LOCUS       NM_001077495            6928 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus phosphoinositide-3-kinase regulatory subunit 1
            (Pik3r1), transcript variant 2, mRNA.
ACCESSION   NM_001077495
VERSION     NM_001077495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6928)
  AUTHORS   Zhu,K., Liu,Y., Dai,R., Wang,X., Li,J., Lin,Z., Du,L., Guo,J.,
            Ju,Y., Zhu,W., Wang,L. and Cao,C.M.
  TITLE     p85alpha deficiency alleviates ischemia-reperfusion injury by
            promoting cardiomyocyte survival
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167318 (2024)
   PUBMED   38909849
REFERENCE   2  (bases 1 to 6928)
  AUTHORS   Fiske,B.E. and Getahun,A.
  TITLE     Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells
            Receptive to Bystander T Cell Help
  JOURNAL   J Immunol 212 (7), 1150-1160 (2024)
   PUBMED   38353615
  REMARK    GeneRIF: Failed Downregulation of PI3K Signaling Makes Autoreactive
            B Cells Receptive to Bystander T Cell Help.
REFERENCE   3  (bases 1 to 6928)
  AUTHORS   Fu,Y., Xiang,Y., Zha,J., Chen,G. and Dong,Z.
  TITLE     Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell
            inflammation and apoptosis in septic-induced acute kidney injury:
            implications for therapeutic intervention
  JOURNAL   Clin Sci (Lond) 138 (6), 351-369 (2024)
   PUBMED   38411015
  REMARK    GeneRIF: Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell
            inflammation and apoptosis in septic-induced acute kidney injury:
            implications for therapeutic intervention.
REFERENCE   4  (bases 1 to 6928)
  AUTHORS   Xu,K., Fei,W., Gao,W., Fan,C., Li,Y., Hong,Y. and Cui,R.
  TITLE     SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways
  JOURNAL   Free Radic Biol Med 212, 65-79 (2024)
   PUBMED   38141889
  REMARK    GeneRIF: SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways.
REFERENCE   5  (bases 1 to 6928)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6928)
  AUTHORS   Tobe,K., Tamemoto,H., Yamauchi,T., Aizawa,S., Yazaki,Y. and
            Kadowaki,T.
  TITLE     Identification of a 190-kDa protein as a novel substrate for the
            insulin receptor kinase functionally similar to insulin receptor
            substrate-1
  JOURNAL   J Biol Chem 270 (11), 5698-5701 (1995)
   PUBMED   7534300
REFERENCE   7  (bases 1 to 6928)
  AUTHORS   Venkitaraman,A.R. and Cowling,R.J.
  TITLE     Interleukin-7 induces the association of phosphatidylinositol
            3-kinase with the alpha chain of the interleukin-7 receptor
  JOURNAL   Eur J Immunol 24 (9), 2168-2174 (1994)
   PUBMED   7522165
REFERENCE   8  (bases 1 to 6928)
  AUTHORS   He,T.C., Zhuang,H., Jiang,N., Waterfield,M.D. and Wojchowski,D.M.
  TITLE     Association of the p85 regulatory subunit of phosphatidylinositol
            3-kinase with an essential erythropoietin receptor subdomain
  JOURNAL   Blood 82 (12), 3530-3538 (1993)
   PUBMED   7505116
REFERENCE   9  (bases 1 to 6928)
  AUTHORS   Sun,X.J., Crimmins,D.L., Myers,M.G. Jr., Miralpeix,M. and
            White,M.F.
  TITLE     Pleiotropic insulin signals are engaged by multisite
            phosphorylation of IRS-1
  JOURNAL   Mol Cell Biol 13 (12), 7418-7428 (1993)
   PUBMED   7504175
REFERENCE   10 (bases 1 to 6928)
  AUTHORS   Escobedo,J.A., Navankasattusas,S., Kavanaugh,W.M., Milfay,D.,
            Fried,V.A. and Williams,L.T.
