LOCUS       NM_181585               5325 bp    mRNA    linear   ROD 11-MAR-2023
DEFINITION  Mus musculus phosphoinositide-3-kinase regulatory subunit 3
            (Pik3r3), transcript variant 1, mRNA.
ACCESSION   NM_181585
VERSION     NM_181585.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5325)
  AUTHORS   Fang Y, Fan W, Xu X, Janoshazi AK, Fargo DC and Li X.
  TITLE     SIRT1 regulates cardiomyocyte alignment during maturation
  JOURNAL   J Cell Sci 135 (7) (2022)
   PUBMED   35260907
REFERENCE   2  (bases 1 to 5325)
  AUTHORS   Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y,
            Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G,
            Staiger JF and Tuoc T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 5325)
  AUTHORS   Yang X, Fu Y, Hu F, Luo X, Hu J and Wang G.
  TITLE     PIK3R3 regulates PPARalpha expression to stimulate fatty acid
            beta-oxidation and decrease hepatosteatosis
  JOURNAL   Exp Mol Med 50 (1), e431 (2018)
   PUBMED   29350678
  REMARK    GeneRIF: PIK3R3 regulates the expression of PPAR-alpha.The
            activation of PIK3R3 decreased hepatosteatosis.The novel
            PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role
            in hepatic lipid metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5325)
  AUTHORS   Seo M, Kim JH and Suk K.
  TITLE     Role of the p55-gamma subunit of PI3K in ALK-induced cell
            migration: RNAi-based selection of cell migration regulators
  JOURNAL   Cell Adh Migr 11 (3), 205-210 (2017)
   PUBMED   27322022
  REMARK    GeneRIF: These data support an important role for the p55gamma
            subunit of PI3K in ALK-induced cell migration during brain
            development
REFERENCE   5  (bases 1 to 5325)
  AUTHORS   He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M,
            Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI,
            Martin DM, Parras C and Lu QR.
  TITLE     Chd7 cooperates with Sox10 and regulates the onset of CNS
            myelination and remyelination
  JOURNAL   Nat Neurosci 19 (5), 678-689 (2016)
   PUBMED   26928066
REFERENCE   6  (bases 1 to 5325)
  AUTHORS   Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB,
            Heard E, Lao K and Surani MA.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 5325)
  AUTHORS   Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W,
            Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP,
            Giese KP, Bradbury EJ and Vanhaesebroeck B.
  TITLE     Control of axonal growth and regeneration of sensory neurons by the
            p110delta PI 3-kinase
  JOURNAL   PLoS One 2 (9), e869 (2007)
   PUBMED   17846664
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5325)
  AUTHORS   Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J,
            Riedel H and Smith RJ.
  TITLE     The adapter protein Grb10 associates preferentially with the
            insulin receptor as compared with the IGF-I receptor in mouse
            fibroblasts
  JOURNAL   J Clin Invest 99 (5), 830-837 (1997)
   PUBMED   9062339
REFERENCE   9  (bases 1 to 5325)
  AUTHORS   Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers
            MG Jr, Sun XJ and White MF.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
REFERENCE   10 (bases 1 to 5325)
  AUTHORS   Venkitaraman AR and Cowling RJ.
  TITLE     Interleukin-7 induces the association of phosphatidylinositol
            3-kinase with the alpha chain of the interleukin-7 receptor
  JOURNAL   Eur J Immunol 24 (9), 2168-2174 (1994)
   PUBMED   7522165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135693.1, CV562336.1, BU612070.1, CD350355.1, CN455231.1,
            CA318834.1 and AW457297.1.
            
            [WARNING] On May 15, 2023 this sequence was replaced by
            NM_181585.7.
