LOCUS       NM_008841               3164 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus phosphoinositide-3-kinase regulatory subunit 2
            (Pik3r2), transcript variant 1, mRNA.
ACCESSION   NM_008841
VERSION     NM_008841.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Wang,Q., Tao,C., Hannan,A., Yoon,S., Min,X., Peregrin,J., Qu,X.,
            Li,H., Yu,H., Zhao,J. and Zhang,X.
  TITLE     Lacrimal gland budding requires PI3K-dependent suppression of EGF
            signaling
  JOURNAL   Sci Adv 7 (27) (2021)
   PUBMED   34193412
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Mendenhall,M.A., Liu,S., Portley,M.K., O'Mard,D., Fattah,R.,
            Szabo,R., Bugge,T.H., Khillan,J.S., Leppla,S.H. and Moayeri,M.
  TITLE     Anthrax lethal factor cleaves regulatory subunits of
            phosphoinositide-3 kinase to contribute to toxin lethality
  JOURNAL   Nat Microbiol 5 (12), 1464-1471 (2020)
   PUBMED   32895527
  REMARK    GeneRIF: Anthrax lethal factor cleaves regulatory subunits of
            phosphoinositide-3 kinase to contribute to toxin lethality.
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Shi,X., Lim,Y., Myers,A.K., Stallings,B.L., Mccoy,A., Zeiger,J.,
            Scheck,J., Cho,G., Marsh,E.D., Mirzaa,G.M., Tao,T. and Golden,J.A.
  TITLE     PIK3R2/Pik3r2 Activating Mutations Result in Brain Overgrowth and
            EEG Changes
  JOURNAL   Ann Neurol 88 (6), 1077-1094 (2020)
   PUBMED   32856318
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   Yamauchi,T., Kaburagi,Y., Ueki,K., Tsuji,Y., Stark,G.R., Kerr,I.M.,
            Tsushima,T., Akanuma,Y., Komuro,I., Tobe,K., Yazaki,Y. and
            Kadowaki,T.
  TITLE     Growth hormone and prolactin stimulate tyrosine phosphorylation of
            insulin receptor substrate-1, -2, and -3, their association with
            p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly
            PI3-kinase activation via JAK2 kinase
  JOURNAL   J Biol Chem 273 (25), 15719-15726 (1998)
   PUBMED   9624169
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Janssen,J.W., Schleithoff,L., Bartram,C.R. and Schulz,A.S.
  TITLE     An oncogenic fusion product of the phosphatidylinositol 3-kinase
            p85beta subunit and HUMORF8, a putative deubiquitinating enzyme
  JOURNAL   Oncogene 16 (13), 1767-1772 (1998)
   PUBMED   9582025
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Laviola,L., Giorgino,F., Chow,J.C., Baquero,J.A., Hansen,H.,
            Ooi,J., Zhu,J., Riedel,H. and Smith,R.J.
  TITLE     The adapter protein Grb10 associates preferentially with the
            insulin receptor as compared with the IGF-I receptor in mouse
            fibroblasts
  JOURNAL   J Clin Invest 99 (5), 830-837 (1997)
   PUBMED   9062339
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Virbasius,J.V., Guilherme,A. and Czech,M.P.
  TITLE     Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2
            domain
  JOURNAL   J Biol Chem 271 (23), 13304-13307 (1996)
   PUBMED   8663140
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162446.2.