  TITLE     cDNA cloning of a novel 85 kd protein that has SH2 domains and
            regulates binding of PI3-kinase to the PDGF beta-receptor
  JOURNAL   Cell 65 (1), 75-82 (1991)
   PUBMED   1849460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF169061.1, AC153139.5, BB647657.1, AC107663.10, CB519962.1,
            AK046259.1, AK164783.1, BM963795.1, AK138868.1 and AI838690.1.
            
            On Sep 24, 2013 this sequence version replaced NM_001077495.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.63668.1,
                                           SRR14777535.319726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               CF169061.1         1-660
            661-783             AC153139.5         34934-35056
            784-1401            BB647657.1         1-618
            1402-1457           AC107663.10        22530-22585
            1458-2137           CB519962.1         1-680
            2138-2947           AK046259.1         1052-1861
            2948-3593           AK164783.1         475-1120
            3594-4012           AK046259.1         2509-2927
            4013-4624           BM963795.1         5-616
            4625-6911           AK138868.1         445-2731
            6912-6928           AI838690.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..6928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.92 cM"
     gene            1..6928
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /note="phosphoinositide-3-kinase regulatory subunit 1"
                     /db_xref="GeneID:18708"
                     /db_xref="MGI:MGI:97583"
     exon            1..241
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            242..955
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..2796
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphatidylinositol 3-kinase regulatory subunit alpha;
                     PI3-kinase subunit p85-alpha; PI3K regulatory subunit
                     alpha; phosphatidylinositol 3-kinase 85 kDa regulatory
                     subunit alpha; phosphatidylinositol 3-kinase, regulatory
                     subunit, polypeptide 1 (p85 alpha)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     alpha isoform 2"
                     /protein_id="NP_001070963.1"
                     /db_xref="CCDS:CCDS36769.1"
                     /db_xref="GeneID:18708"
                     /db_xref="MGI:MGI:97583"
                     /translation="MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSD
                     GQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSS
                     KTEADTEQQALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAE
                     LRQLLDCDAASVDLEMIDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQELQSPED
                     CIQLLKKLIRLPNIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFP
                     AASSDNTEHLIKAIEILISTEWNERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWY
                     WGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF
                     SDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
                     EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEY
                     IEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSI
                     KPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTW
                     NVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFA
                     EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR"
     exon            956..1048
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1123
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1255
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1457
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1537
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1640
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1739
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1920
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2046
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2189
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2366
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2435
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2606
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..6915
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6890..6895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /note="hexamer: AATAAA"
     polyA_site      6915
                     /gene="Pik3r1"
                     /gene_synonym="p50alpha; p55alpha; p85alpha; PI3K"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcctggc gctggagctg cgccgctcag ggagaggagt agctagcagc tggagccgag
       61 ttggaggaag cagcggcagc ggcagcggca gcggtagcgg tgaggacggc tgtgcagcca
      121 aggaaccggg acagcgaagc gacggcaggt cgcagctgga tcgcaggagc ctgggagctg
      181 ggagcttcag aggccgctga agcccaggct gggcagagga aggaagcgag ccgacccgga
      241 ggtgaagctg agagtggagc gtggcagtaa aatcagacga cagatggaca gtgtgacagg
      301 aacgtcagag aggattgggc ctcgctgcga gagtcagcct ggagtcaagg tgttgacaag
      361 ttgctgagaa ggacacgtgg gaggacggtg gcgcgcggag ggagagccct gtcttcagtc
      421 accccgttga tggaggacag atggacagca gccggacggc cagtcacctc tcttaaacct
      481 ttggatagtg gtcctttgtg ctctgctgga cacctgttgg ggattttagc ccattctctg
      541 aactcacttt ctcttaaaac gtaaactcgg acggcagtgt gcgagccagc tcctctgtgg
      601 cagggcacta gagctgcaga catgagtgca gagggctacc agtacagagc actgtacgac
      661 tacaagaagg agcgagagga agacattgac ctacacctgg gggacatact gactgtgaat
      721 aaaggctcct tagtggcact tggattcagt gatggccagg aagcccggcc tgaagatatt
      781 ggctggttaa atggctacaa tgaaaccact ggggagaggg gagactttcc aggaacttac
      841 gttgaataca ttggaaggaa aagaatttca ccccctactc ccaagcctcg gccccctcga
      901 ccgcttcctg ttgctccggg ttcttcaaaa actgaagctg acacggagca gcaagcgttg
      961 ccccttcctg acctggccga gcagtttgcc cctcctgatg ttgccccgcc tctccttata
     1021 aagctcctgg aagccattga gaagaaagga ctggaatgtt cgactctata cagaacacaa
     1081 agctccagca accctgcaga attacgacag cttcttgatt gtgatgccgc gtcagtggac
     1141 ttggagatga tcgacgtaca cgtcttagca gatgctttca aacgctatct cgccgactta
     1201 ccaaatcctg tcattcctgt agctgtttac aatgagatga tgtctttagc ccaagaacta
     1261 cagagccctg aagactgcat ccagctgttg aagaagctca ttagattgcc taatatacct
     1321 catcagtgtt ggcttacgct tcagtatttg ctcaagcatt ttttcaagct ctctcaagcc
     1381 tccagcaaaa accttttgaa tgcaagagtc ctctctgaga ttttcagccc cgtgcttttc
     1441 agatttccag ccgccagctc tgataatact gaacacctca taaaagcgat agagatttta
     1501 atctcaacgg aatggaatga gagacagcca gcaccagcac tgccccccaa accacccaag
     1561 cccactactg tagccaacaa cagcatgaac aacaatatgt ccttgcagga tgctgaatgg