            
            On Sep 21, 2017 this sequence version replaced NM_181585.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2, and 3
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053102.1, AK132341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2562              AK135693.1         4-2565
            2563-2738           CV562336.1         477-652
            2739-3324           BU612070.1         114-699
            3325-3838           CD350355.1         91-604
            3839-4404           CN455231.1         103-668
            4405-4950           CA318834.1         146-691
            4951-5325           AW457297.1         1-375               c
FEATURES             Location/Qualifiers
     source          1..5325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..5325
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /note="phosphoinositide-3-kinase regulatory subunit 3"
                     /db_xref="GeneID:18710"
                     /db_xref="MGI:MGI:109277"
     exon            1..806
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     CDS             701..2086
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol 3-kinase regulatory subunit gamma;
                     phosphatidylinositol 3 kinase, regulatory subunit,
                     polypeptide 3 (p55); PI3-kinase subunit p55-gamma; PI3K
                     regulatory subunit gamma; PI3-kinase regulatory subunit
                     gamma; ptdIns-3-kinase regulatory subunit gamma;
                     ptdIns-3-kinase regulatory subunit p55-gamma;
                     phosphatidylinositol 3-kinase 55 kDa regulatory subunit
                     gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     gamma isoform 1"
                     /protein_id="NP_853616.1"
                     /db_xref="CCDS:CCDS18509.1"
                     /db_xref="GeneID:18710"
                     /db_xref="MGI:MGI:109277"
                     /translation="MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKP
                     MTPAVTNGMKDSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTL
                     TLRKGGNNKLIKIYHRDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPV
                     SRFQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEA
                     FNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKLR
                     LEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKN
                     EDSDESYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYA
                     CSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAY
                     PVHAQMPTLCR"
     exon            807..915
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1014
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1195
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1321
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1464
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1641
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1716
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1887
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..5310
                     /gene="Pik3r3"
                     /gene_synonym="p55; p55pik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttaaaa tgaaactcta gtggttggag ccagggcaga gcgtgagggg agccggcgct
