LOCUS       NM_001099276            7929 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Mus musculus phosphatidylinositol-4-phosphate 3-kinase catalytic
            subunit type 2 beta (Pik3c2b), mRNA.
ACCESSION   NM_001099276 XM_001479658 XM_914845
VERSION     NM_001099276.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7929)
  AUTHORS   Kobialka P, Llena J, Deleyto-Seldas N, Munar-Gelabert M, Dengra JA,
            Villacampa P, Albinya-Pedros A, Muixi L, Andrade J, van Splunder H,
            Angulo-Urarte A, Potente M, Grego-Bessa J, Castillo SD,
            Vanhaesebroeck B, Efeyan A and Graupera M.
  TITLE     PI3K-C2beta limits mTORC1 signaling and angiogenic growth
  JOURNAL   Sci Signal 16 (813), eadg1913 (2023)
   PUBMED   38015911
  REMARK    GeneRIF: PI3K-C2beta limits mTORC1 signaling and angiogenic growth.
REFERENCE   2  (bases 1 to 7929)
  AUTHORS   Goret M, Massana-Munoz X, Nattarayan V, Reiss D and Laporte J.
  TITLE     [PI3KC2beta: A promising therapeutic target in myotubular myopathy]
  JOURNAL   Med Sci (Paris) 39 Hors serie n degrees 1, 32-36 (2023)
   PUBMED   37975768
  REMARK    GeneRIF: [PI3KC2beta: A promising therapeutic target in myotubular
            myopathy].
REFERENCE   3  (bases 1 to 7929)
  AUTHORS   Massana-Munoz X, Goret M, Nattarayan V, Reiss D, Kretz C, Chicanne
            G, Payrastre B, Vanhaesebroeck B and Laporte J.
  TITLE     Inactivating the lipid kinase activity of PI3KC2beta is sufficient
            to rescue myotubular myopathy in mice
  JOURNAL   JCI Insight 8 (9), e151933 (2023)
   PUBMED   36943412
  REMARK    GeneRIF: Inactivating the lipid kinase activity of PI3KC2beta is
            sufficient to rescue myotubular myopathy in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7929)
  AUTHORS   Alliouachene S, Kieswich JE, Bilanges B, McCafferty K, Thiemermann
            C, Vanhaesebroeck B and Yaqoob MM.
  TITLE     Uninephrectomy and class II PI3K-C2beta inactivation
            synergistically protect against obesity, insulin resistance and
            liver steatosis in mice
  JOURNAL   Am J Transplant 21 (8), 2688-2697 (2021)
   PUBMED   33370494
  REMARK    GeneRIF: Uninephrectomy and class II PI3K-C2beta inactivation
            synergistically protect against obesity, insulin resistance and
            liver steatosis in mice.
REFERENCE   5  (bases 1 to 7929)
  AUTHORS   Anquetil T, Solinhac R, Jaffre A, Chicanne G, Viaud J, Darcourt J,
            Orset C, Geuss E, Kleinschnitz C, Vanhaesebroeck B, Vivien D, Hnia
            K, Larrue V, Payrastre B and Gratacap MP.
  TITLE     PI3KC2beta inactivation stabilizes VE-cadherin junctions and
            preserves vascular integrity
  JOURNAL   EMBO Rep 22 (6), e51299 (2021)
   PUBMED   33880878
REFERENCE   6  (bases 1 to 7929)
  AUTHORS   Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti
            S, Loda M, Roberts TM and Zhao JJ.
  TITLE     Essential roles of PI(3)K-p110beta in cell growth, metabolism and
            tumorigenesis
  JOURNAL   Nature 454 (7205), 776-779 (2008)
   PUBMED   18594509
  REMARK    Erratum:[Nature. 2016 May 12;533(7602):278. PMID: 26814969]
REFERENCE   7  (bases 1 to 7929)
  AUTHORS   Das M, Scappini E, Martin NP, Wong KA, Dunn S, Chen YJ, Miller SL,
            Domin J and O'Bryan JP.
  TITLE     Regulation of neuron survival through an
            intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway
  JOURNAL   Mol Cell Biol 27 (22), 7906-7917 (2007)
   PUBMED   17875942
REFERENCE   8  (bases 1 to 7929)
  AUTHORS   Lee AW and States DJ.
