LOCUS       NM_031376               4113 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phosphoinositide-3-kinase adaptor protein 1 (Pik3ap1),
            mRNA.
ACCESSION   NM_031376
VERSION     NM_031376.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Irizarry-Caro,R.A., McDaniel,M.M., Overcast,G.R., Jain,V.G.,
            Troutman,T.D. and Pasare,C.
  TITLE     TLR signaling adapter BCAP regulates inflammatory to reparatory
            macrophage transition by promoting histone lactylation
  JOURNAL   Proc Natl Acad Sci U S A 117 (48), 30628-30638 (2020)
   PUBMED   33199625
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Miao,Y., Jiang,M., Qi,L., Yang,D., Xiao,W. and Fang,F.
  TITLE     BCAP Regulates Dendritic Cell Maturation Through the
            Dual-Regulation of NF-kappaB and PI3K/AKT Signaling During
            Infection
  JOURNAL   Front Immunol 11, 250 (2020)
   PUBMED   32133012
  REMARK    GeneRIF: BCAP Regulates Dendritic Cell Maturation Through the
            Dual-Regulation of NF-kappaB and PI3K/AKT Signaling During
            Infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Carpentier,S.J., Ni,M., Duggan,J.M., James,R.G., Cookson,B.T. and
            Hamerman,J.A.
  TITLE     The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome
            activation in macrophages through interactions with Flightless-1
  JOURNAL   Sci Signal 12 (581) (2019)
   PUBMED   31088976
  REMARK    GeneRIF: B-cell phosphoinositide 3-kinase adapter protein 1 (BCAP)
            delayed the recruitment and activation of pro-caspase-1 within the
            NLRP3/ASC preinflammasome through its association with
            Flightless-1, suggesting BCAP is a multifunctional signaling
            adaptor that inhibits key pathogen-sensing pathways in macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Chu,T., Ni,M., Chen,C., Akilesh,S. and Hamerman,J.A.
  TITLE     Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated
            Type I IFN Induction in Plasmacytoid Dendritic Cells
  JOURNAL   J Immunol 202 (9), 2529-2534 (2019)
   PUBMED   30936294
  REMARK    GeneRIF: a novel role for BCAP in promoting TLR-induced IFN-alpha
            production in pDC and in systemic lupus erythematosus pathogenesis.
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Yamazaki,T. and Kurosaki,T.
  TITLE     Contribution of BCAP to maintenance of mature B cells through c-Rel
  JOURNAL   Nat Immunol 4 (8), 780-786 (2003)
   PUBMED   12833156
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Yamazaki,T. and Kurosaki,T.
  TITLE     [Immunoregulatory role for BCAP in B cell development and function]
  JOURNAL   Tanpakushitsu Kakusan Koso 47 (16 Suppl), 2242-2247 (2002)
   PUBMED   12518443
  REMARK    GeneRIF: plays an immunoregulatory role in B cell development and
            function--review
            Review article
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Yamazaki,T., Takeda,K., Gotoh,K., Takeshima,H., Akira,S. and
            Kurosaki,T.
  TITLE     Essential immunoregulatory role for BCAP in B cell development and
            function
  JOURNAL   J Exp Med 195 (5), 535-545 (2002)
   PUBMED   11877477
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Okada,T., Maeda,A., Iwamatsu,A., Gotoh,K. and Kurosaki,T.
  TITLE     BCAP: the tyrosine kinase substrate that connects B cell receptor
            to phosphoinositide 3-kinase activation
  JOURNAL   Immunity 13 (6), 817-827 (2000)
   PUBMED   11163197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112271.4 and AC133099.3.