       61 gtcgtggtta cctttactac tcgggcacag tcgagctgac tggactctcc aaggggtcgc
      121 catcccgaag ctgcggaagc ttgggttccc agcctgacgc gaatagagcc cgagtcccaa
      181 tcccagaggg aatcgctctc cgcagaccag tgggaccccg aaacttgaac gcaaaccccc
      241 ttttcaagcc tttgtcactt ccccagcttt ctcccaacgc gttctttttt cccccttcct
      301 ctccattctc tcttctccga aggacacaaa agtggcttcc gctgaaagat taggaggcgg
      361 tgggagcttt tccctttgga gagcgattgt gtaggaagga ttttcgggaa gctgcttttt
      421 aacaccactg ctctttgctt tccgagcttc cctgtaaccc tctgaggtaa aaaccccgta
      481 gcttgaaagt tcggggtatt ttgttgggtg ctttaggagg agagaagagg aggaccttgt
      541 cctcatccta gtagtttggc tggacttgta ctggccgttg gaaaccccca agtacatttc
      601 cgtgtggaac ttttgcaaat atatatttag attttaaata tcagataaaa gatatatatg
      661 ctttttatat atttcccgac gacctgcccc tgacagcgcg atgtacaata cggtgtggag
      721 tatggaccgc gatgacgcag actggaggga ggtgatgatg ccctattcga cagaactgat
      781 attttatatt gaaatggatc ctccagctct tccaccaaag ccacctaagc caatgactcc
      841 agcagtcaca aatggaatga aggacagttt catttctctt caagatgcag agtggtactg
      901 gggagatatt tccagggaag aggtaaatga caaattgcgg gacatgccag atggtacctt
      961 cttagttcgt gatgcctcaa cgaaaatgca gggggattat acattgactt tgaggaaggg
     1021 aggaaataat aaattaataa agatctatca tcgggatggt aaatatggct tctctgagcc
     1081 cctgacgttt acttctgtgg tggagcttat taaccactac caccacgagt ctctcgctca
     1141 gtacaatccc aaactcgacg tgaagctgac gtacccagta tccagattcc aacaggatca
     1201 gttggtaaaa gaagataaca ttgatgcagt aggtaaaaat ctgcaggagt tccactctca
     1261 gtatcaggag aagagcaaag agtatgacag gctgtatgaa gagtacacaa ggacatcaca
     1321 ggaaatacaa atgaagagga ctgccattga agcctttaat gaaacaatta aaatatttga
     1381 ggagcagtgt catacccaag aacaacacag taaagactat atcgagcgct ttcgcagaga
     1441 ggggaatgag aaggagatcg agcgaattat gatgaattat gataaattga aatcacgtct
     1501 tggtgagatt catgatagca aactgcgtct tgagcaggac ttgaagaaac aagctttgga
     1561 caaccgggaa atagataaaa aaatgaatag catcaaaccc gacttgatcc agctgcgtaa
     1621 gatccgggat cagcaccttg tatggctcaa tcacagagga gtgaggcaga ggcgcctgaa
     1681 tgcctggctg gggatcaaga atgaggactc agatgaaagc tattttatca atgaggaaga
     1741 tgagaacctg ccgcattatg atgagaaaac ctggtttgtg gaggatatca accgagtaca
     1801 agcagaggac ttgctttatg ggaaaccaga tggtgcattc ttaattcgtg agagtagcaa
     1861 gaaaggatgt tacgcttgtt ctgtggttgc agacggggaa gtgaagcact gtgtcatcta
     1921 cagcacggct cgaggatatg gctttgcaga accctacaac ctgtacagct cactgaagga
     1981 gctggtgctc cattaccagc agacatccct ggttcagcac aacgactccc tcaacgtcag
     2041 gctcgcctac cctgtccatg cacagatgcc tacgctctgc agataagcag agtggaagag
     2101 acacgctctc tagccgtttt tttcctatgg tttttattag actacgatga gggcattctt
     2161 tcaacgtaga ctgcttgttt tgcacaagtg attctgtgaa tgtgaaatgg agaggccaag
     2221 cagtagcttg gatttagaaa tgaggggccc agggtctctg gcctcggctg tgctgctgca
     2281 ctgatggact aagctggaag cagatattgg tttcatgggg tttgggtttg ttgtcaggca
     2341 cctttaaaag aacagctaag gcttgttgtg ggttggggtg ggggttttat ttggaagttt
     2401 ctgaagagtc cacatccctt tgtcctcaac cctaagaatg cagcaggtca cagttctgct
     2461 gggagttgtt ttgatttgat agtctcttcc cctttccccc aaataaagag ccgattttgg
     2521 ctctgtggta aagtgggatt tggtttggag ggaaaaacaa ccaaaggaaa atagggaggt
     2581 atgggattac attttcagaa tctaaaccaa ggaggcaaaa gaccccttca gttgatgtta
     2641 cttcaatttt atcaacataa tctaggcttc agcatcttca ccaactcctc cctctaaagc
