sorini,C., Maurin,M.,
            Kammoun-Chaari,H., Parigi,S.M., Goudot,C., Cabeza-Cabrerizo,M.,
            Baulande,S., Lameiras,S., Guermonprez,P., Reis e Sousa,C.,
            Lecuit,M., Moreau,H.D., Helft,J., Vignjevic,D.M., Villablanca,E.J.
            and Lennon-Dumenil,A.M.
  TITLE     Epithelial colonization by gut dendritic cells promotes their
            functional diversification
  JOURNAL   Immunity 55 (1), 129-144 (2022)
   PUBMED   34910930
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Li,Y.T., Goswami,D., Follmer,M., Artz,A., Pacheco-Blanco,M. and
            Vestweber,D.
  TITLE     Blood flow guides sequential support of neutrophil arrest and
            diapedesis by PILR-beta1 and PILR-alpha
  JOURNAL   Elife 8, e47642 (2019)
   PUBMED   31385804
  REMARK    GeneRIF: Upon neutrophil arrest, binding of PILR-beta1 to CD99
            ceases, shifting the signaling balance towards inhibitory
            PILR-alpha. This enables integrin deactivation and supports cell
            diapedesis in venules of the mouse cremaster muscle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Biswas,S., Adrian,M., Weber,J., Evdokimov,K., Winkler,M. and
            Geraud,C.
  TITLE     Posttranslational proteolytic processing of Leda-1/Pianp involves
            cleavage by MMPs, ADAM10/17 and gamma-secretase
  JOURNAL   Biochem Biophys Res Commun 477 (4), 661-666 (2016)
   PUBMED   27349870
  REMARK    GeneRIF: Thus, Leda-1/Pianp is constitutively processed by
            proprotein convertases, sheddases including MMPs and ADAM10/17 and
            intramembrane protease gamma-secretase.
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   Kohyama,M., Matsuoka,S., Shida,K., Sugihara,F., Aoshi,T.,
            Kishida,K., Ishii,K.J. and Arase,H.
  TITLE     Monocyte infiltration into obese and fibrilized tissues is
            regulated by PILRalpha
  JOURNAL   Eur J Immunol 46 (5), 1214-1223 (2016)
   PUBMED   26840635
  REMARK    GeneRIF: Data suggest that immune inhibitory receptor, PILRalpha,
            plays an important role in the prevention of obesity and liver
            fibrosis.
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Fan,Q. and Longnecker,R.
  TITLE     The Ig-like v-type domain of paired Ig-like type 2 receptor alpha
            is critical for herpes simplex virus type 1-mediated membrane
            fusion
  JOURNAL   J Virol 84 (17), 8664-8672 (2010)
   PUBMED   20573830
  REMARK    GeneRIF: Domain V of paired Ig-like type 2 receptor alpha is
            critical for herpes simplex virus type 1-mediated membrane fusion.
REFERENCE   7  (bases 1 to 2588)
  AUTHORS   Banerjee,A., Stevenaert,F., Pande,K., Haghjoo,E., Antonenko,S.,
            Gorman,D.M., Sathe,M., McClanahan,T.K., Pierce,R., Turner,S.P.,
            Bigler,M.E., Phillips,J.H. and Heyworth,P.G.
  TITLE     Modulation of paired immunoglobulin-like type 2 receptor signaling
            alters the host response to Staphylococcus aureus-induced pneumonia
  JOURNAL   Infect Immun 78 (3), 1353-1363 (2010)
   PUBMED   20065029
  REMARK    GeneRIF: Activation of PILRa or deletion of PILRb helps to control
            acute Staphylococcus aureus-mediated pneumonia and attenuate the
            inflammatory response.
REFERENCE   8  (bases 1 to 2588)
  AUTHORS   Wang,J., Shiratori,I., Satoh,T., Lanier,L.L. and Arase,H.
