LOCUS       NP_001157524            1043 aa            linear   ROD 10-FEB-2025
DEFINITION  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
            delta isoform isoform a [Mus musculus].
ACCESSION   NP_001157524
VERSION     NP_001157524.1
DBSOURCE    REFSEQ: accession NM_001164052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1043)
  AUTHORS   Martucci,N.J., Stoops,J., Bowen,W., Orr,A., Cotner,M.C.,
            Michalopoulos,G.K., Bhushan,B. and Mars,W.M.
  TITLE     A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase
            Delta Isoform in Hepatocellular Proliferation
  JOURNAL   Am J Pathol 194 (8), 1511-1527 (2024)
   PUBMED   38705383
  REMARK    GeneRIF: A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate
            3-Kinase Delta Isoform in Hepatocellular Proliferation.
REFERENCE   2  (residues 1 to 1043)
  AUTHORS   Singh,A.K., Al Qureshah,F., Drow,T., Hou,B. and Rawlings,D.J.
  TITLE     Activated PI3Kdelta Specifically Perturbs Mouse Regulatory T Cell
            Homeostasis and Function Leading to Immune Dysregulation
  JOURNAL   J Immunol 213 (2), 135-147 (2024)
   PUBMED   38829130
  REMARK    GeneRIF: Activated PI3Kdelta Specifically Perturbs Mouse Regulatory
            T Cell Homeostasis and Function Leading to Immune Dysregulation.
REFERENCE   3  (residues 1 to 1043)
  AUTHORS   Qiu,J., Wang,Y.H., Wang,X.M. and Chen,H.S.
  TITLE     PI3Kdelta inhibition alleviates the brain injury during cerebral
            ischemia reperfusion via suppressing pericyte contraction in a
            TNF-alpha dependent manner
  JOURNAL   Exp Neurol 375, 114728 (2024)
   PUBMED   38365134
  REMARK    GeneRIF: PI3Kdelta inhibition alleviates the brain injury during
            cerebral ischemia reperfusion via suppressing pericyte contraction
            in a TNF-alpha dependent manner.
REFERENCE   4  (residues 1 to 1043)
  AUTHORS   Tzenaki,N., Xenou,L., Goulielmaki,E., Tsapara,A., Voudouri,I.,
            Antoniou,A., Valianatos,G., Tzardi,M., De Bree,E., Berdiaki,A.,
            Makrigiannakis,A. and Papakonstanti,E.A.
  TITLE     A combined opposite targeting of p110delta PI3K and RhoA abrogates
            skin cancer
  JOURNAL   Commun Biol 7 (1), 26 (2024)
   PUBMED   38182748
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1043)
  AUTHORS   Nguyen,T., Lau,A., Bier,J., Cooke,K.C., Lenthall,H., Ruiz-Diaz,S.,
            Avery,D.T., Brigden,H., Zahra,D., Sewell,W.A., Droney,L., Okada,S.,
            Asano,T., Abolhassani,H., Chavoshzadeh,Z., Abraham,R.S.,
            Rajapakse,N., Klee,E.W., Church,J.A., Williams,A., Wong,M.,
            Burkhart,C., Uzel,G., Croucher,D.R., James,D.E., Ma,C.S., Brink,R.,
            Tangye,S.G. and Deenick,E.K.
  TITLE     Human PIK3R1 mutations disrupt lymphocyte differentiation to cause
            activated PI3Kdelta syndrome 2
  JOURNAL   J Exp Med 220 (6) (2023)
   PUBMED   36943234
REFERENCE   6  (residues 1 to 1043)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (residues 1 to 1043)
  AUTHORS   Clayton,E., McAdam,S., Coadwell,J., Chantry,D. and Turner,M.
  TITLE     Structural organization of the mouse phosphatidylinositol 3-kinase
            p110d gene
  JOURNAL   Biochem Biophys Res Commun 280 (5), 1328-1332 (2001)
   PUBMED   11162674
REFERENCE   8  (residues 1 to 1043)
  AUTHORS   Matsuzaki,K., Katayama,K., Takahashi,Y., Nakamura,I., Udagawa,N.,
            Tsurukai,T., Nishinakamura,R., Toyama,Y., Yabe,Y., Hori,M.,
            Takahashi,N. and Suda,T.
  TITLE     Human osteoclast-like cells are formed from peripheral blood
            mononuclear cells in a coculture with SaOS-2 cells transfected with
            the parathyroid hormone (PTH)/PTH-related protein receptor gene
  JOURNAL   Endocrinology 140 (2), 925-932 (1999)
   PUBMED   9927325
REFERENCE   9  (residues 1 to 1043)
  AUTHORS   Lakkakorpi,P.T., Wesolowski,G., Zimolo,Z., Rodan,G.A. and
            Rodan,S.B.
  TITLE     Phosphatidylinositol 3-kinase association with the osteoclast
            cytoskeleton, and its involvement in osteoclast attachment and
            spreading
  JOURNAL   Exp Cell Res 237 (2), 296-306 (1997)
   PUBMED   9434625
REFERENCE   10 (residues 1 to 1043)
  AUTHORS   Chantry,D., Vojtek,A., Kashishian,A., Holtzman,D.A., Wood,C.,
            Gray,P.W., Cooper,J.A. and Hoekstra,M.F.
