LOCUS       NM_001004721            1621 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphatidylinositol glycan anchor biosynthesis, class
            U (Pigu), mRNA.
ACCESSION   NM_001004721 XM_130696
VERSION     NM_001004721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Lukacs,M., Roberts,T., Chatuverdi,P. and Stottmann,R.W.
  TITLE     Glycosylphosphatidylinositol biosynthesis and remodeling are
            required for neural tube closure, heart development, and cranial
            neural crest cell survival
  JOURNAL   Elife 8, e45248 (2019)
   PUBMED   31232685
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Guo,Z., Linn,J.F., Wu,G., Anzick,S.L., Eisenberger,C.F.,
            Halachmi,S., Cohen,Y., Fomenkov,A., Hoque,M.O., Okami,K.,
            Steiner,G., Engles,J.M., Osada,M., Moon,C., Ratovitski,E.,
            Trent,J.M., Meltzer,P.S., Westra,W.H., Kiemeney,L.A.,
            Schoenberg,M.P., Sidransky,D. and Trink,B.
  TITLE     CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder
            cancer
  JOURNAL   Nat Med 10 (4), 374-381 (2004)
   PUBMED   15034568
  REMARK    Erratum:[Nat Med. 2004 Oct;10(10):1139]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB839941.1, CK334159.1, AW046539.1, BE646884.1 and AW538039.2.
            
            On Sep 27, 2004 this sequence version replaced XM_130696.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143517.1, AK171988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB839941.1         1-47
            48-706              CK334159.1         1-659
            707-1031            AW046539.1         188-512
            1032-1039           BE646884.1         361-368             c
            1040-1621           AW538039.2         1-582               c
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.18 cM"
     gene            1..1621
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class U"
                     /db_xref="GeneID:228812"
                     /db_xref="MGI:MGI:3039607"
     exon            1..159
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1337
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /note="cell division cycle 91-like 1;
                     phosphatidylinositol-glycan biosynthesis, class U protein;
                     protein CDC91-like 1; GPI transamidase component PIG-U;
                     cell division cycle protein 91-like 1; CDC91 cell division
                     cycle 91-like 1"
                     /codon_start=1
                     /product="phosphatidylinositol glycan anchor biosynthesis
                     class U protein"
                     /protein_id="NP_001004721.1"
                     /db_xref="CCDS:CCDS16946.1"
                     /db_xref="GeneID:228812"
                     /db_xref="MGI:MGI:3039607"
                     /translation="MAAPLALVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRV
                     VEGLALLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDF
                     NKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTC
                     AINNTLIAFFILTTIKGSVFLSAVFLALATYQSLYPVTLFAPGLLYLLQRQYIPVKVK
                     SKAFWIFSWEYAMMYTGSLVVIVCLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWY
                     FFAEMFEHFSLFFVCVFQINVFFYTVPLAIKLKEHPIFFMFIQIAIISIFKSYPTVGD
                     VALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITL
                     TFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK"
     exon            160..224
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..284
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..347
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..457
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..558
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..656
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..811
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..955
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1080
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1223
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1621
                     /gene="Pigu"
                     /gene_synonym="5430426F17Rik; Cdc91l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcctg cgcgcccgcc tcagttatca tggcggctcc cttggccctg gtgcttgtgg
       61 tggccgtgac cgtgagggcg gccttgtttc gctccagttt ggccgagttc atttccgaga
      121 gggtggaggt ggtgtcccca ctgagctctt ggaagagagt ggttgaaggc cttgcactgt
      181 tggatctggg agtgtctcca tattctggag cagtatttca cgaaactcca ttaataatat
      241 acctctttca tttcctaatt gactatgcag aattggtatt tatgataaca gatgccctca
      301 ctgctattgc cctgtatttt gcaattcagg acttcaataa agttgtgttt aaaaagcaga
      361 agcttctcct agagctggac cagtatgctc cagatgtggc tgaactcatc cgaaccccca
      421 tggaaatgcg ctacatccct ctgaaagtgg ccctgttcta tctcctaaat ccctacacga
      481 tcttgtcttg tgttgccaag tctacctgcg ccatcaacaa caccctcatt gctttcttca
      541 ttttgaccac aataaaaggc agcgttttcc tcagtgctgt ttttcttgcc ttagcaacat
      601 accagtctct gtacccagtc accctgtttg ccccaggact tctctatctc ctccagcggc
      661 agtacatccc tgttaaagtg aagagcaaag ccttctggat cttctcgtgg gagtacgcca
      721 tgatgtacac aggaagcctg gtggtgatag tttgcctctc tttcttcctt ctcagctcct
      781 gggacttcat ccctgcagtc tatggtttca tactctctgt tccagatctc actccaaaca
      841 ttggtctttt ctggtacttc tttgcagaga tgtttgagca cttcagcctc ttttttgtct
      901 gcgtgtttca gatcaacgtc ttcttctaca cagttccatt agccatcaaa ttaaaggagc
      961 atcccatctt cttcatgttc attcagattg ccatcatctc tatcttcaag tcctatccaa
     1021 ctgtggggga tgtggccctc tacatggctt tcttccctgt gtggaaccat ctctacagat
     1081 tcctgcggaa catcttcgtc ctcacctgca tcatcatcgt ctgctctctt ctcttccctg
     1141 tcctgtggca cctatggatt tatgcaggaa gtgccaactc taatttcttt tatgccatca
     1201 cactgacctt caatgttggg cagatcctgc tcatctctga ctacttctat gccttcctgc
     1261 ggcgggagta ttacctcaca cacggcctct acttgactgc caaggacggc actgaggcca
     1321 tgcttgtgct caagtagccc tggctggcac agcgctgcat ggacaagagg gggaagggcc
     1381 agaagctggg ccaggtccct catccagagt tgccagcagg cgcgtcctca ggcagaagaa
     1441 gttcaagtcc agggtcacaa atctctggca ccaaagggga ctcatagctg gcaacaaggc
     1501 ccatggggag aagctaggag caccccactt ggacccccac tttgtgactg tgcacagaaa
     1561 ggaagcagcc ggtgagcagg gctttatagg ttgtgactac ttaataaatg tgtggatctt
     1621 t
//