            
            On Feb 7, 2019 this sequence version replaced NM_031376.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171021.1, AK154326.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC112271.4         157027-157172
            147-566             AC112271.4         165864-166283
            567-703             AC133099.3         181305-181441       c
            704-848             AC133099.3         178296-178440       c
            849-991             AC133099.3         177188-177330       c
            992-1124            AC133099.3         176927-177059       c
            1125-1321           AC133099.3         173581-173777       c
            1322-1511           AC133099.3         170598-170787       c
            1512-1607           AC133099.3         157532-157627       c
            1608-1802           AC133099.3         151519-151713       c
            1803-1868           AC133099.3         147308-147373       c
            1869-2074           AC133099.3         145400-145605       c
            2075-2147           AC133099.3         141849-141921       c
            2148-2303           AC133099.3         136566-136721       c
            2304-2374           AC133099.3         132176-132246       c
            2375-2511           AC133099.3         130967-131103       c
            2512-4113           AC133099.3         121848-123449       c
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.61 cM"
     gene            1..4113
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /note="phosphoinositide-3-kinase adaptor protein 1"
                     /db_xref="GeneID:83490"
                     /db_xref="MGI:MGI:1933177"
     exon            1..146
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2569
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /note="B-cell adapter for phosphoinositide 3-kinase;
                     B-cell phosphoinositide 3-kinase adapter protein 1; B cell
                     phosphoinositide 3-kinase adaptor"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase adapter protein 1"
                     /protein_id="NP_113553.1"
                     /db_xref="CCDS:CCDS37987.1"
                     /db_xref="GeneID:83490"
                     /db_xref="MGI:MGI:1933177"
                     /translation="MAASGWGRGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKTQT
                     YRLVPDASFSAQDLWVFRDARCVLVLLSAGLVGCFGQPGLLPMLQRACHPPQRVVRLL
                     CGVQPGDEDFQAFFPDWAHWQEMTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDER
                     ELPFSKQTNLPPEISPGNLMVVQPDRIRCGAETTVYIIVRCKLDEKVSTEAEFSPEDS
                     PSIRVEGTLENEYTVSVKAPDLSSGNVSLKVYSGDLVVCETTVSYYTDMEEIGNLLSS
                     AANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEDDMMTNQRD
                     EELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFI
                     DEYVETVDMLKTHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDDELYESMAA
                     FAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEGNSVKPASWEREQHHPY
                     GEELYHIVDEDETFSVDLANRPPVPVPRPEASAPGPPPPPDNEPYISKVFAEKSQERL
                     GNFYVSSESIRKEPLVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDE
                     AVLHFKEWQLNQKKRSESFRFQQENLKRLRESITRRRKEKPKSGKHTDLEITVPIRHS
                     QHLPEKVEFGVYESGPRKSVLPARTELRRGDWKTDSMSSTASSTSNRSSTRSLLSVSS
                     GMEGDNEDNEIPEITRSRGPGPTQVDGAPVVTGTPVGTLERPPRVPPRAASQRPLTRE
                     SFHPPPPVPPRGR"
     exon            147..566
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            567..703
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            704..848
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            849..991
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1124
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1321
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1511
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1607
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1802
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1868
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2074
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2147
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2303
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2374
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2511
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..4113
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4090..4095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /note="hexamer: ATTAAA"
     polyA_site      4113
                     /gene="Pik3ap1"
                     /gene_synonym="1810044J04Rik; BCAP"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgcca ctgtcctgag cacagctgga ctctgcttct aaccccgcgc cagcgacgtc
       61 gcctaccgcg gctgtgggca ccggataccg tgctccggtg ccagccgggg atgcgagctg
      121 ctcccgggac ggcatggcag cctcagggtg gggccgggga tgcgacatcc tcatcttcta
