LOCUS       NM_029094               4854 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase
            catalytic subunit beta (Pik3cb), mRNA.
ACCESSION   NM_029094
VERSION     NM_029094.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4854)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4854)
  AUTHORS   Bergholz,J.S., Wang,Q., Wang,Q., Ramseier,M., Prakadan,S., Wang,W.,
            Fang,R., Kabraji,S., Zhou,Q., Gray,G.K., Abell-Hart,K., Xie,S.,
            Guo,X., Gu,H., Von,T., Jiang,T., Tang,S., Freeman,G.J., Kim,H.J.,
            Shalek,A.K., Roberts,T.M. and Zhao,J.J.
  TITLE     PI3Kbeta controls immune evasion in PTEN-deficient breast tumours
  JOURNAL   Nature 617 (7959), 139-146 (2023)
   PUBMED   37076617
  REMARK    GeneRIF: PI3Kbeta controls immune evasion in PTEN-deficient breast
            tumours.
REFERENCE   3  (bases 1 to 4854)
  AUTHORS   Ames,K., Kaur,I., Shi,Y., Tong,M.M., Sinclair,T., Hemmati,S.,
            Glushakow-Smith,S.G., Tein,E., Gurska,L., Steidl,U., Dubin,R.,
            Shan,J., Montagna,C., Pradhan,K., Verma,A. and Gritsman,K.
  TITLE     PI3-kinase deletion promotes myelodysplasia by dysregulating
            autophagy in hematopoietic stem cells
  JOURNAL   Sci Adv 9 (8), eade8222 (2023)
   PUBMED   36812307
REFERENCE   4  (bases 1 to 4854)
  AUTHORS   Yang,G., Lu,S., Jiang,J., Weng,J. and Zeng,X.
  TITLE     Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in
            Mice by the FGF Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (11), 6014 (2022)
   PUBMED   35682694
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4854)
  AUTHORS   Wang,Q., Tao,C., Hannan,A., Yoon,S., Min,X., Peregrin,J., Qu,X.,
            Li,H., Yu,H., Zhao,J. and Zhang,X.
  TITLE     Lacrimal gland budding requires PI3K-dependent suppression of EGF
            signaling
  JOURNAL   Sci Adv 7 (27) (2021)
   PUBMED   34193412
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4854)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 4854)
  AUTHORS   Leverrier,Y., Okkenhaug,K., Sawyer,C., Bilancio,A.,
            Vanhaesebroeck,B. and Ridley,A.J.
  TITLE     Class I phosphoinositide 3-kinase p110beta is required for
            apoptotic cell and Fcgamma receptor-mediated phagocytosis by
            macrophages
  JOURNAL   J Biol Chem 278 (40), 38437-38442 (2003)
   PUBMED   12869549
  REMARK    GeneRIF: p110beta is the major class I catalytic isoform required
            for apoptotic cell and Fcgamma receptor-mediated phagocytosis by
            primary macrophages
REFERENCE   8  (bases 1 to 4854)
  AUTHORS   Kang,J.L., Lee,H.S., Pack,I.S., Hur,K.C. and Castranova,V.
  TITLE     Phosphoinositide 3-kinase activity leads to silica-induced
            NF-kappaB activation through interacting with
            tyrosine-phosphorylated I(kappa)B-alpha and contributing to
            tyrosine phosphorylation of p65 NF-kappaB
  JOURNAL   Mol Cell Biochem 248 (1-2), 17-24 (2003)
   PUBMED   12870650
  REMARK    GeneRIF: p85 and p110 subunits of PI3-kinase play a role in
            NF-kappaB activation through interaction with
            tyrosine-phosphorylated I(kappa)B-alpha and contribute to tyrosine
            phosphorylation of p65 NF-kappaB
REFERENCE   9  (bases 1 to 4854)
  AUTHORS   Bi,L., Okabe,I., Bernard,D.J. and Nussbaum,R.L.