            
            On Sep 8, 2016 this sequence version replaced NM_008841.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146195.1, BC006796.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC162446.2         128819-128924       c
            107-803             AC162446.2         126868-127564       c
            804-896             AC162446.2         124815-124907       c
            897-947             AC162446.2         124564-124614       c
            948-1079            AC162446.2         124345-124476       c
            1080-1278           AC162446.2         124045-124243       c
            1279-1364           AC162446.2         123501-123586       c
            1365-1473           AC162446.2         123266-123374       c
            1474-1572           AC162446.2         123059-123157       c
            1573-1753           AC162446.2         122796-122976       c
            1754-1879           AC162446.2         122589-122714       c
            1880-2022           AC162446.2         122117-122259       c
            2023-2199           AC162446.2         121801-121977       c
            2200-2271           AC162446.2         121560-121631       c
            2272-2442           AC162446.2         121274-121444       c
            2443-3164           AC162446.2         120388-121109       c
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3164
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /note="phosphoinositide-3-kinase regulatory subunit 2"
                     /db_xref="GeneID:18709"
                     /db_xref="MGI:MGI:1098772"
     exon            1..106
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            107..803
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..2650
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol 3-kinase regulatory subunit beta;
                     PI3-kinase subunit p85-beta; PI3K regulatory subunit beta;
                     PI3-kinase regulatory subunit beta; ptdIns-3-kinase
                     regulatory subunit p85-beta; phosphatidylinositol 3-kinase
                     85 kDa regulatory subunit beta; phosphatidylinositol
                     3-kinase, regulatory subunit, polypeptide 2 (p85 beta)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     beta isoform 1"
                     /protein_id="NP_032867.2"
                     /db_xref="CCDS:CCDS22381.1"
                     /db_xref="GeneID:18709"
                     /db_xref="MGI:MGI:1098772"
                     /translation="MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVA
                     DGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLD
                     GSSESGHILPDLAEQFSPPDPAPPILVKLVEAIEQAELDSECYSKPELPATRTDWSLS
                     DLEQWDRTALYDAVKGFLLALPAAVVTPEAAAEAYRALREVAGPVGLVLEPPTLPLHQ
                     ALTLRFLLQHLGRVARRAPSPDTAVHALASAFGPLLLRIPPSGGEGDGSEPVPDFPVL
                     LLERLVQEHVEEQDAAPPALPPKPSKAKPAPTALANGGSPPSLQDAEWYWGDISREEV
                     NERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSV
                     VELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQVVKEDSIEAVGAQLKVYHQQYQDK
                     SREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGN
                     EKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRK
                     IRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRT
                     QAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGS
                     LKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPSAAR"
     exon            804..896
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            897..947
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1079
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1278
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1364
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1473
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1572
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1753
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1879
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2022
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2199
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2271