  TITLE     Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism
            for proliferation and survival in myeloid cells
  JOURNAL   Cell Death Differ 13 (11), 1900-1914 (2006)
   PUBMED   16514418
REFERENCE   9  (bases 1 to 7929)
  AUTHORS   Wheeler M and Domin J.
  TITLE     The N-terminus of phosphoinositide 3-kinase-C2beta regulates lipid
            kinase activity and binding to clathrin
  JOURNAL   J Cell Physiol 206 (3), 586-593 (2006)
   PUBMED   16222711
  REMARK    GeneRIF: Our findings demonstrate for the first time that the
            PI3K-C2beta isoform associates with clathrin and thus provides a
            link between receptor mediated intracellular signalling and
            clathrin coated vesicle transport.
REFERENCE   10 (bases 1 to 7929)
  AUTHORS   Harada K, Truong AB, Cai T and Khavari PA.
  TITLE     The class II phosphoinositide 3-kinase C2beta is not essential for
            epidermal differentiation
  JOURNAL   Mol Cell Biol 25 (24), 11122-11130 (2005)
   PUBMED   16314532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137948.12 and AC107842.13.
            
            On or before Sep 19, 2009 this sequence version replaced
            XM_914845.2, XM_001479658.1, NM_001099276.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments. The combination of the
            5' non-coding exon and alternatively spliced exons within the
            coding region is inferred based on available transcript data and
            further supported by similar exon-intron structure of the related
            human gene, GeneID 5287.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AC137948.12        24028-24439         c
            413-1430            AC137948.12        3222-4239           c
            1431-1531           AC137948.12        33-133              c
            1532-1686           AC107842.13        90793-90947
            1687-1807           AC107842.13        91221-91341
            1808-1919           AC107842.13        94130-94241
            1920-1999           AC107842.13        94398-94477
            2000-2063           AC107842.13        95430-95493
            2064-2210           AC107842.13        96945-97091
            2211-2244           AC107842.13        97838-97871
            2245-2440           AC107842.13        99263-99458
            2441-2563           AC107842.13        100580-100702
            2564-2731           AC107842.13        104437-104604
            2732-2843           AC107842.13        105120-105231
            2844-2986           AC107842.13        106556-106698
            2987-3175           AC107842.13        107807-107995
            3176-3269           AC107842.13        109585-109678
            3270-3364           AC107842.13        109790-109884
            3365-3545           AC107842.13        110300-110480
            3546-3653           AC107842.13        111180-111287
            3654-3746           AC107842.13        111891-111983
            3747-3876           AC107842.13        113275-113404
            3877-4013           AC107842.13        114317-114453
            4014-4183           AC107842.13        118250-118419
            4184-4340           AC107842.13        118772-118928
            4341-4450           AC107842.13        119224-119333
            4451-4652           AC107842.13        120344-120545
            4653-4777           AC107842.13        120949-121073
            4778-4895           AC107842.13        121899-122016
            4896-4977           AC107842.13        122972-123053
            4978-5084           AC107842.13        123420-123526
            5085-5213           AC107842.13        124606-124734
            5214-7929           AC107842.13        125592-128307
FEATURES             Location/Qualifiers
