LOCUS       NM_177320               4363 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus phosphoinositide-3-kinase regulatory subunit 5
            (Pik3r5), mRNA.
ACCESSION   NM_177320
VERSION     NM_177320.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Han,X., Guo,B., Zhao,S., Li,Y., Zhu,J., He,Y., Wang,J., Yao,Q.,
            Shao,S., Zheng,L., Shi,Z., Han,T., Hong,W. and Zhang,K.
  TITLE     lncRNA Helf promotes hepatic inflammation and fibrosis by
            interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
  JOURNAL   Cell Mol Biol Lett 28 (1), 77 (2023)
   PUBMED   37805473
  REMARK    GeneRIF: lncRNA Helf promotes hepatic inflammation and fibrosis by
            interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Huang,Z., Peng,Y., Wei,Y. and Tan,Y.
  TITLE     Nonsense-mediated mRNA decay promote C2C12 cell proliferation by
            targeting PIK3R5
  JOURNAL   J Muscle Res Cell Motil 44 (1), 11-23 (2023)
   PUBMED   36512272
  REMARK    GeneRIF: Nonsense-mediated mRNA decay promote C2C12 cell
            proliferation by targeting PIK3R5.
REFERENCE   3  (bases 1 to 4363)
  AUTHORS   Rynkiewicz,N.K., Anderson,K.E., Suire,S., Collins,D.M.,
            Karanasios,E., Vadas,O., Williams,R., Oxley,D., Clark,J.,
            Stephens,L.R. and Hawkins,P.T.
  TITLE     Gbetagamma is a direct regulator of endogenous p101/p110gamma and
            p84/p110gamma PI3Kgamma complexes in mouse neutrophils
  JOURNAL   Sci Signal 13 (656) (2020)
   PUBMED   33144519
  REMARK    GeneRIF: Gbetagamma is a direct regulator of endogenous
            p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse
            neutrophils.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4363)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   5  (bases 1 to 4363)
  AUTHORS   Wang,H., Shun,M.C., Dickson,A.K. and Engelman,A.N.
  TITLE     Embryonic Lethality Due to Arrested Cardiac Development in
            Psip1/Hdgfrp2 Double-Deficient Mice
  JOURNAL   PLoS One 10 (9), e0137797 (2015)
   PUBMED   26367869
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4363)
  AUTHORS   Deladeriere,A., Gambardella,L., Pan,D., Anderson,K.E., Hawkins,P.T.
            and Stephens,L.R.
  TITLE     The regulatory subunits of PI3Kgamma control distinct neutrophil
            responses
  JOURNAL   Sci Signal 8 (360), ra8 (2015)
   PUBMED   25605974
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4363)
  AUTHORS   Janas,M.L., Varano,G., Gudmundsson,K., Noda,M., Nagasawa,T. and
            Turner,M.
  TITLE     Thymic development beyond beta-selection requires
            phosphatidylinositol 3-kinase activation by CXCR4
  JOURNAL   J Exp Med 207 (1), 247-261 (2010)
   PUBMED   20038597
REFERENCE   8  (bases 1 to 4363)
  AUTHORS   Suire,S., Condliffe,A.M., Ferguson,G.J., Ellson,C.D., Guillou,H.,
            Davidson,K., Welch,H., Coadwell,J., Turner,M., Chilvers,E.R.,
            Hawkins,P.T. and Stephens,L.
  TITLE     Gbetagammas and the Ras binding domain of p110gamma are both
            important regulators of PI(3)Kgamma signalling in neutrophils
  JOURNAL   Nat Cell Biol 8 (11), 1303-1309 (2006)
   PUBMED   17041586
REFERENCE   9  (bases 1 to 4363)
  AUTHORS   Suire,S., Coadwell,J., Ferguson,G.J., Davidson,K., Hawkins,P. and
            Stephens,L.
  TITLE     p84, a new Gbetagamma-activated regulatory subunit of the type IB
            phosphoinositide 3-kinase p110gamma
  JOURNAL   Curr Biol 15 (6), 566-570 (2005)
   PUBMED   15797027
REFERENCE   10 (bases 1 to 4363)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089483.1, AL606831.17 and AK149847.1.
