LOCUS       NM_001146200            6644 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase
            catalytic subunit gamma (Pik3cg), transcript variant 3, mRNA.
ACCESSION   NM_001146200
VERSION     NM_001146200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6644)
  AUTHORS   Shepard,R.M., Ghebremedhin,A., Pratumchai,I., Robinson,S.R.,
            Betts,C., Hu,J., Sasik,R., Fisch,K.M., Zak,J., Chen,H.,
            Paradise,M., Rivera,J., Amjad,M., Uchiyama,S., Seo,H., Campos,A.D.,
            Dayao,D.A., Tzipori,S., Piedra-Mora,C., Das,S., Hasteh,F.,
            Russo,H., Sun,X., Xu,L., Crotty Alexander,L.E., Duran,J.M.,
            Odish,M., Pretorius,V., Kirchberger,N.C., Chin,S.M., Von
            Schalscha,T., Cheresh,D., Morrey,J.D., Alargova,R., O'Connell,B.,
            Martinot,T.A., Patel,S.P., Nizet,V., Martinot,A.J., Coussens,L.M.,
            Teijaro,J.R. and Varner,J.A.
  TITLE     PI3Kgamma inhibition circumvents inflammation and vascular leak in
            SARS-CoV-2 and other infections
  JOURNAL   Sci Transl Med 16 (754), eadi6887 (2024)
   PUBMED   38959328
REFERENCE   2  (bases 1 to 6644)
  AUTHORS   Gu,H., Chen,C., Hou,Z.S., He,X.D., Xie,S., Ni,J., Qian,C.,
            Cheng,X., Jiang,T., Yang,C., Roberts,T.M., Zheng,J., Varner,J.A.,
            Armstrong,S.A. and Zhao,J.J.
  TITLE     PI3Kgamma maintains the self-renewal of acute myeloid leukemia stem
            cells by regulating the pentose phosphate pathway
  JOURNAL   Blood 143 (19), 1965-1979 (2024)
   PUBMED   38271660
  REMARK    GeneRIF: PI3Kgamma maintains the self-renewal of acute myeloid
            leukemia stem cells by regulating the pentose phosphate pathway.
REFERENCE   3  (bases 1 to 6644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6644)
  AUTHORS   Wang,Y., Liu,Z., Song,S., Wang,J., Jin,C., Jia,L., Ma,Y., Yuan,T.,
            Cai,Z. and Xiang,M.
  TITLE     IRF5 governs macrophage adventitial infiltration to fuel abdominal
            aortic aneurysm formation
  JOURNAL   JCI Insight 9 (3), e171488 (2024)
   PUBMED   38175709
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6644)
  AUTHORS   Lu,C., Liu,J., Escames,G., Yang,Y., Wu,X., Liu,Q., Chen,J.,
            Song,Y., Wang,Z., Deng,C., Acuna-Castroviejo,D. and Wang,X.
  TITLE     PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic
            Myocardial Injury
  JOURNAL   Inflammation 46 (6), 2416-2432 (2023)
   PUBMED   37676465
  REMARK    GeneRIF: PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic
            Myocardial Injury.
REFERENCE   6  (bases 1 to 6644)
  AUTHORS   Sasaki,T., Irie-Sasaki,J., Horie,Y., Bachmaier,K., Fata,J.E.,
            Li,M., Suzuki,A., Bouchard,D., Ho,A., Redston,M., Gallinger,S.,
            Khokha,R., Mak,T.W., Hawkins,P.T., Stephens,L., Scherer,S.W.,
            Tsao,M. and Penninger,J.M.
  TITLE     Colorectal carcinomas in mice lacking the catalytic subunit of
            PI(3)Kgamma
  JOURNAL   Nature 406 (6798), 897-902 (2000)
   PUBMED   10972292
  REMARK    Erratum:[Nature. 2003 Dec 4;426(6966):584]
REFERENCE   7  (bases 1 to 6644)
  AUTHORS   Hirsch,E., Katanaev,V.L., Garlanda,C., Azzolino,O., Pirola,L.,
            Silengo,L., Sozzani,S., Mantovani,A., Altruda,F. and Wymann,M.P.
  TITLE     Central role for G protein-coupled phosphoinositide 3-kinase gamma
            in inflammation
  JOURNAL   Science 287 (5455), 1049-1053 (2000)
   PUBMED   10669418
REFERENCE   8  (bases 1 to 6644)
  AUTHORS   Li,Z., Jiang,H., Xie,W., Zhang,Z., Smrcka,A.V. and Wu,D.