  TITLE     Early embryonic lethality in mice deficient in the p110beta
            catalytic subunit of PI 3-kinase
  JOURNAL   Mamm Genome 13 (3), 169-172 (2002)
   PUBMED   11919689
  REMARK    GeneRIF: Early embryonic lethality in mice deficient in the
            p110beta catalytic subunit of PI 3-kinase
REFERENCE   10 (bases 1 to 4854)
  AUTHORS   ALLEN,S.L.
  TITLE     H-2f, a tenth allele at the histocompatibility-2 locus in the mouse
            as determined by tumor transplantation
  JOURNAL   Cancer Res 15 (5), 315-319 (1955)
   PUBMED   14379171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129150.1, CV558291.1 and AK090116.1.
            
            On Nov 25, 2009 this sequence version replaced NM_029094.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090116.1, AK154106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               CJ129150.1         2-416
            416-976             CV558291.1         166-726
            977-4854            AK090116.1         854-4731
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.41 cM"
     gene            1..4854
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase
                     catalytic subunit beta"
                     /db_xref="GeneID:74769"
                     /db_xref="MGI:MGI:1922019"
     exon            1..221
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            222..314
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            315..501
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..3543
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.1.153"
                     /note="PI3Kbeta; phosphatidylinositol 4,5-bisphosphate
                     3-kinase 110 kDa catalytic subunit beta;
                     phosphatidylinositol 3-kinase, catalytic, beta
                     polypeptide; PI3K-beta; PI3-kinase subunit beta;
                     ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit
                     p110-beta; serine/threonine protein kinase PIK3CB"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit beta isoform"
                     /protein_id="NP_083370.2"
                     /db_xref="CCDS:CCDS23432.1"
                     /db_xref="GeneID:74769"
                     /db_xref="MGI:MGI:1922019"
                     /translation="MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREA
                     TISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPV
                     LKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGL
                     SWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKIN
                     ELAIQKRLTIRGKEDEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFI
                     LVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRVISHIWDNNNPFQITLVKG
                     NKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMA
                     RLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGD
                     VILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHITFPENKKQPCYYPPFDKIIEK
                     AAELASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENFPQS
                     LPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQM
                     SDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVS
                     VQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLSRAKGKEAMHTCL
                     KQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYSSRAFGEDSVGVIF
                     KNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIAD
                     IQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDR
                     HSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEK
                     FGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEE
                     ALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS"
     exon            502..727
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            728..951
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1131
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1302
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1380
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1632
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1729
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1860
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1911
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2100
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2222
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2366
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2466
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2645
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2755
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2834
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3002
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3126
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3272
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3405
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..4854
                     /gene="Pik3cb"
                     /gene_synonym="1110001J02Rik; p110beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgcgggc acggcggtgg cgcgcgcgtg ctccgtcggg cggtgcagcg gctgcgacgg
       61 agccggccat ggtcgtgggc ggtgggcggg tgtcgcgctg agccccgaag gcagcaagag
      121 actgggagcg gggcatgcgg gtgtcggagc caggcgggca cggctgcggg agctgctgac
      181 ggcgctgcgg gatcgggagc cggtggcggc gcgcggggca gttcatcttc taagctgaaa
      241 aagtcttcca tgaataattc acatttaaaa atcatatatt cctagaagac tgaaatgggg
      301 gctgttattt tgagggccct gaggttatga gtgtgcttcc gccctatcat gcctcctgct
      361 atggcagaca accttgacat ctgggcagtg gactcacaga ttgcatccga tggcgccata
      421 tccgtcgatt tccttctgcc caccgggatt tatatccagt tggaagtacc tcgggaagct
      481 accatttctt atattaaaca gatgttatgg aagcaagttc acaactaccc gatgtttaac
      541 ctcctcatgg acattgactc gtatatgttt gcatgtgtga atcaaactgc tgtatatgag
      601 gaactggaag acgaaacacg aagactttgt gatgtcagac cttttcttcc agttctcaaa
      661 ctagtgacta gaagctgtga ccccgcagaa aaattggact caaaaattgg ggttcttata
      721 ggaaaaggtc ttcatgagtt tgatgccttg aaggatcccg aagtgaatga atttagaaga
      781 aaaatgcgca aattcagtga ggccaagatt cagtctctgg tagggttgtc ttggatcgac
      841 tggctaaagc acacgtatcc gcctgagcac gagccgtccg tcctggagaa cttggaagat
      901 aaactttatg gaggaaagct ggttgtggct gtgcactttg aaaatagcca ggatgtattt
      961 agttttcaag tgtctcccaa tttgaatcct ataaaaataa atgaattggc aatccagaaa
     1021 cgcctcacta ttcgtggaaa ggaagatgaa gctagcccct gtgactatgt gttacaggtc
     1081 agtgggagag tggagtatgt gtttggcgat catccactaa ttcagttcca gtacatccgg
     1141 aattgtgtga tgaatagaac cctgccccac ttcatccttg tggaatgttg taagatcaag
     1201 aaaatgtatg aacaagaaat gattgccata gaggctgcca tcaaccgaaa ctcatccaac
     1261 cttcctctcc ctttaccacc aaagaaaacg cgagttattt ctcatatctg ggacaacaac
     1321 aaccctttcc aaattacctt ggttaaagga aataagctta atacagaaga aactgtgaaa
     1381 gttcatgtcc gagctgggct ttttcacgga accgagctcc tgtgtaaaac cgtcgtaagc
     1441 tcagagatat caggaaagaa cgaccatatt tggaatgaac aactggaatt tgatattaat
     1501 atttgtgact taccaagaat ggctcgatta tgttttgctg tttatgcagt tttggataaa
     1561 gtaaaaacga agaaatcaac aaagactatt aatccctcta agtatcagac catcaggaaa
     1621 gccgggaaag tgcattatcc tgtcgcatgg gtaaatacca tggtttttga cttcaaagga
     1681 cagctgaggt ctggagacgt catattgcat agctggtctt cgtttcctga tgagctggaa
     1741 gaaatgctga atcccatggg gactgtgcag acgaacccat atgctgagaa cgccaccgcc
     1801 ttgcacatta cgttcccaga gaataagaag cagccgtgtt attatccccc cttcgataag