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2442
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..3164
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3161
                     /gene="Pik3r2"
                     /gene_synonym="p85beta"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcccga aggcttggaa ccgcggcgac ggtggctgac gcagggatcc cgcggctgcg
       61 gcgacggcgg cggcggtcgt ggtggtggcg acggcggccg gagtgggctg gtgttcccgg
      121 ctgagcatgg tagcagcctg tggtctgggt cccttcgtct ggtgtcaggc acatcttgaa
      181 gagccagtaa gcctgggcac ccacagccca gctaatgaag gagtgatcca cctatcccag
      241 cttgaccatc tgatgggtga cacaagccaa ataatttgag aaaacaccag gaacatcatt
      301 gcacaggtga ctaaatggtg gcctctgtga cagatggcca tctaggcatg tgcggccccc
      361 gaggtcgcct gtgacttctg gaagtagagg tctacaagcc caccacacag gccgcaccag
      421 cccatggggt ccctagagcc ccggggagcc agctgacggt ccagaacccc ccaggccagc
      481 catggcagga gccgagggct tccagtacag ggctgtgtac ccattccgcc gggagcggcc
      541 tgaagacctg gagctgctcc ctggggacct cctggtggtg agccgggtgg ccctacaggc
      601 acttggtgtg gctgatggag gagagcgctg cccacacaat gtgggctgga tgcctggctt
      661 caacgagcgc acccgacagc gaggggactt ccccgggaca tacgtggagt tcctaggacc
      721 cgtggctctg gctcgaccag gccctcgccc acgggggccc cgtccgttgc ccgccaggcc
      781 cttggatgga tcttctgagt caggccacat actcccagac ctggcagagc agttctcccc
      841 acctgaccct gctcccccga ttctggtgaa gctggtggaa gccattgagc aagcagagct
      901 ggacagtgaa tgctacagta agccggagct gcccgcaaca cggacagact ggtccctgag
      961 tgacttggag cagtgggacc gcaccgcctt gtatgatgct gttaagggct tcctgctggc
     1021 gttgcctgca gctgtggtga cccctgaagc tgcagcagag gcgtaccggg cacttcgaga
     1081 ggttgcaggc cccgtggggc tggtgctgga acccccaaca ctgccgctgc accaggctct
     1141 cacactgcgt ttcctgctgc aacacctggg tcgtgtggcc cgcagagcac cctcgccaga
     1201 tacagctgtc catgcactgg ccagtgcctt cgggccgcta ctgctgcgca tacctccgtc
     1261 agggggcgag ggtgatggga gtgagcctgt acccgacttc cctgtgctgc tgctagagag
     1321 gctggtgcag gagcatgtgg aggagcaaga cgctgccccc ccagcgctac cacctaagcc
     1381 ctctaaggca aagccggcac ccacagctct ggccaatgga gggagcccgc cctcgcttca
     1441 ggatgcagag tggtactggg gggacatctc cagggaagag gtgaatgaga gactccggga
     1501 cacacctgat ggtaccttct tagtcagaga tgcatccagc aagatccaag gagagtacac
     1561 gctcaccctc aggaaaggcg ggaacaacaa gttgatcaaa gtcttccacc gggatggtca
     1621 ctatggcttc tcagagcccc ttaccttctg ctccgtggtg gaactcatct cccactaccg
     1681 ccacgaatca ctggcccagt acaacgccaa gctggacaca cgccttctct accctgtgtc
     1741 caagtaccaa caagaccagg tggtgaagga ggacagcata gaggctgtgg gcgcccagct
     1801 caaggtctac caccagcagt accaggacaa gagccgcgaa tatgaccagc tgtatgaaga
     1861 atacacacgg acctcccagg agctgcagat gaagcgcaca gccatagagg ccttcaacga
     1921 gaccatcaag atcttcgaag agcagggcca gacacaggag aaatgcagca aggagtattt
     1981 ggagcgcttc cggcgagagg gaaatgagaa ggagatgcag aggatcctgc tgaactccga
     2041 gcgactcaag tctcgcatcg cggagataca cgaaagccgc acgaagttgg agcaggatct
     2101 gcgggcgcag gcctccgaca accgtgagat cgacaagcgc atgaacagcc tcaaacctga
     2161 cctcatgcag ctgcgcaaga tcagggacca gtacctcgtg tggctcaccc agaaaggtgc
     2221 ccgacagagg aagatcaacg aatggctggg aatcaagaac gagactgagg accagtattc
     2281 actgatggag gatgaggacg ccctccccca ccacgaggag cgcacgtggt acgtgggcaa
     2341 gatcaaccgc acacaggcgg aggagatgct gagtggcaaa cgagacggga ccttcctcat
     2401 ccgggagagc agccagcggg gctgttacgc atgctccgtg gtggtggacg gcgacacgaa
     2461 gcactgtgtc atctaccgca cagccaccgg cttcggcttc gcagagccct ataacctgta
     2521 cgggtccctg aaggagctgg tgctgcacta ccagcacgca tcactcgtgc agcacaatga
     2581 cgcacttacc gtcaccctcg cacaccctgt gcgtgccccc gggcctggcc caccgtctgc
     2641 agcacgctga gcgcccacct cgcctgcctc cctgtccatg tctgtctcca gatcccctcc
     2701 cctggtgaac acgcgcagga ggccatccct cccgctgcgc ctgccatgtt tacagaggct
     2761 gtggggccac tggcctgggc gccctgagtt cttcaagcca tatccccggg gttagaaagg
     2821 aaccgcgcta ggtggtttcc aggaactcag gcctggacac tcggggccgg gcgggacccg
     2881 ccccgcggac cccaacttcc cctcttaagg tcgaagtgaa accagtcaca gggggttacc
     2941 ccgcagctgc cgagaatctt ccccactctg gcgggcaaaa tacaaactct ggccctcgcc
     3001 caggccctgc gctgttctcc agactgtgca atcgcctccc ctttgggaca agggccctgg
     3061 gtgtgtccct gctccctgga ccccatacct gcccagggcg gatgggcagc aggttttgta
     3121 cggtacattt attgatacga atatgaaaca ttgtacctgt tggc
//