     2701 actgtgttca aaaaccaaca aagcagcatc gccagaccaa ggtctaaggg gaggacagta
     2761 gtagctgaat gtacacttct gtaccaaaac ttgaaagact agaaatgtga gtttcaacaa
     2821 acactaaaat tggtcagtgt atttcctttt gccctggcct tgtttctcag atgaggaata
     2881 gaattatttt gtggaaatag taagctttga gtcataatga agttggtgct tgtgtggtgt
     2941 ttctttaaag aaatgtttga aacccttgta agttgtttta tgagtaaaga aacagtgcaa
     3001 tccagtgctt ttagatggct tgatatacca aataatgata gagaacaaca ttgttgtgtg
     3061 cttcctcaag tttaaaagcc ttgccaaaac tatacaagga ttaatttgcc ttcatctccc
     3121 cttccttttt tggatagggt ttagggagcc ataggtagct aaaggaggac tcgagtttgt
     3181 ggtcagagac ctcagtaaat cacaggcaca tgaggcctgg tatccatggt gaagggtcca
     3241 tcacatgaca tgttattcaa tactgtggtt gaagcgtttg ccagaagagg ggatgacgtg
     3301 gagttcagac tatctgggga aataatccac aggctttcct gcttgccctt tttgtgagcc
     3361 tgctgttaag gcagtgcaca cagcctgctc tcatgcttcc gtggctgtgg tttaagcctt
     3421 cagctaagtg aagttagata gaggagaggg cagccatcta tttatggatt cacactcatt
     3481 taagagttca gctgcttcag agtcagttct ggagccataa caggctcagt atgactcagc
     3541 tgcttgagcc cagtaatgtg cagtcaggca gtttagacaa gcagcctgtg cctgggtcat
     3601 caggcttaca atcagggaag atgaagtttg ggggccaaaa taaagatgaa tatgactttc
     3661 cctgagcact tcctttggtg acagtgtcta gaagaaacca cagtatagag ataggtcaaa
     3721 agttttgaat aattgtcaca gttgataggg catgccattg atggcttttt cttgttcatg
     3781 ctccagtgtg aaagagagga gattgaccac cctcagccac tctgtaaggc ctttttcaaa
     3841 attgccagct taaaatcttg ctcagtttac caagtaatgc caggctattt gttgattgga
     3901 atacctgtga ctttgtactg atgttgaact tgctgaagca gttatatgct caagattagg
     3961 tgtgaggaat ccctctgatc cagcactaaa attttagtat gtcctgaacg cctttttaaa
     4021 gaaatctctt ccaagtaagt caaaatgata aaatatacag ctttagtgtt gaataatgtc
     4081 tttaccttgt aggcagacat ggaagatatg caggagaaag cagcatctac acctgggctg
     4141 gacaatggag aaagacaggt tttcagtcct atattctttc cctttgagta accactttgt
     4201 gggagctgag accagggatc atttaataaa tcggaagcta tctttttatt tttctgccaa
     4261 gttactacat gatttatctg atcctgagct gtggaaatgg catgaggagc agtctcctaa
     4321 gagtggccct gctgtctgag ggagtctgga agcaggtgtt ggtcttcttc tcaaggctag
     4381 ctcaaagttc tgtctcatga tctaggccct gggactatct cttttggcat cttaactgta
     4441 gactcattga ctaaagcaga ggctagagac agattaggac cataggggca ggcagatcag
     4501 ccagtcccca gatcagccag tccccaacag gaaagcagct ttgggttggc tagatacagt
     4561 ttttaaaata aaaacaaaac aaaacaaagc tgtttccacc tggcatagtt cagcttaggt
     4621 aggttgttta tgttcttgtc actgctccag caatagatga agacatccta cagctccaca
     4681 ctactaagac acaagctttc tacatttact tcagactcaa gcccgagtgg catcttcctt
     4741 gtgtcccttc tctgcaaggt accagcttca cccattctcc agaactttaa agaaaaaatg
     4801 tacttgaaca atttctgatt tctaggatga tctctactgc cagttagatc ttcttgaggt
     4861 ttccatgaca tcatacacca gaggtccatt cttggtcctt tgctgccaac tgctcattct
     4921 tgacttagct ctagccattt gtgacaacca cccttgtttc cttacaaatc ctcgcatgta
     4981 actttggtac tttgttgttt cttgtgaaga atctattctg ttgtctttga tgtaataaaa
     5041 aaatttcatg tagtttatgt aaaaataact gactcagaag gaagccaact gtgtcttgtg
     5101 ttggaacaat tcataatgta atttctagac cacttttgca aattgttctt gtcaccaaat
     5161 gtgttcagac attgctgtgc ggttgtgggg aaggggtggg gggaaggtaa ggtgagaaca
     5221 ttgttggggc tttttccttt ttttaacctt ctccaagact tggaatggtt ggcagacttg
     5281 ctccagatgc aataaagaca ttgcagtgaa aaaaaaaaaa aaaaa
//