  TITLE     Roles of PLC-beta2 and -beta3 and PI3Kgamma in
            chemoattractant-mediated signal transduction
  JOURNAL   Science 287 (5455), 1046-1049 (2000)
   PUBMED   10669417
REFERENCE   9  (bases 1 to 6644)
  AUTHORS   Sasaki,T., Irie-Sasaki,J., Jones,R.G., Oliveira-dos-Santos,A.J.,
            Stanford,W.L., Bolon,B., Wakeham,A., Itie,A., Bouchard,D.,
            Kozieradzki,I., Joza,N., Mak,T.W., Ohashi,P.S., Suzuki,A. and
            Penninger,J.M.
  TITLE     Function of PI3Kgamma in thymocyte development, T cell activation,
            and neutrophil migration
  JOURNAL   Science 287 (5455), 1040-1046 (2000)
   PUBMED   10669416
REFERENCE   10 (bases 1 to 6644)
  AUTHORS   Klesse,L.J. and Parada,L.F.
  TITLE     p21 ras and phosphatidylinositol-3 kinase are required for survival
            of wild-type and NF1 mutant sensory neurons
  JOURNAL   J Neurosci 18 (24), 10420-10428 (1998)
   PUBMED   9852579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY194814.1, AC140314.2, AK137470.1 and AK077772.1.
            
            On Jun 10, 2018 this sequence version replaced NM_001146200.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132553.1, AK137470.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY194814.1         1-10
            11-142              AC140314.2         144710-144841       c
            143-2852            AK137470.1         42-2751
            2853-3191           AK077772.1         175-513
            3192-6644           AC140314.2         109589-113041       c
FEATURES             Location/Qualifiers
     source          1..6644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.74 cM"
     gene            1..6644
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase
                     catalytic subunit gamma"
                     /db_xref="GeneID:30955"
                     /db_xref="MGI:MGI:1353576"
     exon            1..142
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            143..2149
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..3463
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /EC_number="2.7.1.137"
                     /EC_number="2.7.1.154"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.1.153"
                     /note="PI3-kinase subunit gamma; ptdIns-3-kinase subunit
                     gamma; ptdIns-3-kinase subunit p110-gamma;
                     serine/threonine protein kinase PIK3CG;
                     phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa
                     catalytic subunit gamma; phosphoinositide-3-kinase,
                     catalytic, gamma polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit gamma isoform"
                     /protein_id="NP_001139672.1"
                     /db_xref="CCDS:CCDS25870.1"
                     /db_xref="GeneID:30955"
                     /db_xref="MGI:MGI:1353576"
                     /translation="MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVL
                     PTSQRISKTPETALLHVAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQK
                     KGQWYEIYDRYQVVQTLDCLHYWKLMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGY
                     DVTDISNVHDDELEFTRRRLVTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIANN
                     CIFIVIHRGTTSQTIKVSADDTPGTILQSFFTKMAKKKSLMNISESQSEQDFVLRVCG
                     RDEYLVGETPLKNFQWVRQCLKNGDEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTG
                     YHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
                     VLCQRRTSPKPFAEEVLWNVWLEFGIKIKDLPKGALLNLQIYCCKTPSLSSKASAETP