            
            On Feb 1, 2006 this sequence version replaced NM_177320.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149847.1, AK154643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AK089483.1         6-167
            163-163             AL606831.17        110082-110082
            164-956             AK089483.1         169-961
            957-957             AL606831.17        127200-127200
            958-2448            AK089483.1         963-2453
            2449-2537           AK149847.1         2417-2505
            2538-2538           AL606831.17        132196-132196
            2539-4363           AK149847.1         2507-4331
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.69 cM"
     gene            1..4363
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /note="phosphoinositide-3-kinase regulatory subunit 5"
                     /db_xref="GeneID:320207"
                     /db_xref="MGI:MGI:2443588"
     exon            1..138
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            139..254
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2767
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /note="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     regulatory subunit; p101-PI3K; phosphoinositide-3-kinase,
                     regulatory subunit 5, p101; ptdIns-3-kinase p101;
                     PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5;
                     ptdIns-3-kinase regulatory subunit"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase regulatory subunit 5"
                     /protein_id="NP_796294.2"
                     /db_xref="CCDS:CCDS24865.1"
                     /db_xref="GeneID:320207"
                     /db_xref="MGI:MGI:2443588"
                     /translation="MQPAATTCTEDRIQHALERCLHGLSLGRRSAPWSAGLCLNCWSL
                     QELVSRDPGHFLILLEQILQKTQEVQEKGTYDLLAPLALLFYSTVLCTPHFPPDSDLL
                     LKAASTYHCFLTWPVPYCSICREMLTFIDAELKAPGISYQRLVRAEQGLPVRSHRSST
                     VTVLLLNPVEVQAEFLAVADKLSTPGQSPHGTYTTLLLHAFQATFGAHCDLPKLHRKL
                     QSKTIEELEDIFTETTEAQELASGIGDVAEAREWLRTKLQAVGEKAGFPGILDTASPG
                     KLHTIPIPVARCYTYSWNQDSFDILQEVLLKEQELLQPGILGDDEEEEEEDLEMDRHC
                     AERDSLLSTSSLVSHDSTLLLTSSQASEPVLSRQMLTTFVSGLSDGMDSGYVEDSEEN
                     SEWPQKPGSQKRQGHRRPGQKFNRFYKLLKSTSQLVLRRDSRSLESSVDPTLPLRRAG
                     SLCSPLDCPAQLPSRAQRSRSLPQAKLTTQLPRWLLAPPSHHQRRRPFLSGDEDPKAS
                     TLRVVVFGSDRISGKVARAYSKLRRLETSHPILTRFFKLQFFYVPVKRSHGTSPSACP
                     SSLSQASPLPADSLKYPSPTDLGMAPWEDSTNDISHYLGMLDPWYERNVLGLMHLPPE
                     VLCQQSLKADSRPLEGSATQLPILADMLLYYCRFAARPVLLQVYQTELTFVTGEKTTE
                     IFIQSLELGHSATTRAIKASGRGRKRLGIDDDREAVPLTLQIIYSKGAISGRSRWSNL
                     EKVCTSVNLSKACQKPEELDSSMEALTLTLTEVVKRQNPKSKKGFNQISTSYIKVDKV
                     QIIGSSSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSSLPPERSFSQPAETGSDLC
                     SLLCLPIMTFSGALP"
     exon            255..355
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            356..424
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            425..563
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            564..633