     1621 tactggggag acatctcaag ggaagaagtg aatgaaaaac tccgagacac tgctgatggg
     1681 acctttttgg tacgagacgc atctactaaa atgcacggcg attacactct tacactaagg
     1741 aaaggaggaa ataacaaatt aatcaaaatc tttcaccgtg atggaaaata tggcttctct
     1801 gatccattaa ccttcaactc tgtggttgag ttaataaacc actaccggaa tgagtcttta
     1861 gctcagtaca accccaagct ggatgtgaag ttgctctacc cagtgtccaa ataccagcag
     1921 gatcaagttg tcaaagaaga taatattgaa gctgtaggga aaaaattaca tgaatataat
     1981 actcaatttc aagaaaaaag tcgggaatat gatagattat atgaggagta cacccgtact
     2041 tcccaggaaa tccaaatgaa aagaacggct atcgaagcat ttaatgaaac cataaaaata
     2101 tttgaagaac aatgccaaac ccaggagcgg tacagcaaag aatacataga gaagtttaaa
     2161 cgcgaaggca acgagaaaga aattcaaagg attatgcata accatgataa gctgaagtcg
     2221 cgtatcagtg agatcattga cagtaggagg aggttggaag aagacttgaa gaagcaggca
     2281 gctgagtacc gagagatcga caaacgcatg aacagtatta agccggacct catccagttg
     2341 agaaagacaa gagaccaata cttgatgtgg ctgacgcaga aaggtgtgcg gcagaagaag
     2401 ctgaacgagt ggctggggaa tgaaaatacc gaagatcaat actccctggt agaagatgat
     2461 gaggatttgc cccaccatga cgagaagacg tggaatgtcg ggagcagcaa ccgaaacaaa
     2521 gcggagaacc tattgcgagg gaagcgagac ggcactttcc ttgtccggga gagcagtaag
     2581 cagggctgct atgcctgctc cgtagtggta gacggcgaag tcaagcattg cgtcattaac
     2641 aagactgcca ccggctatgg ctttgccgag ccctacaacc tgtacagctc cctgaaggag
     2701 ctggtgctac attatcaaca cacctccctc gtgcagcaca atgactccct caatgtcaca
     2761 ctagcatacc cagtatatgc acaacagagg cgatgaagcg ctgccctcgg atccagttcc
     2821 tcaccttcaa gccacccaag gcctctgaga agcaaagggc tcctctccag cccgacctgt
     2881 gaactgagct gcagaaatga agccggctgt ctgcacatgg gactagagct ttcttggaca
     2941 aaaagaagtc ggggaagaca cgcagcctcg gactgttgga tgaccagacg tttctaacct
     3001 tatcctcttt ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct
     3061 ttctttcttt ctttctttct aatttaaagc cacaacacac aaccaacaca cagagagaaa
     3121 gaaatgcaaa aatctctccg tgcagggaca aagaggcctt taaccatggt gcttgttaac
     3181 gctttctgaa gctttaccag ctacaagttg ggactttgga gaccagaagg tagacagggc
     3241 cgaagagcct gcgcctgggg ccgcttggtc cagcctggtg tagcctgggt gtcgctgggt
     3301 gtggtgaacc cagacacatc acactgtgga ttatttcctt tttaaaagag cgaatgatat
     3361 gtatcagaga gccgcgtctg ctcacgcagg acactttgag agaacattga tgcagtctgt
     3421 tcggaggaaa aatgaaacac cagaaaacgt ttttgtttaa acttatcaag tcagcaacca
     3481 acaacccacc aacagaaaaa agagtgtgga gaaggagact tacagtgaca ttcagtatat
     3541 aaaatatgta cataatattg ggtgactaac tatcaaatag atggatttgt atcaatacca
     3601 aatagcttct gttttgtttt gctgaaggct ataaacgtgc agcgctatgc aattcttaat
     3661 ttttattatg ttgttacccg tttcaaatac acctttggaa taagcttccc ttaccccagt
     3721 ttttgttgct tgaaaatatt gtccctgatt tttgttaata tttgtttttg tcatttttac
     3781 tttttttttt taaagaagtg tacaggatgc cagaaaggag aatggcttaa gaattaaaac
     3841 tatgaaatat tttacagttt ttcttgtaca gaatacttgg ctgttagccc aaggttaaaa
     3901 agttcataac agattttttt ttttttggac taaatgttgg gcagggccct gataagcttc
     3961 aaagctgctt tattcaataa aaagagaaaa agaaaatgat atatgatatg acaaagtatt
     4021 gctgagtcca acagtgttaa gactcttgaa atacggtacc tggcaatgtt tgtttcctaa
     4081 tgaattgtga acttcttgaa tctggaggga gggggaggca gtcatgggtt gtaacaggcg
     4141 gggtaagggg agggggggaa gtaaggtggt gtgcactttc tagggatccc agagaaggga
     4201 ggagccaggc tgtttgtctc ctgtctttcc ccatctgagt ttggtagtca ttagcaatta
