LOCUS       NM_001164052            4636 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase
            catalytic subunit delta (Pik3cd), transcript variant 1, mRNA.
ACCESSION   NM_001164052
VERSION     NM_001164052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Martucci,N.J., Stoops,J., Bowen,W., Orr,A., Cotner,M.C.,
            Michalopoulos,G.K., Bhushan,B. and Mars,W.M.
  TITLE     A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase
            Delta Isoform in Hepatocellular Proliferation
  JOURNAL   Am J Pathol 194 (8), 1511-1527 (2024)
   PUBMED   38705383
  REMARK    GeneRIF: A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate
            3-Kinase Delta Isoform in Hepatocellular Proliferation.
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Singh,A.K., Al Qureshah,F., Drow,T., Hou,B. and Rawlings,D.J.
  TITLE     Activated PI3Kdelta Specifically Perturbs Mouse Regulatory T Cell
            Homeostasis and Function Leading to Immune Dysregulation
  JOURNAL   J Immunol 213 (2), 135-147 (2024)
   PUBMED   38829130
  REMARK    GeneRIF: Activated PI3Kdelta Specifically Perturbs Mouse Regulatory
            T Cell Homeostasis and Function Leading to Immune Dysregulation.
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Qiu,J., Wang,Y.H., Wang,X.M. and Chen,H.S.
  TITLE     PI3Kdelta inhibition alleviates the brain injury during cerebral
            ischemia reperfusion via suppressing pericyte contraction in a
            TNF-alpha dependent manner
  JOURNAL   Exp Neurol 375, 114728 (2024)
   PUBMED   38365134
  REMARK    GeneRIF: PI3Kdelta inhibition alleviates the brain injury during
            cerebral ischemia reperfusion via suppressing pericyte contraction
            in a TNF-alpha dependent manner.
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Tzenaki,N., Xenou,L., Goulielmaki,E., Tsapara,A., Voudouri,I.,
            Antoniou,A., Valianatos,G., Tzardi,M., De Bree,E., Berdiaki,A.,
            Makrigiannakis,A. and Papakonstanti,E.A.
  TITLE     A combined opposite targeting of p110delta PI3K and RhoA abrogates
            skin cancer
  JOURNAL   Commun Biol 7 (1), 26 (2024)
   PUBMED   38182748
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4636)
  AUTHORS   Nguyen,T., Lau,A., Bier,J., Cooke,K.C., Lenthall,H., Ruiz-Diaz,S.,
            Avery,D.T., Brigden,H., Zahra,D., Sewell,W.A., Droney,L., Okada,S.,
            Asano,T., Abolhassani,H., Chavoshzadeh,Z., Abraham,R.S.,
            Rajapakse,N., Klee,E.W., Church,J.A., Williams,A., Wong,M.,
            Burkhart,C., Uzel,G., Croucher,D.R., James,D.E., Ma,C.S., Brink,R.,
            Tangye,S.G. and Deenick,E.K.
  TITLE     Human PIK3R1 mutations disrupt lymphocyte differentiation to cause
            activated PI3Kdelta syndrome 2
  JOURNAL   J Exp Med 220 (6) (2023)
   PUBMED   36943234
REFERENCE   6  (bases 1 to 4636)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4636)
  AUTHORS   Clayton,E., McAdam,S., Coadwell,J., Chantry,D. and Turner,M.
  TITLE     Structural organization of the mouse phosphatidylinositol 3-kinase
            p110d gene
  JOURNAL   Biochem Biophys Res Commun 280 (5), 1328-1332 (2001)
   PUBMED   11162674
REFERENCE   8  (bases 1 to 4636)
  AUTHORS   Matsuzaki,K., Katayama,K., Takahashi,Y., Nakamura,I., Udagawa,N.,
            Tsurukai,T., Nishinakamura,R., Toyama,Y., Yabe,Y., Hori,M.,
            Takahashi,N. and Suda,T.