  TITLE     p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit
            that associates with p85 and is expressed predominantly in
            leukocytes
  JOURNAL   J Biol Chem 272 (31), 19236-19241 (1997)
   PUBMED   9235916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607078.26.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the central coding region, compared to variant 4.
            The promoter and 5' UTR for this variant has not been determined.
            The resulting isoform (a) lacks a 1-aa internal segment, compared
            to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U86587.1, ERR3765653.1917740.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.15 cM"
     Protein         1..1043
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform a"
                     /EC_number="2.7.1.137"
                     /EC_number="2.7.1.153"
                     /note="phosphatidylinositol 3-kinase catalytic subunit
                     delta; catalytic phosphatidylinositol 3-kinase delta;
                     phosphoinositide 3 kinase P110delta; phosphatidylinositol
                     3-kinase p110 delta; PI3K-delta; PI3-kinase subunit delta;
                     ptdIns-3-kinase subunit delta; ptdIns-3-kinase subunit
                     p110-delta; p100 delta; PI3Kdelta; phosphatidylinositol
                     4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide"
                     /calculated_mol_wt=119582
     Region          34..107
                     /region_name="PI3K_p85B"
                     /note="PI3-kinase family, p85-binding domain; pfam02192"
                     /db_xref="CDD:460483"
     Region          182..281
                     /region_name="PI3K_rbd"
                     /note="PI3-kinase family, ras-binding domain; pfam00794"
                     /db_xref="CDD:395642"
     Region          287..312
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35904.2)"
     Region          314..481
                     /region_name="C2_PI3K_class_I_beta_delta"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); cd08693"
                     /db_xref="CDD:176075"
     Region          505..683
                     /region_name="PI3Ka"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); smart00145"
                     /db_xref="CDD:214537"
     Site            523
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O00329; propagated from
                     UniProtKB/Swiss-Prot (O35904.2)"
     Region          675..1041
                     /region_name="PI3Kc_IA_delta"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; cd05174"
                     /db_xref="CDD:270718"
     Region          750..756
                     /region_name="G-loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (O35904.2)"
     Site            order(751,753..755,757,759,776,778,781,812,824..827,832,
                     835,897,899,909..910)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270718"
     Site            order(819..820,921..922,924,926,992,995)
                     /site_type="other"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:270718"
     Site            866
                     /site_type="other"
                     /note="Ras binding site [polypeptide binding]"
                     /db_xref="CDD:270718"
     Region          889..897
                     /region_name="Catalytic loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (O35904.2)"
     Site            889..897
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     Region          908..934
                     /region_name="Activation loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (O35904.2)"
     Site            910..934
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270718"
     Site            1038
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:O00329; propagated from
                     UniProtKB/Swiss-Prot (O35904.2)"
     CDS             1..1043
                     /gene="Pik3cd"
                     /gene_synonym="2410099E07Rik; 2610208K16Rik; p110delta"
                     /coded_by="NM_001164052.1:33..3164"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51380.1"
                     /db_xref="GeneID:18707"
                     /db_xref="MGI:MGI:1098211"
ORIGIN      
        1 mppgvdcpme fwtkeesqsv vvdfllptgv ylnfpvsrna nlstikqvlw hraqyeplfh
       61 mlsdpeayvf tcvnqtaeqq eledeqrrlc diqpflpvlr lvaregdrvk klinsqisll
      121 igkglhefds lrdpevndfr tkmrqfceea aahrqqlgwv ewlqysfplq lepsargwra
      181 gllrvsnral lvnvkfegse esftfqvstk dmplalmaca lrkkatvfrq plveqpeeya
      241 lqvngrheyl ygnyplchfq yicsclhsgl tphltmvhss silamrdeqs npapqvqkpr
      301 akpppipakk pssvslwsle qpfsielieg rkvnadermk lvvqaglfhg nemlcktvss
      361 sevnvcsepv wkqrlefdis vcdlprmarl cfalyavvek akkarstkkk skkadcpiaw
      421 anlmlfdykd qlktgercly mwpsvpdekg ellnpagtvr gnpntesaaa lviylpevap
      481 hpvyfpalek ilelgrhger griteeelql reilerrgsg elyehekdlv wkmrhevqeh
      541 fpealarlll vtkwnkhedv aqmlyllcsw pelpvlsale lldfsfpdcy vgsfaikslr
      601 kltddelfqy llqlvqvlky esyldceltk fllgralanr kighflfwhl rsemhvpsva
      661 lrfglimeay crgsthhmkv lmkqgealsk lkalndfvkv ssqkttkpqt kemmhmcmrq
      721 etymealshl qspldpstll eevcveqctf mdskmkplwi mysseeagsa gnvgiifkng
      781 ddlrqdmltl qmiqlmdvlw kqegldlrmt pygclptgdr tglievvlhs dtianiqlnk
      841 snmaataafn kdallnwlks knpgealdra ieeftlscag ycvatyvlgi gdrhsdnimi
      901 resgqlfhid fghflgnfkt kfginrervp filtydfvhv iqqgktnnse kferfrgyce
      961 raytilrrhg llflhlfalm raaglpelsc skdiqylkds lalgkteeea lkhfrvkfne
     1021 alreswktkv nwlahnvskd nrq
//