     source          1..7929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.75 cM"
     gene            1..7929
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /note="phosphatidylinositol-4-phosphate 3-kinase catalytic
                     subunit type 2 beta"
                     /db_xref="GeneID:240752"
                     /db_xref="MGI:MGI:2685045"
     exon            1..412
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            413..1430
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..5399
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /EC_number="2.7.1.154"
                     /note="phosphoinositide-3-kinase, class 2, beta
                     polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta"
                     /protein_id="NP_001092746.2"
                     /db_xref="CCDS:CCDS48360.1"
                     /db_xref="GeneID:240752"
                     /db_xref="MGI:MGI:2685045"
                     /translation="MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK
                     EESRAKQNTEPSLISWDEPALDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSISPPEGL
                     PNSTSQDPQPGPDPWPKGSLSGDYLYIFDGSEGRCSLSPGSGDTDGSCKKLSPPPLPP
                     RVSIWDAPPLPPRKGSPSPSKISQPNDINSFSSAEQPPDKLLVAQDPEEGELPDGRGQ
                     GHTLGSVDYDGINDAITRLNLKSTYDSEISSDATRGWKEGRGPLDFNKDTSGKPVARS
                     KTMPPQVPPRTYTSRYANRKNATPGNNRRISAAPVGSRPHTVANGHELFEVSEERDEE
                     VAAFCHMLDILRTGSDIQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTF
                     TCNCSSTVDLLIHQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR
                     KFDISIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFD
                     TYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQP
                     KIQKDPSVLSVRENREKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEAC
                     HFPGALAFTVYGTHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHL
                     IIWDQQICFPVQVNRLPRETLLCATLYALPVPPPGGSSEANKQKRVPEALGWVTTPLF
                     NFRQVLTCGRKLLGLWPATQENSGARWSAPNFHQPDSVILQIDFPSSAFDIKFTSPPG
                     DKFSPRYEFGSLREEDQRKLKDITQKESLYWLTDADKKQLWEKRYYCHTEVSSLPLVL
                     ASAPSWEWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAEL
                     LDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQY
                     LLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILRVGLEEVKQFFA
                     LNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLR
                     QDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGV
                     TGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKT
                     TGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQ
                     AYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIE
                     SSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFAPRTHTLKSSGRIRDVFLCRHEKIF
                     HPSKGYVYVVKVMRENAHEATYIQRTFEEFQELHNKLRLLFPSSFLPSFPSRFVIGRS
                     RGEAVAERRKEELNGYIWHLIHAAPEVAECDLVYTFFHPLPRDEKASGPSPAPKSSDG
                     TWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQPLQDGNDPDPYVKIYLLPDPQKT
                     TKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENLLLGEVHIRL
                     RELDLAQEKTGWFGLGSRGHGT"
     exon            1431..1531
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1686
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1807
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1919
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1999
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2063
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2210
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2244
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2440