     4261 acagcaactc cagacctaat gttgtaactc catcccagca cagttggcca gcatctccgt
     4321 tgtcatgaag tgctgagttt gttctggggt tcctggaatg tgccctcttt cgttgttgta
     4381 acacactggt ctcaaggttg aatccctgca tttagaaaat gtgttctttt ctctttgtag
     4441 cattggacta gtcacagcag tcagccagtc accattcatt ttggctaaat catggtctga
     4501 aaaaacagca tctagttgga tgcttgatat ttttccagct ctctgttcag agttcagttt
     4561 agaatggaag gcaagtagac ccaagtgggt ggtcactgtg ctttgtggag attgttaagt
     4621 gcaaacattt aacagttcgg acaggtcttc tcattagcgt gattgtgcat gttgcataca
     4681 tcacggtgtg caaagggagc agttggtgac atctttaatt caggacaaaa gttcgagttt
     4741 cccaccctag tgtatatgtg tcaaagctgg tgagttcatg gggaattgcc atgtgctgtg
     4801 atgggtagag gttgatggta gtccctgtcg cagcccaggt agattcatga gccatcatca
     4861 gtttctcttt ctcaatatca gacacacctg cagctttata gctcttccct tatttggggg
     4921 ggggaagggg tcttgtaatg ttgctcttgt tttgatcttg gaatttgcag tccagtgtct
     4981 gggttaatgg tctgtagaat gtgtttttct tcctatgaag ccactgctca ttttcaagag
     5041 caaaagtcag tcaaccagac tgtcagccca caaacttgac ccgaccacct cctgactgcc
     5101 aggaaattga ttccccgggt tgactctggg ctttgcaacc tccagcggta gcattccgcc
     5161 acaccacata caactgaaga gttaatactt atttgtaagc taggtttgtg gttggcttct
     5221 gctctcttct tcctttctct ctttcctttt tctttttgta gcacatcatg tatgctatca
     5281 gatacaaata actttaattt ttaaaaagga tctgagattg cttcgtgaca agttctgtta
     5341 agtggttttt ttttgttttg ttttgttttg ttttgttttg ttttgttttt ttccttcaac
     5401 actctctgca agataacttg caacttaggc agttgcctga atttctcatc tcactgacgt
     5461 gagtacaata gagctttcat gtgtcagaag gcaggagtca ttgagttata gcacacctgt
     5521 cctactgaat gcccttttgg tgacaggtta gcatgctcac caactctgtc cttggagagg
     5581 tttgaccatt aaggttctgt ggattccatc caagccatct tctagtaaca ccgagtggct
     5641 catgaatgca gatagataca gcatagctgg gatgtgagca tgcccactca ggttttctca
     5701 ccaactgtcc cattctagag acagccagac actaagctag actatagaag tgggagggtt
     5761 gggaccttgt gttccacacc agagtgatca tagccatggg ataaggcagc aagcatattt
     5821 tgcaacattt gacaacttca cagccctgga tatatgtata tatgtataat gtgcatggac
     5881 tgtttccaat acacctttca gccacgcaga tccacagtca agttcaagta cataacaagc
     5941 agatgtccag tacaggtctt gtatatgtgt gtgtgtgtgt gtgtgtatgt gtgtgtgtgt
     6001 tcctgtattt ctttgctatt gctttgtttt gtcttataaa gtacaatttg tccacaagtg
     6061 aagtgagaag tccgtcattt gatactttcc tctttttaga agctcttccc tttcagggag
     6121 cagcctggat gatttgctta cctgatggat ccctgttctc agtgttgtca agtcagagtg
     6181 tgtttctgtg agctgtcatt gtggggaacc aatcgctttg tcgtatatct gattatgaac
     6241 tataacttgt ttgggaagtc ctactgatgt tctttattgg gagaaagttc ttgcaggttt
     6301 tctcaactgt gctttcgcaa tgcatggtat ccaagtcagt tggaaagtgg gttttgttgt
     6361 ctgttcgaat ttagggtcat ttaagaaagg ggcagttaag aagcacaatg cctcccatgg
     6421 gacaacattc caaaatgcca aattcttctc tttcttacaa caatctataa ttatataaaa
     6481 taactagtac tgggggtagg gagagggtag aattggctcc attggaaaga ctctcctgct
     6541 tcataccgag cttgtcgcca tgagatagca ttggctgccc aggatgctgc tatttaagaa
     6601 gaaaaaaaaa tcaaaacaaa caaaaaagcc ctcatttata tgtgtgtatt ttttaaagct
     6661 acactctgtt caatgttttt acaaatctgt ttatatgaca ttgataaact aaagttggtc
     6721 ttttgacgag agggaggatg tcatggtcgg ttgtaatttt gcctttacaa ggtaactggg
     6781 gtgggagggg agggagtgtg cctccttgac attttgttca agatatagat tcagtgaagc
     6841 tatgtattgt tttaagttgc ttaatgcatt gtattaggtc ctcaaacaga ataaaggttg
     6901 ttttgaaact taaaaaaaaa aaaaaaaa
//