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            634..808
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            809..962
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1046
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1746
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1909
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2035
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2164
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2258
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2335
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2429
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2512
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2625
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..4363
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4347..4352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /note="putative"
     polyA_site      4363
                     /gene="Pik3r5"
                     /gene_synonym="F730038I15Rik; Foap2; p101"
                     /note="putative"
ORIGIN      
        1 agggttgtag agacccggca gatgctggga cttgctgccc ggttccagcc gctgagcggt
       61 ggtcgggggc ctcaccccaa ctgctgagag tcgccgcagg agaggggctc ggcgcccggc
      121 gcccagcggg gactgcaggc aatgactcag gatgcagcca gcagccacaa cgtgcacaga
      181 ggaccgcatc cagcatgctc tggagcgatg cttgcatgga ctgagcctcg gacgccgttc
      241 tgctccctgg tcagccgggc tgtgtctgaa ctgctggagc ctacaggagc tggtcagcag
      301 ggacccgggc cacttcctca tcctcctgga acagatccta caaaagaccc aagaggtcca
      361 agagaaaggc acctatgacc tcctcgcccc gctggctctg ctcttctatt ccactgtcct
      421 ctgtacacca cacttcccac cagactccga cctcctgctg aaggcagcca gcacctacca
      481 ctgcttcctg acctggccag ttccctactg cagcatctgc agagagatgc tcaccttcat
      541 tgatgctgaa ctcaaggccc caggaatctc ctaccagcgg ctggtgaggg ctgagcaggg
      601 cctgcccgtc aggagccacc gaagttccac tgtcactgtg ctgttgctga acccggtaga
      661 ggtacaggct gaattccttg ctgtggcaga caagctgagc acgcctggac agtcacccca
      721 cggcacctac accaccctgc tcctgcatgc cttccaggcc acctttgggg cccactgcga
      781 ccttcctaaa ctacaccgca aacttcagtc caagacaata gaagagctgg aggacatctt
      841 caccgagacg acagaagccc aggagctggc gtctggcatt ggggatgtag cagaggcccg
      901 agagtggctc cggaccaagc tgcaggcagt gggagaaaaa gcgggcttcc ctggcatctt
      961 agacactgca agccctggga aactccacac catccccatc cctgtcgcca gatgctacac
     1021 ctacagctgg aaccaggaca gctttgacat cctacaggaa gtccttctca aggaacagga
     1081 gctgctgcag ccagggatct tgggagatga tgaagaggag gaagaggagg acttggagat
     1141 ggacaggcat tgcgctgaga gggactctct cctctccacc agctccctgg tgtctcacga
     1201 ctccacactg ttgctcacct cctctcaggc ctcagaaccg gtgctgtccc gccagatgct
     1261 gaccaccttt gtctcaggcc tctcggatgg catggacagt ggctacgtgg aggacagcga
     1321 ggaaaactca gagtggcccc aaaagcccgg cagccagaaa cgccagggtc atcgcaggcc
     1381 tgggcagaag ttcaacaggt tctataaact cttaaagagc accagccagt tagtcctgag
     1441 gagggactct cggagcctgg agagcagtgt agacccaacc ctgcctctgc gaagggctgg
     1501 gagcctctgc agccccttgg actgtcccgc tcagctcccc tcccgggctc agcgctcacg
     1561 gtccttgcct caggccaagc tcaccaccca actccccaga tggcttctgg caccaccctc
     1621 acaccaccag cgccgccgtc ccttcctcag tggggatgag gaccccaaag cttccacact
     1681 acgggttgtg gtctttggct ctgatcggat ttcagggaag gtggctaggg cctatagcaa