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2563
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2731
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2843
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2986
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3175
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3269
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3364
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3545
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3653
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3746
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3876
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4013
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4014..4183
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4340
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4450
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4652
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4653..4777
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..4895
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..4977
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            4978..5084
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..5213
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..7929
                     /gene="Pik3c2b"
                     /gene_synonym="C330011J12Rik; Gm199; PI3K-C2beta;
                     PI3KC2beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactaggcga ttcggcgttg cggctgttgc cggcggcctg ggccgcggtc ctggcaggag
       61 ccggtgagcc tcgcgcgccg tgcagtgcgc cggctgtccg ggagatggct tctccccgct
      121 cgctcgccgt tcgcgctatt gtctcacccg gggctgcctg actgcgagct cgtgcacgct
      181 cccggcagac agcaccgggc ccgggcccgg cccccacgcc cgtcgcttgc ccgtgtgtct
      241 cctgctgcgg ggatcccagt gcccgcgcgg tgcgagcgaa gggagcaggc gacactgaac
      301 atcacgcggg ggctggagcc gcctggatct tccgagcgag ccgggtcggc ggagccctag
      361 acacccagcc acgacagtca gggtgtcgcg gcagaacccg cggccagcgc aggtcccaag
      421 acagcatgta cctgccctcc aggcctgaca ctggcaggaa gtagaaggct ctgtcatctc
      481 ctgtgccccc cgccctcatc atgtcttcca ctcagggcaa tggggagcac tggaagtccc
      541 tggagtcggt gggcatcagc cgcaaagagc tggctatggc cgaagccctg cagatggagt
      601 atgacgctct ttcccggctc cgacatcaca aggaggagag cagggccaag cagaacacag
      661 aaccctctct tatcagctgg gatgagccag ccttggactt ctacagcaag ccagcaggca
      721 ggcggaccga cctcaagctc ttgcgtggtc tttctggctc tgatcccacc ctaaattaca
      781 actccatctc cccaccagag gggctcccca actctacctc ccaggatcca cagcctggcc
      841 cagacccctg gcccaagggc tccctgtctg gagactatct ctatattttt gatggctcag
      901 aggggagatg ctctttgtct ccaggatcag gtgacacaga tggctcttgc aagaaactat
      961 ccccacctcc tctccctcct cgtgtctcta tctgggatgc ccctcccttg cctcctagaa
     1021 aaggatcacc ctcaccctcc aagatctctc agcctaatga catcaacagt ttctcttcgg
     1081 cagaacagcc acctgacaaa ctgctagtgg cccaggaccc agaagaggga gagctgcctg
     1141 atggcagggg acagggacac acgctggggt ctgtggacta cgatggcatc aatgatgcaa
     1201 ttaccaggct caacttgaag tccacctacg actcagagat atcgtctgat gctaccaggg
     1261 gctggaagga gggccgaggg cccctggact tcaacaagga cacctctggg aaacctgtgg
     1321 cccggagcaa gacgatgccc cctcaggtgc cccctcgaac ctatacttct cgatatgcca
     1381 accgaaaaaa tgcaacacct ggcaataacc gacggatttc tgctgctccg gtgggctctc
     1441 ggccccacac tgttgccaat ggccacgaat tgtttgaggt ctcagaggag agagatgagg
     1501 aagttgctgc gttctgccac atgctggata tccttcgaac gggctctgat atccaggact
     1561 attccctaac tgggtgtgtc tggagcactg tcaccccaag tccagaacac cttggggatg
     1621 aggtcaacct gaaggtgaca gtgttgtgtg acagtctccg ggagccactc acctttacct
     1681 gcaactgttc ctccaccgtg gacctgctca tccaccagac cctctgctac actcacgatg
     1741 agctgaggga agtggacgtg ggcgactttg tgctgaagcc ctgtgggctg gaggagttct
     1801 tgcaaaataa gcacgccctg ggaagccatg agtatatcca atattgccgc aagtttgata
