LOCUS       NM_178149               2267 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphoinositide-3-kinase interacting protein 1
            (Pik3ip1), mRNA.
ACCESSION   NM_178149
VERSION     NM_178149.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Xie,W., Fang,J., Shan,Z., Guo,J., Liao,Y., Zou,Z., Wang,J., Wen,S.,
            Yang,L., Zhang,Y., Lu,H., Zhao,H., Kuang,D.M., Huang,P., Chen,Q.
            and Wang,Z.
  TITLE     Regulation of autoimmune disease progression by Pik3ip1 through
            metabolic reprogramming in T cells and therapeutic implications
  JOURNAL   Sci Adv 8 (39), eabo4250 (2022)
   PUBMED   36179018
  REMARK    GeneRIF: Regulation of autoimmune disease progression by Pik3ip1
            through metabolic reprogramming in T cells and therapeutic
            implications.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Ottens,K., Schneider,J., Kane,L.P. and Satterthwaite,A.B.
  TITLE     PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent
            Immune Responses
  JOURNAL   J Immunol 205 (8), 2100-2108 (2020)
   PUBMED   32887751
  REMARK    GeneRIF: PIK3IP1 Promotes Extrafollicular Class Switching in
            T-Dependent Immune Responses.
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Chen,Y., Wang,J., Wang,X., Li,X., Song,J., Fang,J., Liu,X., Liu,T.,
            Wang,D., Li,Q., Wen,S., Ma,D., Xia,J., Luo,L., Zheng,S.G., Cui,J.,
            Zeng,G., Chen,L., Cheng,B. and Wang,Z.
  TITLE     Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor
            T-Cell Immunity
  JOURNAL   Clin Cancer Res 25 (20), 6180-6194 (2019)
   PUBMED   31350312
  REMARK    GeneRIF: Pik3ip1 Is a Negative Immune Regulator that Inhibits
            Antitumor T-Cell Immunity.
            Erratum:[Clin Cancer Res. 2022 May 13;28(10):2197. doi:
            10.1158/1078-0432.CCR-22-1109.. PMID: 35553648]
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Uche,U.U., Piccirillo,A.R., Kataoka,S., Grebinoski,S.J.,
            D'Cruz,L.M. and Kane,L.P.
  TITLE     PIK3IP1/TrIP restricts activation of T cells through inhibition of
            PI3K/Akt
  JOURNAL   J Exp Med 215 (12), 3165-3179 (2018)
   PUBMED   30429249
  REMARK    GeneRIF: PIK3IP1/TrIP restricts activation of T cells through
            inhibition of PI3K/Akt.
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Kleiner,G., Barca,E., Ziosi,M., Emmanuele,V., Xu,Y.,
            Hidalgo-Gutierrez,A., Qiao,C., Tadesse,S., Area-Gomez,E.,
            Lopez,L.C. and Quinzii,C.M.
  TITLE     CoQ10 supplementation rescues nephrotic syndrome through
            normalization of H2S oxidation pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (11), 3708-3722 (2018)
   PUBMED   30251690
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Song,H.K., Kim,J., Lee,J.S., Nho,K.J., Jeong,H.C., Kim,J., Ahn,Y.,
            Park,W.J. and Kim,D.H.
  TITLE     Pik3ip1 modulates cardiac hypertrophy by inhibiting PI3K pathway
  JOURNAL   PLoS One 10 (3), e0122251 (2015)
   PUBMED   25826393
  REMARK    GeneRIF: Pik3ip1 plays a compensatory negative role for physiologic
            cardiac hypertrophy. Collectively, our results elucidate the
            mechanisms for the roles of Pik3ip1 in PI3K/AKT signaling pathway
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Finn,E.H., Smith,C.L., Rodriguez,J., Sidow,A. and Baker,J.C.