  TITLE     An essential role of sialylated O-linked sugar chains in the
            recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR)
  JOURNAL   J Immunol 180 (3), 1686-1693 (2008)
   PUBMED   18209065
REFERENCE   9  (bases 1 to 2588)
  AUTHORS   Shiratori,I., Ogasawara,K., Saito,T., Lanier,L.L. and Arase,H.
  TITLE     Activation of natural killer cells and dendritic cells upon
            recognition of a novel CD99-like ligand by paired
            immunoglobulin-like type 2 receptor
  JOURNAL   J Exp Med 199 (4), 525-533 (2004)
   PUBMED   14970179
REFERENCE   10 (bases 1 to 2588)
  AUTHORS   Fournier,N., Chalus,L., Durand,I., Garcia,E., Pin,J.J.,
            Churakova,T., Patel,S., Zlot,C., Gorman,D., Zurawski,S., Abrams,J.,
            Bates,E.E. and Garrone,P.
  TITLE     FDF03, a novel inhibitory receptor of the immunoglobulin
            superfamily, is expressed by human dendritic and myeloid cells
  JOURNAL   J Immunol 165 (3), 1197-1209 (2000)
   PUBMED   10903717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB583033.1, BY171703.1, AK041670.1 and AC125063.4.
            
            On Aug 21, 2009 this sequence version replaced NM_153510.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041670.1, AK170000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BB583033.1         2-13
            13-89               BY171703.1         1-77
            90-1345             AK041670.1         2-1257
            1346-2588           AC125063.4         62814-64056
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.77 cM"
     gene            1..2588
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /note="paired immunoglobin-like type 2 receptor alpha"
                     /db_xref="GeneID:231805"
                     /db_xref="MGI:MGI:2450529"
     exon            1..244
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1068
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /note="paired immunoglobulin-like type 2 receptor alpha;
                     inhibitory receptor PILR-alpha; cell surface receptor
                     FDF03"
                     /codon_start=1
                     /product="paired immunoglobulin-like type 2 receptor alpha
                     precursor"
                     /protein_id="NP_705730.1"
                     /db_xref="CCDS:CCDS19780.1"
                     /db_xref="GeneID:231805"
                     /db_xref="MGI:MGI:2450529"
                     /translation="MALLISLPGGTPAMAQILLLLSSACLHAGNSERSNRKNGFGVNQ
                     PESCSGVQGGSIDIPFSFYFPWKLAKDPQMSIAWRWKDFHGEFIYNSSLPFIHEHFKG
                     RLILNWTQGQTSGVLRILNLKESDQTRYFGRVFLQTTEGIQFWQSIPGTQLNVTNATC
                     TPTTLPSTTAATSAHTQNDITEVKSANIGGLDLQTTVGLATAAAVFLVGVLGLIVFLW
                     WKRRRQGQKTKAEIPAREPLETSEKHESVGHEGQCMDPKENPKDNNIVYASISLSSPT
                     SPGTAPNLPVHGNPQEETVYSIVKAK"
     exon            245..631
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     exon            632..832
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     exon            833..863
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     exon            864..910
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     exon            911..942
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     exon            943..2588
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /note="hexamer: AATAAA"
     polyA_site      1262