                     GSESKGKAQLLYYVNLLLIDHRFLLRHGDYVLHMWQISGKAEEQGSFNADKLTSATNP
                     DKENSMSISILLDNYCHPIALPKHRPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNP
                     LTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREIWDQSALDV
                     GLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLL
                     KRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLQDFTQQVHVIE
                     MLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLPESFRVPYDPGLKAGTLVI
                     EKCKVMASKKKPLWLEFKCADPTVLSNETIGIIFKHGDDLRQDMLILQILRIMESIWE
                     TESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTGAFKDEVLNHWLKEK
                     CPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNLFHIDFGHILGNY
                     KSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLALRHHTNLLIIL
                     FSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQFNWFL
                     HLVLGIKQGEKHSA"
     exon            2150..2215
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2441
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2545
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2692
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2783
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2914
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3026
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3184
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..6644
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4598..4603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="hexamer: CATAAA"
     polyA_site      4617
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="major polyA site"
     regulatory      5849..5854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="hexamer: AATAAA"
     polyA_site      5884
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
     regulatory      6557..6562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="hexamer: AATAAA"
     polyA_site      6578
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
     regulatory      6620..6625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
                     /note="hexamer: AATAAA"
     polyA_site      6644
                     /gene="Pik3cg"
                     /gene_synonym="5830428L06Rik; p110gamma; p120-PI3K;
                     PI3Kgamma"
ORIGIN      
        1 ttcctctgca tctggatatg aagggagccc cagaaaagag gaagagacga ggtgccccgg
       61 gtaggtctag attcgttttt tttttttttt tcctaaagta aacaaatgat cctcctccgc
      121 atcacctcca gggctgcctc aggtcgcata gggcatggag ctggagaact atgaacaacc
      181 ggtggttcta agagaggaca acctccgccg gcgccggagg atgaagccac gcagcgcagc
      241 aggcagcctg tcttccatgg agctcatccc cattgagttc gtactgccca ccagccagcg
      301 catcagcaag actccagaaa cagcgctgct gcatgtggct ggccatggca atgtggaaca
      361 gatgaaagct caggtgtggc tgcgcgcact ggagaccagt gtggctgcgg agttctacca
      421 ccgattgggc ccggaccaat tcctcctgct ctaccagaag aaaggacaat ggtatgagat
      481 ctatgacagg taccaagtgg tgcagaccct agactgcctg cattactgga agttgatgca
      541 caagagccct ggccagatcc acgtggtaca gcgacacgta ccttctgagg agaccttggc
      601 tttccagaag cagctcacct ccctgattgg ctatgacgtc actgacatca gcaatgtgca
      661 cgatgatgag ctagagttca ctcgccgccg tctggttacg ccccgcatgg ctgaagtggc
      721 tggccgggat gccaaactct atgctatgca cccttgggta acgtccaaac ctctcccaga
      781 ctacctgtca aaaaagattg ccaacaactg catcttcatc gtcatccacc gcggtaccac
      841 cagccaaacc atcaaggtct ccgcagatga tactcctggt accatcctcc agagcttctt
      901 caccaagatg gccaagaaga agtccctaat gaatatctca gaaagtcaaa gtgagcagga