  TITLE     Maternal bias and escape from X chromosome imprinting in the
            midgestation mouse placenta
  JOURNAL   Dev Biol 390 (1), 80-92 (2014)
   PUBMED   24594094
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Schmidt-Strassburger,U., Schips,T.G., Maier,H.J., Kloiber,K.,
            Mannella,F., Braunstein,K.E., Holzmann,K., Ushmorov,A., Liebau,S.,
            Boeckers,T.M. and Wirth,T.
  TITLE     Expression of constitutively active FoxO3 in murine forebrain leads
            to a loss of neural progenitors
  JOURNAL   FASEB J 26 (12), 4990-5001 (2012)
   PUBMED   22935140
  REMARK    GeneRIF: Data suggest that that neural progenitors are particularly
            vulnerable to FOXO3-induced apoptosis, which is mediated by
            PIK3IP1, a negative PI3 kinase regulator.
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   He,X., Zhu,Z., Johnson,C., Stoops,J., Eaker,A.E., Bowen,W. and
            DeFrances,M.C.
  TITLE     PIK3IP1, a negative regulator of PI3K, suppresses the development
            of hepatocellular carcinoma
  JOURNAL   Cancer Res 68 (14), 5591-5598 (2008)
   PUBMED   18632611
  REMARK    GeneRIF: PIK3IP1 is an important regulator of PI3K in vivo, and its
            dysregulation can contribute to liver carcinogenesis
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Zhu,Z., He,X., Johnson,C., Stoops,J., Eaker,A.E., Stoffer,D.S.,
            Bell,A., Zarnegar,R. and DeFrances,M.C.
  TITLE     PI3K is negatively regulated by PIK3IP1, a novel p110 interacting
            protein
  JOURNAL   Biochem Biophys Res Commun 358 (1), 66-72 (2007)
   PUBMED   17475214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI550395.1 and BC079641.1.
            
            On Aug 3, 2006 this sequence version replaced NM_178149.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079641.1, AY522649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AI550395.1         345-420             c
            77-2267             BC079641.1         1-2191
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.33 cM"
     gene            1..2267
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /note="phosphoinositide-3-kinase interacting protein 1"
                     /db_xref="GeneID:216505"
                     /db_xref="MGI:MGI:1917016"
     exon            1..274
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..999
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /note="calcineurin-regulated kringle domain protein;
                     kringle domain-containing protein HGFL;
                     calcineurin-regulated kringle domain-containing protein"
                     /codon_start=1
                     /product="phosphoinositide-3-kinase-interacting protein 1
                     precursor"
                     /protein_id="NP_835362.2"
                     /db_xref="CCDS:CCDS24357.1"
                     /db_xref="GeneID:216505"
                     /db_xref="MGI:MGI:1917016"
                     /translation="MLLAWVHTFLLSNMLLAEAYGSGGCFWDNGHLYREDQPSPAPGL
                     RCLNWLAAQGSRESLTEPSPGNHNYCRNPDQDPRGPWCYISSETGVPEKRPCEDVSCP
                     ETTSQAPPPSSAMELEEKSGAPGDKEAQVFPPANALPARSEAAEVQPVIGISQLVRMN
                     SKEKKDLGTLGYVLGITMMVIILAIGAGIIVGYTYKRGKDLKEQHEKKACEREMQRIT
                     LPLSAFTNPTCETVDENTIIVHSNQTPADVQEGSTLLTGQAGTPGA"
     exon            275..391