  TITLE     Human osteoclast-like cells are formed from peripheral blood
            mononuclear cells in a coculture with SaOS-2 cells transfected with
            the parathyroid hormone (PTH)/PTH-related protein receptor gene
  JOURNAL   Endocrinology 140 (2), 925-932 (1999)
   PUBMED   9927325
REFERENCE   9  (bases 1 to 4636)
  AUTHORS   Lakkakorpi,P.T., Wesolowski,G., Zimolo,Z., Rodan,G.A. and
            Rodan,S.B.
  TITLE     Phosphatidylinositol 3-kinase association with the osteoclast
            cytoskeleton, and its involvement in osteoclast attachment and
            spreading
  JOURNAL   Exp Cell Res 237 (2), 296-306 (1997)
   PUBMED   9434625
REFERENCE   10 (bases 1 to 4636)
  AUTHORS   Chantry,D., Vojtek,A., Kashishian,A., Holtzman,D.A., Wood,C.,
            Gray,P.W., Cooper,J.A. and Hoekstra,M.F.
  TITLE     p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit
            that associates with p85 and is expressed predominantly in
            leukocytes
  JOURNAL   J Biol Chem 272 (31), 19236-19241 (1997)
   PUBMED   9235916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607078.26.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the central coding region, compared to variant 4.
            The promoter and 5' UTR for this variant has not been determined.
            The resulting isoform (a) lacks a 1-aa internal segment, compared
            to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U86587.1, ERR3765653.1917740.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL607078.26        108206-108378       c
            174-402             AL607078.26        105064-105292       c
            403-632             AL607078.26        104755-104984       c
            633-812             AL607078.26        104033-104212       c
            813-962             AL607078.26        103774-103923       c
            963-1052            AL607078.26        103444-103533       c
            1053-1274           AL607078.26        102308-102529       c
            1275-1371           AL607078.26        101666-101762       c
            1372-1502           AL607078.26        101443-101573       c
            1503-1553           AL607078.26        100643-100693       c
            1554-1718           AL607078.26        100398-100562       c
            1719-1840           AL607078.26        100189-100310       c
            1841-1984           AL607078.26        99878-100021        c
            1985-2084           AL607078.26        99580-99679         c
            2085-2263           AL607078.26        99287-99465         c
            2264-2376           AL607078.26        99085-99197         c
            2377-2455           AL607078.26        98869-98947         c
            2456-2623           AL607078.26        98373-98540         c
            2624-2747           AL607078.26        97673-97796         c
            2748-2893           AL607078.26        97289-97434         c
            2894-3026           AL607078.26        96827-96959         c
            3027-4636           AL607078.26        94230-95839         c
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.15 cM"
     gene            1..4636
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase
                     catalytic subunit delta"
                     /db_xref="GeneID:18707"
                     /db_xref="MGI:MGI:1098211"
     exon            1..173
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            174..402
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            403..632
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            633..812