      961 ttttgtattg cgggtttgtg gccgcgatga gtacctggtg ggtgaaacac ccctcaaaaa
     1021 tttccagtgg gtgaggcagt gcctcaagaa cggagatgaa atacacctgg tgctcgacac
     1081 gcctccagac ccagcccttg atgaggtgag gaaggaagaa tggccgctgg tggatgactg
     1141 cactggagtc accggctacc acgagcagct gaccatccat ggcaaggacc acgagagtgt
     1201 gttcacagtg tctttgtggg actgcgaccg aaagttcagg gtcaagatca gaggcattga
     1261 tatccctgtc ctgcctcgga acaccgacct cactgtgttt gtggaagcga acatccagca
     1321 cgggcaacaa gtcctctgcc aaaggagaac cagccctaag cccttcgcag aagaggtact
     1381 ctggaatgtg tggctggagt ttggcatcaa aatcaaagac ttgcccaaag gggctctatt
     1441 gaacctacag atctactgct gcaaaacccc atcactgtcc agcaaggctt ctgcagagac
     1501 tccaggctcc gagtccaagg gcaaagccca gcttctctat tacgtgaact tgctgttaat
     1561 agaccaccgt ttcctcctcc gccacgggga ctatgtgctc cacatgtggc agatatctgg
     1621 caaggcagag gagcagggca gcttcaatgc tgacaagctc acatccgcaa ccaatcctga
     1681 caaggagaac tcaatgtcca tttccatcct gctggacaat tactgtcacc ccatagcttt
     1741 gcctaagcac cggcccaccc ctgacccaga gggagacagg gttcgggctg aaatgcccaa
     1801 tcagcttcga aagcaattgg aggcgatcat agccacagat ccacttaacc ccctcacagc
     1861 agaggacaaa gaattgctct ggcattttcg atatgaaagc ctgaagcatc cgaaggctta
     1921 ccctaagcta ttcagctcag tgaaatgggg gcagcaagaa attgttgcca aaacgtacca
     1981 gctgttagcc agaagggaga tctgggatca aagtgctttg gacgttggct taaccatgca
     2041 gctcctggac tgcaactttt cagacgagaa tgtccgggcc attgcagttc agaaactgga
     2101 gagcttagag gacgatgacg ttttacatta ccttctccag ctggtacagg ctgtgaaatt
     2161 tgaaccgtac cacgacagtg cgctggccag attcctgctg aagcgtggct tgaggaacaa
     2221 aagaatcggt cacttcttgt tctggttcct gcgaagtgag atcgcacagt ccagacacta
     2281 tcagcagagg ttcgctgtga tcctggaggc gtacctgcga ggctgtggca cagccatgtt
     2341 gcaggacttc acacagcagg tccatgtgat tgagatgtta cagaaagtca ccattgatat
     2401 taaatcgctc tcggcagaga agtatgacgt cagttcccaa gttatttcac agcttaagca
     2461 aaagcttgaa agccttcaga actccaatct ccccgagagc tttagagttc cctatgatcc
     2521 tggactaaaa gccggtaccc tggtgatcga gaaatgcaaa gtgatggcct ccaagaagaa
     2581 gcccctgtgg cttgagttta agtgtgctga tcccacagtc ctatccaacg aaaccattgg
     2641 aatcatcttt aaacatggtg atgatctgcg ccaagacatg ttgatcttgc agattctacg
     2701 catcatggag tccatttggg agactgaatc tctggacctg tgccttctgc cttacggttg
     2761 catctcaact ggtgacaaaa taggaatgat cgagattgta aaggatgcca caacgatcgc
     2821 tcaaattcag caaagcacag tgggtaacac gggggcattc aaagatgaag tcctgaatca
     2881 ctggctcaag gaaaaatgtc ctattgaaga aaagtttcag gccgcagtgg aaaggtttgt
     2941 ttactcctgt gcaggctact gtgtggccac atttgttctt gggatcggtg acaggcacaa
     3001 cgacaacatt atgatctcag agacaggaaa cctatttcat atagacttcg gacacattct
     3061 tgggaattac aagagtttcc tgggcatcaa taaagagaga gtgcccttcg tcctaacccc
     3121 agacttcttg tttgtgatgg gatcttctgg aaaaaagaca agtccacact tccagaaatt
     3181 ccaggatgtc tgtgttagag cttacctagc tcttcgccat cacacaaacc tgttgatcat
     3241 cttgttctcc atgatgctga tgacaggaat gccccagctg acaagcaaag aggacattga
     3301 atatatccgg gatgccctca ccgtgggaaa aagcgaggag gacgctaaga aatatttcct
     3361 tgatcagatc gaagtctgca gagacaaagg atggactgtg cagtttaact ggttcctaca
     3421 tcttgttctt ggcatcaaac aaggagaaaa gcactccgct tgatatgtgg tgctagggcc
     3481 caaagcaatg tagtgttctg gagcttttag atcagcatgt caatcatcag cgttaagatt
     3541 taaaacgcaa taagactctc tgaacactgt acttcagaaa tccagctctt tccccagctg
     3601 aactcttcac cagaggggga aaaaaatgtt ggcattactg atggtttggt taatattcag
     3661 tgcgaggctt ctctgttcct tttccctcct ctcagtctcc atgatgttga agaatattct
     3721 cagtttaaat agcttagagc agccttgctt agtatgcctg acgatctcgt attgagtatc