     1741 gctcaggagg ctggagacca gtcaccctat cctcacacgc ttcttcaagc ttcagttctt
     1801 ctatgtgcct gtgaagagaa gccacggaac cagccccagt gcctgcccat cctctctgag
     1861 ccaagcatct ccactccctg cagactccct gaagtacccc agccctacag accttggcat
     1921 ggccccatgg gaggacagta ccaatgacat ctctcactac ctcggtatgc ttgacccctg
     1981 gtacgaacgc aatgtgttgg gcctcatgca cctgcctcct gaagtccttt gtcagcagtc
     2041 cctgaaggca gactctcggc ccctggaggg atcggccacc cagctgccca tcctggccga
     2101 tatgttactc tactactgcc gctttgcggc ccgccccgtg ttgctgcagg tttaccagac
     2161 agagctgacc tttgtcaccg gggagaagac cacagagatc ttcatccagt ctctggagct
     2221 gggtcactct gcgaccactc gggctatcaa ggcttcaggt cggggtagga agaggctggg
     2281 cattgatgac gaccgggagg ccgtccctct aacactacag attatttaca gcaagggagc
     2341 catcagtggg cgaagccgct ggagcaacct ggagaaggtc tgcacctctg ttaacctcag
     2401 caaggcctgc cagaagccgg aggagctaga ctccagcatg gaggcgctaa cgctaaccct
     2461 gacagaagtg gtgaagaggc agaaccctaa atccaaaaag ggctttaacc agatcagtac
     2521 atcctacatc aaagtggaca aggtgcagat catcggctct agcagctgcc cctttgccgt
     2581 gtgtctagac caggatgaga gaaagatcct gcagagtgtg gtcaggtgtg aagtgtcacc
     2641 ctgctacaag ccagagaaga gcagcttgcc acccgagagg tccttcagcc agccagcaga
     2701 gactgggtcc gacctgtgct cccttctctg ccttcccatc atgacattca gtggggctct
     2761 gccctagtgc agctaggtac gaggctgggc aggaagagta cacagcttct cctggactac
     2821 tcttcggggc agccgctctc tacggagaac agaattgccc tgcactgcat caggatccct
     2881 ctgtaagccc tgccatgggc cagggatgtg gccagtggta tctggagccc ctgagagctg
     2941 atgaagaaac aagcactgga gaaagaagga cctgggatgt ccagtcttac agatgcctct
     3001 aagcagaggg agagggatgg gcgagtggcc ccaaagaaag gtgtgaggct tgtctgtggt
     3061 ttaggcctcc tttccaagcc ctgagctgag gtccatcttt ggtttgtcca agactcaggg
     3121 tccctaacta gaggtcattc tctctaaggc acagatagga gagagatggg tgagacattt
     3181 ctttcctggt ctcagatacc atctctctac cctaccacta ccatcatgag cacacatgca
     3241 cacacacaca gacacacaca cacagataca cagacacaca gacacacaca gacacacaca
     3301 gacacacaca cacacacaca cacacacaca cacacacaca cacacacaca caggctttct
     3361 ctctcaagtt ccctggatcc cttgaaaaac agcactaata cttggtcctt tgctaggacc
     3421 tggtacattt tctctcccaa gccccttgct gggtctcaga tgctggggag atgggacaga
     3481 catggttcct ttttagctaa atgcccagag gaagttaagg cacttctttg agcctctgtt
     3541 tcctcagtgc tgaagtgcac gggaagtggg tcctcaaagg gagtgccctt gaaccttgcc
     3601 cagtgcctgg ctcccagcag ctgccctgga aagacagcat cttgccctcc gctactgatg
     3661 ccctcctttg ttcttgaaca ctctcaggat agtccttgct tggccttgcc ccacctaggg
     3721 atgaggcgga actcaggcag gctaagcagc agtcaggaag ggcctcctag gtacggatcc
     3781 tcccccactt ccctagcagg tcggttccca tatgctcact tcctctcagc tggaggactg
     3841 gtgcacattg tgtgctctgg acacaagctc tctggacaag atctcagagg agcagagggc
     3901 agattgctga gtatctaacg gtagagacat gcatggaacc caatacagca agagcctgaa
     3961 gtttaaatct gtcagaccgg agggctggac aagtggacaa gatgtggctg gagcgataag
     4021 gtggtgggct ggctcaggcc ttggcctggc accagtgagt aaggaacctt ggaaacataa
     4081 caagttgcca cagagttctt accatcatgt tctgcaccaa agacctcggt ttgtagaagc
     4141 ccaaggaaac tgcagagggc tcctgacttg agagaccaga tggagccact atgttgtcac
     4201 ccccagtcct agctgacggt atatctgcca ggttccggag cagtgtccag ccatatatac
     4261 cggtgtgctt taacctgctg tgtgagcata ttgttctact gtatgatcaa tatgaatcag
     4321 tgaatgcgat tttaatatta ttatcaaata aaattgattt att
//