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            392..511
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            512..715
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            716..794
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            795..2243
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /note="hexamer: TATAAA"
     polyA_site      2243
                     /gene="Pik3ip1"
                     /gene_synonym="1500004A08Rik; 5830455E04Rik; Crkd; Hgfl"
                     /note="major polyA site"
ORIGIN      
        1 agggggcgcc tttcagctga aaaacacctc ggctgcagca agctagctgg gaagctccca
       61 gttctaaaga gaggctgttt accagaagag cataacaggg gccggccagt ctgactgcaa
      121 ggagacaaaa ctgctgccaa ggaggacccc ccccccccat ttggacactg gctgttgagt
      181 cacctgcgag ccgaagagac gaggatgctg ttggcttggg tacacacatt tcttctcagc
      241 aacatgcttc tggcagaagc ctatggatct ggaggctgct tctgggacaa cggccacctg
      301 taccgggagg accagccctc gcccgcgccg ggtctccgct gcctcaactg gttggccgcg
      361 caaggcagcc gcgagtcgct caccgagccc agcccgggca accacaacta ctgccggaac
      421 ccggaccagg acccgcgcgg gccctggtgc tacatcagca gcgagaccgg cgtccctgaa
      481 aagcggccct gcgaggacgt gagttgccca gagaccactt cccaagcacc accgccatcc
      541 tctgccatgg agctggaaga gaagtctggt gcaccaggtg acaaagaggc acaggtgttc
      601 cctcctgcta acgccctacc agccaggagt gaggcagccg aggtgcagcc agtgatcggg
      661 atcagtcagc ttgtgaggat gaactccaag gaaaaaaaag acctaggaac tctgggctac
      721 gtgctgggca ttactatgat ggtgatcatc ctcgctattg gagctggcat tatcgtgggc
      781 tacacttaca agagggggaa ggacttgaaa gagcaacatg agaagaaagc gtgtgagagg
      841 gagatgcagc gaatcacctt gcccctgtct gccttcacaa accccacctg tgagaccgtg
      901 gatgaaaaca ccatcattgt gcacagcaac cagactcctg ctgacgtgca ggagggcagc
      961 accctcctca cgggccaggc tggcacccct ggggcctgag ccccttcagt gggcaggtgc
     1021 ccatgtaaac actggtacag gacaggccac cctcctgcag ttgggaggag ctacattttg
     1081 tgttgtggtt aaaaccttat cccatttttc ttttgggggg aatgtgactc ctcatgacac
     1141 aagaagatgc aggtagcatt atgggtgagg gtgaggaggc tgggtagggt cctatcaacg
     1201 ctccttttct atcccttgga gcagaatttg cctgcggaga gagactggca cagtagccac
     1261 agtggtgctg tggcaaataa gggcttccac attgcctggg ccaaggaaag actgggagct
     1321 ggctaaagct cttctgtcct gtatactgaa gaaggtggcc tcagtctctg cttttccatt
     1381 cgtcatccag gaacttgagt ggcatatact gttattccta gttaaggtca agcataaaaa
     1441 aaactatata tatataaatg aaagaaatat ttaggatgaa agtcccttct gacttctaag
     1501 aacctgaaat gaatctgctt gctggcagcg atgtgccttg acaactgtgg gataggcctg
     1561 ggcccgaggg tctcttccta tctcgtaagg aaagggaaga attgcactaa actttccact
     1621 taggtgaagg acccgcttct gccttcagcc tcatgcagca gaccagaata tccagactgt
     1681 cttttggggg ctggatagag gaacctctca attttgcgct gataagaaaa tagccaattc
     1741 atgggaatta cacacttgag agtgtggtga cccgcagctg aaaggtgagc ttggagacca
     1801 agccagaagg ttggtaacat gctggggctt gcgttgtagt cctgccgggc ttgcaggcca
     1861 gttccttcca tagggttaag attaactggt acaaaacaat cactgcacca ctgcgaaaga
     1921 cctgaaggag ttccagaaag ggcaaagcag cttcccagtg tcctcctggc cttggcagtg
     1981 tccccagcca ggagcccttc cactcccaac actgggagca ggcttcacca ggctgctctc
     2041 ataagccatt tgttgagggg gcctggatct cagggttccc atggtggtgg tgactgtggg
     2101 aagagagcag tactacttcc tactttccta tgaaagtatt tctctgtatg ttttatatac
     2161 ctcattctga cacctgtgta tgaactatgg caatttgttt tgcttttgac ttatataaac
     2221 acaagacatg gttttacctt gcaaaaaaaa aaaaaaaaaa aaaaaaa
//