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            813..962
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1052
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1274
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1371
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1502
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1553
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1718
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1840
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1984
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2084
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2263
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2376
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2455
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2623
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2747
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2893
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3026
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..4636
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4612..4617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /note="hexamer: AATAAA"
     polyA_site      4636
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /note="major polyA site"
ORIGIN      
        1 gaaaacagac ctcagagaag taacacaaca ggatgccccc tggggtggac tgccccatgg
       61 agttctggac caaagaggag agccagagcg tggttgttga cttcttgctg cccacagggg
      121 tctacttgaa cttccccgtg tcccgcaatg ccaacctcag caccatcaag caggtgctgt
      181 ggcaccgtgc acagtatgag ccactcttcc acatgctcag tgaccccgag gcctatgtgt
      241 tcacctgtgt gaaccagacg gcggagcagc aggagttgga ggatgagcag cggaggctgt
      301 gcgacatcca gcccttcctg cccgtgctgc gcctcgtggc ccgagagggg gaccgcgtga
      361 agaagctcat taactcccag atcagcctcc tcattggcaa aggtctccat gagtttgatt
      421 ccctgcggga cccggaagta aacgacttcc gcactaagat gcgccagttt tgtgaagagg
      481 ctgctgctca ccgccagcag ctgggctggg tggaatggct gcagtacagc ttccccctgc
      541 agctggagcc ctcagcaagg ggttggcggg ccggcttatt gcgtgtcagc aaccgagccc
      601 tgctggtcaa cgtgaagttc gagggcagtg aggagagctt caccttccag gtatccacca
      661 aggacatgcc cctggcactg atggcctgtg ccctccgaaa aaaggccaca gtgttccggc
      721 agcctctggt ggagcagcct gaggaatatg ccctgcaggt gaacgggagg cacgaatacc
      781 tctacggcaa ctacccgctc tgccactttc agtacatctg cagctgccta cacagcgggc
      841 tgacccctca tctgaccatg gtccactcct cctccatcct tgctatgcgg gatgagcaga
      901 gcaatcctgc cccccaagta cagaaaccac gtgccaaacc tcccccgatc cctgccaaga
      961 agccctcctc tgtgtccctg tggtccctgg aacagccatt ctccattgag ctgatcgagg
     1021 gccgaaaagt gaatgctgac gagcggatga agctggttgt tcaggccggg ctcttccatg
     1081 gcaatgagat gctgtgcaag actgtgtcaa gctcggaggt gaatgtatgc tcagagcccg
     1141 tgtggaagca gcgactggag ttcgatatca gcgtctgtga cctcccgcgc atggctcgac
     1201 tctgttttgc tctctatgcc gtcgtggaga aggctaagaa ggcacgctcc acaaagaaga
     1261 agtctaagaa ggcggactgc cccatcgctt gggccaacct catgctattc gactacaaag
     1321 atcagctcaa gacgggggag cgctgcctct acatgtggcc ctctgtccca gatgagaagg
     1381 gagagctgct gaatcctgcg ggtacagtgc gcgggaaccc caacacggag agtgccgctg
     1441 ccctggtcat ctacctgcct gaggtggccc cccaccctgt gtacttcccc gctctggaga
     1501 agatcctgga gctggggcgt cacggggagc gtgggcgcat cacggaggag gagctgcagc
     1561 tgcgggagat cctggaacgg cggggatccg gggaactgta cgaacatgag aaggacctgg
     1621 tgtggaagat gcgccacgaa gtccaggagc atttcccaga ggcgctggcc cgcctgctgc
     1681 tggtcaccaa gtggaataaa cacgaggatg tggcccagat gctctatttg ctgtgctcct
     1741 ggcccgagct gcctgtgctg agcgccctgg aacttctgga ctttagcttt cccgactgct