      181 cagcccagat gcggaggaat ggtgtcagta cctacaggat cttttcgtgt cctgccggca
      241 ggttcgtagc cagaagacgc agacataccg gctggtcccg gatgcctctt tctctgccca
      301 ggacctgtgg gtcttcaggg atgcgcgatg cgtgctggtg ctactgtcgg cggggctggt
      361 aggatgcttc ggccagccag gactgctgcc aatgctgcag cgtgcctgcc atccgccgca
      421 gcgtgtggtg cggctgttgt gtggagtgca gccaggcgac gaggacttcc aggccttctt
      481 tcctgactgg gcccactggc aggaaatgac ttgtgatgat gagccagaga cctacctggc
      541 ggctgtgagg aaggccattt ctgaagattc tggctgtgac tcagtaaccg acacggagcc
      601 cgaggacgag agagagcttc ctttctcaaa gcagacaaac ctgcctccgg agatatcgcc
      661 tgggaacctg atggtggtac agccggaccg cattcgctgt ggggcagaaa ccactgtgta
      721 tatcattgtg agatgcaagc tggacgagaa ggtatcaaca gaagcagagt tctctcctga
      781 ggattctccc tccatccggg tggaaggcac actggagaat gagtacacgg tctctgtgaa
      841 agcaccagac ctctcctcgg ggaatgtttc tctgaaggtc tattctgggg acctggtggt
      901 ctgcgaaacc accgtcagct attataccga catggaggaa attgggaact tactgtcgag
      961 tgctgcaaat cctgtggagt ttatgtgtca ggcctttaaa atcgtgccct acaacacaga
     1021 gactctcgat aaactgctca ccgagtccct gaagaacaac atccccgcaa gtggactgca
     1081 cctctttggg atcaaccaac tggaagaaga cgatatgatg acaaatcaga gggacgaaga
     1141 gctgcccacg ctgttgcatt ttgctgccaa gtatggactg aagaacctca ctgccttgct
     1201 gctcacctgt ccaggggctc tccaggccta cagtgtagcc aacaagcacg gccactatcc
     1261 caacaccatt gccgagaaac acggcttcag ggacctgcgc cagttcatcg acgagtatgt
     1321 ggagacggtg gacatgctga agacacacat taaggaggag ttgatgcaag gggaggaggc
     1381 ggacgatgtg tacgagtcca tggcccacct atccacagac ctgctgatga agtgctccct
     1441 caaccctggc tgtgacgatg agctctacga gtccatggct gccttcgccc cagcagccac
     1501 agaagacctc tatgttgaaa tgcttcaggc cagtgcaggt aacccagtct cgggagaaag
     1561 tttctctcgg cccactaaag actcgatgat ccgcaagttt ctagaaggta acagtgtgaa
     1621 accggccagt tgggagagag aacaacacca tccctatggg gaggaacttt atcacattgt
     1681 ggatgaagat gagaccttct ctgtggacct agccaacagg ccccctgtcc ctgtgcccag
     1741 gccagaggcc agcgctcctg gccctccccc accgcctgac aatgagccat acatttctaa
     1801 agtttttgca gaaaaaagtc aggagcggct cgggaatttc tacgtttctt ctgagagcat
     1861 cagaaaagag ccacttgtga ggccatggag ggacaggccg ccatcgagca tctacgaccc
     1921 atttgctgga atgaagaccc cgggccagcg gcagctcatc accctgcagg agcaggtgaa
     1981 gctgggcatc gtcaacgtgg acgaggccgt gctgcatttc aaagagtggc aactcaatca
     2041 gaagaagcga tccgagtcct tccgcttcca gcaggaaaat cttaaaagac taagagagag
     2101 catcacccga agacggaaag agaagccaaa gtctgggaag cacacagacc tggagatcac
     2161 agtcccaatc cgacattcac agcacctgcc agagaaagtg gagtttggcg tgtatgagag
     2221 cggccccagg aagagtgtct tgccggccag gacagagctg agacgtgggg actggaaaac
     2281 ggacagcatg tccagcacag caagcagcac gagtaaccgg tcgagcacac ggagcctcct
     2341 cagtgtgagc agtggaatgg agggcgacaa cgaggacaac gaaatccccg aaattacccg
     2401 gagtcgtggc ccaggtccta cgcaggtgga cggagctcca gttgtgaccg gaacaccagt
     2461 cgggaccctt gagagacccc ctagggtgcc tcctcgagcc gcttctcaga ggcctctaac
     2521 ccgggagtcc ttccatcctc ctccgccggt tccacccaga ggtcgctgat cccgcctcct
     2581 atatctggcc aacttcagga cttttcagac tagcaattct cagcctgttg atgaagtctt
     2641 catattgagt tttctgcatg actatggacc ttgagagcca ctgtcactgg tgatggtgta
     2701 gccctgctgg tttgggtaat ccttgaagac atcattaagg catgatgaaa cctgagatga
     2761 aggcgtcttt gttcaacgtt gccgaatata ttggctcaca ttctagtttg ccaaaaggat
     2821 gaagatactt acctctcgta tcctacagca ggagactacc aggattgatg ggcatgttct
     2881 tatcaagtga gcctactgta gtcaacatcc attatcccat acatacctgg cagagcagcc
     2941 taatctctgg aagtggttat aaccctccca gcagaggtag gaagggacct aactttcaag
     3001 tagttcttcc acatttctat gtttgtcctg gggctggtca catacaacaa gctgaaaaac
     3061 atcttagaag gggttaagcc agactcctgt gccactgtgg catttggagt cccccagacg
     3121 tgtggaacag gtggttctgt catcaccctc tttctcttga gtatgtacgt gtgtggtgtg
     3181 catgtgcagg tgtctgtctg tctgtgggca tatgtatgca cctctgtatg gagattagaa
     3241 gcaatgttgg aagtctctgt cactctccct ctatttactg aggcagagat tactggtaca
     3301 atcagtctag cttgctccag ggatctcctg gctcccgcag ccaggttacc atggcccctt
     3361 ggtatctgtg ggatgctggg gatccgaatc ctggccctca tgcttggaca gcaagcactt
     3421 tatctactga tccatctccc cagcccctgt cagcacactt tgtgtctcta agaagtccaa
     3481 tccttccacg gctcaccctc tcttaagaac tctccaaatg tagaaataga gagccatacc
     3541 tcactgtctg ccttccagac atttcccttt tctgaatcac ccaggtatgg gactatcagc
     3601 tgccgccttc actttgggct ttcatacctc tgtatgctgt ccaactagct gtgttatagg
     3661 aaaccactga aaatgatcag aaccagacta tggtctggcc tttatatgtc ttagttctgg
     3721 ccattaaaga aggagaagga cccttgattt ttctttccct cctgaggagc ctgaaggagt
     3781 agagaaagaa gctaaaatgt tttctcccaa taataataca actgctacta cagaccgtta
     3841 caatcaaatc tggtaaatat gtatagagag tatagacctg tcaccatgtt atgaattttg
     3901 agttcctgtt atataaacct accttcagag catagatcct taattttacc tatgtataca
     3961 gtaaggttat caggaggggt ccttttaaaa tataagtaat atggttgttt ctcatgaaac
     4021 cattgtccat tcccatatat atacatattg atctgtttaa gtgtattctt actgggccct
     4081 tttctcataa ttaaagattc cccttcattc tca
//