     1861 atcattgaga aggcagctga gcttgccagc ggagacagtg ctaatgtgtc aagtcgtggt
     1921 ggaaaaaaat ttcttgctgt gctgaaagaa atcttggaca gggaccccct gtctcagctg
     1981 tgtgagaacg aaatggacct tatttggact ctacggcaag actgccgaga aaatttccct
     2041 cagtcactgc caaaactact cttgtcaatc aagtggaata aacttgaaga tgttgctcag
     2101 cttcaggcgc tcctgcagat atggcccaaa ctgcccccca gggaagccct ggaactcctg
     2161 gatttcaact atccagacca gtatgtccgg gaatacgctg taggctgcct tcgacagatg
     2221 agtgatgaag aactctctca gtatctttta caattggtgc aagttttgaa atatgagcct
     2281 tttctcgatt gtgccctctc cagattccta ttagaaagag cacttgataa tcggaggatt
     2341 gggcagtttc tgttttggca tcttaggtca gaggtgcaca ctcctgctgt gtccgtacag
     2401 tttggtgtca tcctggaagc atactgtcga ggaagcgtgg ggcacatgaa agtgctttcc
     2461 aaacaggtgg aagcactcaa taagttaaaa actttaaata gcttaatcaa actgaatgcg
     2521 gtgaagctga gcagagctaa gggaaaggag gccatgcaca cgtgcctgaa acagagtgct
     2581 taccgggagg cgctctctga cctgcagtcg ccgctgaacc cctgcgtcat cctctcagag
     2641 ctctatgttg aaaagtgcaa atacatggac tccaagatga agcccctgtg gctggtctac
     2701 agcagcagag cctttggaga ggactcggtt ggagtgatct ttaaaaatgg tgacgatttg
     2761 cggcaggaca tgctgacgct gcagatgttg cgcctgatgg atctgctttg gaaagaagct
     2821 ggcttggacc tgcggatgct cccctatggc tgcttagcaa caggagatcg ctctggcctc
     2881 attgaggttg tgagcacctc tgagacaatc gctgacattc agctgaacag tagtaacgtg
     2941 gctgccacgg cagccttcaa caaagacgca ctcctgaact ggctcaagga gtacaactct
     3001 ggggatgacc tggaccgagc gattgaggag tttaccttgt cctgtgctgg ctactgtgta
     3061 gcctcttatg tcctcggcat tggtgacagg cacagtgaca acatcatggt gaagaaaacc
     3121 ggccagctct tccacataga ttttgggcat attcttggaa atttcaaatc taaatttggc
     3181 attaaaaggg agcgagtacc ttttattctt acttatgact tcattcatgt cattcaacaa
     3241 ggaaaaacgg gaaacactga aaaatttggc agattccgcc agtgctgtga agatgcgtat
     3301 ctgattttac ggcggcatgg gaatctcttc atcaccctgt ttgccctgat gttgactgca
     3361 gggctgcctg agctcacatc ggtcaaagat atacagtatc ttaaggactc gcttgcctta
     3421 gggaagagcg aggaggaagc actgaagcag ttcaagcaga agtttgacga ggccctcagg
     3481 gaaagctgga ctactaaagt gaactggatg gctcacacag tacggaaaga ctacaggtcc
     3541 tagcgtccgc cctactctgc cgcacttgcc tgttcgtttc ctttccattt tgcacttgca
     3601 ctattgaaca tgaccctgcc agaaatgcaa agggaatgaa atcctgaagc tcagagtgaa
     3661 gttcaaacca cggcgtcccg cagagcctag tctgaaccac cccatgccca ccctgtgttc
     3721 ccgagcgctt ccaggactca tcgtgagcag cagcatggag gccccttcct gctgaccttg
     3781 cacgcgaggg atgctactag ggactgctgg ggatcttttc tttctttcct tcagtatttg
     3841 gtactttacc agagaggtgt acatacttct tttcagtgtt gtgaccaagt gctgcgactc
     3901 agccaacaac ttaccacatt cggggctggg agctgttcta agaaagggac ctccctctcc
     3961 tttttaaatt ggtgagccac aaattacatt gattatgttg aacttattat tcttcaaaga
     4021 aaatatttta aacctgtgaa aactcactaa ttttgttaat atttatcatg atggcatcat
     4081 ttcagccaga ctcgctgaga atctattggt ggggcaaata taatatatat ataatatata
     4141 tatatatata tgctgcatat atatttataa aatttctagt gggagttcta tataaaaaga
     4201 tgtttctttg gtattcttca gcctgtgttt tcaagtttta cagaagcaga gcttttccct
     4261 aagttcctct tcggttcact gtagatccag ttcttccagc cgcttcagca ctgaggcgcc
     4321 atgaatgcgg tttctctgtg tagctctgag agttcgtttc atagaacaca acacttgagc
     4381 agatgcatcc aaggaggcga gcaaatgaaa aggaatctat ttatggaata aactcgaaac
     4441 ctaaatttca gtattttagt aatatgccag ctgttcttaa tgtatttatt aaaatgtata
     4501 acaatgtgat ttttcaatgg tattagttca aattgacgtg gattcatgcc acatggaaat
     4561 ctttaattta tttgttgagg taccatatag ccagggtgct aggtgatgag tggtgttagc
     4621 atgtgcaata ggaactactg gtttgctgtg taaatggatg tcaggatcca gcaaaactac
     4681 tgctttcttc tccaaagaca tgtgggagcc ttcaatcctc agtggcatgg gaaacagctg
     4741 agtacttgcc ccgtgacttc agttttctat aggaatttta ttaaagagtg tttaattttg
     4801 ttgtccttct taatgttctc agtcaaataa atgggtggtt tcatctgttt gggg
//