                     /gene="Pilra"
                     /gene_synonym="FDF03"
                     /note="major polyA site"
ORIGIN      
        1 aaaggaagtt gctggccaca aggaggtgga gatggagagg tcctgcccca actcagtcct
       61 ccacatgtga aggcctgggg atctgtctca ctttaccctg gttctctctg gactcctgag
      121 cactccagtg tccctagaca gagcatcctt gccttcctga tggctttgct gatctcgctt
      181 cctggaggga ctccagccat ggctcagatc ctgcttctgc tctcatcagc ctgtctgcat
      241 gctggaaatt cagaaagatc caacagaaaa aatggctttg gggtcaacca acctgaaagc
      301 tgctctggag tccagggtgg ctccatcgac atccccttct ccttctactt cccctggaag
      361 ttggccaagg atccacagat gagcatagcc tggagatgga aggatttcca tggggaattc
      421 atctacaact cctccctgcc tttcatacat gagcacttca agggccggct catcctgaac
      481 tggacacagg gtcagacatc tggagtcctc agaatcctga acttgaagga gtctgaccag
      541 acccggtact ttggcagagt ttttctgcaa acaacagaag gcatacagtt ttggcagtca
      601 attcctggga cccaactcaa tgtgaccaat gccacctgca cccccactac acttccaagc
      661 accactgctg caacttctgc acacacccaa aatgacataa cagaagtcaa gagtgctaac
      721 attggtggcc tggatctgca aaccacagtt gggttggcaa cggctgctgc tgtgttcctg
      781 gttggggttt tgggattgat agtgttcctc tggtggaaga gaagaaggca aggccagaag
      841 actaaagctg aaatcccagc cagggagcca ttggaaacca gtgagaaaca tgagagtgtt
      901 ggccatgaag gacaatgtat ggatcccaaa gaaaacccca aggataataa catcgtgtat
      961 gcttccatct ccctctcaag cccgacctca ccaggaacag cgcccaacct gcctgtccat
     1021 gggaaccccc aggaagagac tgtgtactcc atcgtaaagg ccaaataagt tggtctggat
     1081 gacactctta gagtcacctt tgtttctagt aggaagactc tcagcttccc acaggcagac
     1141 acagaaattc actcatcaga aggtctgacc acagacaaac tgagaaactc caagttcctt
     1201 tttctaactt cctaggcctt tctcacaaaa ataaaaagat ctacagaatc tgcctaaatg
     1261 aatctaaaga gagcactgat gagacccttg acttctcacc ctctaaggac ccccccatca
     1321 cttttttttt tgttttgttt tttggttttt cttttttttt tttaaagatt tatttattga
     1381 ttatatgtaa gtacactata gctgtcttca gacactctag aagagggagt cagatcttgt
     1441 tggggatggt tgttgagcca ccatgtggtt gctgggattt gaactctgga ccttcagaag
     1501 agcagtcggg tgctcttacc cactgagcca tttcgccagc cccccccccc catcactttt
     1561 tctagcagcc caaggcaagg aagagatcct aatgctggca gatagactga ctccatgaca
     1621 tgcacccaca tctgtgacta taataacctg cacacagtgt acttgctcat gtaccatggc
     1681 actggacatc agcccaaagc ctagacagat ggtgtgagac atggaactaa aataaacacc
     1741 aggtggccaa ggcatttgcc taaggccatg cagttcccag aagtagctca agcccaaaca
     1801 tgatcttcta gaggttctcc cagctctggg tctcactgct gtccccaatt tcctatattc
     1861 tccagagatg gcagtttgcc atagcgacac acacacacac acacacacaa agcacagctc
     1921 aggagtaatt ccagagacct gctttattaa cccaggctgc acagctgact tgaacaacag
     1981 agcaggtcaa caaccccaac atttatcagc tgctcgggaa gaaatgagag gctctccctg
     2041 caggcaaaca acagcagggg gaccagaata ctctactcct caaagagggc cgccaggaac
     2101 tcctctgagc tgcctctctg ctgcatctcc cctctctctt ctggctctcc aatgtcttcc
     2161 atgagttgct ccaagtccag gtcactggag caatcatcgt caggagggaa acttgctgcc
     2221 tcctgtgtcg ggggcatgtg gggcacaagc ccttcctttc ccaatggaca agccccatgc
     2281 tgagctgatg gagtagggca tttggacaca attttaattt ctttctcctc agataagttg
     2341 gtggctgaag tcttgttctc aggagcttta aattttttct tagggactaa aggaaataag
     2401 ggacaaagtt aagagtcaac gtaccctgag tttttacaag ccagatttct gaattcttgt
     2461 ttaaaacata tgaaaggata atcttcttca aaatacggaa tatgggcttt caggtcacac
     2521 ttggattcta gccttgggtc agctatgtat tcagcatggg tggtcaataa atttgaaacc
     2581 tgagtctc
//