     3781 tctgaaagcc ctttagttag aataactggc aatacctgtt ttctcgtgtg tccaccatgt
     3841 attttggctc tccttgtgtt ctctaagctc ttggcagaaa aaggtgcaag cattgctaag
     3901 ctctgctgca ttctttaaag ggtgtttcta agcatcccct cagtgcccac agagcaagga
     3961 atgcaagtta gctcatagaa taccagagta ctgtcagcag tttgtttccc acagtatacc
     4021 actgagatgc ccaggcactg aacacaagct ctgagcctga gccttgcccc tccccagctg
     4081 ctgtggctct agggttatgg acgtgaaaag tggaggtgac accttttacc aagagcgaat
     4141 aacctattac agccagtgtc atcttctcct gcacaaagca ggaagtcgct agctggaccc
     4201 ctggatgccc acaaatgtca tctttccctc ttgttctgtt cccccttacc catgctgcaa
     4261 cacttcctgt acttcttcct ggacttgtgg actcttcaaa gacatctcaa aatgacttga
     4321 aaaagaaagt ctactctagg ctcaggagag ttataggtac gtatttgtgg agccgttcca
     4381 tggattttta aaaagaatat tattttaaaa aaaaaaagag ttccagaaaa tactagtttc
     4441 taaatgcttt aattttacat tttaaatctg agaagttttt ctttattttt taatagaaga
     4501 tacctgctat caaatgtatt ctaagcttat aacaatactt attaggtatt cattttttca
     4561 gtttaaagga ctttaaattt tgaggcatcc cagagttcat aaagacaatt gaaccaattt
     4621 cctttgaagt actttttcat ttcttaaata ttatgctgtt tgtcatcagt gttgatccac
     4681 ctttgagagg aatcagtaaa ttatttaatc aaatatcttt agctatcatt aattccatag
     4741 aaagaaagat gtcaaagatg tccatattta gatataatca gatataattc tttctgattt
     4801 ttaaattgtc aaaatagaca cttccattag aaggaaccca acattccctt tgtgtctcca
     4861 gaagccaagt agcacctaat tctgctacaa ataagaacca tcagggacac tttcaacata
     4921 gccttgcatt ttaaagtcac cccactttca gattataatt tcattagtgt gaatgagcct
     4981 gggtatggtt ttctaagcac tgtggctgaa tctaacacac atgcagggga aggaggctta
     5041 tttggtgcgt gatggtatag gtaaccctgc ctccttgcgg actggacctt ccctggctca
     5101 taacgagcta caaaaacatc tcctcatccc tgggaagtaa ctgttctaaa actacgctgt
     5161 ctcctgtaca ggccatgccc tgtgctgaaa ctgtgcttct ctctatgaat gtaattttat
     5221 ggcatttctg gagtgtgatt cctgctaatc taagaacagg acaaatggga cgcaagctta
     5281 ggcttctaaa gaaccataca cagactctgc ctttcatttg aattgctgaa acgatgatct
     5341 tgatgataaa acaattacgg agtatatcta tacttagctt ccgacaccac atgcatacat
     5401 attagttctt taaatgagcc agtcttttca taaggctgaa ctacatggcg ccgtagactg
     5461 ggtttcattc ttccatttcc caaagaatgc aatttcaact ccatagactt gcatataagt
     5521 aaaagccacc ttcatatgct accttgccat tcctgtgagt gatattgtcc agtgatttct
     5581 acacctttga aaataatcta gacctagggt ctccaggtaa ataccaatat ctctaccttc
     5641 agtgctgagt gaagaaaaca gatcacaggt cagatggatc gggttaaagc aacttatgtg
     5701 tgtatttaag acaacaaaag acacaaagct tccgttgtag acttggtcca atatgactct
     5761 actggttttg gtggtgctct gaaaaatgca gaaagacatt atgaataaaa tatatcaacc
     5821 agaaaaagaa aaaagctcta gacttgcaaa taaattaagt atagtaagtc catctttttc
     5881 aggagacaag ttgttttggt tttattagtt ctttgagaat tgtgtacaaa gagttttgac
     5941 catatgcacc cacttcccca acatctccca gattcacccc ctttccctgc ccacccaatt
     6001 gtgtcctctc tttttttttc tttttgtcca tcaatggcaa cactcttcaa gaaaacttcc
     6061 tctctccgca gctatcaatt gccaacagtt cttggctagg ggtggaactt catatccacc
     6121 tcccctctcc atgctgggat ttggtgcacg cgccctgagc tttcctgggg cttgtcctag
     6181 ctgctgtgag ttcatatgtg cagctgccct gccatgtcca gaggatcctg cttcctcgta
     6241 ttcgttcacc acctctgtct ctcaccgtct ctccaggtcc tcttccaatg atcactgagc
     6301 cttgggagga gatggggagg taatagatgc tccatttagg gctgagtatt ctgcaggctc
     6361 ttactctctg caccaggact agctatgaat ctcagtggtg atcatcatct atgcaaacag
     6421 acactgctct gatgcaggct gagagatata ctaatctata gataaaacag caagtcatga
     6481 agggtcattt tgggaattct atagcatgat ttggaagctg ttagtcctat attaatgaca
     6541 attgaatata atcttaaata aaaaaattag aaaaaacatt tctgaaatca tcagcaatta
     6601 tgtttaacaa cgtgaagaaa ataaaatgag ctaggatttc ttaa
//