     1861 tcagcatccg gctacagctg atggagcaga aggctatccg gagcgacctg gcccggacgg
     1921 tgaatgacga ccagagccct tccaccttga actacctcat ccatctccaa gagaggccag
     1981 tcaagcagac catcagcagg caggccttga gtcttctgtt tgacacttac cacaatgagg
     2041 tggacgcctt cctgctggct gatggggatt tcccactgaa ggctgacagg gtggtccagt
     2101 ctgtcaaggc catttgcaat gctctggctg ctgtggagac tcccgagatc acgagcgctc
     2161 tcaaccagct gcctccctgc ccctcgcgca tgcagccaaa aatccagaag gatcccagcg
     2221 tgttgagtgt gagggaaaac cgagagaagg tggtagaagc cttgacagcg gccatcttgg
     2281 acttggtgga gctgtactgc agcacattca atgcagactt ccagacggcg gtgcctggga
     2341 gccgaaagca tgatttggtt caagaggcct gccacttccc tggggccctg gccttcactg
     2401 tctatggcac tcaccgtatt cccatcatct gggctaccag ctatgaagat ttctacctct
     2461 cctgctccct cagccacggt ggcaaggaac tttgcagccc cctgcagacc cggcgggctc
     2521 acttctccaa gtacctgttc cacctcatca tctgggacca gcagatctgc tttccagtgc
     2581 aggtgaacag gctacctcgg gagactctgc tgtgtgccac actctatgcc ctgcccgttc
     2641 cccctcctgg gggttcctct gaagcgaata agcagaagcg ggtgcctgaa gctctgggtt
     2701 gggtcactac ccctctcttc aacttcaggc aagtcttgac ctgtggtcga aagctcctgg
     2761 gcttgtggcc agcgacacag gaaaactccg gtgcccgctg gagtgcgcct aatttccacc
     2821 agccagacag tgttatcctg cagattgact tccccagctc ggcctttgac atcaagttca
     2881 ccagcccccc tggagacaag ttcagccccc gctatgagtt tggcagtctc cgggaggagg
     2941 accagcgcaa acttaaagac attacgcaga aggagtccct atactggctc acggatgctg
     3001 acaagaagca gctgtgggag aaacgctatt actgccacac tgaggtgagc tcactccccc
     3061 tggttctcgc cagtgcaccc agctgggagt gggcttgcct gccggacatc tatgctctcc
     3121 tgcaacagtg gactcacatg aaccaccaag atgccctggg actcctgcat gccaccttcc
     3181 cggaccagga ggtgcggcgg atggccgtgc agtggatcgg ctccctctca gatgcggagc
     3241 tgctggacta cctgccccag ctagtccagg ccctgaagta tgagtgctac ctggatagcc
     3301 ccttggtgcg ctttctcctg aaacgagcca tctctgacct gcgagtgacc cactacttct
     3361 tctggttact gaaggacagc ctcaaggact ctcagttcag tatccgctac caatacctgc
     3421 tagcagccct gctgtgctgc tgtggcaagg gactgaggga ggagtttaac cgccagtgct
     3481 ggcttgtcaa caccctggcc aaactggccc agcaggtccg agaggccacc ccatccgccc
     3541 gccagggcat ccttcgtgtg ggcttggagg aggtgaagca gttctttgcc ctcaatggtt
     3601 cgtgccgtct gccgctcagt cccagtctcc tggtgaaggg catcgtgccc agggactgct
     3661 cctacttcaa ttccaacgca gtgcccctga agcttgcctt ccaaaatgtg gatccgctgg
     3721 gcgagaacat cagagtcatc tttaagtgtg gggatgatct tcgtcaggac atgctcaccc
     3781 tgcagatgat tcgcatcatg agcaagatct gggtacagga ggggctggac atgcgcatgg
     3841 tcatcttccg ctgcttctcc actggccgag gaaaagggat ggtagagatg atacccaatg
     3901 cagagacact gcgcaagatc caggtggaac atggggtgac tggctccttc aaggaccgtc
     3961 ccctggccga ctggctacaa aaacacaacc ctggggagga tgaatatgaa aaggctgtgg
     4021 agaacttcat ctactcttgt gctggctgct gtgtagctac atacatcttg ggcatctgtg
     4081 acagacacaa tgacaacatc atgctaaaga ccacgggcca catgttccat atagatttcg
     4141 gccgcttcct gggtcacgca cagatgtttg gtaacatcaa gagggaccgt gccccgtttg
     4201 tcttcacctc agacatggcg tatgtcatca atgggggtga caagccttcc agccgcttcc
     4261 atgattttgt tgacctttgc tgccaagcct acaacctcat tcgcaagcac acccacctct
     4321 tcctcaacct tctgggcctg atgctgtcct gtggaatccc cgagctctca gacctggagg
     4381 acctcaagta tgtgtatgat gccctgagac ctcaggacac agaggccaat gccaccacct
     4441 acttcacaag gttgattgag tccagcctgg gcagcgtagc cacgaaactc aactttttca
     4501 tccataacct ggctcagatg aagttcacag gctcagatga ccggctgacc ctctccttcg
     4561 ctccccggac acacactctc aagagctctg gccgcatccg agatgtcttc ctctgccgac
     4621 atgagaagat cttccacccc agcaagggct atgtatatgt ggtgaaggtg atgcgagaga
     4681 atgctcacga ggcgacatac atccagagga cattcgagga gttccaggaa ctgcacaata
     4741 agctgcgcct gctcttccct tcttccttcc tgcccagctt ccctagccgg tttgtgattg
     4801 gccgctcccg gggagaggca gtggctgaga ggaggaagga ggagttaaat ggctacatct
     4861 ggcacctgat tcatgcagcc cctgaggtgg ctgagtgtga tctggtgtat actttcttcc