     1801 acgtgggctc cttcgccatc aagtcccttc ggaagctgac ggacgatgag ctcttccagt
     1861 accttctgca gctggtgcaa gtgctcaaat atgagtccta cctggactgc gagctgacca
     1921 aattcttgct gggccgagcc ctggctaacc gcaagatcgg acacttcctg ttctggcacc
     1981 tccgctctga gatgcacgta ccatcagtgg ctctgcggtt tggtctcatc atggaagcct
     2041 actgcagagg cagcacccac cacatgaagg tgctgatgaa gcagggggaa gcactgagca
     2101 agcttaaggc actgaatgac tttgtgaagg tgagttccca gaagaccacc aagccccaaa
     2161 ccaaggagat gatgcatatg tgcatgcgcc aggagaccta catggaggcc ctgtcccacc
     2221 tgcagtctcc actcgacccc agcaccctgc tggaggaagt ctgtgtggag cagtgcacct
     2281 tcatggactc caaaatgaag cccctgtgga tcatgtacag cagcgaggag gcgggcagtg
     2341 ctggcaacgt gggcatcatc tttaagaacg gggatgacct ccgccaggac atgctgactc
     2401 tgcagatgat ccagctcatg gacgtcctgt ggaagcagga gggcctggac ctgaggatga
     2461 cgccctacgg ctgcctcccc accggggacc gcacaggtct catcgaggtg gtcctccact
     2521 cggacaccat cgccaacatc cagctgaaca aaagcaacat ggcggccaca gctgccttca
     2581 acaaggacgc cctgctcaac tggctcaagt ccaagaaccc tggggaggcc ctggatcggg
     2641 ccattgagga attcaccctc tcctgtgctg gctactgtgt ggccacatat gttctgggca
     2701 tcggtgaccg gcacagcgac aacatcatga tcagagagag tgggcagctc ttccacattg
     2761 attttggcca ctttctgggg aacttcaaga ccaagtttgg aatcaaccga gagcgcgtcc
     2821 ccttcattct cacctacgac tttgtccacg tgatccagca ggggaagact aacaacagtg
     2881 agaagtttga aaggttccgc ggctactgtg aacgagccta taccatcctg cggcgccacg
     2941 ggctgctttt cctccatctc ttcgccctga tgcgggccgc aggtctgcct gagcttagct
     3001 gctccaaaga tatccagtat ctcaaggact ctctggcact ggggaagacg gaggaagagg
     3061 cgctaaagca cttccgggtg aagttcaacg aagctctccg agaaagctgg aaaaccaaag
     3121 tcaactggct ggcgcacaat gtgtccaagg ataaccgaca gtaggaggcg ccccctggtg
     3181 gtcatacggc ggttccctcc tggctttcag ccctagaggt aaaaggacag tcctggagac
     3241 caggcatgtc cagtggtcac caaagggacc ccagagcctg aactgtccct catggggaag
     3301 aaccacacca ctgcttcttg tttacactgg taatttattt atgactcgaa atgtttaagg
     3361 aacagaatag ccataaatgg aagtgcattt ctgtgcaggg gaggggtgat gtcctcatga
     3421 tgtcatcccc ggtcagcact gtaacagcac cttgaggatc gaacccctag tcttccaacc
     3481 tgtgggtctt ggcccagcaa ggacagttct tggggccttc ttcccaggct cccagcaggc
     3541 tgcctggaac aagcctggcg gtcacctggt gcctccatcc tcagctcacc tccggccacc
     3601 gttgtgtggc ctacccaacc aagcctccgg cagctcttga ggaagccagg agcttccctc
     3661 tagactcagg cacacttgct cggcactgct gaagcgacct cttgggtttg ggtacgggaa
     3721 cgccctcacc tctcatttgc gggtaagaac acgatatgta gactctgtcc cttaccccga
     3781 tggctggggt aagggacctg gcctccacta cagttagtgt attccaggcc ttgaagcact
     3841 cagaccggtg ccccatttag ctccgtgtgg tcacgaatca agacgaaggg ccagccagaa
     3901 ttgaagtcct cttcgaagtt cgtgtgaggg gcacacaagg cagctttatg gacggacagg
     3961 actgatctct tccagagctg aaatcgcaga aggcagctgg ggagctaggc tcgaaaagtg
     4021 tgagcaagga cgagaacgga attcagtgta gtctgggcag tcagaggaac tcgagaaacg
     4081 cagtctcggc ctcctcccag ggatccaaac gccagccacc cgcccggctt ttagagagcc
     4141 cagctcaggg gtcgcacatg cttatcgtcc caccccaagc acatctccat gtatcagctg
     4201 ccacctcagg acctggatct cccggtagca ttctgagact ttgagaacca tcaccgctgt
     4261 ctcgccagca gcccagaaca tggctcaagg agccccttca tgttgatgag cccagggtcc
     4321 agcagtgagc ggtggtgcct ccgcagcacc cgctgaaccc ctagtctgcc ccaccaactc
     4381 tgaaatagga aacgtgtctg tgtgtgtgta tgtatgtatg ccatgttatt tattgaaaag
     4441 agtctaggtg ctctctggtg tggctgcaga ttctgcacag gctcggcctt tctgggttgg
     4501 gtgtgtactt ggctggaaga cgggtttttt gttaagtttt ttcctctcat tgatgggggc
     4561 tgagaccagt ttgtgcaacc ttgacacaac aggtaaagac aggtgaaaag aaataaaaac
     4621 gtttttatgt tcttaa
//