     4921 accccctgcc ccgagatgag aaggcttcag gccccagccc agctccgaag tcctcagatg
     4981 ggacgtgggc ccggccggtt gggaaggtcg gtggggaggt gaagctgtct atctcctaca
     5041 aaaacaacaa actcttcatc atggtgatgc atattcgggg cttgcaaccg ctccaggatg
     5101 gcaatgaccc tgacccctat gtaaagattt acctccttcc tgaccctcag aaaaccacaa
     5161 agaggaaaac caaggtggcc cggaaaacct gcaaccctac ctacaatgag atgctggtat
     5221 atgatgggat ccccaaggga gacctgcagc agcgggagct acagttgagt gtgctgagtg
     5281 agcaaggatt ttgggagaat ctgcttctcg gggaggtgca catccgcctt cgggagctgg
     5341 acctggccca ggagaagacc ggctggtttg gactgggttc tcgaggtcat ggaacctaat
     5401 gaacccactc ctggcccaga cctgcggctg cggcccagag ctggaagaga agcctctacc
     5461 ccacctaact cctttgctag gaaggagcag aaccctcggt ggccttcccc acgcacggtc
     5521 catgtggacc tgacctccgt gagggggctg gaagagtcaa gcgctatcca ctgccccttc
     5581 ctccgcaggc tgcactgggg tgggttgtgc tgaacagccc ccctctcctg cccccagaag
     5641 ctgtgggctt gcagcagagt tttatgttta ccttgtgtca agggagcaat gcctgctttg
     5701 gggtatgtgg agtgcgggct atatgaagta gcacttagaa agggagggtg ggtggatatt
     5761 ttatttttat ttttaaaaaa tgaaatagta atgttgtcct aactgggaca ggaagctttg
     5821 tgtgagaggg gcctgccatg cctgggaagg caaaagagaa agactatttg gtttttgggt
     5881 tttgtttttt ttgttttggt ttggtttggt ttggtttttt gtatgatgag agttcttatt
     5941 ggactttttc tccaggattt ttgggggttt gttttctagc tataggaaat atcggggagg
     6001 gccccggtgg gtcctcaata aagccctccc tctctcgggc atactgggga ggggtgggga
     6061 ggactaactg acagccggac tgacgcccac tctgggccat ctgattttgc ctccaaagga
     6121 gggcatcgtg aaaactacat gtgtaaggaa gggccttcca ttgtagagtt ccgccaagga
     6181 cctagattca gggacctgtg ctctttaggg caaagtgttt cctctcctct tccccctctg
     6241 cttggactca gctcaggcgc cttcctgtcc cctctacccc tgtgttctct cggcccgcta
     6301 tgggtcaccc cgtcctggag aatgcactgg ggtgcttctg tgccccatct tgtttgatgg
     6361 gataaaatgc tgctacccct cagctctagc cacgcctgta gggcaggcac gtcgtgccat
     6421 ttgctgcagc ttctgggaaa tgtcccctga gaccgtctac tactttctct tcaaaccctg
     6481 tttctgtcac actttaaaaa gagcttcatt ctgtagggtc acaaagctgt atagggcata
     6541 gacaaagaga tgcccaaccc atagcagagt gggctggagt gagccctggt caatgcagtt
     6601 gtttcttctg gatattttcc tggctggatt ggagcagctt cctctttgga aaacaaacaa
     6661 aagattattt caacctcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     6721 ctttctttct ttctttcttt ctttcttcct tccttccttc cttccttcct tccttccttc
     6781 cttccttcct tccttccctc cttccttccc tcaagacagg gtttctctgt gtagccctgg
     6841 ctgccttgga acatagaggt ccatctgcct ctgcctccca agtgttggga ttaaagacat
     6901 ttgccgccac catctcctgg cttatttggc ttccttatgt ggtgctaggg atcaaaccca
     6961 ggaccctttg agtgccaggc aagccctgca ccgcaccacc aagcttcgtc tccagtccac
     7021 cttgcgttct tcctttctca cccttctctc tcttgggttt ccaaagagtt gtctcgtctt
     7081 aaaggtaaca gctagggact ctgtttaact ttttatgttt ttttttttaa gacagtgtct
     7141 cactatgtag agcaggctgg ccttgaactc atagaactct gcctgcctct gcctctatac
     7201 gggaactaac ttttaaatga agagttagca aggacaaggc aaatagtttc tctgtgaccc
     7261 catttctgga gagagaaaag ctccattgaa gccacatgga aacaagaaag gtgtttgttt
     7321 tgttgttgtt tattttgctt ctggttttta attttttttt tttttttttt ttatgagaga
     7381 gggtatcata tagcccaggt tggcctcaaa ctcctatgta gataaggata gtcttaagct
     7441 cctgacctac ttgcctttcc aactcacagg tgctaagatt acagacatga gctgccccat
     7501 ccattttctc cttaatttaa aatgacaggc cagtgaggtg gctcaggact tgcctggtca
     7561 acttaagttt gatcactgag acctttaagg tggcgggagg caaccaactc ctacaagtta
     7621 gttttttttt tttttttgtc cttcatatgc actacacaac atgtgcacac acatacacac
     7681 agataacata attttaaaat gccaaggata aagcagcctg atgaaggcag gagagtagag
     7741 cgggaaagca atggaacctt ccagatgttt ggaccataga cgagctgctg gctttttgcc
     7801 tgcagctcat tttcttttga ccctttatgt ctgacttaaa gaggtctatg tactgtaccc
     7861 acttcccaca ctcctttatc ttctactttc tctggaattg tattttttaa taaacgacat
     7921 ttgagaaac
//
